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Select item 112626191.

Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis

Elizabeth R. Volkmann, Christopher P. Denton, Martin Kolb, Marlies S. Wijsenbeek-Lourens, Claire Emson, Krischan Hudson, Anthony J. Amatucci, Oliver Distler, Yannick Allanore, Dinesh Khanna

Eur Respir Rev. 2024 Apr 30; 33(172): 240015. Published online 2024 Jun 12. doi: 10.1183/16000617.0015-2024

PMCID:: PMC11262619

Abstract Article PDF–814K

Select item 85309652.

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Jianglan Liu, Vito W. Rebecca, Andrew V. Kossenkov, Thomas Connelly, Qin Liu, Alexis Gutierrez, Min Xiao, Ling Li, Gao Zhang, Anastasia Samarkina, Delaine Zayasbazan, Jie Zhang, Chaoran Cheng, Zhi Wei, Gretchen M. Alicea, Mizuho Fukunaga-Kalabis, Clemens Krepler, Pedro Aza-Blanc, Chih-Cheng Yang, Bela Delvadia, Cynthia Tong, Ye Huang, Maya Delvadia, Alice S. Morias, Katrin Sproesser, Patricia Brafford, Joshua X. Wang, Marilda Beqiri, Rajasekharan Somasundaram, Adina Vultur, Denitsa M. Hristova, Lawrence W. Wu, Yiling Lu, Gordon B. Mills, Wei Xu, Giorgos C. Karakousis, Xiaowei Xu, Lynn M. Schuchter, Tara C. Mitchell, Ravi K. Amaravadi, Lawrence N. Kwong, Dennie T. Frederick, Genevieve M. Boland, Joseph M. Salvino, David W. Speicher, Keith T. Flaherty, Ze'ev A. Ronai, Meenhard Herlyn

Cancer Res. 2021 Oct 15; 81(20): 5230–5241. Published online 2021 Aug 30. doi: 10.1158/0008-5472.CAN-20-1496

PMCID:: PMC8530965

Abstract Article PDF–14M

Select item 84290423.

Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis

Satoshi Takagi, Yuki Sasaki, Sumie Koike, Ai Takemoto, Yosuke Seto, Mizuki Haraguchi, Takao Ukaji, Tokuichi Kawaguchi, Minoru Sugawara, Masanori Saito, Yuki Funauchi, Keisuke Ae, Seiichi Matsumoto, Naoya Fujita, Ryohei Katayama

Oncogene. 2021; 40(36): 5548–5558. Published online 2021 Jul 23. doi: 10.1038/s41388-021-01956-6

PMCID:: PMC8429042

Abstract Article PDF–4.2M

Select item 61938834.

Lysophosphatidic acid acts on LPA₁ receptor to increase H₂O₂ during flow‐induced dilation in human adipose arterioles

Dawid S Chabowski, Andrew O Kadlec, Karima Ait‐Aissa, Joseph C Hockenberry, Paul J Pearson, Andreas M Beyer, David D Gutterman

Br J Pharmacol. 2018 Nov; 175(22): 4266–4280. Published online 2018 Oct 11. doi: 10.1111/bph.14492

PMCID:: PMC6193883

Abstract Article PDF–860K

Select item 45426285.

Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA₁ N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor Activation

Olaposi I. Omotuyi, Jun Nagai, Hiroshi Ueda

Sci Rep. 2015; 5: 13343. Published online 2015 Aug 13. doi: 10.1038/srep13343

PMCID:: PMC4542628

Abstract Article PDF–1.2M

Select item 44760596.

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

Jill E. Chrencik, Christopher B. Roth, Masahiko Terakado, Haruto Kurata, Rie Omi, Yasuyuki Kihara, Dora Warshaviak, Shinji Nakade, Guillermo Asmar-Rovira, Mauro Mileni, Hirotaka Mizuno, Mark T. Griffith, Caroline Rodgers, Gye Won Han, Jeffrey Velasquez, Jerold Chun, Raymond C. Stevens, Michael A. Hanson

Cell. Author manuscript; available in PMC 2016 Jun 18.

Published in final edited form as: Cell. 2015 Jun 18; 161(7): 1633–1643. doi: 10.1016/j.cell.2015.06.002

PMCID:: PMC4476059

Abstract Article PDF–1.8M

Select item 42039667.

Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid–lysophosphatidic acid receptor 1 cascade

Yoshishige Miyabe, Chie Miyabe, Yoshiko Iwai, Waka Yokoyama, Chiyoko Sekine, Kazutaka Sugimoto, Masayoshi Harigai, Masayuki Miyasaka, Nobuyuki Miyasaka, Toshihiro Nanki

Arthritis Res Ther. 2014; 16(5): 461. Published online 2014 Oct 2. doi: 10.1186/s13075-014-0461-9

PMCID:: PMC4203966

Abstract Article PDF–1.2M

Select item 15250198.

Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA₁) in mammalian cells

Catherine M. Waters, Bahman Saatian, Noreen A. Moughal, Yutong Zhao, Gabor Tigyi, Viswanathan Natarajan, Susan Pyne, Nigel J. Pyne

Biochem J. 2006 Aug 15; 398(Pt 1): 55–62. Prepublished online 2006 May 23. Published online 2006 Jul 27. doi: 10.1042/BJ20060155

PMCID:: PMC1525019

Abstract Article PDF–600K

Select item 111583569.

Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA₁ and LPA₂

Tadaaki Yamada, Seiji Yano, Hirokazu Ogino, Kenji Ikuta, Soji Kakiuchi, Masaki Hanibuchi, Takanori Kanematsu, Tetsuo Taniguchi, Yoshitaka Sekido, Saburo Sone

Cancer Sci. 2008 Aug; 99(8): 1603–1610. Published online 2008 Aug 14. doi: 10.1111/j.1349-7006.2008.00848.x

PMCID:: PMC11158356

Abstract Article PDF–383K

Select item 986810110.

LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells

SHANNON WEBER DOUTT, JODY FROMM LONGO, STEVEN L. CARROLL

Glia. Author manuscript; available in PMC 2024 Mar 1.

Published in final edited form as: Glia. 2023 Mar; 71(3): 742–757. Published online 2022 Nov 23. doi: 10.1002/glia.24308

PMCID:: PMC9868101

Abstract Article PDF–2.9M

Select item 882642111.

Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate

Shian Liu, Navid Paknejad, Lan Zhu, Yasuyuki Kihara, Manisha Ray, Jerold Chun, Wei Liu, Richard K. Hite, Xin-Yun Huang

Nat Commun. 2022; 13: 731. Published online 2022 Feb 8. doi: 10.1038/s41467-022-28417-2

PMCID:: PMC8826421

Abstract Article PDF–2.9M

Select item 580219612.

ATX-LPA axis facilitates estrogen-induced endometrial cancer cell proliferation via MAPK/ERK signaling pathway

Guo Zhang, Yuan Cheng, Qi Zhang, Xiaoping Li, Jingwei Zhou, Jianliu Wang, Lihui Wei

Mol Med Rep. 2018 Mar; 17(3): 4245–4252. Published online 2018 Jan 8. doi: 10.3892/mmr.2018.8392

PMCID:: PMC5802196

Abstract Article PDF–1.7M

Select item 402085213.

Identification of Heparin-Binding EGF-Like Growth Factor (HB-EGF) as a Biomarker for Lysophosphatidic Acid Receptor Type 1 (LPA₁) Activation in Human Breast and Prostate Cancers

Marion David, Debashish Sahay, Florence Mege, Françoise Descotes, Raphaël Leblanc, Johnny Ribeiro, Philippe Clézardin, Olivier Peyruchaud

PLoS One. 2014; 9(5): e97771. Published online 2014 May 14. doi: 10.1371/journal.pone.0097771

PMCID:: PMC4020852

Abstract Article PDF–999K

Select item 348097614.

Gene Expression of the Lysophosphatidic Acid Receptor 1 Is a Target of Transforming Growth Factor Beta

Jinhua Wu, Abir Mukherjee, Deborah A Lebman, Xianjun Fang

Oncogene. Author manuscript; available in PMC 2013 Dec 27.

Published in final edited form as: Oncogene. 2013 Jun 27; 32(26): 3198–3206. Published online 2012 Jul 23. doi: 10.1038/onc.2012.325

PMCID:: PMC3480976

Abstract Article PDF–1.1M

Select item 1051894015.

LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration

Jong Min Hong, Jin-Woo Lee, Dong-Seung Seen, Jae-Yeon Jeong, Won-Ki Huh

Cell Commun Signal. 2023; 21: 257. Published online 2023 Sep 25. doi: 10.1186/s12964-023-01261-7

PMCID:: PMC10518940

Abstract Article PDF–2.7M

Select item 893419716.

A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses

Sarah J Taleb, Jianxin Wei, Rachel K Mialki, Su Dong, Yanhui Li, Jing Zhao, Yutong Zhao

J Cell Biochem. Author manuscript; available in PMC 2022 Mar 19.

Published in final edited form as: J Cell Biochem. 2021 Aug; 122(8): 827–834. Published online 2021 Apr 13. doi: 10.1002/jcb.29919

PMCID:: PMC8934197

Abstract Article PDF–646K

Select item 806612617.

LPA₁ Receptor Promotes Progesterone Receptor Phosphorylation through PKCα in Human Glioblastoma Cells

Silvia Anahi Valdés-Rives, Denisse Arcos-Montoya, Marisol de la Fuente-Granada, Carmen J. Zamora-Sánchez, Luis Enrique Arias-Romero, Olga Villamar-Cruz, Ignacio Camacho-Arroyo, Sonia M. Pérez-Tapia, Aliesha González-Arenas

Cells. 2021 Apr; 10(4): 807. Published online 2021 Apr 4. doi: 10.3390/cells10040807

PMCID:: PMC8066126

Abstract Article PDF–3.1M

Select item 756126018.

CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model

Y Ward, R Lake, PL Martin, K Killian, P Salerno, T Wang, P Meltzer, M Merino, S-y Cheng, M Santoro, G Garcia-Rostan, K Kelly

Oncogene. Author manuscript; available in PMC 2020 Oct 15.

Published in final edited form as: Oncogene. 2013 May 30; 32(22): 2726–2738. Published online 2012 Jul 16. doi: 10.1038/onc.2012.301

PMCID:: PMC7561260

Abstract Article PDF–4.8M

Select item 709909719.

The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages

Dapeng Zhang, Rongchen Shi, Wei Xiang, Xia Kang, Bo Tang, Chuan Li, Linfeng Gao, Xuan Zhang, Lili Zhang, Rongyang Dai, Hongming Miao

Signal Transduct Target Ther. 2020; 5: 24. Published online 2020 Mar 27. doi: 10.1038/s41392-020-0117-y

PMCID:: PMC7099097

Abstract Article PDF–6.3M

Select item 699169920.

Long noncoding RNA ZFAS1 promotes tumorigenesis and metastasis in nasopharyngeal carcinoma by sponging miR‐892b to up‐regulate LPAR1 expression

Jiaojiao Peng, Feng Liu, Hong Zheng, Qi Wu, Shixi Liu

J Cell Mol Med. 2020 Jan; 24(2): 1437–1450. Published online 2019 Dec 18. doi: 10.1111/jcmm.14823

PMCID:: PMC6991699

Abstract Article PDF–2.0M

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