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Select item 76626351.

The Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts

Christin Neuber, Alix Tröster, Reik Löser, Birgit Belter, Harald Schwalbe, Jens Pietzsch

Molecules. 2020 Nov; 25(21): 5115. Published online 2020 Nov 3. doi: 10.3390/molecules25215115

PMCID:: PMC7662635

Abstract Article PDF–2.5M

Select item 72941332.

Kinome multigenic panel identified novel druggable EPHB4‐V871I somatic variant in high‐risk neuroblastoma

Immacolata Andolfo, Vito A. Lasorsa, Francesco Manna, Barbara E. Rosato, Daniela Formicola, Achille Iolascon, Mario Capasso

J Cell Mol Med. 2020 Jun; 24(11): 6459–6471. Published online 2020 Apr 26. doi: 10.1111/jcmm.15297

PMCID:: PMC7294133

Abstract Article PDF–1.5M

Select item 71705173.

Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance

Chaohao Li, Nadia A. Lanman, Yifan Kong, Daheng He, Fengyi Mao, Elia Farah, Yanquan Zhang, Jinghui Liu, Chi Wang, Qiou Wei, Xiaoqi Liu

J Biol Chem. 2020 Apr 17; 295(16): 5470–5483. Published online 2020 Mar 17. doi: 10.1074/jbc.RA119.011385

PMCID:: PMC7170517

Abstract Article PDF–5.0M

Select item 71097124.

Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts

Lea A. Hampton-O’Neil, Charlotte E. Severn, Stephen J. Cross, Sonam Gurung, Catherine D. Nobes, Ashley M. Toye

Haematologica. 2020 Apr; 105(4): 914–924. Prepublished online 2019 Jun 13. doi: 10.3324/haematol.2018.215160

PMCID:: PMC7109712

Abstract Article PDF–2.0M

Select item 69473825.

Core Element Cloning, Cis-Element Mapping and Serum Regulation of the Human EphB4 Promoter: A Novel TATA-Less Inr/MTE/DPE-Like Regulated Gene

Pierluigi Scalia, Stephen J. Williams, Antonio Giordano

Genes (Basel) 2019 Dec; 10(12): 997. Published online 2019 Dec 2. doi: 10.3390/genes10120997

PMCID:: PMC6947382

Abstract Article PDF–1.0M

Select item 62088836.

EphB4 mediates resistance to antiangiogenic therapy in experimental glioma

Christian Uhl, Moritz Markel, Thomas Broggini, Melina Nieminen, Irina Kremenetskaia, Peter Vajkoczy, Marcus Czabanka

Angiogenesis. 2018; 21(4): 873–881. Published online 2018 Jul 10. doi: 10.1007/s10456-018-9633-6

PMCID:: PMC6208883

Abstract Article PDF–4.4M

Select item 60178467.

Overexpression of Receptor Tyrosine Kinase EphB4 Triggers Tumor Growth and Hypoxia in A375 Melanoma Xenografts: Insights from Multitracer Small Animal Imaging Experiments ^‡

Christin Neuber, Birgit Belter, Sebastian Meister, Frank Hofheinz, Ralf Bergmann, Hans-Jürgen Pietzsch, Jens Pietzsch

Molecules. 2018 Feb; 23(2): 444. Published online 2018 Feb 17. doi: 10.3390/molecules23020444

PMCID:: PMC6017846

Abstract Article PDF–4.3M

Select item 48797698.

EphB4/ephrinB2 Contributes to Imatinib Resistance in Chronic Myeloid Leukemia Involved in Cytoskeletal Proteins

Lin Li, Na Xu, Jin-fang Zhang, Lu-lu Xu, Xuan Zhou, Bin-tao Huang, Yu-ling Li, Xiao-li Liu

Int J Med Sci. 2016; 13(5): 365–373. Published online 2016 Apr 28. doi: 10.7150/ijms.14989

PMCID:: PMC4879769

Abstract Article PDF–1018K

Select item 44665819.

Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer

Benjamin D. Ferguson, Yi-Hung Carol Tan, Rajani S. Kanteti, Ren Liu, Matthew J. Gayed, Everett E. Vokes, Mark K. Ferguson, A. John Iafrate, Parkash S. Gill, Ravi Salgia

Sci Rep. 2015; 5: 10641. Published online 2015 Jun 15. doi: 10.1038/srep10641

PMCID:: PMC4466581

Abstract Article PDF–1.5M

Select item 440944410.

Eph-B4 activation reduces neointimal hyperplasia in human saphenous vein in vitro

Daniel J Wong, Daniel Y Lu, Clinton D Protack, Go Kuwahara, Hualong Bai, Nirvana Sadaghianloo, George Tellides, Alan Dardik

J Vasc Surg. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: J Vasc Surg. 2016 Mar; 63(3): 795–804. Published online 2014 Oct 24. doi: 10.1016/j.jvs.2014.09.036

PMCID:: PMC4409444

Abstract Article PDF–1.3M

Select item 427866011.

Expression of the EPHB4 receptor tyrosine kinase in head and neck and renal malignancies—implications for solid tumors and potential for therapeutic inhibition

Benjamin D. Ferguson, Maria S. Tretiakova, Mark W. Lingen, Parkash S. Gill, Ravi Salgia

Growth Factors. Author manuscript; available in PMC 2014 Dec 29.

Published in final edited form as: Growth Factors. 2014 Dec; 32(6): 202–206. Published online 2014 Nov 13. doi: 10.3109/08977194.2014.980904

PMCID:: PMC4278660

Abstract Article PDF–701K

Select item 414429012.

Arterial Shear Stress Reduces Eph-B4 Expression in Adult Human Veins

Lynn S. Model, Michael R. Hall, Daniel J. Wong, Akihito Muto, Yuka Kondo, Kenneth R. Ziegler, Amanda Feigel, Clay Quint, Laura Niklason, Alan Dardik

Yale J Biol Med. 2014 Sep; 87(3): 359–371. Published online 2014 Sep 3.

PMCID:: PMC4144290

Abstract Article PDF–20M

Select item 388462313.

EphB4 Tyrosine Kinase Stimulation Inhibits Growth of MDA-MB-231 Breast Cancer Cells in a Dose and Time Dependent Manner

Farnaz Barneh, Mona Moshayedi, Hamid Mirmohammadsadeghi, Shaghayegh Haghjooy-Javanmard, Ali Mohammad Sabzghabaee, Shirinsadat Badri

Dis Markers. 2013; 35(6): 933–938. Published online 2013 Dec 23. doi: 10.1155/2013/857895

PMCID:: PMC3884623

Abstract Article PDF–959K

Select item 369962414.

The EphB4 Receptor Tyrosine Kinase Promotes Lung Cancer Growth: A Potential Novel Therapeutic Target

Benjamin D. Ferguson, Ren Liu, Cleo E. Rolle, Yi-Hung Carol Tan, Valery Krasnoperov, Rajani Kanteti, Maria S. Tretiakova, Gustavo M. Cervantes, Rifat Hasina, Robyn D. Hseu, A. John Iafrate, Theodore Karrison, Mark K. Ferguson, Aliya N. Husain, Leonardo Faoro, Everett E. Vokes, Parkash S. Gill, Ravi Salgia

PLoS One. 2013; 8(7): e67668. Published online 2013 Jul 2. doi: 10.1371/journal.pone.0067668

PMCID:: PMC3699624

Abstract Article PDF–2.9M

Select item 367196015.

EphB4 as a therapeutic target in mesothelioma

Ren Liu, Benjamin D Ferguson, Yue Zhou, Kranthi Naga, Ravi Salgia, Parkash S Gill, Valery Krasnoperov

BMC Cancer. 2013; 13: 269. Published online 2013 May 30. doi: 10.1186/1471-2407-13-269

PMCID:: PMC3671960

Abstract Article PDF–1.6M

Select item 354020416.

Targeting EphB4 receptor for cancer diagnosis and therapy monitoring

Dan Li, Shuanglong Liu, Ren Liu, Ryan Park, Lindsey Hughes, Valery Krasnoperov, Parkash S. Gill, Zibo Li, Hong Shan, Peter S. Conti

Mol Pharm. Author manuscript; available in PMC 2014 Jan 7.

Published in final edited form as: Mol Pharm. 2013 Jan 7; 10(1): 329–336. Published online 2012 Dec 18. doi: 10.1021/mp300461b

PMCID:: PMC3540204

Abstract Article PDF–4.5M

Select item 293974517.

EPH Receptor B4 (EPHB4) Gene Polymorphisms and Risk of Intracranial Hemorrhage in Patients with Brain Arteriovenous Malformations

Shantel Weinsheimer, Helen Kim, Ludmila Pawlikowska, Yongmei Chen, Michael T. Lawton, Stephen Sidney, Pui-Yan Kwok, Charles E. McCulloch, William L. Young

Circ Cardiovasc Genet. Author manuscript; available in PMC 2010 Oct 1.

Published in final edited form as: Circ Cardiovasc Genet. 2009 Oct; 2(5): 476–482. Published online 2009 Aug 22. doi: 10.1161/CIRCGENETICS.109.883595