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Select item 109445341.

A novel role for phospholamban in the thalamic reticular nucleus

Benjamin Klocke, Aikaterini Britzolaki, Joseph Saurine, Hayden Ott, Kylie Krone, Kiara Bahamonde, Connor Thelen, Christos Tzimas, Despina Sanoudou, Evangelia G. Kranias, Pothitos M. Pitychoutis

Sci Rep. 2024; 14: 6376. Published online 2024 Mar 16. doi: 10.1038/s41598-024-56447-x

PMCID:: PMC10944534

Abstract Article PDF–6.7M

Select item 99173592.

Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy

Mohit Kumar, Kobra Haghighi, Sheryl Koch, Jack Rubinstein, Francesca Stillitano, Roger J. Hajjar, Evangelia G. Kranias, Sakthivel Sadayappan

Int J Mol Sci. 2023 Feb; 24(3): 2675. Published online 2023 Jan 31. doi: 10.3390/ijms24032675

PMCID:: PMC9917359

Abstract Article PDF–7.2M

Select item 82269093.

Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias

Kobra Haghighi, George Gardner, Elizabeth Vafiadaki, Mohit Kumar, Lisa C. Green, Jianyong Ma, Jeffrey S. Crocker, Sheryl Koch, Demetrios A. Arvanitis, Phillip Bidwell, Jack Rubinstein, Rutger van de Leur, Pieter A. Doevendans, Fadi G. Akar, Michael Tranter, Hong-Sheng Wang, Sakthivel Sadayappan, Deeptankar DeMazumder, Despina Sanoudou, Roger J. Hajjar, Francesca Stillitano, Evangelia G. Kranias

J Pers Med. 2021 Jun; 11(6): 502. Published online 2021 Jun 3. doi: 10.3390/jpm11060502

PMCID:: PMC8226909

Abstract Article PDF–4.1M

Select item 73000324.

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy

Tim R. Eijgenraam, Bastiaan J. Boukens, Cornelis J. Boogerd, E. Marloes Schouten, Cees W. A. van de Kolk, Nienke M. Stege, Wouter P. te Rijdt, Edgar T. Hoorntje, Paul A. van der Zwaag, Eva van Rooij, J. Peter van Tintelen, Maarten P. van den Berg, Peter van der Meer, Jolanda van der Velden, Herman H. W. Silljé, Rudolf A. de Boer

Sci Rep. 2020; 10: 9819. Published online 2020 Jun 17. doi: 10.1038/s41598-020-66656-9

Correction in:: Sci Rep. 2020; 10: 16710.

PMCID:: PMC7300032

Abstract Article PDF–7.3M

Select item 70758585.

Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response

Shamim A. K. Chowdhury, Chad M. Warren, Jillian N. Simon, David M. Ryba, Ashley Batra, Peter Varga, Evangelia G. Kranias, Jil C. Tardiff, R. John Solaro, Beata M. Wolska

Front Physiol. 2020; 11: 107. Published online 2020 Mar 10. doi: 10.3389/fphys.2020.00107

PMCID:: PMC7075858

Abstract Article PDF–5.2M

Select item 62053006.

Phospholamban Regulates Nuclear Ca²⁺ Stores and Inositol 1,4,5-Trisphosphate Mediated Nuclear Ca²⁺ Cycling in Cardiomyocytes

Mu Chen, Dongzhu Xu, Adonis Z. Wu, Evangelia Kranias, Shien-Fong Lin, Peng-Sheng Chen, Zhenhui Chen

J Mol Cell Cardiol. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: J Mol Cell Cardiol. 2018 Oct; 123: 185–197. Published online 2018 Sep 24. doi: 10.1016/j.yjmcc.2018.09.008

PMCID:: PMC6205300

Abstract Article PDF–3.0M

Select item 51614757.

Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model

Manami Kaneko, Kentarou Hashikami, Satoshi Yamamoto, Hirokazu Matsumoto, Tomoyuki Nishimoto

PLoS One. 2016; 11(12): e0168486. Published online 2016 Dec 16. doi: 10.1371/journal.pone.0168486

PMCID:: PMC5161475

Abstract Article PDF–1.4M

Select item 45272968.

Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype

Val A. Fajardo, Eric Bombardier, Elliott McMillan, Khanh Tran, Brennan J. Wadsworth, Daniel Gamu, Andrew Hopf, Chris Vigna, Ian C. Smith, Catherine Bellissimo, Robin N. Michel, Mark A. Tarnopolsky, Joe Quadrilatero, A. Russell Tupling

Dis Model Mech. 2015 Aug 1; 8(8): 999–1009. doi: 10.1242/dmm.020859

PMCID:: PMC4527296

Abstract Article

Select item 44478099.

Cardioprotection by H₂S engages a cGMP-dependent protein kinase G/phospholamban pathway

Sofia-Iris Bibli, Ioanna Andreadou, Athanasia Chatzianastasiou, Christos Tzimas, Despina Sanoudou, Evangelia Kranias, Peter Brouckaert, Ciro Coletta, Csaba Szabo, Dimitrios Th. Kremastinos, Efstathios K. Iliodromitis, Andreas Papapetropoulos

Cardiovasc Res. 2015 Jun 1; 106(3): 432–442. Published online 2015 Apr 13. doi: 10.1093/cvr/cvv129

PMCID:: PMC4447809

Abstract Article PDF–600K

Select item 424016610.

Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes

Sarah J. Briston, Katharine M. Dibb, R. John Solaro, David A. Eisner, Andrew W. Trafford

Cardiovasc Res. 2014 Nov 1; 104(2): 347–354. Published online 2014 Sep 2. doi: 10.1093/cvr/cvu201

PMCID:: PMC4240166

Abstract Article PDF–450K

Select item 376306511.

Microarray analysis of active cardiac remodeling genes in a familial hypertrophic cardiomyopathy mouse model rescued by a phospholamban knockout

Sudarsan Rajan, James R. Pena, Anil G. Jegga, Bruce J. Aronow, Beata M. Wolska, David F. Wieczorek

Physiol Genomics. 2013 Sep 1; 45(17): 764–773. Published online 2013 Jun 25. doi: 10.1152/physiolgenomics.00023.2013

PMCID:: PMC3763065

Abstract Article

Select item 352275212.

Tuning the Structural Coupling between the Transmembrane and Cytoplasmic Domains of Phospholamban to Control Sarcoplasmic Reticulum Ca²⁺-ATPase (SERCA) Function

Kim N. Ha, Martin Gustavsson, Gianluigi Veglia

J Muscle Res Cell Motil. Author manuscript; available in PMC 2013 Dec 1.

Published in final edited form as: J Muscle Res Cell Motil. 2012 Dec; 33(6): 485–492. Published online 2012 Sep 13. doi: 10.1007/s10974-012-9319-4

PMCID:: PMC3522752

Abstract Article PDF–952K

Select item 322141013.

Long-term Rescue of a Familial Hypertrophic Cardiomyopathy Caused by a Mutation in the Thin Filament Protein, Tropomyosin, via Modulation of a Calcium Cycling Protein

Robert D Gaffin, James R Peña, Marco S L Alves, Fernando A L Dias, Shamim Chowdhury, Lynley S Heinrich, Paul H Goldspink, Evangelia G Kranias, David F Wieczorek, Beata M Wolska

J Mol Cell Cardiol. Author manuscript; available in PMC 2012 Nov 1.

Published in final edited form as: J Mol Cell Cardiol. 2011 Nov; 51(5): 812–820. Published online 2011 Aug 5. doi: 10.1016/j.yjmcc.2011.07.026

PMCID:: PMC3221410

Abstract Article PDF–1.3M

Select item 309233114.

SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts

Hong-Sheng Wang, Demetrios A. Arvanitis, Min Dong, Paul J. Niklewski, Wen Zhao, Chi Keung Lam, Evangelia G. Kranias, Despina Sanoudou

Physiol Genomics. 2011 Apr; 43(7): 357–364. Published online 2011 Jan 25. doi: 10.1152/physiolgenomics.00032.2010

PMCID:: PMC3092331

Abstract Article

Select item 269405315.

Targeting of phospholamban by peroxynitrite decreases β-adrenergic stimulation in cardiomyocytes

Mark J. Kohr, Honglan Wang, Debra G. Wheeler, Murugesan Velayutham, Jay L. Zweier, Mark T. Ziolo

Cardiovasc Res. Author manuscript; available in PMC 2009 Jun 9.

Published in final edited form as: Cardiovasc Res. 2008 Jan 15; 77(2): 353–361. Published online 2007 Sep 19. doi: 10.1093/cvr/cvm018

PMCID:: PMC2694053

Abstract Article PDF–346K

Select item 261406216.

Modulation of murine gastric antrum smooth muscle STOC activity and excitability by phospholamban

Minkyung Kim, Grant W Hennig, Kyungsik Park, In Soo Han, Terence K Smith, Sang Don Koh, Brian A Perrino

J Physiol. 2008 Oct 15; 586(Pt 20): 4977–4991. Published online 2008 Aug 28. doi: 10.1113/jphysiol.2008.156836

PMCID:: PMC2614062

Abstract Article PDF–694K

Select item 249360717.

Biphasic Effect of SIN-1 is Reliant upon Cardiomyocyte Contractile State

Mark J Kohr, Honglan Wang, Debra G Wheeler, Murugesan Velayutham, Jay L Zweier, Mark T Ziolo

Free Radic Biol Med. Author manuscript; available in PMC 2009 Jul 1.

Published in final edited form as: Free Radic Biol Med. 2008 Jul 1; 45(1): 73–80. Published online 2008 Apr 4. doi: 10.1016/j.freeradbiomed.2008.03.019

PMCID:: PMC2493607

Abstract Article PDF–560K

Select item 227880918.

Phospholamban regulation of bladder contractility: evidence from gene-altered mouse models

Koji Nobe, Roy L Sutliff, Evangelia G Kranias, Richard J Paul

J Physiol. 2001 Sep 15; 535(Pt 3): 867–878. doi: 10.1111/j.1469-7793.2001.00867.x

PMCID:: PMC2278809

Abstract Article PDF–635K

Select item 50704819.

Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice.

V J Kadambi, S Ponniah, J M Harrer, B D Hoit, G W Dorn, 2nd, R A Walsh, E G Kranias

J Clin Invest. 1996 Jan 15; 97(2): 533–539. doi: 10.1172/JCI118446

PMCID:: PMC507048

Summary PDF–237K

Select item 35693520.

Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics

Yan Pan, Thomas Kislinger, Anthony O. Gramolini, Elena Zvaritch, Evangelia G. Kranias, David H. MacLennan, Andrew Emili

Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8): 2241–2246. Published online 2004 Feb 13. doi: 10.1073/pnas.0308174101

PMCID:: PMC356935

Abstract Article PDF–391K

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