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Select item 100009461.

Maternal and Intrauterine Influences on Feto-Placental Growth Are Accompanied by Sexually Dimorphic Changes in Placental Mitochondrial Respiration, and Metabolic Signalling Pathways

Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri

Cells. 2023 Mar; 12(5): 797. Published online 2023 Mar 3. doi: 10.3390/cells12050797

PMCID:: PMC10000946

Abstract Article PDF–2.8M

Select item 89153202.

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

Natalie B Collins, Rose Al Abosy, Brian C Miller, Kevin Bi, Qihong Zhao, Michael Quigley, Jeffrey J Ishizuka, Kathleen B Yates, Hans W Pope, Robert T Manguso, Yashaswi Shrestha, Marc Wadsworth, Travis Hughes, Alex K Shalek, Jesse S Boehm, William C Hahn, John G Doench, W Nicholas Haining

J Immunother Cancer. 2022; 10(3): e003402. Published online 2022 Mar 9. doi: 10.1136/jitc-2021-003402

PMCID:: PMC8915320

Abstract Article PDF–8.4M

Select item 86627373.

Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of PIK3CA-Driven Intractable Epilepsy

Achira Roy, Victor Z. Han, Angela M. Bard, Devin T. Wehle, Stephen E. P. Smith, Jan-Marino Ramirez, Franck Kalume, Kathleen J. Millen

Front Mol Neurosci. 2021; 14: 772847. Published online 2021 Nov 26. doi: 10.3389/fnmol.2021.772847

PMCID:: PMC8662737

Abstract Article PDF–17M

Select item 83954174.

PI3-Kinase p110α Deficiency Modulates T Cell Homeostasis and Function and Attenuates Experimental Allergic Encephalitis in Mature Mice

José M. Rojo, María Montes-Casado, Laura Aragoneses-Fenoll, Gloria Ojeda, Umberto Dianzani, Pilar Portolés

Int J Mol Sci. 2021 Aug; 22(16): 8698. Published online 2021 Aug 13. doi: 10.3390/ijms22168698

PMCID:: PMC8395417

Abstract Article PDF–1.8M

Select item 82327905.

The PI-3-Kinase P110α Catalytic Subunit of T Lymphocytes Modulates Collagen-Induced Arthritis

María Montes-Casado, Gloria Ojeda, Gabriel Criado, José M. Rojo, Pilar Portolés

Int J Mol Sci. 2021 Jun; 22(12): 6405. Published online 2021 Jun 15. doi: 10.3390/ijms22126405

PMCID:: PMC8232790

Abstract Article PDF–2.4M

Select item 78015106.

The role of the PIK3CA gene in the development and aging of the brain

Shaozhen Xie, Jing Ni, Hanbing Guo, Victor Luu, Yanzhi Wang, Jean J. Zhao, Thomas M. Roberts

Sci Rep. 2021; 11: 291. Published online 2021 Jan 11. doi: 10.1038/s41598-020-79416-6

PMCID:: PMC7801510

Abstract Article PDF–2.3M

Select item 67286027.

Inhibition of phosphatidylinositol 3‐kinase α (PI3Kα) prevents heterotopic ossification

José Antonio Valer, Cristina Sánchez‐de‐Diego, Beatriz Gámez, Yuji Mishina, José Luis Rosa, Francesc Ventura

EMBO Mol Med. 2019 Sep; 11(9): e10567. Published online 2019 Aug 2. doi: 10.15252/emmm.201910567

PMCID:: PMC6728602

Abstract Article PDF–2.9M

Select item 64493918.

Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue

Caroline Araiz, Anqi Yan, Lucia Bettedi, Isabella Samuelson, Sam Virtue, Anne K. McGavigan, Christian Dani, Antonio Vidal-Puig, Lazaros C. Foukas

Nat Commun. 2019; 10: 1546. Published online 2019 Apr 4. doi: 10.1038/s41467-019-09514-1

Correction in:: Nat Commun. 2020; 11: 1078.

PMCID:: PMC6449391

Abstract Article PDF–1.3M

Select item 64239849.

Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes

Myeong-Kyun Shin, Susan Payne, Andrea Bilger, Kristina A. Matkowskyj, Evie Carchman, Dominique S. Meyer, Mohamed Bentires-Alj, Dustin A. Deming, Paul F. Lambert

Clin Cancer Res. Author manuscript; available in PMC 2020 Mar 15.

Published in final edited form as: Clin Cancer Res. 2019 Mar 15; 25(6): 1889–1900. Published online 2018 Dec 7. doi: 10.1158/1078-0432.CCR-18-2843

PMCID:: PMC6423984

Abstract Article PDF–1.9M

Select item 636552910.

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function

Samantha F. Moore, Nina R. Smith, Thomas A. Blair, Tom N. Durrant, Ingeborg Hers

Sci Rep. 2019; 9: 1468. Published online 2019 Feb 6. doi: 10.1038/s41598-018-37012-9

PMCID:: PMC6365529

Abstract Article PDF–2.2M

Select item 614078611.

PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

Paul M Daniel, Gulay Filiz, Daniel V Brown, Michael Christie, Paul M Waring, Yi Zhang, John M Haynes, Colin Pouton, Dustin Flanagan, Elizabeth Vincan, Terrance G Johns, Karen Montgomery, Wayne A Phillips, Theo Mantamadiotis

Neuro Oncol. 2018 Sep; 20(10): 1344–1355. Published online 2018 Apr 30. doi: 10.1093/neuonc/noy068

PMCID:: PMC6140786

Abstract Article PDF–26M

Select item 583534212.

T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response

Laura Aragoneses-Fenoll, Gloria Ojeda, María Montes-Casado, Yeny Acosta-Ampudia, Umberto Dianzani, Pilar Portolés, José M. Rojo

Front Immunol. 2018; 9: 332. Published online 2018 Feb 27. doi: 10.3389/fimmu.2018.00332

PMCID:: PMC5835342

Abstract Article PDF–4.0M

Select item 535752513.

Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice

Victoria L. Boughton Nelson, Ariel L. Negrón, Inefta Reid, Justin A. Thomas, Leon Yang, Richard Z. Lin, Maricedes Acosta-Martínez

Biomed Res Int. 2017; 2017: 3756089. Published online 2017 Mar 5. doi: 10.1155/2017/3756089

PMCID:: PMC5357525

Abstract Article PDF–2.9M

Select item 505607114.

Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation

Amanda N. Sferruzzi-Perri, Jorge López-Tello, Abigail L. Fowden, Miguel Constancia

Proc Natl Acad Sci U S A. 2016 Oct 4; 113(40): 11255–11260. Published online 2016 Sep 12. doi: 10.1073/pnas.1602012113

PMCID:: PMC5056071

Abstract Article PDF–998K

Select item 490109615.

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

Samira Alliouachene, Benoit Bilanges, Claire Chaussade, Wayne Pearce, Lazaros C. Foukas, Cheryl L. Scudamore, Larissa S. Moniz, Bart Vanhaesebroeck

Diabetologia. 2016; 59: 1503–1512. Published online 2016 Apr 30. doi: 10.1007/s00125-016-3963-y

PMCID:: PMC4901096

Abstract Article PDF–1.1M

Select item 479690116.

PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice

Kenji Saito, Yanlin He, Yongjie Yang, Liangru Zhu, Chunmei Wang, Pingwen Xu, Antentor Othrell Hinton, Xiaofeng Yan, Jean Zhao, Makoto Fukuda, Qingchun Tong, Deborah J. Clegg, Yong Xu

Sci Rep. 2016; 6: 23459. Published online 2016 Mar 18. doi: 10.1038/srep23459

PMCID:: PMC4796901

Abstract Article PDF–1.3M

Select item 456172417.

p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity

Aditi Chaudhari, Daniel Krumlinde, Annika Lundqvist, Levent M. Akyürek, Sashidhar Bandaru, Kristina Skålén, Marcus Ståhlman, Jan Borén, Yvonne Wettergren, Katarina Ejeskär, Victoria Rotter Sopasakis

Mol Cell Biol. 2015 Oct; 35(19): 3258–3273. Prepublished online 2015 Jul 13. Published online 2015 Sep 4. doi: 10.1128/MCB.00471-15

PMCID:: PMC4561724

Abstract Article PDF–4.3M

Select item 440227018.

The p110α Isoform of Phosphoinositide 3-Kinase is Essential for Cone Photoreceptor Survival

Raju V.S. Rajala, Michelle Ranjo-Bishop, Yuhong Wang, Ammaji Rajala, Robert E. Anderson

Biochimie. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Biochimie. 2015 May; 112: 35–40. Published online 2015 Mar 3. doi: 10.1016/j.biochi.2015.02.018

PMCID:: PMC4402270

Abstract Article PDF–1.7M

Select item 362810319.

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

Lazaros C Foukas, Benoit Bilanges, Lucia Bettedi, Wayne Pearce, Khaled Ali, Sara Sancho, Dominic J Withers, Bart Vanhaesebroeck

EMBO Mol Med. 2013 Apr; 5(4): 563–571. Published online 2013 Mar 11. doi: 10.1002/emmm.201201953

PMCID:: PMC3628103

Abstract Article PDF–470K

Select item 355059520.

Conditional activation of Pik3ca^H1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations

W Yuan, E Stawiski, V Janakiraman, E Chan, S Durinck, K A Edgar, N M Kljavin, C S Rivers, F Gnad, M Roose-Girma, P M Haverty, G Fedorowicz, S Heldens, R H Soriano, Z Zhang, J J Wallin, L Johnson, M Merchant, Z Modrusan, H M Stern, S Seshagiri

Oncogene. 2013 Jan 17; 32(3): 318–326. Published online 2012 Feb 27. doi: 10.1038/onc.2012.53