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Select item 109608031.

Voluntary exercise preserves visual function and reduces inflammatory response in an adult mouse model of autosomal dominant retinitis pigmentosa

Katie L. Bales, Austin M. Karesh, Kelleigh Hogan, Alicia S. Chacko, GianMarco L. Douglas, Andrew J. Feola, John M. Nickerson, Alyssa Pybus, Levi Wood, Jeffrey H. Boatright, Machelle T. Pardue

Sci Rep. 2024; 14: 6940. Published online 2024 Mar 23. doi: 10.1038/s41598-024-57027-9

PMCID:: PMC10960803

Abstract Article PDF–4.2M

Select item 108734272.

Aggregation of rhodopsin mutants in mouse models of autosomal dominant retinitis pigmentosa

Sreelakshmi Vasudevan, Subhadip Senapati, Maryanne Pendergast, Paul S.–H. Park

Nat Commun. 2024; 15: 1451. Published online 2024 Feb 16. doi: 10.1038/s41467-024-45748-4

PMCID:: PMC10873427

Abstract Article PDF–12M

Select item 107739393.

Super-resolution mapping in rod photoreceptors identifies rhodopsin trafficking through the inner segment plasma membrane as an essential subcellular pathway

Kristen N. Haggerty, Shannon C. Eshelman, Lauren A. Sexton, Emmanuel Frimpong, Leah M. Rogers, Melina A. Agosto, Michael A. Robichaux

PLoS Biol. 2024 Jan; 22(1): e3002467. Published online 2024 Jan 8. doi: 10.1371/journal.pbio.3002467

PMCID:: PMC10773939

Abstract Article PDF–8.1M

Select item 104126414.

Rho enhancers play unexpectedly minor roles in Rhodopsin transcription and rod cell integrity

Chi Sun, Philip A. Ruzycki, Shiming Chen

Sci Rep. 2023; 13: 12899. Published online 2023 Aug 9. doi: 10.1038/s41598-023-39979-6

PMCID:: PMC10412641

Abstract Article PDF–3.3M

Select item 103353755.

Structural abnormalities of retinal pigment epithelial cells in a light‐inducible, rhodopsin mutant mouse

Debora Napoli, Enrica Strettoi

J Anat. 2023 Aug; 243(2): 223–234. Published online 2022 Apr 15. doi: 10.1111/joa.13667

PMCID:: PMC10335375

Abstract Article PDF–8.6M

Select item 99976946.

Investigating the Role of Rhodopsin F45L Mutation in Mouse Rod Photoreceptor Signaling and Survival

Deepak Poria, Alexander V. Kolesnikov, Tae Jun Lee, David Salom, Krzysztof Palczewski, Vladimir J. Kefalov

eNeuro. 2023 Mar; 10(3): ENEURO.0330-22.2023. Prepublished online 2023 Feb 21. Published online 2023 Mar 2. doi: 10.1523/ENEURO.0330-22.2023

PMCID:: PMC9997694

Abstract Article PDF–2.4M

Select item 97307327.

Overexpression of Rhodopsin or Its Mutants Leads to Energy Metabolism Dysfunction in 661w Cells

Yang Liu, Xin Wang, Ruowen Gong, Gezhi Xu, Min Zhu

Invest Ophthalmol Vis Sci. 2022 Dec; 63(13): 2. Published online 2022 Dec 5. doi: 10.1167/iovs.63.13.2

PMCID:: PMC9730732

Abstract Article PDF–2.0M

Select item 96151088.

Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice

Joseph Thomas Ortega, Tanu Parmar, Miguel Carmena-Bargueño, Horacio Pérez-Sánchez, Beata Jastrzebska

J Neurosci Res. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: J Neurosci Res. 2022 Apr; 100(4): 1063–1083. Published online 2022 Feb 15. doi: 10.1002/jnr.25021

PMCID:: PMC9615108

Abstract Article PDF–2.5M

Select item 80794769.

Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration

Zhongjie Fu, Chenxi Qiu, Gael Cagnone, Yohei Tomita, Shuo Huang, Bertan Cakir, Yumi Kotoda, William Allen, Edward Bull, James D. Akula, Jean-Sébastien Joyal, Ann Hellström, Saswata Talukdar, Lois E.H. Smith

iScience. 2021 Apr 23; 24(4): 102376. Published online 2021 Mar 29. doi: 10.1016/j.isci.2021.102376

PMCID:: PMC8079476

Abstract Article PDF–4.6M

Select item 755239210.

Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa

Michael T. Massengill, Neil F. Ash, Brianna M. Young, Cristhian J. Ildefonso, Alfred S. Lewin

Sci Rep. 2020; 10: 16967. Published online 2020 Oct 12. doi: 10.1038/s41598-020-73749-y

PMCID:: PMC7552392

Abstract Article PDF–3.7M

Select item 720066211.

The F220C and F45L rhodopsin mutations identified in retinitis pigmentosa patients do not cause pathology in mice

Tylor R. Lewis, Camilla R. Shores, Martha A. Cady, Ying Hao, Vadim Y. Arshavsky, Marie E. Burns

Sci Rep. 2020; 10: 7538. Published online 2020 May 5. doi: 10.1038/s41598-020-64437-y

PMCID:: PMC7200662

Abstract Article PDF–4.3M

Select item 715805712.

Retinal degeneration in mice expressing the constitutively active G90D rhodopsin mutant

Alejandro T Colozo, Sreelakshmi Vasudevan, Paul S-H Park

Hum Mol Genet. 2020 Apr 15; 29(6): 881–891. Published online 2020 Jan 21. doi: 10.1093/hmg/ddaa008

PMCID:: PMC7158057

Abstract Article PDF–966K

Select item 679534113.

Visual Contrast Sensitivity Correlates to the Retinal Degeneration in Rhodopsin Knockout Mice

Jiaxin Xiao, Muhammed Yasin Adil, Karen Chang, Zicheng Yu, Lanbo Yang, Tor P Utheim, Dong Feng Chen, Kin-Sang Cho

Invest Ophthalmol Vis Sci. 2019 Oct; 60(13): 4196–4204. doi: 10.1167/iovs.19-26966

PMCID:: PMC6795341

Abstract Article PDF–1.2M

Select item 676265414.

Constitutive “Light” Adaptation in Rods from G90D Rhodopsin: A Mechanism for Human Congenital Nightblindness without Rod Cell Loss

Paul A. Sieving, Michael L. Fowler, Ronald A. Bush, Shigeki Machida, Peter D. Calvert, Daniel G. Green, Clint L. Makino, Christina L. McHenry

J Neurosci. 2001 Aug 1; 21(15): 5449–5460. doi: 10.1523/JNEUROSCI.21-15-05449.2001

PMCID:: PMC6762654

Abstract Article PDF–1015K

Select item 670775715.

Wheel running exercise protects against retinal degeneration in the I307N rhodopsin mouse model of inducible autosomal dominant retinitis pigmentosa

Xian Zhang, Preston E. Girardot, Jana T. Sellers, Ying Li, Jiaxing Wang, Micah A. Chrenek, Wenfei Wu, Henry Skelton, John M. Nickerson, Machelle T. Pardue, Jeffrey H. Boatright

Mol Vis. 2019; 25: 462–476. Published online 2019 Aug 21.

PMCID:: PMC6707757

Abstract Article PDF–11M

Select item 669366516.

Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa

Wei Wang, Ashwini Kini, Yekai Wang, Tingting Liu, Yao Chen, Eric Vukmanic, Douglas Emery, Yongqing Liu, Xiaoqin Lu, Lei Jin, San Joon Lee, Patrick Scott, Xiao Liu, Kevin Dean, Qingxian Lu, Enzo Fortuny, Robert James, Henry J. Kaplan, Jianhai Du, Douglas C. Dean

Cell Rep. Author manuscript; available in PMC 2019 Aug 14.

Published in final edited form as: Cell Rep. 2019 Jul 30; 28(5): 1323–1334.e4. doi: 10.1016/j.celrep.2019.06.093

PMCID:: PMC6693665

Abstract Article PDF–2.2M

Select item 663935917.

Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis

Yaoyan Qiu, Jingyu Yao, Lin Jia, Debra A. Thompson, David N. Zacks

Cell Death Dis. 2019 Aug; 10(8): 547. Published online 2019 Jul 18. doi: 10.1038/s41419-019-1780-1

PMCID:: PMC6639359

Abstract Article PDF–3.6M

Select item 640457318.

Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease

Sanae Sakami, Yoshikazu Imanishi, Krzysztof Palczewski

FASEB J. 2019 Mar; 33(3): 3680–3692. Published online 2018 Nov 21. doi: 10.1096/fj.201801662R

PMCID:: PMC6404573

Abstract Article

Select item 627919519.

Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice

Cristina García-Caballero, Burke Lieppman, Alicia Arranz-Romera, Irene. T. Molina-Martínez, Irene Bravo-Osuna, Michael Young, Petr Baranov, Rocío Herrero-Vanrell

Mol Vis. 2018; 24: 733–745. Published online 2018 Nov 16.