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Select item 62048961.

The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains

Andrew J. Fleet, Paul A. Hamel

J Biol Chem. 2018 Oct 26; 293(43): 16583–16595. Published online 2018 Aug 30. doi: 10.1074/jbc.RA118.004478

PMCID:: PMC6204896

Abstract Article PDF–1.4M

Select item 47499212.

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression

Claudius Klein, Anabel Zwick, Sandra Kissel, Christine Ulrike Forster, Dietmar Pfeifer, Marie Follo, Anna Lena Illert, Sarah Decker, Thomas Benkler, Heike Pahl, Robert A.J. Oostendorp, Konrad Aumann, Justus Duyster, Christine Dierks

J Exp Med. 2016 Feb 8; 213(2): 273–290. doi: 10.1084/jem.20150556

PMCID:: PMC4749921

Abstract Article PDF–3.4M

Select item 78599803.

Functionally distinctive Ptch receptors establish multimodal Hedgehog signaling in the tooth epithelial stem cell niche

Martin Binder, Piotr Chmielarz, Peter J McKinnon, Leah Biggs, Irma Thesleff, Anamaria Balic

Stem Cells. Author manuscript; available in PMC 2021 Feb 4.

Published in final edited form as: Stem Cells. 2019 Sep; 37(9): 1238–1248. Published online 2019 Jun 10. doi: 10.1002/stem.3042

PMCID:: PMC7859980

Abstract Article PDF–2.2M

Select item 50560954.

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog

Hanna Tukachinsky, Kostadin Petrov, Miyako Watanabe, Adrian Salic

Proc Natl Acad Sci U S A. 2016 Oct 4; 113(40): E5866–E5875. Published online 2016 Sep 19. doi: 10.1073/pnas.1606719113

PMCID:: PMC5056095

Abstract Article PDF–2.3M

Select item 41991295.

Ptch2 mediates the Shh response in Ptch1^−/− cells

Astrid C. Alfaro, Brock Roberts, Lina Kwong, Maarten F. Bijlsma, Henk Roelink

Development. 2014 Sep; 141(17): 3331–3339. doi: 10.1242/dev.110056

PMCID:: PMC4199129

Abstract Article

Select item 83404416.

Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback

Crystal L. Sigulinsky, Xiaodong Li, Edward M. Levine

BMC Res Notes. 2021; 14: 300. Published online 2021 Aug 5. doi: 10.1186/s13104-021-05714-5

PMCID:: PMC8340441

Abstract Article PDF–4.5M

Select item 50145477.

Patched1 and Patched2 inhibit Smoothened non-cell autonomously

Brock Roberts, Catalina Casillas, Astrid C Alfaro, Carina Jägers, Henk Roelink

eLife. 2016; 5: e17634. Published online 2016 Aug 23. doi: 10.7554/eLife.17634

PMCID:: PMC5014547

Abstract Article PDF–5.4M

Select item 34573488.

A Distinct Smoothened Mutation Causes Severe Cerebellar Developmental Defects and Medulloblastoma in a Novel Transgenic Mouse Model

Joyoti Dey, Sally Ditzler, Sue E. Knoblaugh, Beryl A. Hatton, Janell M. Schelter, Michele A. Cleary, Brig Mecham, Lucy B. Rorke-Adams, James M. Olson

Mol Cell Biol. 2012 Oct; 32(20): 4104–4115. doi: 10.1128/MCB.00862-12

PMCID:: PMC3457348

Abstract Article PDF–5.8M

Select item 24537249.

A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1⁺ smooth muscle progenitor cells

Jenna N. Passman, Xiu Rong Dong, San-Pin Wu, Colin T. Maguire, Kelly A. Hogan, Victoria L. Bautch, Mark W. Majesky

Proc Natl Acad Sci U S A. 2008 Jul 8; 105(27): 9349–9354. Published online 2008 Jun 30. doi: 10.1073/pnas.0711382105

PMCID:: PMC2453724

Abstract Article PDF–1.0M

Select item 411828310.

In Situ Hybridization Methods for Mouse Whole Mounts and Tissue Sections with and Without Additional β-Galactosidase Staining

Yoshihiro Komatsu, Satoshi Kishigami, Yuji Mishina

Methods Mol Biol. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: Methods Mol Biol. 2014; 1092: 1–15. doi: 10.1007/978-1-60327-292-6_1

PMCID:: PMC4118283

Abstract Article PDF–1.2M

Select item 971853211.

Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

Xiaodong Li, Patrick J Gordon, John A Gaynes, Alexandra W Fuller, Randy Ringuette, Clayton P Santiago, Valerie Wallace, Seth Blackshaw, Pulin Li, Edward M Levine

eLife. 2022; 11: e78342. Published online 2022 Dec 2. doi: 10.7554/eLife.78342

PMCID:: PMC9718532

Abstract Article PDF–14M

Select item 267128912.

Vsx2 / Chx10 Ensures the Correct Timing and Magnitude of Hedgehog Signaling in the Mouse Retina

Crystal L. Sigulinsky, Eric S. Green, Anna M. Clark, Edward M. Levine

Dev Biol. Author manuscript; available in PMC 2009 May 15.

Published in final edited form as: Dev Biol. 2008 May 15; 317(2): 560–575. Published online 2008 Mar 14. doi: 10.1016/j.ydbio.2008.02.055

PMCID:: PMC2671289

Abstract Article PDF–3.0M

Select item 265938313.

Genetically Engineered Mouse Models of Brain Cancer and the Promise of Preclinical Testing

Jason T. Huse, Eric C. Holland

Brain Pathol. 2009 Jan; 19(1): 132–143. Published online 2008 Dec 3. doi: 10.1111/j.1750-3639.2008.00234.x

PMCID:: PMC2659383

Abstract Article PDF–584K

Select item 31694914.

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

Benoit St-Jacques, Matthias Hammerschmidt, Andrew P. McMahon

Genes Dev. 1999 Aug 15; 13(16): 2072–2086. doi: 10.1101/gad.13.16.2072

PMCID:: PMC316949

Abstract Article PDF–7.2M

Select item 718175115.

Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration

Yeonjoo Kim, Jiyoung Lee, Maisa Seppala, Martyn T. Cobourne, Soo-Hyun Kim

Nat Commun. 2020; 11: 1994. Published online 2020 Apr 24. doi: 10.1038/s41467-020-15897-3

Correction in:: Nat Commun. 2020; 11: 2275.

PMCID:: PMC7181751

Abstract Article PDF–5.9M

Select item 271717416.

Paracrine Hedgehog signaling in stomach and intestine: new roles for Hedgehog in gastrointestinal patterning

Åsa Kolterud, Ann S. Grosse, William J. Zacharias, Katherine D. Walton, Katherine E. Kretovich, Blair Madison, Meghna Waghray, Jennifer E. Ferris, Chunbo Hu, Juanita L. Merchant, Andrzej Dlugosz, Andreas H. Kottmann, Deborah L. Gumucio

Gastroenterology. Author manuscript; available in PMC 2010 Aug 1.

Published in final edited form as: Gastroenterology. 2009 Aug; 137(2): 618–628. Published online 2009 May 13. doi: 10.1053/j.gastro.2009.05.002

PMCID:: PMC2717174

Abstract Article PDF–7.0M

Select item 284362317.

Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis

Fei Liu, Emily Y. Chu, Brenda Watt, Yuhang Zhang, Natalie M. Gallant, Thomas Andl, Steven H. Yang, Min-Min Lu, Stefano Piccolo, Ruth Schmidt-Ullrich, Makoto M. Taketo, Edward E. Morrisey, Radhika Atit, Andrzej A. Dlugosz, Sarah E. Millar

Dev Biol. Author manuscript; available in PMC 2010 Mar 22.

Published in final edited form as: Dev Biol. 2008 Jan 1; 313(1): 210–224. Published online 2007 Oct 23. doi: 10.1016/j.ydbio.2007.10.016