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Select item 101948231.

Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with K_ATP channel gain-of-function

Michael J Davis, Jorge A Castorena-Gonzalez, Hae Jin Kim, Min Li, Maria Remedi, Colin G Nichols

Function (Oxf) 2023; 4(3): zqad017. Published online 2023 Apr 18. doi: 10.1093/function/zqad017

PMCID:: PMC10194823

Abstract Article PDF–5.1M

Select item 97979592.

Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels

Cristiana Bercea, Roshan Limbu, Kamila Behnam, Keat-Eng Ng, Qadeer Aziz, Andrew Tinker, Francesco Tamagnini, Graeme S Cottrell, Alister J McNeish

Front Physiol. 2022; 13: 1033216. Published online 2022 Dec 15. doi: 10.3389/fphys.2022.1033216

PMCID:: PMC9797959

Abstract Article PDF–1.6M

Select item 77343373.

Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome

Rosa Scala, Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Giulia Maria Camerino, Francesco Alfredo Zito, Girolamo Ranieri, Conor McClenaghan, Theresa M. Harter, Colin G. Nichols, Domenico Tricarico

Front Pharmacol. 2020; 11: 604885. Published online 2020 Nov 30. doi: 10.3389/fphar.2020.604885

PMCID:: PMC7734337

Abstract Article PDF–2.7M

Select item 73996914.

Vascular K_ATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia

Qadeer Aziz, Jianmin Chen, Amie J Moyes, Yiwen Li, Naomi A Anderson, Richard Ang, Dunja Aksentijevic, Sonia Sebastian, Adrian J Hobbs, Christoph Thiemermann, Andrew Tinker

J Mol Med (Berl) 2020; 98(8): 1149–1160. Published online 2020 Jul 6. doi: 10.1007/s00109-020-01946-3

PMCID:: PMC7399691

Abstract Article PDF–2.0M

Select item 69273325.

Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate–sensitive potassium channel subunit Kir6.1

Matthew C. Henn, M. Burhan Janjua, Haixia Zhang, Evelyn M. Kanter, Carol M. Makepeace, Richard B. Schuessler, Colin G. Nichols, Jennifer S. Lawton

J Surg Res. Author manuscript; available in PMC 2019 Dec 23.

Published in final edited form as: J Surg Res. 2016 Dec; 206(2): 460–465. Published online 2016 Aug 12. doi: 10.1016/j.jss.2016.08.043

PMCID:: PMC6927332

Abstract Article PDF–841K

Select item 67755906.

A critical role for the ATP-sensitive potassium channel subunit K_IR6.1 in the control of cerebral blood flow

Patrick S Hosford, Isabel N Christie, Arun Niranjan, Qadeer Aziz, Naomi Anderson, Richard Ang, Mark F Lythgoe, Jack A Wells, Andrew Tinker, Alexander V Gourine

J Cereb Blood Flow Metab. 2019 Oct; 39(10): 2089–2095. Published online 2018 Jun 4. doi: 10.1177/0271678X18780602

PMCID:: PMC6775590

Abstract Article PDF–450K

Select item 64933797.

Iptakalim Enhances Adult Mouse Hippocampal Neurogenesis Via Opening Kir6.1‐Composed K‐ATP Channels Expressed in Neural Stem Cells

Jing‐Zhe Yang, Xu Huang, Fang‐Fang Zhao, Qiang Xu, Gang Hu

CNS Neurosci Ther. 2012 Sep; 18(9): 737–744. Published online 2012 Jun 28. doi: 10.1111/j.1755-5949.2012.00359.x

PMCID:: PMC6493379

Abstract Article PDF–351K

Select item 64933428.

Kir6.1 Knockdown Aggravates Cerebral Ischemia/Reperfusion‐Induced Neural Injury in Mice

Yin‐Feng Dong, Lin‐Xiao Wang, Xu Huang, Wen‐Jing Cao, Ming Lu, Jian‐Hua Ding, Xiu‐Lan Sun, Gang Hu

CNS Neurosci Ther. 2013 Aug; 19(8): 617–624. Published online 2013 May 11. doi: 10.1111/cns.12117

PMCID:: PMC6493342

Abstract Article PDF–530K

Select item 60789429.

Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy

Yasuhiro Watanabe, Takashi Kishimoto, Takashi Miki, Susumu Seino, Haruaki Nakaya, Akio Matsumoto

Sci Rep. 2018; 8: 11723. Published online 2018 Aug 6. doi: 10.1038/s41598-018-30175-5

PMCID:: PMC6078942

Abstract Article PDF–1.3M

Select item 581006110.

Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A. Weigand, Cornelius J. Busch

Respir Res. 2018; 19: 29. Published online 2018 Feb 13. doi: 10.1186/s12931-018-0735-x

PMCID:: PMC5810061

Abstract Article PDF–787K

Select item 521708611.

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the K_ATP channel

Maria S. Remedi, Jonathan B. Friedman, Colin G. Nichols

J Gen Physiol. 2017 Jan; 149(1): 75–84. doi: 10.1085/jgp.201611653

PMCID:: PMC5217086

Abstract Article PDF–1.7M

Select item 481590212.

Disruption of ATP-sensitive potassium channel function in skeletal muscles promotes production and secretion of musclin

Ana Sierra, Ekaterina Subbotina, Zhiyong Zhu, Zhan Gao, Siva Rama Krishna Koganti, William Coetzee, David Goldhamer, Denice M. Hodgson-Zingman, Leonid V. Zingman

Biochem Biophys Res Commun. Author manuscript; available in PMC 2017 Feb 26.

Published in final edited form as: Biochem Biophys Res Commun. 2016 Feb 26; 471(1): 129–134. Published online 2016 Jan 30. doi: 10.1016/j.bbrc.2016.01.166

PMCID:: PMC4815902

Abstract Article PDF–798K

Select item 462404013.

Electrophysiological consequences of K_ATP Gain-of-function in the heart: Conduction abnormalities in Cantu Syndrome

Mark D. Levin, Haixia Zhang, Keita Uchida, Dorothy K. Grange, Gautam K. Singh, Colin G. Nichols

Heart Rhythm. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Heart Rhythm. 2015 Nov; 12(11): 2316–2324. Published online 2015 Jun 30. doi: 10.1016/j.hrthm.2015.06.042

PMCID:: PMC4624040

Abstract Article PDF–3.6M

Select item 451517714.

Diazoxide Cardioprotection Is Independent of Adenosine Triphosphate-Sensitive Potassium Channel Kir6.1 Subunit in Response to Stress

Matthew C Henn, M Burhan Janjua, Haixia Zhang, Evelyn M Kanter, Carol M Makepeace, Richard B Schuessler, Colin G Nichols, Jennifer S Lawton

J Am Coll Surg. Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: J Am Coll Surg. 2015 Aug; 221(2): 319–325. Published online 2015 Feb 21. doi: 10.1016/j.jamcollsurg.2015.02.014

PMCID:: PMC4515177

Abstract Article PDF–1.0M

Select item 425640315.

Endurance Exercise Accelerates Myocardial Tissue Oxygenation Recovery and Reduces Ischemia Reperfusion Injury in Mice

Yuanjing Li, Ming Cai, Li Cao, Xing Qin, Tiantian Zheng, Xiaohua Xu, Taylor M. Sandvick, Kirk Hutchinson, Loren E. Wold, Keli Hu, Qinghua Sun, D. Paul Thomas, Jun Ren, Guanglong He

PLoS One. 2014; 9(12): e114205. Published online 2014 Dec 4. doi: 10.1371/journal.pone.0114205

PMCID:: PMC4256403

Abstract Article PDF–1.2M

Select item 227663116.

Is Kir6.1 a subunit of mitoK_ATP?

D. Brian Foster, Jasma J. Rucker, Eduardo Marbán

Biochem Biophys Res Commun. Author manuscript; available in PMC 2009 Feb 15.

Published in final edited form as: Biochem Biophys Res Commun. 2008 Feb 15; 366(3): 649–656. Published online 2007 Dec 7. doi: 10.1016/j.bbrc.2007.11.154

PMCID:: PMC2276631

Abstract Article PDF–1.5M

Select item 1038688717.

K_ATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer’s disease–related pathology

John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, James A. Snipes, Derek Kellar, Emily E. Caesar, Ryan J. Pettit-Mee, Stephen M. Day, Jonathon P. Sens, Noelle I. Nicol, Jasmeen Dhillon, Maria S. Remedi, Drew D. Kiraly, Celeste M. Karch, Colin G. Nichols, David M. Holtzman, Shannon L. Macauley

JCI Insight. 2023 May 22; 8(10): e162454. Published online 2023 May 22. doi: 10.1172/jci.insight.162454

PMCID:: PMC10386887

Abstract Article PDF–6.2M

Select item 771440918.

Kir6.1- and SUR2-dependent K_ATP overactivity disrupts intestinal motility in murine models of Cantú syndrome

Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols

JCI Insight. 2020 Dec 3; 5(23): e141443. Published online 2020 Nov 10. doi: 10.1172/jci.insight.141443

PMCID:: PMC7714409

Abstract Article PDF–11M

Select item 726958819.

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by K_ATP channel overactivity

Conor McClenaghan, Yan Huang, Zihan Yan, Theresa M. Harter, Carmen M. Halabi, Rod Chalk, Attila Kovacs, Gijs van Haaften, Maria S. Remedi, Colin G. Nichols

J Clin Invest. 2020 Mar 2; 130(3): 1116–1121. Published online 2020 Feb 17. doi: 10.1172/JCI130571

PMCID:: PMC7269588

Abstract Article PDF–1.1M

Select item 612911720.

Cardiovascular consequences of K_ATP overactivity in Cantu syndrome

Yan Huang, Conor McClenaghan, Theresa M. Harter, Kristina Hinman, Carmen M. Halabi, Scot J. Matkovich, Haixia Zhang, G. Schuyler Brown, Robert P. Mecham, Sarah K. England, Attila Kovacs, Maria S. Remedi, Colin G. Nichols

JCI Insight. 2018 Aug 9; 3(15): e121153. Published online 2018 Aug 9. doi: 10.1172/jci.insight.121153

PMCID:: PMC6129117

Abstract Article PDF–5.5M

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