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Select item 110616061.

Jak2^V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms

Andrew J. Dunbar, Robert L. Bowman, Young C. Park, Kavi O'Connor, Franco Izzo, Robert M. Myers, Abdul Karzai, Zachary Zaroogian, Won Jun Kim, Inés Fernández-Maestre, Michael R. Waarts, Abbas Nazir, Wenbin Xiao, Tamara Codilupi, Max Brodsky, Mirko Farina, Louise Cai, Sheng F. Cai, Benjamin Wang, Wenbin An, Julie L. Yang, Shoron Mowla, Shira E. Eisman, Amritha Varshini Hanasoge Somasundara, Jacob L. Glass, Tanmay Mishra, Remie Houston, Emily Guzzardi, Anthony R. Martinez Benitez, Aaron D. Viny, Richard P. Koche, Sara C. Meyer, Dan A. Landau, Ross L. Levine

Cancer Discov. 2024 May 1; 14(5): 737–751. Published online 2024 Jan 12. doi: 10.1158/2159-8290.CD-22-0952

PMCID:: PMC11061606

Abstract Article PDF–20M

Select item 99921332.

Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms

Lindsay M. Gurska, Rachel Okabe, Alexandra Schurer, Meng Maxine Tong, Mark Soto, Daniel Choi, Kristina Ames, Shira Glushakow-Smith, Allison Montoya, Ellen Tein, Linde A. Miles, Haiying Cheng, Pamela Hankey-Giblin, Ross L. Levine, Swati Goel, Balazs Halmos, Kira Gritsman

Clin Cancer Res. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Clin Cancer Res. 2023 Mar 1; 29(5): 943–956. doi: 10.1158/1078-0432.CCR-22-1763

PMCID:: PMC9992133

Abstract Article PDF–1.6M

Select item 96337553.

JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Rida Al-Rifai, Marie Vandestienne, Jean-Rémi Lavillegrand, Tristan Mirault, Julie Cornebise, Johanne Poisson, Ludivine Laurans, Bruno Esposito, Chloé James, Olivier Mansier, Pierre Hirsch, Fabrizia Favale, Rayan Braik, Camille Knosp, Jose Vilar, Giuseppe Rizzo, Alma Zernecke, Antoine-Emmanuel Saliba, Alain Tedgui, Maxime Lacroix, Lionel Arrive, Ziad Mallat, Soraya Taleb, Marc Diedisheim, Clément Cochain, Pierre-Emmanuel Rautou, Hafid Ait-Oufella

Nat Commun. 2022; 13: 6592. Published online 2022 Nov 3. doi: 10.1038/s41467-022-34469-1

Correction in:: Nat Commun. 2022; 13: 7921.

PMCID:: PMC9633755

Abstract Article PDF–3.8M

Select item 95391294.

Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms

Amanda Fernandes de Oliveira Costa, Leticia Olops Marani, Thiago Mantello Bianco, Adriana Queiroz Arantes, Izabela Aparecida Lopes, Diego Antonio Pereira-Martins, Leonardo Carvalho Palma, Priscila Santos Scheucher, Josiane Lilian dos Santos Schiavinato, Larissa Sarri Binelli, Cleide Araújo Silva, Susumu S. Kobayashi, João Agostinho Machado-Neto, Eduardo Magalhães Rego, Robert Samuel Welner, Lorena Lobo de Figueiredo-Pontes

Front Immunol. 2022; 13: 768592. Published online 2022 Sep 23. doi: 10.3389/fimmu.2022.768592

PMCID:: PMC9539129

Abstract Article PDF–2.6M

Select item 94707025.

Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm

Mohammed Ferdous-Ur Rahman, Yue Yang, Bao T. Le, Avik Dutta, Julia Posyniak, Patrick Faughnan, Mohammad A. Sayem, Nadine S. Aguilera, Golam Mohi

Nat Commun. 2022; 13: 5347. Published online 2022 Sep 13. doi: 10.1038/s41467-022-32928-3

PMCID:: PMC9470702

Abstract Article PDF–3.9M

Select item 87505126.

Altered Ca²⁺ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

Ralfs Buks, Tracy Dagher, Maria Giustina Rotordam, David Monedero Alonso, Sylvie Cochet, Emilie-Fleur Gautier, Philippe Chafey, Bruno Cassinat, Jean-Jacques Kiladjian, Nadine Becker, Isabelle Plo, Stéphane Egée, Wassim El Nemer

Cells. 2022 Jan; 11(1): 49. Published online 2021 Dec 24. doi: 10.3390/cells11010049

PMCID:: PMC8750512

Abstract Article PDF–2.8M

Select item 87285387.

Depletion of Janus kinase-2 promotes neuronal differentiation of mouse embryonic stem cells

Mihee Oh, Sun Young Kim, Jeong-Su Byun, Seonha Lee, Won-Kon Kim, Kyoung-Jin Oh, Eun-Woo Lee, Kwang-Hee Bae, Sang Chul Lee, Baek-Soo Han

BMB Rep. 2021 Dec 31; 54(12): 626–631. Published online 2021 Dec 31. doi: 10.5483/BMBRep.2021.54.12.154

PMCID:: PMC8728538

Abstract Article PDF–2.7M

Select item 86873918.

JAK2V617F mutant endothelial cells promote neoplastic hematopoiesis in a mixed vascular microenvironment

Christopher Mazzeo, Moqing Quan, Helen Wong, Melissa Castiglione, Kenneth Kaushansky, Huichun Zhan

Blood Cells Mol Dis. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Blood Cells Mol Dis. 2021 Sep; 90: 102585. Published online 2021 May 31. doi: 10.1016/j.bcmd.2021.102585

PMCID:: PMC8687391

Abstract Article PDF–561K

Select item 83614599.

Bleeding diathesis in mice lacking JAK2 in platelets

Nathan Eaton, Saravanan Subramaniam, Marie L. Schulte, Caleb Drew, David Jakab, Sandra L. Haberichter, Hartmut Weiler, Hervé Falet

Blood Adv. 2021 Aug 10; 5(15): 2969–2981. Published online 2021 Aug 3. doi: 10.1182/bloodadvances.2020003032

PMCID:: PMC8361459

Abstract Article PDF–2.6M

Select item 825295410.

Crucial role of hematopoietic JAK2 V617F in the development of aortic aneurysms

Tetsuro Yokokawa, Tomofumi Misaka, Yusuke Kimishima, Kento Wada, Keiji Minakawa, Koichi Sugimoto, Takafumi Ishida, Soji Morishita, Norio Komatsu, Kazuhiko Ikeda, Yasuchika Takeishi

Haematologica. 2021 Jul 1; 106(7): 1910–1922. Published online 2021 Feb 11. doi: 10.3324/haematol.2020.264085

PMCID:: PMC8252954

Abstract Article PDF–2.3M

Select item 775629511.

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm

Melissa Castiglione, Ya‐Ping Jiang, Christopher Mazzeo, Sandy Lee, Juei‐Suei Chen, Kenneth Kaushansky, Wei Yin, Richard Z. Lin, Haoyi Zheng, Huichun Zhan

J Thromb Haemost. 2020 Dec; 18(12): 3359–3370. Published online 2020 Oct 5. doi: 10.1111/jth.15095

PMCID:: PMC7756295

Abstract Article PDF–1.2M

Select item 751204312.

Coniferyl Aldehyde Inhibits the Inflammatory Effects of Leptomeningeal Cells by Suppressing the JAK2 Signaling

Yao Wang, Yajun Gao, Xue Li, Xiaolin Sun, Zhanqi Wang, Hanchi Wang, Ran Nie, Weixian Yu, Yanmin Zhou

Biomed Res Int. 2020; 2020: 4616308. Published online 2020 Sep 14. doi: 10.1155/2020/4616308

PMCID:: PMC7512043

Abstract Article PDF–1.3M

Select item 620064113.

Stabilization of Foxp3 Stability by Targeting JAK2 Enhances Efficacy of CD8 iTregs to Prevent Graft-versus-Host Disease

Supinya Iamsawat, Anusara Daenthanasanmak, Jessica Heinrichs Voss, Hung Nguyen, David Bastian, Chen Liu, Xue-Zhong Yu

J Immunol. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: J Immunol. 2018 Nov 1; 201(9): 2812–2823. Published online 2018 Sep 21. doi: 10.4049/jimmunol.1800793

PMCID:: PMC6200641

Abstract Article PDF–4.1M

Select item 604951714.

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Sang-Kyu Kim, Deborah A. Knight, Lisa R. Jones, Stephin Vervoort, Ashley P. Ng, John F. Seymour, James E. Bradner, Michaela Waibel, Lev Kats, Ricky W. Johnstone

Genes Dev. 2018 Jun 1; 32(11-12): 849–864. doi: 10.1101/gad.307504.117

PMCID:: PMC6049517

Abstract Article PDF–4.3M

Select item 603465515.

Oncogenic JAK2^V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Alessandro Prestipino, Alica J. Emhardt, Konrad Aumann, David O’Sullivan, Sivahari P. Gorantla, Sandra Duquesne, Wolfgang Melchinger, Lukas Braun, Slavica Vuckovic, Melanie Boerries, Hauke Busch, Sebastian Halbach, Sandra Pennisi, Teresa Poggio, Petya Apostolova, Pia Veratti, Michael Hettich, Gabriele Niedermann, Mark Bartholomä, Khalid Shoumariyeh, Jonas S. Jutzi, Julius Wehrle, Christine Dierks, Heiko Becker, Annette Schmitt-Graeff, Marie Follo, Dietmar Pfeifer, Jan Rohr, Sebastian Fuchs, Stephan Ehl, Frederike A. Hartl, Susana Minguet, Cornelius Miething, Florian H. Heidel, Nicolaus Kröger, Ioanna Triviai, Tilman Brummer, Jürgen Finke, Anna L. Illert, Eliana Ruggiero, Chiara Bonini, Justus Duyster, Heike L. Pahl, Steven W. Lane, Geoffrey R. Hill, Bruce R. Blazar, Nikolas von Bubnoff, Erika L. Pearce, Robert Zeiser

Sci Transl Med. Author manuscript; available in PMC 2019 Feb 21.

Published in final edited form as: Sci Transl Med. 2018 Feb 21; 10(429): eaam7729. doi: 10.1126/scitranslmed.aam7729

PMCID:: PMC6034655

Abstract Article PDF–2.1M

Select item 602953416.

JAK2V617F-bearing vascular niche enhances malignant hematopoietic regeneration following radiation injury

Chi Hua Sarah Lin, Yu Zhang, Kenneth Kaushansky, Huichun Zhan

Haematologica. 2018 Jul; 103(7): 1160–1168. Prepublished online 2018 Mar 22. doi: 10.3324/haematol.2017.185736

PMCID:: PMC6029534

Abstract Article PDF–1.1M

Select item 581615317.

Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation

Brian C. Betts, David Bastian, Supinya Iamsawat, Hung Nguyen, Jessica L. Heinrichs, Yongxia Wu, Anusara Daenthanasanmak, Anandharaman Veerapathran, Alison O’Mahony, Kelly Walton, Jordan Reff, Pedro Horna, Elizabeth M. Sagatys, Marie C. Lee, Jack Singer, Ying-Jun Chang, Chen Liu, Joseph Pidala, Claudio Anasetti, Xue-Zhong Yu

Proc Natl Acad Sci U S A. 2018 Feb 13; 115(7): 1582–1587. Published online 2018 Jan 30. doi: 10.1073/pnas.1712452115

PMCID:: PMC5816153

Abstract Article PDF–1.5M

Select item 568580418.

JAK2^V617I results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction-transplantation model

Stefan A. Brooks, Samuel B. Luty, Hew Yeng Lai, Sarah J. Morse, Thanh Kim Nguyen, Lacey R. Royer, Anupriya Agarwal, Brian J. Druker, Angela G. Fleischman

Exp Hematol. Author manuscript; available in PMC 2017 Nov 14.

Published in final edited form as: Exp Hematol. 2016 Jan; 44(1): 24–9.e1. Published online 2015 Oct 13. doi: 10.1016/j.exphem.2015.09.006

PMCID:: PMC5685804

Abstract Article PDF–435K

Select item 551853619.

JAK2 inhibitor CEP-33779 prevents mouse oocyte maturation in vitro

Changli Wu, Rong Li, Haibing Luo, Mingfeng Xu, Xiujuan Zhang

Biosci Rep. 2017 Aug 31; 37(4): BSR20170642. Prepublished online 2017 Jun 14. Published online 2017 Jul 12. doi: 10.1042/BSR20170642

PMCID:: PMC5518536

Abstract Article PDF–821K

Select item 545748420.

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment

Kristina Kirschner, Tamir Chandra, Vladimir Kiselev, David Flores-Santa Cruz, Iain C. Macaulay, Hyun Jun Park, Juan Li, David G. Kent, Rupa Kumar, Dean C. Pask, Tina L. Hamilton, Martin Hemberg, Wolf Reik, Anthony R. Green

Cell Rep. 2017 May 23; 19(8): 1503–1511. Published online 2017 May 23. doi: 10.1016/j.celrep.2017.04.074

PMCID:: PMC5457484

Abstract Article PDF–2.9M

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