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Select item 100620121.

PIKFYVE Inhibition Mitigates Disease in Models of Diverse Forms of ALS

Shu-Ting Hung, Gabriel R. Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samuel V. Alworth, Eric Hendricks, Yaoming Wang, Berislav V. Zlokovic, Dion K. Dickman, J. Alex Parker, Daniela C. Zarnescu, Fen-Biao Gao, Justin K. Ichida

Cell. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Cell. 2023 Feb 16; 186(4): 786–802.e28. Published online 2023 Feb 7. doi: 10.1016/j.cell.2023.01.005

PMCID:: PMC10062012

Abstract Article PDF–3.2M

Select item 49084902.

Unexpected severe consequences of Pikfyve deletion by aP2‐ or Aq‐promoter‐driven Cre expression for glucose homeostasis and mammary gland development

Ognian C. Ikonomov, Diego Sbrissa, Khortnal Delvecchio, James A. Rillema, Assia Shisheva

Physiol Rep. 2016 Jun; 4(11): e12812. Published online 2016 Jun 7. doi: 10.14814/phy2.12812

PMCID:: PMC4908490

Abstract Article PDF–2.2M

Select item 37255673.

Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching

Ognian C. Ikonomov, Diego Sbrissa, Khortnal Delvecchio, Han-Zhong Feng, Gregory D. Cartee, Jian-Ping Jin, Assia Shisheva

Am J Physiol Endocrinol Metab. 2013 Jul 1; 305(1): E119–E131. Published online 2013 May 14. doi: 10.1152/ajpendo.00030.2013

PMCID:: PMC3725567

Abstract Article

Select item 31732194.

The Nucleophosmin-Anaplastic Lymphoma Kinase Oncogene Interacts, Activates, and Uses the Kinase PIKfyve to Increase Invasiveness

Sophie Dupuis-Coronas, Frédéric Lagarrigue, Damien Ramel, Gaëtan Chicanne, Estelle Saland, Frédérique Gaits-Iacovoni, Bernard Payrastre, Hélène Tronchère

J Biol Chem. 2011 Sep 16; 286(37): 32105–32114. Published online 2011 Jul 7. doi: 10.1074/jbc.M111.227512

PMCID:: PMC3173219

Abstract Article PDF–1.4M

Select item 30756865.

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development: PREIMPLANTATION LETHALITY OF PIKfyve^−/− EMBRYOS BUT NORMALITY OF PIKfyve^+/− MICE

Ognian C. Ikonomov, Diego Sbrissa, Khortnal Delvecchio, Yufen Xie, Jian-Ping Jin, Daniel Rappolee, Assia Shisheva

J Biol Chem. 2011 Apr 15; 286(15): 13404–13413. Published online 2011 Feb 24. doi: 10.1074/jbc.M111.222364

PMCID:: PMC3075686

Abstract Article PDF–3.1M

Select item 28065946.

An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

Gregory D. Fairn, Koji Ogata, Roberto J. Botelho, Philip D. Stahl, Richard A. Anderson, Pietro De Camilli, Tobias Meyer, Shoshana Wodak, Sergio Grinstein

J Cell Biol. 2009 Nov 30; 187(5): 701–714. doi: 10.1083/jcb.200909025

PMCID:: PMC2806594

Abstract Article PDF–5.2M

Select item 112139537.

PIKfyve, expressed by CD11c-positive cells, controls tumor immunity

Jae Eun Choi, Yuanyuan Qiao, Ilona Kryczek, Jiali Yu, Jonathan Gurkan, Yi Bao, Mahnoor Gondal, Jean Ching-Yi Tien, Tomasz Maj, Sahr Yazdani, Abhijit Parolia, Houjun Xia, JiaJia Zhou, Shuang Wei, Sara Grove, Linda Vatan, Heng Lin, Gaopeng Li, Yang Zheng, Yuping Zhang, Xuhong Cao, Fengyun Su, Rui Wang, Tongchen He, Marcin Cieslik, Michael D. Green, Weiping Zou, Arul M. Chinnaiyan

Nat Commun. 2024; 15: 5487. Published online 2024 Jun 28. doi: 10.1038/s41467-024-48931-9

PMCID:: PMC11213953

Abstract Article PDF–1.8M

Select item 93047918.

Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity

Golam T. Saffi, Cheng An Wang, Emily M. Mangialardi, Jean Vacher, Roberto J. Botelho, Leonardo Salmena

J Biol Chem. 2022 Aug; 298(8): 102187. Published online 2022 Jun 26. doi: 10.1016/j.jbc.2022.102187

PMCID:: PMC9304791

Abstract Article PDF–3.0M

Select item 90670839.

Inhibition of PIKfyve Ameliorates the Proliferation and Migration of Vascular Smooth Muscle Cells and Vascular Intima Hyperplasia By Reducing mTORC1 Activity

Min Gu, Zhen Wang, Feifei Feng, Yongjian Yang, Xiongshan Sun, Dachun Yang

J Cardiovasc Pharmacol. 2022 May; 79(5): 739–748. Published online 2022 Mar 11. doi: 10.1097/FJC.0000000000001243

PMCID:: PMC9067083

Abstract Article PDF–950K

Select item 603133110.

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Christopher H. Choy, Golam Saffi, Matthew A. Gray, Callen Wallace, Roya M. Dayam, Zhen-Yi A. Ou, Guy Lenk, Rosa Puertollano, Simon C. Watkins, Roberto J. Botelho

J Cell Sci. 2018 May 15; 131(10): jcs213587. Published online 2018 May 21. doi: 10.1242/jcs.213587

PMCID:: PMC6031331

Abstract Article

Select item 547004211.

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice

Takumi Kawasaki, Kosuke Ito, Haruhiko Miyata, Shizuo Akira, Taro Kawai

EMBO J. 2017 Jun 14; 36(12): 1707–1718. Published online 2017 May 22. doi: 10.15252/embj.201695528

PMCID:: PMC5470042

Abstract Article PDF–1.5M

Select item 545204812.

Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice

Helene Tronchere, Mathieu Cinato, Andrei Timotin, Laurie Guitou, Camille Villedieu, Helene Thibault, Delphine Baetz, Bernard Payrastre, Philippe Valet, Angelo Parini, Oksana Kunduzova, Frederic Boal

EMBO Mol Med. 2017 Jun; 9(6): 770–785. Published online 2017 Apr 10. doi: 10.15252/emmm.201607096

PMCID:: PMC5452048

Abstract Article PDF–3.0M

Select item 456003913.

Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity

Kachiko Hayashi, Miwa Sasai, Akiko Iwasaki

Int Immunol. 2015 Sep; 27(9): 435–445. Published online 2015 Apr 29. doi: 10.1093/intimm/dxv021

PMCID:: PMC4560039

Abstract Article PDF–2.9M

Select item 443154414.

Class III PI 3-Kinase is the Main Source of PtdIns3P Substrate and Membrane Recruitment Signal for PIKfyve Constitutive Function in Podocyte Endomembrane Homeostasis

Ognian C. Ikonomov, Diego Sbrissa, Madhusudan Venkatareddy, Ellen Tisdale, Puneet Garg, Assia Shisheva

Biochim Biophys Acta. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Biochim Biophys Acta. 2015 May; 1853(5): 1240–1250. Published online 2015 Jan 22. doi: 10.1016/j.bbamcr.2015.01.008

PMCID:: PMC4431544

Abstract Article PDF–2.1M

Select item 342298415.

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P₂ by means of the PIKfyve inhibitor YM201636

Diego Sbrissa, Ognian C. Ikonomov, Catherine Filios, Khortnal Delvecchio, Assia Shisheva

Am J Physiol Cell Physiol. 2012 Aug 15; 303(4): C436–C446. Published online 2012 May 23. doi: 10.1152/ajpcell.00105.2012

PMCID:: PMC3422984

Abstract Article

Select item 247567916.

ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes

Ognian C. Ikonomov, Diego Sbrissa, Rajeswari Dondapati, Assia Shisheva

Exp Cell Res. Author manuscript; available in PMC 2008 Jul 21.

Published in final edited form as: Exp Cell Res. 2007 Jul 1; 313(11): 2404–2416. Published online 2007 Mar 30. doi: 10.1016/j.yexcr.2007.03.024

PMCID:: PMC2475679

Abstract Article PDF–1.3M

Select item 8392017.

Cloning, Characterization, and Expression of a Novel Zn²⁺-Binding FYVE Finger-Containing Phosphoinositide Kinase in Insulin-Sensitive Cells

Assia Shisheva, Diego Sbrissa, Ognian Ikonomov

Mol Cell Biol. 1999 Jan; 19(1): 623–634. doi: 10.1128/mcb.19.1.623

PMCID:: PMC83920

Abstract Article PDF–2.3M

Select item 719775018.

PI(4,5)P₂ regulates plasma cholesterol through LDL receptor lysosomal degradation

Yuanyuan Qin, Flora Ting, Mee J Kim, Jacob Strelnikov, Joseph Harmon, Feng Gao, Andrea Dose, Ba-Bie Teng, M. Amir Alipour, Zemin Yao, Rosanne Crooke, Ronald M. Krauss, Marisa W. Medina

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 May; 40(5): 1311–1324. Published online 2020 Mar 19. doi: 10.1161/ATVBAHA.120.314033

PMCID:: PMC7197750

Abstract Article PDF–2.1M

Select item 679165419.

PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice

Sang Hee Min, Aae Suzuki, Lehn Weaver, Jessica Guzman, Yutein Chung, Huiyan Jin, Francina Gonzalez, Claire Trasorras, Liang Zhao, Lynn A. Spruce, Steven H. Seeholzer, Edward M. Behrens, Charles S. Abrams

Mol Cell Biol. 2019 Nov 1; 39(21): e00158-19. Prepublished online 2019 Aug 19. Published online 2019 Oct 11. doi: 10.1128/MCB.00158-19

PMCID:: PMC6791654

Abstract Article PDF–4.8M

Select item 588918520.

PIKfyve regulates melanosome biogenesis

Marc C. Liggins, Jessica L. Flesher, Sohail Jahid, Priya Vasudeva, Victoria Eby, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki, Raymond E. Boissy, Anand K. Ganesan

PLoS Genet. 2018 Mar; 14(3): e1007290. Published online 2018 Mar 27. doi: 10.1371/journal.pgen.1007290

PMCID:: PMC5889185

Abstract Article PDF–23M

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