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Select item 109494361.

DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling

Han Li, Zhen Yang, Wukaiyang Liang, Hao Nie, Yuqi Guan, Ni Yang, Tianyi Ji, Yu Liu, Yi Huang, Le Zhang, Jinhua Yan, Cuntai Zhang

J Gerontol A Biol Sci Med Sci. 2024 Apr; 79(4): glae059. Published online 2024 Feb 26. doi: 10.1093/gerona/glae059

PMCID:: PMC10949436

Abstract Article PDF–21M

Select item 97242482.

Anticancer peptide Q7 suppresses the growth and migration of human endometrial cancer by inhibiting DHCR24 expression and modulating the AKT-mediated pathway

Chia-Hung Chen, Tzu-Hsiang Weng, Kai-Yao Huang, Hui-Ju Kao, Kuang-Wen Liao, Shun-Long Weng

Int J Med Sci. 2022; 19(14): 2008–2021. Published online 2022 Nov 7. doi: 10.7150/ijms.78349

PMCID:: PMC9724248

Abstract Article PDF–2.5M

Select item 94486723.

Hsa_circ_0003221 facilitates the malignant development of bladder cancer cells via resulting in the upregulation of DHCR24 by targeting miR-892b

Peng Lu, Yingchun Jiang, Zongyu Xia

Investig Clin Urol. 2022 Sep; 63(5): 577–588. Published online 2022 Aug 23. doi: 10.4111/icu.20220153

PMCID:: PMC9448672

Abstract Article PDF–12M

Select item 89252234.

The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis

Xiaojing Bai, Meiting Mai, Kai Yao, Mengqi Zhang, Yue Huang, Wenbin Zhang, Xiaorou Guo, Yixuan Xu, Ying Zhang, Atikam Qurban, Lijie Duan, Jimei Bu, Jianfeng Zhang, Junfeng Wu, Yongfei Zhao, Xiangshan Yuan, Hengbing Zu

Acta Neuropathol Commun. 2022; 10: 35. Published online 2022 Mar 16. doi: 10.1186/s40478-022-01338-3

PMCID:: PMC8925223

Abstract Article PDF–2.8M

Select item 88059005.

24-Dehydrocholesterol Reductase alleviates oxidative damage-induced apoptosis in alveolar epithelial cells via regulating Phosphatidylinositol-3-Kinase/Protein Kinase B activation

Ming Yao, Feng Li, Liang Xu, Li Ma, Shutong Zhang

Bioengineered. 2022; 13(1): 155–163. Published online 2021 Dec 24. doi: 10.1080/21655979.2021.2011634

PMCID:: PMC8805900

Abstract Article PDF–1.2M

Select item 79704016.

Amiodarone Alters Cholesterol Biosynthesis through Tissue-Dependent Inhibition of Emopamil Binding Protein and Dehydrocholesterol Reductase 24

Luke B. Allen, Thiago C. Genaro-Mattos, Allison Anderson, Ned A. Porter, Károly Mirnics, Zeljka Korade

ACS Chem Neurosci. Author manuscript; available in PMC 2021 Mar 18.

Published in final edited form as: ACS Chem Neurosci. 2020 May 20; 11(10): 1413–1423. Published online 2020 Apr 29. doi: 10.1021/acschemneuro.0c00042

PMCID:: PMC7970401

Abstract Article PDF–1.9M

Select item 75409957.

24‐Dehydrocholesterol reductase promotes the growth of breast cancer stem‐like cells through the Hedgehog pathway

Ting Qiu, Jiawei Cao, Wanzhou Chen, Jieyi Wang, Yaqi Wang, Lingjie Zhao, Min Liu, Licai He, Guang Wu, Hongzhi Li, Haihua Gu

Cancer Sci. 2020 Oct; 111(10): 3653–3664. Published online 2020 Aug 13. doi: 10.1111/cas.14587

PMCID:: PMC7540995

Abstract Article PDF–1.4M

Select item 74588158.

Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase

Lorillee Tallorin, Valerie A. Villareal, Chih-Yun Hsia, Mary A. Rodgers, Dominique J. Burri, Marc-Philipp Pfeil, Paula Montero Llopis, Brett D. Lindenbach, Priscilla L. Yang

J Biol Chem. 2020 Aug 28; 295(35): 12426–12436. Published online 2020 Jul 8. doi: 10.1074/jbc.RA120.013455

PMCID:: PMC7458815

Abstract Article PDF–1.9M

Select item 73323719.

A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents

Eeva Sliz, Jean Shin, Catriona Syme, Yash Patel, Nadine Parker, Louis Richer, Daniel Gaudet, Steffany Bennett, Tomas Paus, Zdenka Pausova

Mol Psychiatry. Author manuscript; available in PMC 2021 Jul 3.

Published in final edited form as: Mol Psychiatry. 2021 Aug; 26(8): 3795–3805. Published online 2020 Jan 3. doi: 10.1038/s41380-019-0640-9

PMCID:: PMC7332371

Abstract Article PDF–1.4M

Select item 618145610.

DHCR24 predicts poor clinicopathological features of patients with bladder cancer: A STROBE-compliant study

Xiao-Ping Liu, Xiao-Hong Yin, Xiang-Yu Meng, Xin-Hui Yan, Yue Cao, Xian-Tao Zeng, Xing-Huan Wang

Medicine (Baltimore) 2018 Sep; 97(39): e11830. Published online 2018 Sep 28. doi: 10.1097/MD.0000000000011830

PMCID:: PMC6181456

Abstract Article PDF–346K

Select item 596326911.

Desmosterolosis presenting with multiple congenital anomalies

Mersedeh Rohanizadegan, Stephanie Sacharow

Eur J Med Genet. Author manuscript; available in PMC 2018 May 22.

Published in final edited form as: Eur J Med Genet. 2018 Mar; 61(3): 152–156. Published online 2017 Nov 23. doi: 10.1016/j.ejmg.2017.11.009

PMCID:: PMC5963269

Abstract Article PDF–254K

Select item 525610312.

Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma

Miao Dai, Xiao-Lu Zhu, Fei Liu, Qin-Yang Xu, Qiu-Lin Ge, Shu-Heng Jiang, Xiao-Mei Yang, Jun Li, Ya-Hui Wang, Qing-Kai Wu, Zhi-Hong Ai, Yin-Cheng Teng, Zhi-Gang Zhang

Sci Rep. 2017; 7: 41404. Published online 2017 Jan 23. doi: 10.1038/srep41404

PMCID:: PMC5256103

Abstract Article PDF–2.2M

Select item 453530913.

Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C

Sayeh Ezzikouri, Kiminori Kimura, Hajime Sunagozaka, Shuichi Kaneko, Kazuaki Inoue, Tomohiro Nishimura, Tsunekazu Hishima, Michinori Kohara, Kyoko Tsukiyama-Kohara

EBioMedicine. 2015 Jun; 2(6): 604–612. Published online 2015 Apr 13. doi: 10.1016/j.ebiom.2015.04.007

PMCID:: PMC4535309

Abstract Article PDF–1.2M

Select item 450616514.

Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content

C Cecchi, F Rosati, A Pensalfini, L Formigli, D Nosi, G Liguri, F Dichiara, M Morello, G Danza, G Pieraccini, A Peri, M Serio, M Stefani

J Cell Mol Med. 2008 Oct; 12(5b): 1990–2002. Published online 2008 Jan 11. doi: 10.1111/j.1582-4934.2008.00216.x

PMCID:: PMC4506165

Abstract Article PDF–634K

Select item 395812815.

DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme

Eser J. Zerenturk, Laura J. Sharpe, Andrew J. Brown

Biosci Rep. 2014; 34(2): e00098. Prepublished online 2014 Feb 6. Published online 2014 Mar 18. doi: 10.1042/BSR20130127

PMCID:: PMC3958128

Abstract Article PDF–1.2M

Select item 393472616.

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis

Winnie Luu, Eser J. Zerenturk, Ika Kristiana, Martin P. Bucknall, Laura J. Sharpe, Andrew J. Brown

J Lipid Res. 2014 Mar; 55(3): 410–420. doi: 10.1194/jlr.M043257

PMCID:: PMC3934726

Abstract Article PDF–1.1M

Select item 390606817.

3 β-Hydroxysteroid-Δ 24 Reductase (DHCR24) Protects Neuronal Cells from Apoptotic Cell Death Induced by Endoplasmic Reticulum (ER) Stress

Xiuli Lu, Yang Li, Weiqi Wang, Shuchao Chen, Ting Liu, Dan Jia, Xiaoping Quan, Deliang Sun, Alan K. Chang, Bing Gao

PLoS One. 2014; 9(1): e86753. Published online 2014 Jan 29. doi: 10.1371/journal.pone.0086753

PMCID:: PMC3906068

Abstract Article PDF–2.7M

Select item 352247718.

Promoter analysis of the DHCR24 (3β-hydroxysterol Δ²⁴-reductase) gene: characterization of SREBP (sterol-regulatoryelement-binding protein)-mediated activation

Lidia A. Daimiel, María E. Fernández-Suárez, Sara Rodríguez-Acebes, Lorena Crespo, Miguel A. Lasunción, Diego Gómez-Coronado, Javier Martínez-Botas

Biosci Rep. 2013; 33(1): e00006. Prepublished online 2012 Oct 10. Published online 2012 Dec 6. doi: 10.1042/BSR20120095

PMCID:: PMC3522477

Abstract Article PDF–1.4M

Select item 325626119.

Amyloid pathway-based candidate gene analysis of [¹¹C]PiB-PET in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort

Shanker Swaminathan, Li Shen, Shannon L. Risacher, Karmen K. Yoder, John D. West, Sungeun Kim, Kwangsik Nho, Tatiana Foroud, Mark Inlow, Steven G. Potkin, Matthew J. Huentelman, David W. Craig, William J. Jagust, Robert A. Koeppe, Chester A. Mathis, Clifford R. Jack, Jr., Michael W. Weiner, Andrew J. Saykin, the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Brain Imaging Behav. 2012 Mar; 6(1): 1–15. Published online 2011 Sep 8. doi: 10.1007/s11682-011-9136-1

PMCID:: PMC3256261

Abstract Article PDF–361K

Select item 317937020.

The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter

Jenny Zolotushko, Hagit Flusser, Barak Markus, Ilan Shelef, Yshaia Langer, Maura Heverin, Ingemar Björkhem, Sara Sivan, Ohad S Birk

Eur J Hum Genet. 2011 Sep; 19(9): 942–946. Published online 2011 May 11. doi: 10.1038/ejhg.2011.74

PMCID:: PMC3179370

Abstract Article PDF–349K

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