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Select item 106301201.

Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes

Jun-ichi Morishige, Kazuaki Yoshioka, Hiroki Nakata, Kazuhiro Ishimaru, Naoto Nagata, Tamotsu Tanaka, Yoh Takuwa, Hitoshi Ando

J Lipid Res. 2023 Nov; 64(11): 100450. Published online 2023 Sep 24. doi: 10.1016/j.jlr.2023.100450

PMCID:: PMC10630120

Abstract Article PDF–4.2M

Select item 84911382.

Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNFα-dependent inflammation and apoptosis

Dorit Avni, Kuzhuvelil B. Harikumar, Arun J. Sanyal, Sarah Spiegel

FASEB J. Author manuscript; available in PMC 2021 Oct 5.

Published in final edited form as: FASEB J. 2021 Mar; 35(3): e21415. doi: 10.1096/fj.202002540R

PMCID:: PMC8491138

Abstract Article PDF–1.9M

Select item 84197513.

SphK1‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer

Jiang‐Ni Wu, Lan Lin, Shi‐Bo Luo, Xin‐Ze Qiu, Li‐Ye Zhu, Da Chen, Er‐Dan Wei, Zhen‐Hua Fu, Meng‐Bin Qin, Zhi‐Hai Liang, Jie‐An Huang, Shi‐Quan Liu

Cancer Med. 2021 Sep; 10(17): 6010–6021. Published online 2021 Jul 16. doi: 10.1002/cam4.4129

PMCID:: PMC8419751

Abstract Article PDF–2.0M

Select item 81588624.

Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer

Fabiola N. Velazquez, Leiqing Zhang, Valentina Viscardi, Carolena Trocchia, Yusuf A. Hannun, Lina M. Obeid, Ashley J. Snider

PLoS One. 2021; 16(5): e0252311. Published online 2021 May 27. doi: 10.1371/journal.pone.0252311

PMCID:: PMC8158862

Abstract Article PDF–2.0M

Select item 80374045.

Silencing of Sphingosine kinase 1 Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes

Ewelina Jozefczuk, Piotr Szczepaniak, Tomasz Jan Guzik, Mateusz Siedlinski

Int J Mol Sci. 2021 Apr; 22(7): 3616. Published online 2021 Mar 31. doi: 10.3390/ijms22073616

PMCID:: PMC8037404

Abstract Article PDF–1.8M

Select item 76762746.

K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice

Jing Xie, Yong Shao, Jin Liu, Meilan Cui, Xiuxiao Xiao, Jingbo Gong, Binghua Xue, Qunwei Zhang, Xianwen Hu, Haifeng Duan

Sci Rep. 2020; 10: 20038. Published online 2020 Nov 18. doi: 10.1038/s41598-020-77096-w

PMCID:: PMC7676274

Abstract Article PDF–5.5M

Select item 75592887.

Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity

Sabira Mohammed, Nalanda S. Vineetha, Shirley James, Jayasekharan S. Aparna, Manendra Babu Lankadasari, Takahiro Maeda, Abhirupa Ghosh, Sudipto Saha, Quan-Zhen Li, Sarah Spiegel, Kuzhuvelil B. Harikumar

FASEB J. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: FASEB J. 2020 Mar; 34(3): 4329–4347. Published online 2020 Jan 23. doi: 10.1096/fj.201902847R

PMCID:: PMC7559288

Abstract Article PDF–2.6M

Select item 75290528.

Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease

Andrea K. Anderson, Johana M. Lambert, David J. Montefusco, Bao Ngan Tran, Patrick Roddy, William L. Holland, L. Ashley Cowart

J Lipid Res. 2020 Oct; 61(10): 1328–1340. doi: 10.1194/jlr.RA120000875

PMCID:: PMC7529052

Abstract Article PDF–1.6M

Select item 72748559.

Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene

Gang Qing Yao, Meiling Zhu, Joanne Walker, Karl Insogna

Calcif Tissue Int. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Calcif Tissue Int. 2020 Jul; 107(1): 52–59. Published online 2020 Apr 3. doi: 10.1007/s00223-020-00685-4

PMCID:: PMC7274855

Abstract Article PDF–530K

Select item 721634810.

Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice

Bingqing Lyu, Weili Wang, Xin-Ying Ji, Joseph K. Ritter, Ningjun Li

BMC Nephrol. 2020; 21: 173. Published online 2020 May 11. doi: 10.1186/s12882-020-01815-8

PMCID:: PMC7216348

Abstract Article PDF–1.5M

Select item 675462711.

Knockout of Sphingosine Kinase 1 Attenuates Renal Fibrosis in Unilateral Ureteral Obstruction Model

Xiwen Zhang, Weili Wang, Xin-Ying Ji, Joseph K. Ritter, Ningjun Li

Am J Nephrol. Author manuscript; available in PMC 2020 Aug 15.

Published in final edited form as: Am J Nephrol. 2019; 50(3): 196–203. Published online 2019 Aug 15. doi: 10.1159/000502448

PMCID:: PMC6754627

Abstract Article PDF–1.1M

Select item 659109112.

Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells

Zhong-Jiao Jiang, Taylor L. Delaney, Mark P Zanin, Rainer V Haberberger, Stuart M Pitson, Jian Huang, Simon Alford, Stephanie Cologna, Damien J Keating, Liang-Wei Gong

J Neurochem. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: J Neurochem. 2019 Jun; 149(6): 729–746. Published online 2019 May 8. doi: 10.1111/jnc.14703

PMCID:: PMC6591091

Abstract Article PDF–1.4M

Select item 586230413.

Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis

Hideki Furuya, Paulette M Tamashiro, Yoshiko Shimizu, Kayoko Iino, Rafael Peres, Runpu Chen, Yijun Sun, Yusuf A Hannun, Lina M Obeid, Toshihiko Kawamori

Carcinogenesis. 2017 Dec; 38(12): 1218–1227. Published online 2017 Sep 23. doi: 10.1093/carcin/bgx104

PMCID:: PMC5862304

Abstract Article PDF–4.8M

Select item 571716714.

Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

Masaya Funaki, Juria Kitabayashi, Tetsuro Shimakami, Naoto Nagata, Yuriko Sakai, Kai Takegoshi, Hikari Okada, Kazuhisa Murai, Takayoshi Shirasaki, Takeru Oyama, Taro Yamashita, Tsuguhito Ota, Yoh Takuwa, Masao Honda, Shuichi Kaneko

Sci Rep. 2017; 7: 16978. Published online 2017 Dec 5. doi: 10.1038/s41598-017-17285-2

PMCID:: PMC5717167

Abstract Article PDF–5.2M

Select item 565606115.

Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis

Hiroaki Aoki, Masayo Aoki, Eriko Katsuta, Rajesh Ramanathan, Michael O. Idowu, Sarah Spiegel, Kazuaki Takabe

J Surg Res. Author manuscript; available in PMC 2017 Oct 25.

Published in final edited form as: J Surg Res. 2016 Oct; 205(2): 510–517. Published online 2016 Jul 9. doi: 10.1016/j.jss.2016.05.034

PMCID:: PMC5656061

Abstract Article PDF–911K

Select item 534349716.

Vascular transcriptome profiling identifies Sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction

Mateusz Siedlinski, Ryszard Nosalski, Piotr Szczepaniak, Agnieszka H. Ludwig-Gałęzowska, Tomasz Mikołajczyk, Magdalena Filip, Grzegorz Osmenda, Grzegorz Wilk, Michał Nowak, Paweł Wołkow, Tomasz J. Guzik

Sci Rep. 2017; 7: 44131. Published online 2017 Mar 9. doi: 10.1038/srep44131

PMCID:: PMC5343497

Abstract Article PDF–1.3M

Select item 494715817.

Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

Kaiqi Sun, Yujin Zhang, Angelo D'Alessandro, Travis Nemkov, Anren Song, Hongyu Wu, Hong Liu, Morayo Adebiyi, Aji Huang, Yuan E. Wen, Mikhail V. Bogdanov, Alejandro Vila, John O'Brien, Rodney E. Kellems, William Dowhan, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Martin Safo, Kirk C. Hansen, Robert C. Roach, Yang Xia

Nat Commun. 2016; 7: 12086. Published online 2016 Jul 15. doi: 10.1038/ncomms12086

PMCID:: PMC4947158

Abstract Article PDF–1.8M

Select item 483258918.

Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1

Anja Schwiebs, Olga Friesen, Elisabeth Katzy, Nerea Ferreirós, Josef M. Pfeilschifter, Heinfried H. Radeke

Front Pharmacol. 2016; 7: 94. Published online 2016 Apr 15. doi: 10.3389/fphar.2016.00094

PMCID:: PMC4832589

Abstract Article PDF–2.1M

Select item 465599119.

SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes

Tuoyu Geng, Alton Sutter, Michael D. Harland, Brittany A. Law, Jessica S. Ross, David Lewin, Arun Palanisamy, Sarah B. Russo, Kenneth D. Chavin, L. Ashley Cowart

J Lipid Res. 2015 Dec; 56(12): 2359–2371. doi: 10.1194/jlr.M063511