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Select item 80798221.

Natural variation in Caenorhabditis elegans responses to the anthelmintic emodepside

Janneke Wit, Briana C. Rodriguez, Erik C. Andersen

Int J Parasitol Drugs Drug Resist. 2021 Aug; 16: 1–8. Published online 2021 Apr 17. doi: 10.1016/j.ijpddr.2021.04.001

PMCID:: PMC8079822

Abstract Article PDF–3.4M

Select item 67792732.

Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel

Sudhanva S. Kashyap, Saurabh Verma, Denis Voronin, Sara Lustigman, Daniel Kulke, Alan P. Robertson, Richard J. Martin

PLoS Pathog. 2019 Sep; 15(9): e1008041. Published online 2019 Sep 25. doi: 10.1371/journal.ppat.1008041

PMCID:: PMC6779273

Abstract Article PDF–3.9M

Select item 66298593.

BK channel clustering is required for normal behavioral alcohol sensitivity in C. elegans

Kelly H. Oh, Hongkyun Kim

Sci Rep. 2019; 9: 10224. Published online 2019 Jul 15. doi: 10.1038/s41598-019-46615-9

PMCID:: PMC6629859

Abstract Article PDF–1.9M

Select item 63148204.

Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in C. elegans

Guang Li, Jianke Gong, Jie Liu, Jinzhi Liu, Huahua Li, Ao-Lin Hsu, Jianfeng Liu, X.Z. Shawn Xu

Sci Adv. 2019 Jan; 5(1): eaau5041. Published online 2019 Jan 2. doi: 10.1126/sciadv.aau5041

PMCID:: PMC6314820

Abstract Article PDF–469K

Select item 61781255.

A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo

Luisa L. Scott, Sangeetha Iyer, Ashley E. Philpo, Melva N. Avalos, Natalie S. Wu, Ted Shi, Brooke A. Prakash, Thanh-Tu Nguyen, S. John Mihic, Richard W. Aldrich, Jonathan T. Pierce

J Pharmacol Exp Ther. 2018 Nov; 367(2): 282–290. Published online 2018 Nov. doi: 10.1124/jpet.118.251918

PMCID:: PMC6178125

Abstract Article PDF–1.0M

Select item 58247416.

Serotonin Disinhibits a Caenorhabditis elegans Sensory Neuron by Suppressing Ca²⁺-Dependent Negative Feedback

Paul D.E. Williams, Jeffrey A. Zahratka, Matthew Rodenbeck, Jason Wanamaker, Hilary Linzie, Bruce A. Bamber

J Neurosci. 2018 Feb 21; 38(8): 2069–2080. doi: 10.1523/JNEUROSCI.1908-17.2018

PMCID:: PMC5824741

Abstract Article PDF–4.9M

Select item 55809377.

Aldicarb-induced Paralysis Assay to Determine Defects in Synaptic Transmission in Caenorhabditis elegans

Kelly H. Oh, Hongkyun Kim

Bio Protoc. 2017 Jul 20; 7(14): e2400. Published online 2017 Jul 20. doi: 10.21769/BioProtoc.2400

PMCID:: PMC5580937

Abstract Article PDF–937K

Select item 55626298.

Nematodes feel a craving - Using Caenorhabditis elegans as a model to study alcohol addiction

Geng Zhu, Fen Zhang, Wei Li

Neurosci Bull. 2014 Aug; 30(4): 595–600. Published online 2014 Jul 9. doi: 10.1007/s12264-014-1451-7

PMCID:: PMC5562629

Abstract Article PDF–243K

Select item 48856439.

Putative calcium-binding domains of the Caenorhabditis elegans BK channel are dispensable for intoxication and ethanol activation

S. J. Davis, L. L. Scott, G. Ordemann, A. Philpo, J. Cohn, J. T. Pierce-Shimomura

Genes Brain Behav. Author manuscript; available in PMC 2016 May 30.

Published in final edited form as: Genes Brain Behav. 2015 Jul; 14(6): 454–465. doi: 10.1111/gbb.12229

PMCID:: PMC4885643

Abstract Article PDF–1.1M

Select item 427069310.

Characterization of the Ca²⁺-Gated and Voltage-Dependent K⁺-Channel Slo-1 of Nematodes and Its Interaction with Emodepside

Daniel Kulke, Georg von Samson-Himmelstjerna, Sandra M. Miltsch, Adrian J. Wolstenholme, Aaron R. Jex, Robin B. Gasser, Cristina Ballesteros, Timothy G. Geary, Jennifer Keiser, Simon Townson, Achim Harder, Jürgen Krücken

PLoS Negl Trop Dis. 2014 Dec; 8(12): e3401. Published online 2014 Dec 18. doi: 10.1371/journal.pntd.0003401

PMCID:: PMC4270693

Abstract Article PDF–2.5M

Select item 409954011.

Conserved Single Residue in the BK Potassium Channel Required for Activation by Alcohol and Intoxication in C. elegans

Scott J. Davis, Luisa L. Scott, Kevin Hu, Jonathan T. Pierce-Shimomura

J Neurosci. 2014 Jul 16; 34(29): 9562–9573. doi: 10.1523/JNEUROSCI.0838-14.2014

PMCID:: PMC4099540

Abstract Article PDF–2.9M

Select item 404618912.

Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans

James Dillon, Ioannis Andrianakis, Richard Mould, Ben Ient, Wei Liu, Christopher James, Vincent O'Connor, Lindy Holden-Dye

FASEB J. 2013 Oct; 27(10): 4266–4278. doi: 10.1096/fj.11-189340

PMCID:: PMC4046189

Abstract Article

Select item 336086313.

Worms take to the slo lane: a perspective on the mode of action of emodepside

Lindy Holden-Dye, Anna Crisford, Claudia Welz, Georg von Samson-Himmelstjerna, Robert J. Walker, Vincent O’Connor

Invert Neurosci. 2012; 12(1): 29–36. Published online 2012 Apr 27. doi: 10.1007/s10158-012-0133-x

PMCID:: PMC3360863

Abstract Article PDF–356K

Select item 325111314.

Intragenic alternative splicing coordination is essential for Caenorhabditis elegans slo-1 gene function

Dominique A. Glauser, Brandon E. Johnson, Richard W. Aldrich, Miriam B. Goodman

Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51): 20790–20795. Published online 2011 Nov 14. doi: 10.1073/pnas.1116712108

PMCID:: PMC3251113

Abstract Article PDF–355K

Select item 325109415.

Alternatively spliced domains interact to regulate BK potassium channel gating

Brandon E. Johnson, Dominique A. Glauser, Elise S. Dan-Glauser, D. Brent Halling, Richard W. Aldrich, Miriam B. Goodman

Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51): 20784–20789. Published online 2011 Nov 2. doi: 10.1073/pnas.1116795108

PMCID:: PMC3251094

Abstract Article PDF–1.0M

Select item 310255316.

Selective Toxicity of the Anthelmintic Emodepside Revealed by Heterologous Expression of Human KCNMA1 in Caenorhabditis elegans

Anna Crisford, Caitriona Murray, Vincent O'Connor, Richard J. Edwards, Nina Kruger, Claudia Welz, Georg von Samson-Himmelstjerna, Achim Harder, Robert J. Walker, Lindy Holden-Dye

Mol Pharmacol. 2011 Jun; 79(6): 1031–1043. doi: 10.1124/mol.111.071043

PMCID:: PMC3102553

Abstract Article PDF–4.4M

Select item 307237217.

SLO-1-Channels of Parasitic Nematodes Reconstitute Locomotor Behaviour and Emodepside Sensitivity in Caenorhabditis elegans slo-1 Loss of Function Mutants

Claudia Welz, Nina Krüger, Monika Schniederjans, Sandra M. Miltsch, Jürgen Krücken, Marcus Guest, Lindy Holden-Dye, Achim Harder, Georg von Samson-Himmelstjerna

PLoS Pathog. 2011 Apr; 7(4): e1001330. Published online 2011 Apr 7. doi: 10.1371/journal.ppat.1001330