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Select item 112564351.

ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets

Yuehong Chen, Huan Liu, Zhongling Luo, Jiaqian Zhang, Min Dong, Geng Yin, Qibing Xie

Skelet Muscle. 2024; 14: 16. Published online 2024 Jul 18. doi: 10.1186/s13395-024-00347-1

PMCID:: PMC11256435

Abstract Article PDF–6.2M

Select item 107774412.

Regulation of NLRP3 Inflammasome Activation and Inflammatory Exosome Release in Podocytes by Acid Sphingomyelinase During Obesity

Dandan Huang, Jason M. Kidd, Yao Zou, Xiaoyuan Wu, Todd W. B. Gehr, Pin-Lan Li, Guangbi Li

Inflammation. Author manuscript; available in PMC 2024 Jan 10.

Published in final edited form as: Inflammation. 2023 Oct; 46(5): 2037–2054. Published online 2023 Jul 21. doi: 10.1007/s10753-023-01861-y

PMCID:: PMC10777441

Abstract Article PDF–3.2M

Select item 102598393.

Ultrasound-stimulated microbubbles enhanced vascular disruption in fractionated radiotherapy-treated tumours via ASMase activation

Kai Xuan Leong, Wenyi Yang, Deepa Sharma, Stanley Liu, Gregory J. Czarnota

Dis Model Mech. 2023 Jun 1; 16(6): dmm049531. Published online 2023 Jun 6. doi: 10.1242/dmm.049531

PMCID:: PMC10259839

Abstract Article

Select item 102534724.

Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency

Ángel Gaudioso, Pilar Moreno-Huguet, Josefina Casas, Edward H. Schuchman, María Dolores Ledesma

Int J Mol Sci. 2023 Jun; 24(11): 9756. Published online 2023 Jun 5. doi: 10.3390/ijms24119756

PMCID:: PMC10253472

Abstract Article PDF–8.0M

Select item 100799615.

Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency

Ángel Gaudioso, Xuntian Jiang, Josefina Casas, Edward H. Schuchman, María Dolores Ledesma

Cell Death Dis. 2023 Apr; 14(4): 248. Published online 2023 Apr 6. doi: 10.1038/s41419-023-05784-2

PMCID:: PMC10079961

Abstract Article PDF–9.6M

Select item 96729206.

Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia

Xinxu Yuan, Owais M. Bhat, Yao Zou, Xiang Li, Yang Zhang, Pin-Lan Li

J Lipid Res. 2022 Dec; 63(12): 100298. Published online 2022 Oct 15. doi: 10.1016/j.jlr.2022.100298

PMCID:: PMC9672920

Abstract Article PDF–5.2M

Select item 89851257.

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease

Tamara Marín, Andrés E. Dulcey, Fabián Campos, Catalina de la Fuente, Mariana Acuña, Juan Castro, Claudio Pinto, María José Yañez, Cristian Cortez, David W. McGrath, Pablo J. Sáez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugán, Alejandra R. Alvarez, Silvana Zanlungo

Front Cell Dev Biol. 2022; 10: 844297. Published online 2022 Mar 18. doi: 10.3389/fcell.2022.844297

PMCID:: PMC8985125

Abstract Article PDF–3.6M

Select item 86163638.

Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype

Paulina Roux-Biejat, Marco Coazzoli, Pasquale Marrazzo, Silvia Zecchini, Ilaria Di Renzo, Cecilia Prata, Alessandra Napoli, Claudia Moscheni, Matteo Giovarelli, Maria Cristina Barbalace, Elisabetta Catalani, Maria Teresa Bassi, Clara De Palma, Davide Cervia, Marco Malaguti, Silvana Hrelia, Emilio Clementi, Cristiana Perrotta

Cells. 2021 Nov; 10(11): 3028. Published online 2021 Nov 5. doi: 10.3390/cells10113028

PMCID:: PMC8616363

Abstract Article PDF–4.8M

Select item 85112839.

Evidence for Ceramide induced Cytotoxicity in Retinal Ganglion Cells

Jie Fan, Jiali Liu, Jian Liu, Chunhe Chen, Yiannis Koutalos, Craig E Crosson

Exp Eye Res. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Exp Eye Res. 2021 Oct; 211: 108762. Published online 2021 Sep 7. doi: 10.1016/j.exer.2021.108762

PMCID:: PMC8511283

Abstract Article PDF–794K

Select item 819880210.

mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment

Cosima Rhein, Iulia Zoicas, Lena M. Marx, Stefanie Zeitler, Tobias Hepp, Claudia von Zimmermann, Christiane Mühle, Tanja Richter-Schmidinger, Bernd Lenz, Yesim Erim, Martin Reichel, Erich Gulbins, Johannes Kornhuber

Int J Mol Sci. 2021 Jun; 22(11): 5700. Published online 2021 May 27. doi: 10.3390/ijms22115700

PMCID:: PMC8198802

Abstract Article PDF–1.2M

Select item 812208011.

Contribution of Podocyte Inflammatory Exosome Release to Glomerular Inflammation and Sclerosis during Hyperhomocysteinemia

Dandan Huang, Guangbi Li, Qinghua Zhang, Owais M. Bhat, Yao Zou, Joseph K. Ritter, Pin-Lan Li

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Jul 1; 1867(7): 166146. Published online 2021 Apr 14. doi: 10.1016/j.bbadis.2021.166146

PMCID:: PMC8122080

Abstract Article PDF–2.1M

Select item 808604212.

Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency

Joanna M. Poczobutt, Andrew M. Mikosz, Christophe Poirier, Erica L. Beatman, Karina A. Serban, Fabienne Gally, Danting Cao, Alexandra L. McCubbrey, Christina F. Cornell, Kelly S. Schweitzer, Evgeny V. Berdyshev, Irina A. Bronova, François Paris, Irina Petrache

Am J Respir Cell Mol Biol. 2021 May; 64(5): 629–640. doi: 10.1165/rcmb.2020-0229OC

PMCID:: PMC8086042

Abstract Article PDF–1.5M

Select item 778790513.

Functional inhibition or genetic deletion of acid sphingomyelinase bacteriostatically inhibits Anaplasma phagocytophilum infection in vivo

Waheeda A Naimi, Jacob J Gumpf, Chelsea L Cockburn, Sarah Camus, Charles E Chalfant, Pin-Lan Li, Jason A Carlyon

Pathog Dis. 2021 Feb; 79(1): ftaa072. Published online 2020 Nov 21. doi: 10.1093/femspd/ftaa072

PMCID:: PMC7787905

Abstract Article PDF–1.0M

Select item 756093914.

Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia

Nina Hagemann, Ayan Mohamud Yusuf, Carlotta Martiny, Xiaoni Zhang, Christoph Kleinschnitz, Matthias Gunzer, Richard Kolesnick, Erich Gulbins, Dirk M. Hermann

Basic Res Cardiol. 2020; 115(6): 64. Published online 2020 Oct 14. doi: 10.1007/s00395-020-00823-x

PMCID:: PMC7560939

Abstract Article PDF–4.8M

Select item 728563015.

Adeno-associated viral vector serotype 9-based gene therapy for Niemann-Pick disease type A

Lluis Samaranch, Azucena Pérez-Cañamás, Beatriz Soto-Huelin, Vivek Sudhakar, Jerónimo Jurado-Arjona, Piotr Hadaczek, Jesús Ávila, John R. Bringas, Josefina Casas, Haifeng Chen, Xingxuan He, Edward H. Schuchman, Seng H. Cheng, John Forsayeth, Krystof S. Bankiewicz, María Dolores Ledesma

Sci Transl Med. Author manuscript; available in PMC 2020 Aug 21.

Published in final edited form as: Sci Transl Med. 2019 Aug 21; 11(506): eaat3738. doi: 10.1126/scitranslmed.aat3738

PMCID:: PMC7285630

Abstract Article PDF–2.8M

Select item 722674116.

Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma

Marco Coazzoli, Alessandra Napoli, Paulina Roux-Biejat, Clara De Palma, Claudia Moscheni, Elisabetta Catalani, Silvia Zecchini, Vincenzo Conte, Matteo Giovarelli, Sonia Caccia, Patrizia Procacci, Davide Cervia, Emilio Clementi, Cristiana Perrotta

Cells. 2020 Apr; 9(4): 848. Published online 2020 Mar 31. doi: 10.3390/cells9040848

PMCID:: PMC7226741

Abstract Article PDF–6.5M

Select item 721125617.

Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase

Lucy K. Reiss, Ute Raffetseder, Lydia Gibbert, Hannah K. Drescher, Konrad L. Streetz, Agatha Schwarz, Christian Martin, Stefan Uhlig, Dieter Adam

Mediators Inflamm. 2020; 2020: 3650508. Published online 2020 May 1. doi: 10.1155/2020/3650508

PMCID:: PMC7211256

Abstract Article PDF–2.0M

Select item 661834518.

Enhanced Alcohol Preference and Anxiolytic Alcohol Effects in Niemann-Pick Disease Model in Mice

Liubov S. Kalinichenko, Christiane Mühle, Volker Eulenburg, Marc Praetner, Martin Reichel, Erich Gulbins, Johannes Kornhuber, Christian P. Müller

Front Neurol. 2019; 10: 731. Published online 2019 Jul 3. doi: 10.3389/fneur.2019.00731

PMCID:: PMC6618345

Abstract Article PDF–2.2M

Select item 659420519.

Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis

Jana Meiners, Vittoria Palmieri, Robert Klopfleisch, Jana-Fabienne Ebel, Lukasz Japtok, Fabian Schumacher, Ayan Mohamud Yusuf, Katrin A. Becker, Julia Zöller, Matthias Hose, Burkhard Kleuser, Dirk M. Hermann, Richard N. Kolesnick, Jan Buer, Wiebke Hansen, Astrid M. Westendorf

Front Immunol. 2019; 10: 1386. Published online 2019 Jun 19. doi: 10.3389/fimmu.2019.01386

PMCID:: PMC6594205

Abstract Article PDF–4.6M

Select item 654354520.

An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo

Thomas V. Galassi, Prakrit V. Jena, Janki Shah, Geyou Ao, Elizabeth Molitor, Yaron Bram, Angela Frankel, Jiwoon Park, Jose Jessurun, Daniel S. Ory, Adriana Haimovitz-Friedman, Daniel Roxbury, Jeetain Mittal, Ming Zheng, Robert E. Schwartz, Daniel A. Heller

Sci Transl Med. Author manuscript; available in PMC 2019 May 31.

Published in final edited form as: Sci Transl Med. 2018 Oct 3; 10(461): eaar2680. doi: 10.1126/scitranslmed.aar2680

PMCID:: PMC6543545

Abstract Article PDF–1.1M

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