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Items: 1 to 20 of 197

1.
The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus
Elan L’Estrange-Stranieri, Timothy A. Gottschalk, Mark D. Wright, Margaret L. Hibbs
Front Immunol. 2024; 15: 1395427. Published online 2024 Jun 28. doi: 10.3389/fimmu.2024.1395427
PMCID:
PMC11239442
AbstractArticlePDF–2.6M
2.
AMG853, A Bispecific Prostaglandin D2 Receptor 1 and 2 Antagonist, Dampens Basophil Activation and Related Lupus-Like Nephritis Activity in Lyn-Deficient Mice
Christophe Pellefigues, John Tchen, Chaimae Saji, Yasmine Lamri, Nicolas Charles
Front Immunol. 2022; 13: 824686. Published online 2022 Apr 4. doi: 10.3389/fimmu.2022.824686
PMCID:
PMC9014266
AbstractArticlePDF–4.8M
3.
Signal integration by translocation and phosphorylation of PKCδ in the B cell alternate pathway
Naeem Khan, Yongmei Hu, Clifford A. Lowell, Thomas L. Rothstein
J Immunol. Author manuscript; available in PMC 2022 Nov 1.
Published in final edited form as: J Immunol. 2021 Nov 1; 207(9): 2288–2296. Published online 2021 Sep 29. doi: 10.4049/jimmunol.2100295
PMCID:
PMC8638162
AbstractArticlePDF–1.7M
4.
Lyn Kinase Regulates Mesolimbic Dopamine Release: Implication for Alcohol Reward
Stuart L. Gibb, Jerome Jeanblanc, Segev Barak, Quinn V. Yowell, Rami Yaka, Dorit Ron
J Neurosci. 2011 Feb 9; 31(6): 2180–2187. doi: 10.1523/JNEUROSCI.5540-10.2011
PMCID:
PMC6633047
AbstractArticlePDF–883K
5.
Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells
Meenal Sinha, Clifford A. Lowell
Am J Respir Cell Mol Biol. 2016 Jun; 54(6): 802–813. doi: 10.1165/rcmb.2015-0171OC
PMCID:
PMC4942217
AbstractArticlePDF–1.6M
6.
Lyn cooperating with lipid rafts regulates inflammatory responses in Klebsiella pneumoniae infection through the p38/NF-κB pathway
Xuefeng Li, Xikun Zhou, Yi Li, Jiaxin Li, Breanna Privratsky, Yan Ye, Erxi Wu, Hongwei Gao, Canhua Huang, Min Wu
Eur J Immunol. Author manuscript; available in PMC 2015 Mar 1.
Published in final edited form as: Eur J Immunol. 2014 Mar; 44(3): 763–773. Published online 2013 Dec 16. doi: 10.1002/eji.201343972
PMCID:
PMC4103995
AbstractArticlePDF–3.5M
7.
A systems toxicology approach identifies Lyn as a key signaling phosphoprotein modulated by mercury in a B lymphocyte cell model
Joseph A. Caruso, Paul M. Stemmer, Alan Dombkowski, Nicholas J. Caruthers, Randall Gill, Allen J. Rosenspire
Toxicol Appl Pharmacol. Author manuscript; available in PMC 2015 Apr 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2014 Apr 1; 276(1): 47–54. Published online 2014 Jan 14. doi: 10.1016/j.taap.2014.01.002
PMCID:
PMC4005802
AbstractArticlePDF–3.1M
8.
Lyn mitigates mouse airway remodeling by down-regulating the TGF-β3 isoform in house dust mite models
Guoping Li, John Fox, III, Zhigang Liu, Jun Liu, George Fu Gao, Yang Jin, Hongwei Gao, Min Wu
J Immunol. Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: J Immunol. 2013 Dec 1; 191(11): 10.4049/jimmunol.1301596. Published online 2013 Oct 14. doi: 10.4049/jimmunol.1301596
PMCID:
PMC3863691
AbstractArticlePDF–2.2M
9.
Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations
Katherine R. Bull, Andrew J. Rimmer, Owen M. Siggs, Lisa A. Miosge, Carla M. Roots, Anselm Enders, Edward M. Bertram, Tanya L. Crockford, Belinda Whittle, Paul K. Potter, Michelle M. Simon, Ann-Marie Mallon, Steve D. M. Brown, Bruce Beutler, Christopher C. Goodnow, Gerton Lunter, Richard J. Cornall
PLoS Genet. 2013 Jan; 9(1): e1003219. Published online 2013 Jan 31. doi: 10.1371/journal.pgen.1003219
PMCID:
PMC3561070
AbstractArticlePDF–823K
10.
Lyn deficiency affects B cell maturation as well as survival
Gitit Shahaf, Andrew J. Gross, Michal Sternberg-Simon, Deborah Kaplan, Anthony L. DeFranco, Ramit Mehr
Eur J Immunol. Author manuscript; available in PMC 2013 Feb 1.
Published in final edited form as: Eur J Immunol. 2012 Feb; 42(2): 511–521. Published online 2011 Dec 14. doi: 10.1002/eji.201141940
PMCID:
PMC3516919
AbstractArticlePDF–870K
11.
A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE Receptor
Michael Poderycki, Yoshiaki Tomimori, Tomoaki Ando, Wenbin Xiao, Mari Maeda-Yamamoto, Karsten Sauer, Yuko Kawakami, Toshiaki Kawakami
J Immunol. Author manuscript; available in PMC 2010 Aug 13.
Published in final edited form as: J Immunol. 2010 Jan 1; 184(1): 84–93. Published online 2009 Nov 30. doi: 10.4049/jimmunol.0901590
PMCID:
PMC2921446
AbstractArticlePDF–2.9M
12.
A Conserved Salt Bridge in the G-Loop of Multiple Protein Kinases is Important for Catalysis and for in Vivo Lyn Function
Rina Barouch-Bentov, Jianwei Che, Christian C. Lee, Yating Yang, Ann Herman, Yong Jia, Anastasia Velentza, James Watson, Luise Sternberg, Sunjun Kim, Niusha Ziaee, Andrew Miller, Carie Jackson, Manabu Fujimoto, Mike Young, Serge Batalov, Yi Liu, Markus Warmuth, Tim Wiltshire, Michael P. Cooke, Karsten Sauer
Mol Cell. Author manuscript; available in PMC 2010 Jan 16.
Published in final edited form as: Mol Cell. 2009 Jan 16; 33(1): 43–52. doi: 10.1016/j.molcel.2008.12.024
PMCID:
PMC2683036
AbstractArticlePDF–2.0M
13.
Membrane heterogeneities in the formation of B cell receptor–Lyn kinase microclusters and the immune synapse
Hae Won Sohn, Pavel Tolar, Susan K. Pierce
J Cell Biol. 2008 Jul 28; 182(2): 367–379. doi: 10.1083/jcb.200802007
PMCID:
PMC2483512
AbstractArticlePDF–7.3M
14.
A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor–mediated Signals
Hirofumi Nishizumi, Keisuke Horikawa, Irena Mlinaric-Rascan, Tadashi Yamamoto
J Exp Med. 1998 Apr 20; 187(8): 1343–1348. doi: 10.1084/jem.187.8.1343
PMCID:
PMC2212230
AbstractArticlePDF–157K
15.
Sustained Activation of Lyn Tyrosine Kinase In Vivo Leads to Autoimmunity
Margaret L. Hibbs, Kenneth W. Harder, Jane Armes, Nicole Kountouri, Cathy Quilici, Franca Casagranda, Ashley R. Dunn, David M. Tarlinton
J Exp Med. 2002 Dec 16; 196(12): 1593–1604. doi: 10.1084/jem.20020515
PMCID:
PMC2196073
AbstractArticlePDF–529K
16.
Lyn kinase promotes erythroblast expansion and late-stage development
Vinit G. Karur, Clifford A. Lowell, Peter Besmer, Valter Agosti, Don M. Wojchowski
Blood. 2006 Sep 1; 108(5): 1524–1532. Prepublished online 2006 May 16. doi: 10.1182/blood-2005-09-008243
PMCID:
PMC1895506
AbstractArticle
17.
Alternatively spliced murine lyn mRNAs encode distinct proteins.
E Stanley, S Ralph, S McEwen, I Boulet, D A Holtzman, P Lock, A R Dunn
Mol Cell Biol. 1991 Jul; 11(7): 3399–3406. doi: 10.1128/mcb.11.7.3399
PMCID:
PMC361064
SummaryPage BrowsePDF–1.8M
18.
Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.
T L Yi, J B Bolen, J N Ihle
Mol Cell Biol. 1991 May; 11(5): 2391–2398. doi: 10.1128/mcb.11.5.2391
PMCID:
PMC359994
SummaryPage BrowsePDF–1.7M
19.
Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model
Giusy Tornillo, Lauren Warrington, Howard Kendrick, Adam T. Higgins, Trevor Hay, Sam Beck, Matthew J. Smalley
Dis Model Mech. 2024 Jan 1; 17(1): dmm050211. Published online 2024 Jan 25. doi: 10.1242/dmm.050211
PMCID:
PMC10846530
AbstractArticle
20.
Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain
Erskine Chu, Richelle Mychasiuk, Evelyn Tsantikos, April L. Raftery, Elan L’Estrange-Stranieri, Larissa K. Dill, Bridgette D. Semple, Margaret L. Hibbs
Cells. 2023 Oct; 12(19): 2378. Published online 2023 Sep 28. doi: 10.3390/cells12192378
PMCID:
PMC10571795
AbstractArticlePDF–11M

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