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Select item 109870061.

Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity

Robin C. Orozco, Kristi Marquardt, Isaraphorn Pratumchai, Anam Fatima Shaikh, Kerri Mowen, Alain Domissy, John R. Teijaro, Linda A. Sherman

PLoS Pathog. 2024 Mar; 20(3): e1012095. Published online 2024 Mar 21. doi: 10.1371/journal.ppat.1012095

PMCID:: PMC10987006

Abstract Article PDF–3.7M

Select item 91196772.

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

Jaime James, Yifei Chen, Clara M Hernandez, Florian Forster, Markus Dagnell, Qing Cheng, Amir A Saei, Hassan Gharibi, Gonzalo Fernandez Lahore, Annika Åstrand, Rajneesh Malhotra, Bernard Malissen, Roman A Zubarev, Elias SJ Arnér, Rikard Holmdahl

eLife. 2022; 11: e74549. Published online 2022 May 19. doi: 10.7554/eLife.74549

PMCID:: PMC9119677

Abstract Article PDF–2.2M

Select item 89293863.

Targeting Protein Tyrosine Phosphatase 22 Does Not Enhance the Efficacy of Chimeric Antigen Receptor T Cells in Solid Tumors

Xin Du, Phillip K. Darcy, Florian Wiede, Tony Tiganis

Mol Cell Biol. 2022 Mar; 42(3): e00449-21. Prepublished online 2022 Jan 18. Published online 2022 Mar 17. doi: 10.1128/mcb.00449-21

PMCID:: PMC8929386

Abstract Article PDF–3.0M

Select item 84287504.

Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity

Robin C. Orozco, Kristi Marquardt, Kerri Mowen, Linda A. Sherman

J Immunol. 2021 Sep 15; 207(6): 1662–1671. Published online 2021 Sep 15. doi: 10.4049/jimmunol.2100304

PMCID:: PMC8428750

Abstract Article PDF–2.7M

Select item 70656005.

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Diana Dudziak, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope

Front Immunol. 2020; 11: 376. Published online 2020 Mar 4. doi: 10.3389/fimmu.2020.00376

PMCID:: PMC7065600

Abstract Article PDF–1.0M

Select item 67778146.

Deletion of PTPN22 improves effector and memory CD8⁺ T cell responses to tumors

Rebecca J. Brownlie, David Wright, Rose Zamoyska, Robert J. Salmond

JCI Insight. 2019 Aug 22; 4(16): e127847. Published online 2019 Aug 22. doi: 10.1172/jci.insight.127847

PMCID:: PMC6777814

Abstract Article PDF–1.4M

Select item 65464517.

Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner

Marianne R. Spalinger, Thomas S.B. Schmidt, Marlene Schwarzfischer, Larissa Hering, Kirstin Atrott, Silvia Lang, Claudia Gottier, Annelies Geirnaert, Christophe Lacroix, Xuezhi Dai, David J. Rawlings, Andrew C. Chan, Christian von Mering, Gerhard Rogler, Michael Scharl

J Clin Invest. 2019 Jun 3; 129(6): 2527–2541. Published online 2019 May 20. doi: 10.1172/JCI123263

PMCID:: PMC6546451

Abstract Article PDF–13M

Select item 61075518.

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens

Fiona Clarke, Harriet A. Purvis, Cristina Sanchez-Blanco, Enrique Gutiérrez-Martinez, Georgina H. Cornish, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope

Sci Rep. 2018; 8: 12692. Published online 2018 Aug 23. doi: 10.1038/s41598-018-31179-x

PMCID:: PMC6107551

Abstract Article PDF–1.9M

Select item 58599489.

Protein tyrosine phosphatase PTPN22 regulates IL‐1β dependent Th17 responses by modulating dectin‐1 signaling in mice

Harriet A Purvis, Fiona Clarke, Christine K Jordan, Cristina Sanchez Blanco, Georgina H Cornish, Xuezhi Dai, David J Rawlings, Rose Zamoyska, Andrew P Cope

Eur J Immunol. 2018 Feb; 48(2): 306–315. Published online 2017 Oct 20. doi: 10.1002/eji.201747092

PMCID:: PMC5859948

Abstract Article PDF–1.8M

Select item 583699910.

Lack of PTPN22 increases LFA-1-dependent adhesion of Murine Regulatory T Cells improving their regulatory Function

Rebecca J Brownlie, Lisa A Miosge, Demetrios Vassilakos, Lena M Svensson, Andrew Cope, Rose Zamoyska

Sci Signal. Author manuscript; available in PMC 2018 Mar 5.

Published in final edited form as: Sci Signal. 2012 Nov 27; 5(252): ra87. Published online 2012 Nov 27. doi: 10.1126/scisignal.2003365

PMCID:: PMC5836999

Abstract Article PDF–2.5M

Select item 567684211.

Resistance to TGFβ suppression and improved anti-tumor responses in CD8⁺ T cells lacking PTPN22

Rebecca J. Brownlie, Celine Garcia, Mate Ravasz, Dietmar Zehn, Robert J. Salmond, Rose Zamoyska

Nat Commun. 2017; 8: 1343. Published online 2017 Nov 7. doi: 10.1038/s41467-017-01427-1

PMCID:: PMC5676842

Abstract Article PDF–1.1M

Select item 564510812.

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells

Fiona Clarke, Christine K. Jordan, Enrique Gutiérrez-Martinez, Jack A. Bibby, Cristina Sanchez-Blanco, Georgina H. Cornish, Xuezhi Dai, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope, Harriet A. Purvis

PLoS One. 2017; 12(10): e0186625. Published online 2017 Oct 17. doi: 10.1371/journal.pone.0186625

PMCID:: PMC5645108

Abstract Article PDF–3.2M

Select item 513647013.

PTPN22 Is a Critical Regulator of Fcγ Receptor–Mediated Neutrophil Activation

Sonja Vermeren, Katherine Miles, Julia Y. Chu, Donald Salter, Rose Zamoyska, Mohini Gray

J Immunol. 2016 Dec 15; 197(12): 4771–4779. Published online 2016 Nov 2. doi: 10.4049/jimmunol.1600604

PMCID:: PMC5136470

Abstract Article PDF–1.0M

Select item 513530614.

PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection

Christian J. Maine, John R. Teijaro, Kristi Marquardt, Linda A. Sherman

Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46): E7231–E7239. Published online 2016 Oct 31. doi: 10.1073/pnas.1603738113

PMCID:: PMC5135306

Abstract Article PDF–1.2M

Select item 495597915.

CRISPR-Cas9–Mediated Modification of the NOD Mouse Genome With Ptpn22^R619W Mutation Increases Autoimmune Diabetes

Xiaotian Lin, Stephane Pelletier, Sebastien Gingras, Stephanie Rigaud, Christian J. Maine, Kristi Marquardt, Yang D. Dai, Karsten Sauer, Alberto R. Rodriguez, Greg Martin, Sergey Kupriyanov, Ling Jiang, Liping Yu, Douglas R. Green, Linda A. Sherman

Diabetes. 2016 Aug; 65(8): 2134–2138. Published online 2016 Apr 26. doi: 10.2337/db16-0061