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Items: 1 to 20 of 112

1.
Germline NPM1 mutations lead to altered rRNA 2’-O-methylation and cause dyskeratosis congenita
Daphna Nachmani, Anne H. Bothmer, Silvia Grisendi, Aldo Mele, Dietmar Bothmer, Jonathan D. Lee, Emanuele Monteleone, Ke Cheng, Yang Zhang, Assaf C. Bester, Alison Guzzetti, Caitlin A. Mitchell, Lourdes M. Mendez, Olga Pozdnyakova, Paolo Sportoletti, Maria-Paola Martelli, Tom J. Vulliamy, Modi Safra, Schraga Schwartz, Lucio Luzzatto, Olivier Bluteau, Jean Soulier, Robert B. Darnell, Brunangelo Falini, Inderjeet Dokal, Keisuke Ito, John G. Clohessy, Pier Paolo Pandolfi
Nat Genet. Author manuscript; available in PMC 2020 Mar 30.
Published in final edited form as: Nat Genet. 2019 Oct; 51(10): 1518–1529. Published online 2019 Sep 30. doi: 10.1038/s41588-019-0502-z
PMCID:
PMC6858547
AbstractArticlePDF–2.1M
2.
Nucleophosmin/B23 is a negative regulator of estrogen receptor α expression via AP2γ in endometrial cancer cells
Chiao-Yun Lin, Angel Chao, Tzu-Hao Wang, Li-Yu Lee, Lan-Yan Yang, Chia-Lung Tsai, Hsin-Shih Wang, Chyong-Huey Lai
Oncotarget. 2016 Sep 13; 7(37): 60038–60052. Published online 2016 Aug 4. doi: 10.18632/oncotarget.11048
PMCID:
PMC5312367
AbstractArticlePDF–4.5M
3.
Effect of Nucleophosmin1 (Npm1) Haploinsufficiency on Hematopoietic Stem Cells (HSC)
Aparna Raval, Brenda Kusler, Wendy W Pang, Irving L Weissman, Beverly S Mitchell, Christopher Y Park
Leukemia. Author manuscript; available in PMC 2014 Aug 8.
Published in final edited form as: Leukemia. 2012 Apr; 26(4): 853–855. Published online 2011 Oct 7. doi: 10.1038/leu.2011.270
PMCID:
PMC4126903
ArticlePDF–254K
4.
Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis
Fiona Kate Elizabeth McDuff, C. Elizabeth Hook, Reuben Tooze, Brian J Huntly, Pier Paolo Pandolfi, Suzanne Dawn Turner
Lab Invest. Author manuscript; available in PMC 2012 Mar 1.
Published in final edited form as: Lab Invest. 2011 Sep; 91(9): 1298–1303. Published online 2011 Jun 27. doi: 10.1038/labinvest.2011.96
PMCID:
PMC3166849
AbstractArticlePDF–508K
5.
Nucleophosmin protein expression level, but not threonine 198 phosphorylation, is essential in growth and proliferation
SN Brady, LB Maggi, Jr, CL Winkeler, EA Toso, AS Gwinn, CL Pelletier, JD Weber
Oncogene. Author manuscript; available in PMC 2010 May 27.
Published in final edited form as: Oncogene. 2009 Sep 10; 28(36): 3209–3220. Published online 2009 Jun 29. doi: 10.1038/onc.2009.178
PMCID:
PMC2877400
AbstractArticlePDF–1.9M
6.
Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse
Paolo Sportoletti, Silvia Grisendi, Samia M. Majid, Ke Cheng, John G. Clohessy, Agnes Viale, Julie Teruya-Feldstein, Pier Paolo Pandolfi
Blood. 2008 Apr 1; 111(7): 3859–3862. Prepublished online 2008 Jan 22. doi: 10.1182/blood-2007-06-098251
PMCID:
PMC2275037
AbstractArticle
7.
Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism
Sheng Zhang, Yunkai Zhang, Xuewen Duan, Bo Wang, Zhenzhen Zhan
Circulation. 2024 Jun 18; 149(25): 1982–2001. Published online 2024 Feb 23. doi: 10.1161/CIRCULATIONAHA.123.065506
PMCID:
PMC11175795
AbstractArticlePDF–7.0M
8.
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression
Annalisa Izzo, Ipek Akol, Alejandro Villarreal, Shannon Lebel, Marta Garcia-Miralles, Arquimedes Cheffer, Patrick Bovio, Stefanie Heidrich, Tanja Vogel
Epigenetics Chromatin. 2023; 16: 36. Published online 2023 Sep 28. doi: 10.1186/s13072-023-00511-9
PMCID:
PMC10537513
AbstractArticlePDF–6.2M
9.
Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells
Xin Zhao, Xiaomin Li, Haiyang Sun, Xuan Zhao, Tingting Gao, Panpan Shi, Fuquan Chen, Lin Liu, Xinyi Lu
Nucleic Acids Res. 2023 Sep 22; 51(17): 8970–8986. Published online 2023 Jul 31. doi: 10.1093/nar/gkad640
PMCID:
PMC10516645
AbstractArticlePDF–3.7M
10.
Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice
Andrew Muranyi, Tobias Ammer, Anna Kechter, Vijay P.S. Rawat, Amit Sinha, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Anca Azoitei, Cagatay Günes, Annalisa Mupo, George Vassiliou, Shiva Bamezai, Christian Buske
Blood Adv. 2023 Feb 14; 7(3): 351–364. Published online 2022 Apr 27. doi: 10.1182/bloodadvances.2022007015
PMCID:
PMC9898611
AbstractArticlePDF–2.6M
11.
Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy
Jennifer M. SanMiguel, Elizabeth Eudy, Matthew A. Loberg, Linde A. Miles, Tim Stearns, Jayna J. Mistry, Michael J. Rauh, Ross L. Levine, Jennifer J. Trowbridge
Blood Adv. 2022 Jun 28; 6(12): 3666–3677. Published online 2022 Jun 22. doi: 10.1182/bloodadvances.2022006968
PMCID:
PMC9631557
AbstractArticlePDF–1.3M
12.
Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia
Eliza Yankova, Wesley Blackaby, Mark Albertella, Justyna Rak, Etienne De Braekeleer, Georgia Tsagkogeorga, Ewa S. Pilka, Demetrios Aspris, Dan Leggate, Alan G. Hendrick, Natalie A. Webster, Byron Andrews, Richard Fosbeary, Patrick Guest, Nerea Irigoyen, Maria Eleftheriou, Malgorzata Gozdecka, Joao M. L. Dias, Andrew J. Bannister, Binje Vick, Irmela Jeremias, George S. Vassiliou, Oliver Rausch, Konstantinos Tzelepis, Tony Kouzarides
Nature. Author manuscript; available in PMC 2022 Jul 23.
Published in final edited form as: Nature. 2021 May 1; 593(7860): 597–601. Published online 2021 Apr 26. doi: 10.1038/s41586-021-03536-w
PMCID:
PMC7613134
AbstractArticlePDF–4.8M
13.
Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1
Jianhuang Lin, Mitsuyasu Kato, Kyosuke Nagata, Mitsuru Okuwaki
Nucleic Acids Res. 2017 Apr 20; 45(7): 3707–3723. Published online 2016 Dec 21. doi: 10.1093/nar/gkw1285
PMCID:
PMC5397172
AbstractArticlePDF–11M
14.
Regulation of Neuronal Survival by Nucleophosmin 1 (NPM1) Is Dependent on Its Expression Level, Subcellular Localization, and Oligomerization Status
Jason A. Pfister, Santosh R. D'Mello
J Biol Chem. 2016 Sep 23; 291(39): 20787–20797. Published online 2016 Aug 10. doi: 10.1074/jbc.M116.723015
PMCID:
PMC5034067
AbstractArticlePDF–1.9M
15.
The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions
Donatella Ponti, Daniela Bastianelli, Paolo Rosa, Luca Pacini, Mohsen Ibrahim, Erino Angelo Rendina, Giuseppe Ragona, Antonella Calogero
BMC Cell Biol. 2015; 16: 27. Published online 2015 Nov 17. doi: 10.1186/s12860-015-0073-5
PMCID:
PMC4650859
AbstractArticlePDF–1.6M
16.
Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins
Mattia Poletto, Lisa Lirussi, David M. Wilson, 3rd, Gianluca Tell
Mol Biol Cell. 2014 May 15; 25(10): 1641–1652. doi: 10.1091/mbc.E13-12-0717
PMCID:
PMC4019495
AbstractArticlePDF–5.1M
17.
Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development
Edgar J. Vogt, Maciej Meglicki, Kristina Ilka Hartung, Ewa Borsuk, Rüdiger Behr
Development. 2012 Dec 15; 139(24): 4514–4523. doi: 10.1242/dev.083279
PMCID:
PMC3912245
AbstractArticle
18.
A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice
A Mupo, L Celani, O Dovey, J L Cooper, C Grove, R Rad, P Sportoletti, B Falini, A Bradley, G S Vassiliou
Leukemia. 2013 Sep; 27(9): 1917–1920. Prepublished online 2013 Mar 12. Published online 2013 Apr 19. doi: 10.1038/leu.2013.77
PMCID:
PMC3768110
ArticlePDF–1.2M
19.
Nucleophosmin, a Critical Bax Cofactor in Ischemia-Induced Cell Death
Zhiyong Wang, Jonathan M. Gall, Ramon Bonegio, Andrea Havasi, Katarina Illanes, John H. Schwartz, Steven C. Borkan
Mol Cell Biol. 2013 May; 33(10): 1916–1924. doi: 10.1128/MCB.00015-13
Correction in:
Mol Cell Biol. 2017 Oct 1; 37(19): e00258-17.
PMCID:
PMC3647959
AbstractArticlePDF–1.1M
20.
A Knock-In Npm1 Mutation in Mice Results in Myeloproliferation and Implies a Perturbation in Hematopoietic Microenvironment
Shiu-Huey Chou, Bor-Sheng Ko, Ji-Shain Chiou, Yueh-Chwen Hsu, Mong-Hsun Tsai, Yu-Chiao Chiu, I-Shing Yu, Shu-Wha Lin, Hsin-An Hou, Yi-Yi Kuo, Hsiu-Mei Lin, Ming-Fang Wu, Wen-Chien Chou, Hwei-Fang Tien
PLoS One. 2012; 7(11): e49769. Published online 2012 Nov 30. doi: 10.1371/journal.pone.0049769
PMCID:
PMC3511491
AbstractArticlePDF–854K

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