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Select item 93941191.

Fbxo45‐mediated NP‐STEP₄₆ degradation via K6‐linked ubiquitination sustains ERK activity in lung cancer

Qian Wang, Ci Xu, Renjie Cai, Weishu An, Haihua Yuan, Ming Xu

Mol Oncol. 2022 Aug; 16(16): 3017–3033. Published online 2022 Aug 5. doi: 10.1002/1878-0261.13290

PMCID:: PMC9394119

Abstract Article PDF–7.4M

Select item 89183222.

Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation

Linhui Wu, Ke Yu, Kai Chen, Xuelian Zhu, Zheng Yang, Qi Wang, Junjie Gao, Yingying Wang, Tong Cao, Hui Xu, Xueshan Pan, Lixia Wang, Jun Xia, Yuyun Li, Zhiwei Peter Wang, Jia Ma

Cell Death Dis. 2022 Mar; 13(3): 231. Published online 2022 Mar 12. doi: 10.1038/s41419-022-04675-2

PMCID:: PMC8918322

Abstract Article PDF–5.2M

Select item 86419473.

Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

Xiao-Tong Lin, Hong-Qiang Yu, Lei Fang, Ye Tan, Ze-Yu Liu, Di Wu, Jie Zhang, Hao-Jun Xiong, Chuan-Ming Xie

eLife. 2021; 10: e70715. Published online 2021 Nov 15. doi: 10.7554/eLife.70715

PMCID:: PMC8641947

Abstract Article PDF–10M

Select item 55407614.

Naturally Generated Decoy of the Prostate Apoptosis Response-4 Protein Overcomes Therapy Resistance in Tumors

Nikhil Hebbar, Ravshan Burikhanov, Nidhi Shukla, Shirley Qiu, Yanming Zhao, Kojo S. J. Elenitoba-Johnson, Vivek M. Rangnekar

Cancer Res. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Cancer Res. 2017 Aug 1; 77(15): 4039–4050. Published online 2017 Jun 16. doi: 10.1158/0008-5472.CAN-16-1970

PMCID:: PMC5540761

Abstract Article PDF–1014K

Select item 81066775.

DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1

Hye-Youn Kim, Young-Mi Kim, Suntaek Hong

Cell Death Dis. 2021 May; 12(5): 461. Published online 2021 May 8. doi: 10.1038/s41419-021-03757-x

PMCID:: PMC8106677

Abstract Article PDF–5.1M

Select item 41586936.

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival

X Chen, A A Sahasrabuddhe, P Szankasi, F Chung, V Basrur, V M Rangnekar, M Pagano, M S Lim, K S J Elenitoba-Johnson

Cell Death Differ. 2014 Oct; 21(10): 1535–1545. Published online 2014 Jul 4. doi: 10.1038/cdd.2014.92

PMCID:: PMC4158693

Abstract Article PDF–1.8M

Select item 93205527.

E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism

Jun Shao, Qian Feng, Weifan Jiang, Yuting Yang, Zhiqiang Liu, Liang Li, Wenlong Yang, Yufeng Zou

Aging (Albany NY) 2022 Jul 15; 14(13): 5493–5510. Published online 2022 Jul 8. doi: 10.18632/aging.204163

PMCID:: PMC9320552

Abstract Article PDF–1.8M

Select item 61309508.

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

Muriel Desbois, Oliver Crawley, Paul R. Evans, Scott T. Baker, Ikuo Masuho, Ryohei Yasuda, Brock Grill

J Biol Chem. 2018 Sep 7; 293(36): 13897–13909. Published online 2018 Jul 11. doi: 10.1074/jbc.RA118.002176

PMCID:: PMC6130950

Abstract Article PDF–2.5M

Select item 44663099.

Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus

Daniela Salat, Anja Winkler, Henning Urlaub, Manfred Gessler

PLoS One. 2015; 10(6): e0130288. Published online 2015 Jun 12. doi: 10.1371/journal.pone.0130288

PMCID:: PMC4466309

Abstract Article PDF–7.8M

Select item 386585410.

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

A Peschiaroli, F Scialpi, F Bernassola, M Pagano, G Melino

Oncogene. Author manuscript; available in PMC 2013 Dec 17.

Published in final edited form as: Oncogene. 2009 Sep 3; 28(35): 10.1038/onc.2009.177. Published online 2009 Jul 6. doi: 10.1038/onc.2009.177

PMCID:: PMC3865854

Abstract Article PDF–2.4M

Select item 435926911.

Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors

Ming Xu, Changhong Zhu, Xian Zhao, Cheng Chen, Hailong Zhang, Haihua Yuan, Rong Deng, Jinzhuo Dou, Yanli Wang, Jian Huang, Qin Chen, Bin Jiang, Jianxiu Yu

Oncotarget. 2015 Jan; 6(2): 979–994. Published online 2014 Nov 25. doi: 10.18632/oncotarget.2825

Correction in:: Oncotarget. 2019 Oct 8; 10(56): 5888.

PMCID:: PMC4359269

Abstract Article PDF–13M

Select item 974758612.

The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection

MuChun Tsai, Wissam Osman, Jessica Adair, Rabab ElMergawy, Lexie Chafin, Finny Johns, Daniela Farkas, Ajit Elhance, James Londino, Rama K. Mallampalli

J Biol Chem. 2022 Dec; 298(12): 102698. Published online 2022 Nov 13. doi: 10.1016/j.jbc.2022.102698

PMCID:: PMC9747586

Abstract Article PDF–2.6M

Select item 419249613.

Fbxo45 Inhibits Calcium-sensitive Proteolysis of N-cadherin and Promotes Neuronal Differentiation

Fu-Zon Chung, Anagh A. Sahasrabuddhe, Kaiyu Ma, Xiaofei Chen, Venkatesha Basrur, Megan S. Lim, Kojo S. J. Elenitoba-Johnson

J Biol Chem. 2014 Oct 10; 289(41): 28448–28459. Published online 2014 Aug 20. doi: 10.1074/jbc.M114.561241

PMCID:: PMC4192496

Abstract Article PDF–2.2M

Select item 720600814.

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

Kai T. Richter, Yvonne T. Kschonsak, Barbara Vodicska, Ingrid Hoffmann

Cell Death Differ. 2020 Feb; 27(2): 758–772. Published online 2019 Jul 8. doi: 10.1038/s41418-019-0385-7

PMCID:: PMC7206008

Abstract Article PDF–2.8M

Select item 269876615.

Fbxo45 Forms a Novel Ubiquitin Ligase Complex and Is Required for Neuronal Development

Toru Saiga, Takaichi Fukuda, Masaki Matsumoto, Hirobumi Tada, Hirotaka James Okano, Hideyuki Okano, Keiichi I. Nakayama

Mol Cell Biol. 2009 Jul; 29(13): 3529–3543. Published online 2009 Apr 27. doi: 10.1128/MCB.00364-09

PMCID:: PMC2698766

Abstract Article PDF–11M

Select item 470210316.

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety

Sang Jun Han, Khurshida Begum, Charles E. Foulds, Ross A. Hamilton, Suzanna Bailey, Anna Malovannaya, Doug Chan, Jun Qin, Bert W. O’Malley

Mol Pharmacol. 2016 Jan; 89(1): 14–26. Published online 2016 Jan. doi: 10.1124/mol.115.100925

PMCID:: PMC4702103

Abstract Article PDF–1.6M

Select item 1015617517.

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes

Kheewoong Baek, Daniel C. Scott, Lukas T. Henneberg, Moeko T. King, Matthias Mann, Brenda A. Schulman

Cell. 2023 Apr 27; 186(9): 1895–1911.e21. doi: 10.1016/j.cell.2023.02.035

Correction in:: Cell. 2023 May 25; 186(11): 2492.

PMCID:: PMC10156175

Abstract Article

Select item 571159518.

Composition and regulation of the cellular repertoire of SCF ubiquitin ligases

Justin M. Reitsma, Xing Liu, Kurt M. Reichermeier, Annie Moradian, Michael J. Sweredoski, Sonja Hess, Raymond J. Deshaies

Cell. Author manuscript; available in PMC 2018 Nov 30.

Published in final edited form as: Cell. 2017 Nov 30; 171(6): 1326–1339.e14. Published online 2017 Nov 2. doi: 10.1016/j.cell.2017.10.016

PMCID:: PMC5711595

Abstract Article PDF–2.4M

Select item 534359319.

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor

Yuri Kotani, Daisuke Morito, Kenshiro Sakata, Shiori Ainuki, Munechika Sugihara, Tomohisa Hatta, Shun-ichiro Iemura, Seiji Takashima, Tohru Natsume, Kazuhiro Nagata

Sci Rep. 2017; 7: 44293. Published online 2017 Mar 9. doi: 10.1038/srep44293

PMCID:: PMC5343593

Abstract Article PDF–1.4M

Select item 440166220.

FBXW7 modulates cellular stress response and metastatic potential via HSF1 post-translational modification

Nikos Kourtis, Rana S. Moubarak, Beatriz Aranda-Orgilles, Kevin Lui, Iraz T. Aydin, Thomas Trimarchi, Farbod Darvishian, Christine Salvaggio, Judy Zhong, Kamala Bhatt, Emily I. Chen, Julide T. Celebi, Charalampos Lazaris, Aristotelis Tsirigos, Iman Osman, Eva Hernando, Iannis Aifantis

Nat Cell Biol. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Nat Cell Biol. 2015 Mar; 17(3): 322–332. doi: 10.1038/ncb3121