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Select item 110050921.

ROR𝛾t upregulates RAG gene expression in DP thymocytes to expand the Tcra repertoire

Abani Kanta Naik, Danielle J. Dauphars, Elizabeth Corbett, Lunden Simpson, David G. Schatz, Michael S. Krangel

Sci Immunol. Author manuscript; available in PMC 2024 Apr 10.

Published in final edited form as: Sci Immunol. 2024 Mar 15; 9(93): eadh5318. Published online 2024 Mar 15. doi: 10.1126/sciimmunol.adh5318

PMCID:: PMC11005092

Abstract Article PDF–2.1M

Select item 101036442.

“RORγt-Expressing Pathogenic CD4⁺T Cells Cause Brain Inflammation During Chronic Colitis”

Michel Edwar Mickael, Suniti Bhaumik, Ayanabha Chakraborti, Alan A Umfress, Thomas van Groen, Matthew Macaluso, John Totenhagen, Anna G Sorace, James A Bibb, David G Standaert, Rajatava Basu

J Immunol. Author manuscript; available in PMC 2023 Apr 14.

Published in final edited form as: J Immunol. 2022 Apr 15; 208(8): 2054–2066. Published online 2022 Apr 4. doi: 10.4049/jimmunol.2100869

PMCID:: PMC10103644

Abstract Article PDF–2.4M

Select item 100344043.

A cis-element at the Rorc locus regulates the development of type 3 innate lymphoid cells

Dehui Chang, Hao Zhang, Jing Ge, Qi Xing, Xinyi Guo, Xiaohu Wang, Chen Dong

Front Immunol. 2023; 14: 1105145. Published online 2023 Mar 9. doi: 10.3389/fimmu.2023.1105145

PMCID:: PMC10034404

Abstract Article PDF–9.1M

Select item 92013934.

A Japanese Herbal Formula, Daikenchuto, Alleviates Experimental Colitis by Reshaping Microbial Profiles and Enhancing Group 3 Innate Lymphoid Cells

Zhengzheng Shi, Tadashi Takeuchi, Yumiko Nakanishi, Tamotsu Kato, Katharina Beck, Ritsu Nagata, Tomoko Kageyama, Ayumi Ito, Hiroshi Ohno, Naoko Satoh-Takayama

Front Immunol. 2022; 13: 903459. Published online 2022 Jun 2. doi: 10.3389/fimmu.2022.903459

PMCID:: PMC9201393

Abstract Article PDF–8.5M

Select item 90186125.

Alcohol-driven metabolic reprogramming promotes development of RORγt-deficient thymic lymphoma

Rui Sun, Chao Lei, Liang Chen, Liqing He, Haixun Guo, Xiang Zhang, Wenke Feng, Jun Yan, Craig J. McClain, Zhongbin Deng

Oncogene. Author manuscript; available in PMC 2022 Sep 4.

Published in final edited form as: Oncogene. 2022 Apr; 41(16): 2287–2302. Published online 2022 Mar 4. doi: 10.1038/s41388-022-02257-2

PMCID:: PMC9018612

Abstract Article PDF–3.0M

Select item 82617946.

The role of RORγt at maternal-fetal interface during Murine Pregnancy

Yan Li, Gladys E. Lopez, Payton N. Lindner, Luke Parrella, Mariah Larson, Yan Sun, Aleksandar K. Stanic

Am J Reprod Immunol. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Am J Reprod Immunol. 2020 Aug; 84(2): e13250. Published online 2020 Jun 18. doi: 10.1111/aji.13250

PMCID:: PMC8261794

Abstract Article PDF–4.8M

Select item 81829587.

Effects of RORγt overexpression on the murine central nervous system

Tetsuya Sasaki, Rei Nagata, Satoru Takahashi, Yosuke Takei

Neuropsychopharmacol Rep. 2021 Mar; 41(1): 102–110. Published online 2021 Feb 6. doi: 10.1002/npr2.12162

PMCID:: PMC8182958

Abstract Article PDF–1.0M

Select item 71042398.

Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis

Maryann P. Platt, Kevin A. Bolding, Charlotte R. Wayne, Sarah Chaudhry, Tyler Cutforth, Kevin M. Franks, Dritan Agalliu

Proc Natl Acad Sci U S A. 2020 Mar 24; 117(12): 6708–6716. Published online 2020 Mar 11. doi: 10.1073/pnas.1911097117

PMCID:: PMC7104239

Abstract Article PDF–2.1M

Select item 62382089.

In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo

Xiao Hu, Kinga Majchrzak, Xikui Liu, Megan M. Wyatt, Chauncey J. Spooner, Jacques Moisan, Weiping Zou, Laura L. Carter, Chrystal M. Paulos

Cancer Res. Author manuscript; available in PMC 2018 Nov 16.

Published in final edited form as: Cancer Res. 2018 Jul 15; 78(14): 3888–3898. Published online 2018 May 16. doi: 10.1158/0008-5472.CAN-17-3973

PMCID:: PMC6238208

Abstract Article PDF–834K

Select item 567898110.

Two amino acid mutation disrupts ROR?t function in Th17 differentiation but not thymocyte development

Zhiheng He, Jian Ma, Ruiqing Wang, Jing Zhang, Zhaofeng Huang, Fei Wang, Subha Sen, Ellen V. Rothenberg, Zuoming Sun

Nat Immunol. Author manuscript; available in PMC 2018 Feb 28.

Published in final edited form as: Nat Immunol. 2017 Oct; 18(10): 1128–1138. Published online 2017 Aug 28. doi: 10.1038/ni.3832

PMCID:: PMC5678981

Abstract Article PDF–2.6M

Select item 556517811.

RORγt-expressing cells attenuate cardiac remodeling after myocardial infarction

Daichi Enomoto, Kotaro Matsumoto, Tomomi Yamashita, Arisa Kobayashi, Makiko Maeda, Hiroyuki Nakayama, Masanori Obana, Yasushi Fujio

PLoS One. 2017; 12(8): e0183584. Published online 2017 Aug 21. doi: 10.1371/journal.pone.0183584

PMCID:: PMC5565178

Abstract Article PDF–2.8M

Select item 521790612.

RORγt antagonist suppresses M3 muscarinic acetylcholine receptor‐induced Sjögren's syndrome‐like sialadenitis

M. Tahara, H. Tsuboi, S. Segawa, H. Asashima, M. Iizuka‐Koga, T. Hirota, H. Takahashi, Y. Kondo, M. Matsui, I. Matsumoto, T. Sumida

Clin Exp Immunol. 2017 Feb; 187(2): 213–224. Published online 2016 Oct 11. doi: 10.1111/cei.12868

PMCID:: PMC5217906

Abstract Article PDF–708K

Select item 479988513.

Small molecule mediated inhibition of RORγ‐dependent gene expression and autoimmune disease pathology in vivo

Daliya Banerjee, Linlin Zhao, Lan Wu, Arumugam Palanichamy, Ayla Ergun, Liaomin Peng, Catherine Quigley, Stefan Hamann, Robert Dunstan, Patrick Cullen, Norm Allaire, Kevin Guertin, Tao Wang, Jianhua Chao, Christine Loh, Jason D. Fontenot

Immunology. 2016 Apr; 147(4): 399–413. Published online 2016 Jan 26. doi: 10.1111/imm.12570

PMCID:: PMC4799885

Abstract Article PDF–1.6M

Select item 471864914.

Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium

Masashi Matsuyama, Yukio Ishii, Hirofumi Sakurai, Satoshi Ano, Yuko Morishima, Keigyou Yoh, Satoru Takahashi, Kenji Ogawa, Nobuyuki Hizawa

PLoS One. 2016; 11(1): e0147064. Published online 2016 Jan 19. doi: 10.1371/journal.pone.0147064

PMCID:: PMC4718649

Abstract Article PDF–7.1M

Select item 443614615.

Involvement of RORγt-overexpressing T cells in the development of autoimmune arthritis in mice

Yuya Kondo, Zhaojin Yao, Masahiro Tahara, Mana Iizuka, Masahiro Yokosawa, Shunta Kaneko, Seiji Segawa, Hiroto Tsuboi, Keigyou Yoh, Satoru Takahashi, Isao Matsumoto, Takayuki Sumida

Arthritis Res Ther. 2015; 17(1): 105. Published online 2015 Apr 20. doi: 10.1186/s13075-015-0606-5

PMCID:: PMC4436146

Abstract Article PDF–1.5M

Select item 406687416.

Small molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

Sheng Xiao, Nir Yosef, Jianfei Yang, Yonghui Wang, Ling Zhou, Chen Zhu, Chuan Wu, Erkan Baloglu, Darby Schmidt, Radha Ramesh, Mercedes Lobera, Mark S. Sundrud, Pei-Yun Tsai, Zhijun Xiang, Jinsong Wang, Yan Xu, Xichen Lin, Karsten Kretschmer, Peter B. Rahl, Richard A. Young, Zhong Zhong, David A. Hafler, Aviv Regev, Shomir Ghosh, Alexander Marson, Vijay K. Kuchroo

Immunity. Author manuscript; available in PMC 2015 Apr 17.

Published in final edited form as: Immunity. 2014 Apr 17; 40(4): 477–489. doi: 10.1016/j.immuni.2014.04.004

PMCID:: PMC4066874

Abstract Article PDF–1.6M

Select item 393499917.

RORγt⁺IL-17⁺ neutrophils play a critical role in hepatic ischemia–reperfusion injury

Zhongming Tan, Runqiu Jiang, Xuehao Wang, Youjing Wang, Ling Lu, Qianghui Liu, Song Guo Zheng, Beicheng Sun, Bernhard Ryffel

J Mol Cell Biol. 2013 Apr; 5(2): 143–146. Published online 2013 Jan 28. doi: 10.1093/jmcb/mjs065

PMCID:: PMC3934999

Article PDF–418K

Select item 363453918.

T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour

Sarah Nuñez, Juan Jose Saez, Dominique Fernandez, Felipe Flores-Santibañez, Karla Alvarez, Gabriela Tejon, Paulina Ruiz, Paula Maldonado, Yessia Hidalgo, Valeria Manriquez, Maria Rosa Bono, Mario Rosemblatt, Daniela Sauma

Immunology. 2013 May; 139(1): 61–71. Published online 2013 Apr 8. doi: 10.1111/imm.12055

PMCID:: PMC3634539

Abstract Article PDF–455K

Select item 306044119.

The Th17-Defining Transcription Factor RORγt Promotes Glomerulonephritis

Oliver M. Steinmetz, Shaun A. Summers, Poh-Yi Gan, Timothy Semple, Stephen R. Holdsworth, A. Richard Kitching

J Am Soc Nephrol. 2011 Mar; 22(3): 472–483. doi: 10.1681/ASN.2010040435

PMCID:: PMC3060441

Abstract Article

Select item 277666820.

RORγt, a Novel Isoform of an Orphan Receptor, Negatively Regulates Fas Ligand Expression and IL-2 Production in T Cells

You-Wen He, Michael L. Deftos, Ethan W. Ojala, Michael J. Bevan

Immunity. Author manuscript; available in PMC 2009 Nov 12.

Published in final edited form as: Immunity. 1998 Dec; 9(6): 797–806. doi: 10.1016/s1074-7613(00)80645-7

PMCID:: PMC2776668

Abstract Article PDF–837K

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