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Select item 58591111.

Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons

Philippine C. Geiszler, Aslihan Ugun-Klusek, Karen Lawler, Marie-Christine Pardon, Ding Yuchun, Li Bai, Clare A. Daykin, Dorothee P. Auer, Lynn Bedford

Sci Rep. 2018; 8: 4833. Published online 2018 Mar 19. doi: 10.1038/s41598-018-23155-2

PMCID:: PMC5859111

Abstract Article PDF–3.2M

Select item 41512302.

Proteasome function is required for platelet production

Dallas S. Shi, Matthew C.P. Smith, Robert A. Campbell, Patrick W. Zimmerman, Zechariah B. Franks, Bjorn F. Kraemer, Kellie R. Machlus, Jing Ling, Patrick Kamba, Hansjörg Schwertz, Jesse W. Rowley, Rodney R. Miles, Zhi-Jian Liu, Martha Sola-Visner, Joseph E. Italiano, Jr., Hilary Christensen, Walter H.A. Kahr, Dean Y. Li, Andrew S. Weyrich

J Clin Invest. 2014 Sep 2; 124(9): 3757–3766. Published online 2014 Jul 25. doi: 10.1172/JCI75247

PMCID:: PMC4151230

Abstract Article PDF–3.6M

Select item 66705643.

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

Lynn Bedford, David Hay, Anny Devoy, Simon Paine, Des G. Powe, Rashmi Seth, Trevor Gray, Ian Topham, Kevin Fone, Nooshin Rezvani, Maureen Mee, Tim Soane, Robert Layfield, Paul W. Sheppard, Ted Ebendal, Dmitry Usoskin, James Lowe, R. John Mayer

J Neurosci. 2008 Aug 13; 28(33): 8189–8198. doi: 10.1523/JNEUROSCI.2218-08.2008

PMCID:: PMC6670564

Abstract Article PDF–630K

Select item 53863604.

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

Aslihan Ugun-Klusek, Michael H Tatham, Jamal Elkharaz, Dumitru Constantin-Teodosiu, Karen Lawler, Hala Mohamed, Simon M L Paine, Glen Anderson, R John Mayer, James Lowe, E Ellen Billett, Lynn Bedford

Cell Death Dis. 2017 Jan; 8(1): e2531. Published online 2017 Jan 5. doi: 10.1038/cddis.2016.443

PMCID:: PMC5386360

Abstract Article PDF–2.2M

Select item 49512425.

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

Shaogui Wang, Hong-Min Ni, Kenneth Dorko, Sean C. Kumer, Timothy M. Schmitt, Atta Nawabi, Masaaki Komatsu, Heqing Huang, Wen-Xing Ding

Oncotarget. 2016 Apr 5; 7(14): 17681–17698. Published online 2016 Jan 12. doi: 10.18632/oncotarget.6893

PMCID:: PMC4951242

Abstract Article PDF–12M

Select item 12760806.

Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome

Guangtao Li, Xiaoke Zhou, Gang Zhao, Hermann Schindelin, William J. Lennarz

Proc Natl Acad Sci U S A. 2005 Nov 1; 102(44): 15809–15814. Published online 2005 Oct 25. doi: 10.1073/pnas.0507155102

Correction in:: Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4): 1153.

PMCID:: PMC1276080

Abstract Article PDF–395K

Select item 47523497.

TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene

Barbara Czub, Amna Z. Shah, Giovanna Alfano, Przemysław M. Kruczek, Christina F. Chakarova, Shomi S. Bhattacharya

PLoS One. 2016; 11(2): e0148678. Published online 2016 Feb 12. doi: 10.1371/journal.pone.0148678

PMCID:: PMC4752349

Abstract Article PDF–2.8M

Select item 35597528.

Pale Body-Like Inclusion Formation and Neurodegeneration following Depletion of 26S Proteasomes in Mouse Brain Neurones are Independent of α-Synuclein

Simon M. L. Paine, Glenn Anderson, Karen Bedford, Karen Lawler, R. John Mayer, James Lowe, Lynn Bedford

PLoS One. 2013; 8(1): e54711. Published online 2013 Jan 30. doi: 10.1371/journal.pone.0054711

PMCID:: PMC3559752

Abstract Article PDF–2.6M

Select item 41556639.

Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway

Shun Kageyama, Yu-shin Sou, Takefumi Uemura, Satoshi Kametaka, Tetsuya Saito, Ryosuke Ishimura, Tsuguka Kouno, Lynn Bedford, R. John Mayer, Myung-Shik Lee, Masayuki Yamamoto, Satoshi Waguri, Keiji Tanaka, Masaaki Komatsu

J Biol Chem. 2014 Sep 5; 289(36): 24944–24955. Published online 2014 Jul 21. doi: 10.1074/jbc.M114.580357

PMCID:: PMC4155663

Abstract Article PDF–9.2M

Select item 289844410.

Caspase-3 Cleaves Specific 19 S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity

Xiaonan H. Wang, Liping Zhang, William E. Mitch, Joseph M. LeDoux, Junping Hu, Jie Du

J Biol Chem. 2010 Jul 9; 285(28): 21249–21257. Published online 2010 Apr 27. doi: 10.1074/jbc.M109.041707

PMCID:: PMC2898444

Abstract Article PDF–1.6M

Select item 148249711.

The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor

Guangtao Li, Gang Zhao, Xiaoke Zhou, Hermann Schindelin, William J. Lennarz

Proc Natl Acad Sci U S A. 2006 May 30; 103(22): 8348–8353. Published online 2006 May 18. doi: 10.1073/pnas.0602747103

PMCID:: PMC1482497

Abstract Article PDF–1.5M

Select item 51883212.

A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins

Samiksha Katiyar, Guangtao Li, William J. Lennarz

Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38): 13774–13779. Published online 2004 Sep 9. doi: 10.1073/pnas.0405663101

PMCID:: PMC518832

Abstract Article PDF–463K

Select item 1068657313.

Lipid-anchored proteasomes control membrane protein homeostasis

Ruizhu Zhang, Shuxian Pan, Suya Zheng, Qingqing Liao, Zhaodi Jiang, Dixian Wang, Xuemei Li, Ao Hu, Xinran Li, Yezhang Zhu, Xiaoqi Shen, Jing Lei, Siming Zhong, Xiaomei Zhang, Lingyun Huang, Xiaorong Wang, Lan Huang, Li Shen, Bao-Liang Song, Jing-Wei Zhao, Zhiping Wang, Bing Yang, Xing Guo

Sci Adv. 2023 Dec 1; 9(48): eadj4605. Published online 2023 Nov 29. doi: 10.1126/sciadv.adj4605

PMCID:: PMC10686573

Abstract Article PDF–2.4M

Select item 5870114.

Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation

Hangil Park, Tadashi Suzuki, William J. Lennarz

Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20): 11163–11168. Published online 2001 Sep 18. doi: 10.1073/pnas.201393498

PMCID:: PMC58701

Abstract Article PDF–323K

Select item 474776815.

The LMO2 oncogene regulates DNA replication in hematopoietic cells

Marie-Claude Sincennes, Magali Humbert, Benoît Grondin, Véronique Lisi, Diogo F. T. Veiga, André Haman, Christophe Cazaux, Nazar Mashtalir, EL Bachir Affar, Alain Verreault, Trang Hoang

Proc Natl Acad Sci U S A. 2016 Feb 2; 113(5): 1393–1398. Published online 2016 Jan 13. doi: 10.1073/pnas.1515071113

PMCID:: PMC4747768

Abstract Article PDF–1.0M

Select item 291640416.

PAC1 Gene Knockout Reveals an Essential Role of Chaperone-Mediated 20S Proteasome Biogenesis and Latent 20S Proteasomes in Cellular Homeostasis

Katsuhiro Sasaki, Jun Hamazaki, Masato Koike, Yuko Hirano, Masaaki Komatsu, Yasuo Uchiyama, Keiji Tanaka, Shigeo Murata

Mol Cell Biol. 2010 Aug; 30(15): 3864–3874. Published online 2010 May 24. doi: 10.1128/MCB.00216-10

PMCID:: PMC2916404

Abstract Article PDF–3.9M

Select item 501612217.

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4^CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

Dolores Del Prete, Richard C. Rice, Anjali M. Rajadhyaksha, Luciano D'Adamio

J Biol Chem. 2016 Aug 12; 291(33): 17209–17227. Published online 2016 Jun 20. doi: 10.1074/jbc.M116.733626

PMCID:: PMC5016122

Abstract Article PDF–1.8M

Select item 592777118.

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon

eLife. 2018; 7: e32866. Published online 2018 Apr 20. doi: 10.7554/eLife.32866

PMCID:: PMC5927771

Abstract Article PDF–9.1M

Select item 309339519.

RAD21 Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity

Anja Nitzsche, Maciej Paszkowski-Rogacz, Filomena Matarese, Eva M. Janssen-Megens, Nina C. Hubner, Herbert Schulz, Ingrid de Vries, Li Ding, Norbert Huebner, Matthias Mann, Hendrik G. Stunnenberg, Frank Buchholz

PLoS One. 2011; 6(5): e19470. Published online 2011 May 12. doi: 10.1371/journal.pone.0019470