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Select item 107882671.

AAV-based gene therapy ameliorated CNS-specific GPI defect in mouse models

Yoshiko Murakami, Saori Umeshita, Kae Imanishi, Yoshichika Yoshioka, Akinori Ninomiya, Takehiko Sunabori, Shibi Likhite, Masato Koike, Kathrin C. Meyer, Taroh Kinoshita

Mol Ther Methods Clin Dev. 2024 Mar 14; 32(1): 101176. Published online 2023 Dec 14. doi: 10.1016/j.omtm.2023.101176

PMCID:: PMC10788267

Abstract Article PDF–3.9M

Select item 92336842.

Gut microbiota alternation under the intestinal epithelium-specific knockout of mouse Piga gene

Aditi Jangid, Shinji Fukuda, Masahide Seki, Yutaka Suzuki, Todd D. Taylor, Hiroshi Ohno, Tulika Prakash

Sci Rep. 2022; 12: 10812. Published online 2022 Jun 25. doi: 10.1038/s41598-022-15150-5

PMCID:: PMC9233684

Abstract Article PDF–3.3M

Select item 73733223.

Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays

Christopher Kirby, Ayesha Baig, Svetlana L Avlasevich, Dorothea K Torous, Shuchang Tian, Priyanka Singh, Jeffrey C Bemis, Lawrence J Saubermann, Stephen D Dertinger

Mutagenesis. 2020 Mar; 35(2): 161–167. Published online 2020 Feb 12. doi: 10.1093/mutage/geaa006

PMCID:: PMC7373322

Abstract Article PDF–1.0M

Select item 72068484.

CNS glycosylphosphatidylinositol deficiency results in delayed white matter development, ataxia and premature death in a novel mouse model

Marshall Lukacs, Lauren E Blizzard, Rolf W Stottmann

Hum Mol Genet. 2020 May 8; 29(7): 1205–1217. Published online 2020 Mar 17. doi: 10.1093/hmg/ddaa046

PMCID:: PMC7206848

Abstract Article PDF–1.7M

Select item 57718575.

Glycosylphosphatidylinositol (GPI) Anchored Protein Deficiency Serves as a Reliable Reporter of Pig-a Gene Mutation—Support from an In vitro Assay Based on L5178Y/Tk^+/− Cells and the CD90.2 Antigen

Jeffrey C. Bemis, Svetlana L. Avlasevich, Carson Labash, Page McKinzie, Javier Revollo, Vasily N. Dobrovolsky, Stephen D. Dertinger

Environ Mol Mutagen. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Environ Mol Mutagen. 2018 Jan; 59(1): 18–29. Published online 2017 Nov 8. doi: 10.1002/em.22154

PMCID:: PMC5771857

Abstract Article PDF–2.3M

Select item 51181596.

Diet-induced obesity increases the frequency of Pig-a mutant erythrocytes in male C57BL/6J mice

Jeffrey K. Wickliffe, Stephen D. Dertinger, Dorothea K. Torous, Svetlana L. Avlasevich, Bridget R. Simon-Friedt, Mark J. Wilson

Environ Mol Mutagen. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Environ Mol Mutagen. 2016 Dec; 57(9): 668–677. Published online 2016 Oct 14. doi: 10.1002/em.22058

PMCID:: PMC5118159

Abstract Article PDF–896K

Select item 28170237.

Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells

Valeria Visconte, Nalini Raghavachari, Delong Liu, Keyvan Keyvanfar, Marie J. Desierto, Jichun Chen, Neal S. Young

Haematologica. 2010 Feb; 95(2): 214–223. Published online 2009 Aug 13. doi: 10.3324/haematol.2009.011650

PMCID:: PMC2817023

Abstract Article PDF–430K

Select item 21959418.

Fes-Cre Targets Phosphatidylinositol Glycan Class a (Piga) Inactivation to Hematopoietic Stem Cells in the Bone Marrow

Peter Keller, Jennifer L. Payne, Gabi Tremml, Peter A. Greer, Mirella Gaboli, Pier P. Pandolfi, Monica Bessler

J Exp Med. 2001 Sep 3; 194(5): 581–590. doi: 10.1084/jem.194.5.581

PMCID:: PMC2195941

Abstract Article PDF–193K

Select item 5082779.

Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.

V Rosti, G Tremml, V Soares, P P Pandolfi, L Luzzatto, M Bessler

J Clin Invest. 1997 Sep 1; 100(5): 1028–1036. doi: 10.1172/JCI119613

PMCID:: PMC508277

Summary PDF–278K

Select item 2383310.

Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development

Masahito Tarutani, Satoshi Itami, Masaru Okabe, Masahito Ikawa, Tadashi Tezuka, Kunihiko Yoshikawa, Taroh Kinoshita, Junji Takeda

Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14): 7400–7405. doi: 10.1073/pnas.94.14.7400

PMCID:: PMC23833

Abstract Article PDF–536K

Select item 2211111.

X inactivation and somatic cell selection rescue female mice carrying a Piga-null mutation

Peter Keller, Gabi Tremml, Vittorio Rosti, Monica Bessler

Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13): 7479–7483. doi: 10.1073/pnas.96.13.7479

PMCID:: PMC22111

Abstract Article PDF–222K

Select item 816152012.

Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models

Lenin C Kandasamy, Mina Tsukamoto, Vitaliy Banov, Sambuu Tsetsegee, Yutaro Nagasawa, Mitsuhiro Kato, Naomichi Matsumoto, Junji Takeda, Shigeyoshi Itohara, Sonoko Ogawa, Larry J Young, Qi Zhang

Hum Mol Genet. 2021 May 1; 30(9): 758–770. Published online 2021 Feb 19. doi: 10.1093/hmg/ddab052

PMCID:: PMC8161520

Abstract Article PDF–2.1M

Select item 419619813.

Single Cell Gel Electrophoresis (SCGE) and Pig-a mutation assay in vivo - tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1^−/− mice

Anne Graupner, Christine Instanes, Stephen D. Dertinger, Jill Mari Andersen, Birgitte Lindeman, Tonje Danielsen Rongved, Gunnar Brunborg, Ann-Karin Olsen

Mutat Res Genet Toxicol Environ Mutagen. Author manuscript; available in PMC 2015 Sep 15.

Published in final edited form as: Mutat Res Genet Toxicol Environ Mutagen. 2014 Sep 15; 0: 34–41. Published online 2014 Aug 7. doi: 10.1016/j.mrgentox.2014.07.010

PMCID:: PMC4196198

Abstract Article PDF–467K

Select item 311203514.

3′UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice

Kazuhiko Ikeda, Philip J. Mason, Monica Bessler

Blood. 2011 Jun 2; 117(22): 5860–5869. Prepublished online 2011 Apr 1. doi: 10.1182/blood-2011-02-334425

PMCID:: PMC3112035

Abstract Article

Select item 320490915.

Impaired FcϵRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins

Wouter L. W. Hazenbos, Ping Wu, Jeffrey Eastham-Anderson, Taroh Kinoshita, Eric J. Brown

Blood. 2011 Oct 20; 118(16): 4377–4383. Prepublished online 2011 Aug 24. doi: 10.1182/blood-2011-02-338053

PMCID:: PMC3204909

Abstract Article

Select item 452532816.

Selective overexpression of Toll-like receptor-4 in skeletal muscle impairs metabolic adaptation to high-fat feeding

Ryan P. McMillan, Yaru Wu, Kevin Voelker, Gabrielle Fundaro, John Kavanaugh, Joseph R. Stevens, Elika Shabrokh, Mostafa Ali, Mordecai Harvey, Angela S. Anderson, Nabil E. Boutagy, Randall L. Mynatt, Madlyn I. Frisard, Matthew W. Hulver

Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1; 309(3): R304–R313. Published online 2015 Jun 17. doi: 10.1152/ajpregu.00139.2015

PMCID:: PMC4525328

Abstract Article

Select item 661169417.

Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

Marshall Lukacs, Tia Roberts, Praneet Chatuverdi, Rolf W Stottmann

eLife. 2019; 8: e45248. Published online 2019 Jun 24. doi: 10.7554/eLife.45248

PMCID:: PMC6611694

Abstract Article PDF–6.5M

Select item 275239618.

Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins

Molly J. Ahrens, Yuwei Li, Hongmei Jiang, Andrew T. Dudley

Development. 2009 Oct 15; 136(20): 3463–3474. Published online 2009 Sep 17. doi: 10.1242/dev.040592

PMCID:: PMC2752396

Abstract Article

Select item 30876319.

GenePaint.org: an atlas of gene expression patterns in the mouse embryo

Axel Visel, Christina Thaller, Gregor Eichele

Nucleic Acids Res. 2004 Jan 1; 32(Database issue): D552–D556. doi: 10.1093/nar/gkh029

PMCID:: PMC308763

Abstract Article PDF–253K

Select item 255627020.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

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