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Select item 91331161.

An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility

Keita Negishi, Kenichi Aizawa, Takayuki Shindo, Toru Suzuki, Takayuki Sakurai, Yuichiro Saito, Takuya Miyakawa, Masaru Tanokura, Yosky Kataoka, Mitsuyo Maeda, Shota Tomida, Hiroyuki Morita, Norifumi Takeda, Issei Komuro, Kazuomi Kario, Ryozo Nagai, Yasushi Imai

Sci Rep. 2022; 12: 8844. Published online 2022 May 25. doi: 10.1038/s41598-022-12418-8

Correction in:: Sci Rep. 2024; 14: 7874.

PMCID:: PMC9133116

Abstract Article PDF–10M

Select item 58332782.

Genetic approaches to identify pathological limitations in aortic smooth muscle contraction

Jian Huang, Ning Gao, Shanzhi Wang, Dianna M. Milewicz, Kristine E. Kamm, James T. Stull

PLoS One. 2018; 13(3): e0193769. Published online 2018 Mar 1. doi: 10.1371/journal.pone.0193769

PMCID:: PMC5833278

Abstract Article PDF–2.2M

Select item 35468103.

SMB myosin heavy chain knockout enhances tonic contraction and reduces the rate of force generation in ileum and stomach antrum

Qian Huang, Gopal J. Babu, Muthu Periasamy, Thomas J. Eddinger

Am J Physiol Cell Physiol. 2013 Jan 15; 304(2): C194–C206. Published online 2012 Nov 7. doi: 10.1152/ajpcell.00280.2012

PMCID:: PMC3546810

Abstract Article

Select item 26601834.

Deletion of SM-B, the high ATPase isoform of myosin, upregulates the PKC-mediated signal transduction pathway in murine urinary bladder smooth muscle

Joseph A. Hypolite, Shaohua Chang, Edward LaBelle, Gopal J. Babu, Muthu Periasamy, Alan J. Wein, Samuel Chacko

Am J Physiol Renal Physiol. 2009 Mar; 296(3): F658–F665. Published online 2008 Dec 3. doi: 10.1152/ajprenal.90221.2008

PMCID:: PMC2660183

Abstract Article

Select item 25875335.

Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice

Mei Chi, Yingbi Zhou, Srikanth Vedamoorthyrao, Gopal J. Babu, Muthu Periasamy

Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47): 18614–18618. Published online 2008 Nov 14. doi: 10.1073/pnas.0808162105

PMCID:: PMC2587533

Abstract Article PDF–2.1M

Select item 22173716.

Nonmuscle Myosin Motor of Smooth Muscle

Mia Löfgren, Eva Ekblad, Ingo Morano, Anders Arner

J Gen Physiol. 2003 Apr; 121(4): 301–310. doi: 10.1085/jgp.200208720

PMCID:: PMC2217371

Abstract Article PDF–2.4M

Select item 60353707.

Variants of Unknown Significance in Genes Associated with Heritable Thoracic Aortic Disease Can Be Low Penetrant “Risk Variants”

Callie S. Kwartler, Limin Gong, Jiyuan Chen, Shanzhi Wang, Richard Kulmacz, Xue-yan Duan, Alexandra Janda, Jian Huang, Kristine E. Kamm, James T. Stull, Dongchuan Guo, Dianna M. Milewicz

Am J Hum Genet. 2018 Jul 5; 103(1): 138–143. Published online 2018 Jun 28. doi: 10.1016/j.ajhg.2018.05.012

PMCID:: PMC6035370

Abstract Article PDF–1.1M

Select item 23426538.

The Smooth Muscle Myosin Seven Amino Acid Heavy Chain Insert's Kinetic Role in the Crossbridge Cycle for Mouse Bladder

Peter Karagiannis, Gopal J Babu, Muthu Periasamy, Frank V Brozovich

J Physiol. 2003 Mar 1; 547(Pt 2): 463–473. Published online 2003 Jan 17. doi: 10.1113/jphysiol.2002.035717

PMCID:: PMC2342653

Abstract Article PDF–625K

Select item 22147609.

Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development

Ya-Huei Kuo, Rachel M. Gerstein, Lucio H. Castilla

Blood. 2008 Feb 1; 111(3): 1543–1551. Prepublished online 2007 Oct 16. doi: 10.1182/blood-2007-07-104422

PMCID:: PMC2214760

Abstract Article

Select item 38735010.

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia

L. H. Castilla, P. Perrat, N. J. Martinez, S. F. Landrette, R. Keys, S. Oikemus, J. Flanegan, S. Heilman, L. Garrett, A. Dutra, S. Anderson, G. A. Pihan, L. Wolff, P. P. Liu

Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14): 4924–4929. Published online 2004 Mar 24. doi: 10.1073/pnas.0400930101

PMCID:: PMC387350

Abstract Article PDF–509K

Select item 1044379311.

Generating endogenous Myh11-driven Cre mice for sex-independent gene deletion in smooth muscle cells

Yang Zhao, Guizhen Zhao, Ziyi Chang, Tianqing Zhu, Ying Zhao, Haocheng Lu, Chao Xue, Thomas L. Saunders, Yanhong Guo, Lin Chang, Y. Eugene Chen, Jifeng Zhang

JCI Insight. 2023 Jul 24; 8(14): e171661. Published online 2023 Jul 24. doi: 10.1172/jci.insight.171661

PMCID:: PMC10443793

Abstract Article PDF–1.3M

Select item 768520812.

RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development

Tao Zhen, Yaqiang Cao, Gang Ren, Ling Zhao, R. Katherine Hyde, Guadalupe Lopez, Dechun Feng, Lemlem Alemu, Keji Zhao, P. Paul Liu

Blood. 2020 Nov 19; 136(21): 2373–2385. Prepublished online 2020 Sep 14. doi: 10.1182/blood.2020007747

PMCID:: PMC7685208

Abstract Article

Select item 570978513.

Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11

Tao Zhen, Erika M. Kwon, Ling Zhao, Jingmei Hsu, R. Katherine Hyde, Ying Lu, Lemlem Alemu, Nancy A. Speck, P. Paul Liu

Blood. 2017 Nov 30; 130(22): 2431–2442. Prepublished online 2017 Oct 10. doi: 10.1182/blood-2017-04-780106

PMCID:: PMC5709785

Abstract Article

Select item 410271314.

Nras^G12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis

Liting Xue, John A. Pulikkan, Peter J. M. Valk, Lucio H. Castilla

Blood. 2014 Jul 17; 124(3): 426–436. Prepublished online 2014 Jun 3. doi: 10.1182/blood-2013-12-541730

PMCID:: PMC4102713

Abstract Article

Select item 391769015.

Rare, Non-Synonymous Variant in the Smooth Muscle-Specific Isoform of Myosin Heavy Chain, MYH11, R247C, Alters Force Generation in the Aorta and Phenotype of Smooth Muscle Cells

Shao-Qing Kuang, Callie S. Kwartler, Katerina L. Byanova, John Pham, Limin Gong, Siddharth K. Prakash, Jian Huang, Kristine E. Kamm, James T. Stull, H. Lee Sweeney, Dianna M. Milewicz

Circ Res. Author manuscript; available in PMC 2014 Feb 7.

Published in final edited form as: Circ Res. 2012 May 25; 110(11): 1411–1422. Published online 2012 Apr 17. doi: 10.1161/CIRCRESAHA.111.261743

PMCID:: PMC3917690

Abstract Article PDF–1.8M

Select item 328621416.

KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice

Ling Zhao, Jan J. Melenhorst, Lemlem Alemu, Martha Kirby, Stacie Anderson, Maggie Kench, Shelley Hoogstraten-Miller, Lauren Brinster, Yasuhiko Kamikubo, D. Gary Gilliland, P. Paul Liu

Blood. 2012 Feb 9; 119(6): 1511–1521. Prepublished online 2011 Dec 7. doi: 10.1182/blood-2011-02-338210