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Select item 112699501.

Altered neuronal lactate dehydrogenase A expression affects cognition in a sex- and age-dependent manner

Ariel K. Frame, Jessica L. Sinka, Marc Courchesne, Rashad A. Muhammad, Sandra Grahovac-Nemeth, Mark A. Bernards, Robert Bartha, Robert C. Cumming

iScience. 2024 Jul 19; 27(7): 110342. Published online 2024 Jun 21. doi: 10.1016/j.isci.2024.110342

PMCID:: PMC11269950

Abstract Article PDF–9.0M

Select item 97941172.

Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer

Juan Liu, Cen Zhang, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Ludvinna Bazile, Lanjing Zhang, Bruce G. Haffty, Wenwei Hu, Zhaohui Feng

Nat Metab. Author manuscript; available in PMC 2023 Jun 19.

Published in final edited form as: Nat Metab. 2022 Dec; 4(12): 1830–1846. Published online 2022 Dec 19. doi: 10.1038/s42255-022-00708-4

PMCID:: PMC9794117

Abstract Article PDF–5.9M

Select item 94379063.

LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization

Yijin Chen, Guangkai Wu, Mengsha Li, Michael Hesse, Yusheng Ma, Wei Chen, Haoxiang Huang, Yu Liu, Wenlong Xu, Yating Tang, Hao Zheng, Chuling Li, Zhongqiu Lin, Guojun Chen, Wangjun Liao, Yulin Liao, Jianping Bin, Yanmei Chen

Redox Biol. 2022 Oct; 56: 102446. Published online 2022 Aug 23. doi: 10.1016/j.redox.2022.102446

PMCID:: PMC9437906

Abstract Article PDF–27M

Select item 93079434.

Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development

Marina Serra, Mario Di Matteo, Jens Serneels, Rajesh Pal, Sarah Trusso Cafarello, Martina Lanza, Carlos Sanchez-Martin, Matthias Evert, Alessandra Castegna, Diego Francesco Calvisi, Massimiliano Mazzone, Amedeo Columbano

Cell Mol Gastroenterol Hepatol. 2022; 14(3): 609–624. Published online 2022 Jun 15. doi: 10.1016/j.jcmgh.2022.06.003

PMCID:: PMC9307943

Abstract Article PDF–5.6M

Select item 87647985.

Visualizing the effects of Lactate Dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR

Gopal Varma, Pankaj Seth, Patricia Coutinho de Souza, Cody Callahan, Jocelin Pinto, Manushka Vaidya, Olmo Sonzogni, Vikas Sukhatme, Gerburg M. Wulf, Aaron K. Grant

NMR Biomed. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: NMR Biomed. 2021 Aug; 34(8): e4560. Published online 2021 Jun 4. doi: 10.1002/nbm.4560

PMCID:: PMC8764798

Abstract Article PDF–2.0M

Select item 75209166.

Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Chongshan Dai, Qinfeng Li, Herman I. May, Chao Li, Guangyu Zhang, Gaurav Sharma, A. Dean Sherry, Craig R. Malloy, Chalermchai Khemtong, Yuannyu Zhang, Yingfeng Deng, Thomas G. Gillette, Jian Xu, David T. Scadden, Zhao V. Wang

Cell Rep. Author manuscript; available in PMC 2020 Sep 28.

Published in final edited form as: Cell Rep. 2020 Sep 1; 32(9): 108087. doi: 10.1016/j.celrep.2020.108087

PMCID:: PMC7520916

Abstract Article PDF–3.2M

Select item 70841617.

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8⁺ T cell stemness and antitumor immunity

Dalton Hermans, Sanjivan Gautam, Juan C. García-Cañaveras, Daniel Gromer, Suman Mitra, Rosanne Spolski, Peng Li, Stephen Christensen, Rosa Nguyen, Jian-Xin Lin, Jangsuk Oh, Ning Du, Sharon Veenbergen, Jessica Fioravanti, Risa Ebina-Shibuya, Christopher Bleck, Leonard M. Neckers, Joshua D. Rabinowitz, Luca Gattinoni, Warren J. Leonard

Proc Natl Acad Sci U S A. 2020 Mar 17; 117(11): 6047–6055. Published online 2020 Mar 2. doi: 10.1073/pnas.1920413117

PMCID:: PMC7084161

Abstract Article PDF–1.8M

Select item 58282968.

Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis

Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita

EBioMedicine. 2018 Jan; 27: 71–85. Published online 2017 Dec 7. doi: 10.1016/j.ebiom.2017.10.033

PMCID:: PMC5828296

Abstract Article PDF–1.7M

Select item 56575439.

Lactate dehydrogenase activity drives hair follicle stem cell activation

Flores Aimee, Schell John, Krall Abby, Jelinek David, Miranda Matilde, Grigorian Melina, Braas Daniel, C White Andrew, Zhou Jessica, Graham Nick, Graeber Thomas, Seth Pankaj, Evseenko Denis, Coller Hilary, Rutter Jared, Christofk Heather, E Lowry William

Nat Cell Biol. Author manuscript; available in PMC 2018 Feb 14.

Published in final edited form as: Nat Cell Biol. 2017 Sep; 19(9): 1017–1026. Published online 2017 Aug 14. doi: 10.1038/ncb3575

PMCID:: PMC5657543

Abstract Article PDF–2.4M

Select item 387768010.

Relationships between LDH-A, Lactate and Metastases in 4T1 Breast Tumors

Asif Rizwan, Inna Serganova, Raya Khanin, Hazem Karabeber, Xiaohui Ni, Sunitha Thakur, Kristen L. Zakian, Ronald Blasberg, Jason A. Koutcher

Clin Cancer Res. Author manuscript; available in PMC 2014 Sep 15.

Published in final edited form as: Clin Cancer Res. 2013 Sep 15; 19(18): 10.1158/1078-0432.CCR-12-3300. Published online 2013 Jul 5. doi: 10.1158/1078-0432.CCR-12-3300

PMCID:: PMC3877680

Abstract Article PDF–2.1M

Select item 120501511.

Hereditary Lactate Dehydrogenase a-Subunit Deficiency as Cause of Early Postimplantation Death of Homozygotes in Mus Musculus

S. Merkle, J. Favor, J. Graw, S. Hornhardt, W. Pretsch

Genetics. 1992 Jun; 131(2): 413–421. doi: 10.1093/genetics/131.2.413

PMCID:: PMC1205015

Summary PDF–2.6M

Select item 120312612.

Complete Nucleotide Sequence of the Mouse Lactate Dehydrogenase-a Functional Gene: Comparison of the Exon-Intron Organization of Dehydrogenase Genes

Kayoko M. Fukasawa, Steven S.-L. Li

Genetics. 1987 May; 116(1): 99–105. doi: 10.1093/genetics/116.1.99

PMCID:: PMC1203126

Summary PDF–1.4M

Select item 114670513.

Nucleotide sequence of the putative regulatory region of mouse lactate dehydrogenase-A gene.

K M Fukasawa, S S Li

Biochem J. 1986 Apr 15; 235(2): 435–439. doi: 10.1042/bj2350435

PMCID:: PMC1146705

Summary Page Browse PDF–1011K

Select item 991179014.

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

Shan Yao, Min-Dong Xu, Ying Wang, Shen-Ting Zhao, Jin Wang, Gui-Fu Chen, Wen-Bing Chen, Jian Liu, Guo-Bin Huang, Wen-Juan Sun, Yan-Yan Zhang, Huan-Li Hou, Lei Li, Xiang-Dong Sun

Nat Commun. 2023; 14: 729. Published online 2023 Feb 9. doi: 10.1038/s41467-023-36209-5

PMCID:: PMC9911790

Abstract Article PDF–4.4M

Select item 851446815.

p107 mediated mitochondrial function controls muscle stem cell proliferative fates

Debasmita Bhattacharya, Vicky Shah, Oreoluwa Oresajo, Anthony Scimè

Nat Commun. 2021; 12: 5977. Published online 2021 Oct 13. doi: 10.1038/s41467-021-26176-0

PMCID:: PMC8514468

Abstract Article PDF–2.4M

Select item 842455416.

Expression of lactate dehydrogenase A and B isoforms in the mouse kidney

Gunars Osis, Amie M. Traylor, Laurence M. Black, Daryll Spangler, James F. George, Abolfazl Zarjou, Jill W. Verlander, Anupam Agarwal

Am J Physiol Renal Physiol. 2021 May 1; 320(5): F706–F718. Published online 2021 Mar 15. doi: 10.1152/ajprenal.00628.2020

PMCID:: PMC8424554

Abstract Article

Select item 615300017.

LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response

Inna Serganova, Ivan J. Cohen, Kiranmayi Vemuri, Masahiro Shindo, Masatomo Maeda, Mayuresh Mane, Ekaterina Moroz, Raya Khanin, Jaya Satagopan, Jason A. Koutcher, Ronald Blasberg

PLoS One. 2018; 13(9): e0203965. Published online 2018 Sep 24. doi: 10.1371/journal.pone.0203965

PMCID:: PMC6153000

Abstract Article PDF–9.0M

Select item 608838518.

Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1–Regulated Lactate Metabolism

Jun-Hong Dong, Yi-Jing Wang, Min Cui, Xiao-Jing Wang, Wen-Shuai Zheng, Ming-Liang Ma, Fan Yang, Dong-Fang He, Qiao-Xia Hu, Dao-Lai Zhang, Shang-Lei Ning, Chun-Hua Liu, Chuan Wang, Yue Wang, Xiang-Yao Li, Fan Yi, Amy Lin, Alem W. Kahsai, Thomas Joseph Cahill, III, Zhe-Yu Chen, Xiao Yu, Jin-Peng Sun

Biol Psychiatry. Author manuscript; available in PMC 2018 Aug 13.

Published in final edited form as: Biol Psychiatry. 2017 Apr 15; 81(8): 654–670. Published online 2016 Oct 13. doi: 10.1016/j.biopsych.2016.09.025

PMCID:: PMC6088385

Abstract Article PDF–3.2M

Select item 460993919.

Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase

J. L. Judge, K. M. Owens, S. J. Pollock, C. F. Woeller, T. H. Thatcher, J. P. Williams, R. P. Phipps, P. J. Sime, R. M. Kottmann

Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15; 309(8): L879–L887. Published online 2015 Aug 7. doi: 10.1152/ajplung.00153.2015

PMCID:: PMC4609939

Abstract Article

Select item 419705620.

Cell state-specific metabolic dependency in hematopoiesis and leukemogenesis

Ying-Hua Wang, William J. Israelsen, Dongjun Lee, Vionnie W.C. Yu, Nathaniel T. Jeanson, Clary B Clish, Lewis C. Cantley, Matthew G. Vander Heiden, David T. Scadden

Cell. Author manuscript; available in PMC 2015 Sep 11.

Published in final edited form as: Cell. 2014 Sep 11; 158(6): 1309–1323. doi: 10.1016/j.cell.2014.07.048

PMCID:: PMC4197056

Abstract Article PDF–1.4M

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