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Items: 1 to 20 of 29

1.
Modelling the functional genomics of Parkinson’s disease in Caenorhabditis elegans: LRRK2 and beyond
Rachael J. Chandler, Susanna Cogo, Patrick A. Lewis, Eva Kevei
Biosci Rep. 2021 Sep 30; 41(9): BSR20203672. Published online 2021 Aug 31. doi: 10.1042/BSR20203672
PMCID:
PMC8415217
AbstractArticlePDF–2.0M
2.
The role of human LRRK2 in methylmercury-induced inhibition of microvesicle formation of cephalic neurons in Caenorhabditis elegans
Tao Ke, Abel Santamaria, Joao BT Rocha, Alexey A. Tinkov, Rongzhu Lu, Aaron B Bowman, Michael Aschner
Neurotox Res. Author manuscript; available in PMC 2021 Oct 1.
Published in final edited form as: Neurotox Res. 2020 Oct; 38(3): 751–764. Published online 2020 Jul 29. doi: 10.1007/s12640-020-00262-5
PMCID:
PMC7484354
AbstractArticlePDF–2.0M
3.
G2019S LRRK2 Increases Stress Susceptibility Through Inhibition of DAF-16 Nuclear Translocation in a 14-3-3 Associated-Manner in Caenorhabditis elegans
Simei Long, Wenyuan Guo, Sophie Hu, Fengjuan Su, Yixuan Zeng, Jinsheng Zeng, Eng-King Tan, Christopher A. Ross, Zhong Pei
Front Neurosci. 2018; 12: 782. Published online 2018 Nov 7. doi: 10.3389/fnins.2018.00782
PMCID:
PMC6234837
AbstractArticlePDF–2.9M
4.
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease
William M. Johnson, Chen Yao, Sandra L. Siedlak, Wenzhang Wang, Xiongwei Zhu, Guy A. Caldwell, Amy L. Wilson-Delfosse, John J. Mieyal, Shu G. Chen
Hum Mol Genet. 2015 Mar 1; 24(5): 1322–1335. Published online 2014 Oct 29. doi: 10.1093/hmg/ddu542
PMCID:
PMC4321441
AbstractArticlePDF–701K
5.
Leucine-Rich Repeat Kinase 2-Linked Parkinson’s Disease: Clinical and Molecular Findings
Udhaya Kumari, Eng-King Tan
J Mov Disord. 2010 Oct; 3(2): 25–31. Published online 2010 Oct 30. doi: 10.14802/jmd.10008
PMCID:
PMC4027672
AbstractArticlePDF–1.1M
6.
LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
Shamol Saha, Maria D. Guillily, Andrew Ferree, Joel Lanceta, Diane Chan, Joy Ghosh, Cindy H. Hsu, Lilach Segal, Kesav Raghavan, Kunihiro Matsumoto, Naoki Hisamoto, Tomoki Kuwahara, Takeshi Iwatsubo, Landon Moore, Lee Goldstein, Mark Cookson, Benjamin Wolozin
J Neurosci. 2009 Jul 22; 29(29): 9210–9218. doi: 10.1523/JNEUROSCI.2281-09.2009
PMCID:
PMC3127548
AbstractArticlePDF–1.9M
7.
Investigating Convergent Actions of Genes Linked to Familial Parkinson's Disease
Benjamin Wolozin, Shamol Saha, Maria Guillily, Andrew Ferree, Misha Riley
Neurodegener Dis. 2008 Mar; 5(3-4): 182–185. Published online 2008 Mar 6. doi: 10.1159/000113697
PMCID:
PMC2826451
AbstractArticlePDF–97K
8.
Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth
Julia Sämann, Jan Hegermann, Erika von Gromoff, Stefan Eimer, Ralf Baumeister, Enrico Schmidt
J Biol Chem. 2009 Jun 12; 284(24): 16482–16491. Published online 2009 Feb 27. doi: 10.1074/jbc.M808255200
PMCID:
PMC2713553
AbstractArticlePDF–1.0M
9.
Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson’s disease
Megan M. Senchuk, Jeremy M. Van Raamsdonk, Darren J. Moore
Neurobiol Dis. Author manuscript; available in PMC 2021 Apr 1.
Published in final edited form as: Neurobiol Dis. 2021 Apr; 151: 105267. Published online 2021 Jan 12. doi: 10.1016/j.nbd.2021.105267
PMCID:
PMC7925424
AbstractArticlePDF–2.2M
10.
Historical Perspective: Models of Parkinson’s Disease
Shyh Jenn Chia, Eng-King Tan, Yin-Xia Chao
Int J Mol Sci. 2020 Apr; 21(7): 2464. Published online 2020 Apr 2. doi: 10.3390/ijms21072464
PMCID:
PMC7177377
AbstractArticlePDF–293K
11.
Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
Adam Schaffner, Xianting Li, Yacob Gomez-Llorente, Emmanouela Leandrou, Anna Memou, Nicolina Clemente, Chen Yao, Farinaz Afsari, Lianteng Zhi, Nina Pan, Keita Morohashi, Xiaoluan Hua, Ming-Ming Zhou, Chunyu Wang, Hui Zhang, Shu G. Chen, Christopher J. Elliott, Hardy Rideout, Iban Ubarretxena-Belandia, Zhenyu Yue
Cell Res. 2019 Apr; 29(4): 313–329. Published online 2019 Mar 11. doi: 10.1038/s41422-019-0153-8
PMCID:
PMC6462009
AbstractArticlePDF–6.5M
12.
UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes
Bikash Choudhary, Madhushree Kamak, Neena Ratnakaran, Jitendra Kumar, Anjali Awasthi, Chun Li, Ken Nguyen, Kunihiro Matsumoto, Naoki Hisamoto, Sandhya P. Koushika
PLoS Genet. 2017 Nov; 13(11): e1007100. Published online 2017 Nov 16. doi: 10.1371/journal.pgen.1007100
PMCID:
PMC5716593
AbstractArticlePDF–10M
13.
Interaction of LRRK2 with kinase and GTPase signaling cascades
Joon Y. Boon, Julien Dusonchet, Chelsea Trengrove, Benjamin Wolozin
Front Mol Neurosci. 2014; 7: 64. Prepublished online 2014 May 24. Published online 2014 Jul 9. doi: 10.3389/fnmol.2014.00064
PMCID:
PMC4087324
AbstractArticlePDF–520K
14.
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson’s disease
Chen Yao, Rabih El Khoury, Wen Wang, Tara A. Byrd, Elizabeth A. Pehek, Colin Thacker, Xiongwei Zhu, Mark A. Smith, Amy L. Wilson-Delfosse, Shu G. Chen
Neurobiol Dis. Author manuscript; available in PMC 2011 Oct 1.
Published in final edited form as: Neurobiol Dis. 2010 Oct; 40(1): 73–81. Published online 2010 Apr 9. doi: 10.1016/j.nbd.2010.04.002
PMCID:
PMC2926296
AbstractArticlePDF–1.3M
15.
Aligning Cross-Species Interactomes for Studying Complex and Chronic Diseases
Marianna Milano, Pietro Cinaglia, Pietro Hiram Guzzi, Mario Cannataro
Life (Basel) 2023 Jul; 13(7): 1520. Published online 2023 Jul 6. doi: 10.3390/life13071520
PMCID:
PMC10381714
AbstractArticlePDF–333K
16.
LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
Eun-Jin Bae, Dong-Kyu Kim, Changyoun Kim, Michael Mante, Anthony Adame, Edward Rockenstein, Ayse Ulusoy, Michael Klinkenberg, Ga Ram Jeong, Jae Ryul Bae, Cheolsoon Lee, He-Jin Lee, Byung-Dae Lee, Donato A. Di Monte, Eliezer Masliah, Seung-Jae Lee
Nat Commun. 2018; 9: 3465. Published online 2018 Aug 27. doi: 10.1038/s41467-018-05958-z
PMCID:
PMC6110743
AbstractArticlePDF–5.8M
17.
The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
Alexandra Beilina, Luis Bonet-Ponce, Ravindran Kumaran, Jennifer J. Kordich, Morié Ishida, Adamantios Mamais, Alice Kaganovich, Sara Saez-Atienzar, David C. Gershlick, Dorien A. Roosen, Laura Pellegrini, Vlad Malkov, Matthew J. Fell, Kirsten Harvey, Juan S. Bonifacino, Darren J. Moore, Mark R. Cookson
Cell Rep. Author manuscript; available in PMC 2020 Jun 25.
Published in final edited form as: Cell Rep. 2020 May 5; 31(5): 107614. doi: 10.1016/j.celrep.2020.107614
PMCID:
PMC7315779
AbstractArticlePDF–2.6M
18.
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
Tomoki Kuwahara, Keiichi Inoue, Vivette D. D’Agati, Tetta Fujimoto, Tomoya Eguchi, Shamol Saha, Benjamin Wolozin, Takeshi Iwatsubo, Asa Abeliovich
Sci Rep. 2016; 6: 29945. Published online 2016 Jul 18. doi: 10.1038/srep29945
PMCID:
PMC4947924
AbstractArticlePDF–1.8M
19.
Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans
Yiyuan Yuan, Pengxiu Cao, Mark A. Smith, Kristopher Kramp, Ying Huang, Naoki Hisamoto, Kunihiro Matsumoto, Maria Hatzoglou, Hui Jin, Zhaoyang Feng
PLoS One. 2011; 6(8): e22354. Published online 2011 Aug 3. doi: 10.1371/journal.pone.0022354
PMCID:
PMC3153934
AbstractArticlePDF–1.9M
20.
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity
Julien Dusonchet, Hu Li, Maria Guillily, Min Liu, Klodjan Stafa, Claudio Derada Troletti, Joon Y. Boon, Shamol Saha, Liliane Glauser, Adamantios Mamais, Allison Citro, Katherine L. Youmans, LiQun Liu, Bernard L. Schneider, Patrick Aebischer, Zhenyu Yue, Rina Bandopadhyay, Marcie A. Glicksman, Darren J. Moore, James J. Collins, Benjamin Wolozin
Hum Mol Genet. 2014 Sep 15; 23(18): 4887–4905. Published online 2014 May 2. doi: 10.1093/hmg/ddu202
PMCID:
PMC4140468
AbstractArticlePDF–1.5M

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