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Select item 106535281.

Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex

Anoek L. I. van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A. M. Dekker, Marjolein R. A. van der Steen, Joris J. T. H. Roelofs, Matijs van Meurs, Grietje Molema, Charissa E. van den Brom

PLoS One. 2023; 18(11): e0293673. Published online 2023 Nov 16. doi: 10.1371/journal.pone.0293673

PMCID:: PMC10653528

Abstract Article PDF–3.1M

Select item 103783252.

Reduced Tie2 in Microvascular Endothelial Cells Is Associated with Organ-Specific Adhesion Molecule Expression in Murine Health and Endotoxemia

Peter J. Zwiers, Jacqueline P. F. E. Lucas, Rianne M. Jongman, Matijs van Meurs, Eliane R. Popa, Grietje Molema

Cells. 2023 Jul; 12(14): 1850. Published online 2023 Jul 14. doi: 10.3390/cells12141850

PMCID:: PMC10378325

Abstract Article PDF–6.2M

Select item 102788033.

Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-Specific Pathways

Yanyang Li, Pan Liu, Yalu Zhou, Hiroshi Maekawa, John B. Silva, Mohammed Javeed Ansari, Khaled Boubes, Yazan Alia, Dilip K. Deb, Benjamin R. Thomson, Jing Jin, Susan E. Quaggin

J Am Soc Nephrol. 2023 Jun; 34(6): 969–987. Published online 2023 Feb 14. doi: 10.1681/ASN.0000000000000098

PMCID:: PMC10278803

Abstract Article

Select item 75714834.

Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients

Pawel A Kabala, Beatriz Malvar-Fernández, Ana P Lopes, Tiago Carvalheiro, Sarita A Y Hartgring, Man Wai Tang, Carmen Conde, Dominique L Baeten, Matthew Sleeman, Paul P Tak, Jane Connor, Timothy R Radstake, Kris A Reedquist, Samuel García

Rheumatology (Oxford) 2020 Feb; 59(2): 426–438. Published online 2019 Aug 4. doi: 10.1093/rheumatology/kez315

PMCID:: PMC7571483

Abstract Article PDF–801K

Select item 74474245.

Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis

Temitayo O Idowu, Valerie Etzrodt, Benjamin Seeliger, Patricia Bolanos-Palmieri, Kristina Thamm, Hermann Haller, Sascha David

eLife. 2020; 9: e59520. Published online 2020 Aug 24. doi: 10.7554/eLife.59520

PMCID:: PMC7447424

Abstract Article PDF–1.4M

Select item 65114316.

Partial Deletion of Tie2 Affects Microvascular Endothelial Responses to Critical Illness in A Vascular Bed and Organ-Specific Way

Rianne M. Jongman, Peter J. Zwiers, Bart van de Sluis, Marleen van der Laan, Jill Moser, Jan G. Zijlstra, Daphne Dekker, Nicolette Huijkman, Henk E. Moorlag, Eliane R. Popa, Grietje Molema, Matijs van Meurs

Shock. 2019 Jun; 51(6): 757–769. Published online 2019 May 14. doi: 10.1097/SHK.0000000000001226

PMCID:: PMC6511431

Abstract Article PDF–1.5M

Select item 62220647.

Angiopoietin/Tie2 Axis Regulates the Age-at-Injury Cerebrovascular Response to Traumatic Brain Injury

Thomas R. Brickler, Amanda Hazy, Fernanda Guilhaume Correa, Rujuan Dai, Elizabeth J.A. Kowalski, Ross Dickerson, Jiang Chen, Xia Wang, Paul D. Morton, Abby Whittington, Ansar Ahmed, Michelle H. Theus

J Neurosci. 2018 Nov 7; 38(45): 9618–9634. doi: 10.1523/JNEUROSCI.0914-18.2018

PMCID:: PMC6222064

Abstract Article PDF–7.9M

Select item 48686858.

Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations

Susanne Lorenz, Tale Barøy, Jinchang Sun, Torfinn Nome, Daniel Vodák, Jan-Christian Bryne, Anne-Mari Håkelien, Lynnette Fernandez-Cuesta, Birte Möhlendick, Harald Rieder, Karoly Szuhai, Olga Zaikova, Terje C. Ahlquist, Gard O. S. Thomassen, Rolf I. Skotheim, Ragnhild A. Lothe, Patrick S. Tarpey, Peter Campbell, Adrienne Flanagan, Ola Myklebost, Leonardo A. Meza-Zepeda

Oncotarget. 2016 Feb 2; 7(5): 5273–5288. Published online 2015 Dec 11. doi: 10.18632/oncotarget.6567

PMCID:: PMC4868685

Abstract Article PDF–3.0M

Select item 47806199.

Gene control of tyrosine kinase TIE2 and vascular manifestations of infections

Chandra C. Ghosh, Sascha David, Ruyang Zhang, Anthony Berghelli, Katelyn Milam, Sarah J. Higgins, Jon Hunter, Aditi Mukherjee, Yongyue Wei, Mei Tran, Freeman Suber, Lester Kobzik, Kevin C. Kain, Shulin Lu, Ansgar Santel, Kiichiro Yano, Prajna Guha, Daniel J. Dumont, David C. Christiani, Samir M. Parikh

Proc Natl Acad Sci U S A. 2016 Mar 1; 113(9): 2472–2477. Published online 2016 Feb 16. doi: 10.1073/pnas.1519467113

PMCID:: PMC4780619

Abstract Article PDF–1.5M

Select item 424114510.

Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

Angela L. Rasmussen, Atsushi Okumura, Martin T. Ferris, Richard Green, Friederike Feldmann, Sara M. Kelly, Dana P. Scott, David Safronetz, Elaine Haddock, Rachel LaCasse, Matthew J. Thomas, Pavel Sova, Victoria S. Carter, Jeffrey M. Weiss, Darla R. Miller, Ginger D. Shaw, Marcus J. Korth, Mark T. Heise, Ralph S. Baric, Fernando Pardo-Manuel de Villena, Heinz Feldmann, Michael G. Katze

Science. Author manuscript; available in PMC 2014 Nov 22.

Published in final edited form as: Science. 2014 Nov 21; 346(6212): 987–991. Published online 2014 Oct 30. doi: 10.1126/science.1259595

PMCID:: PMC4241145

Abstract Article PDF–458K

Select item 377944811.

TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb

Ashish S Patel, Alberto Smith, Silvia Nucera, Daniela Biziato, Prakash Saha, Rizwan Q Attia, Julia Humphries, Katherine Mattock, Steven P Grover, Oliver T Lyons, Luca G Guidotti, Richard Siow, Aleksandar Ivetic, Stuart Egginton, Matthew Waltham, Luigi Naldini, Michele De Palma, Bijan Modarai

EMBO Mol Med. 2013 Jun; 5(6): 858–869. Published online 2013 May 7. doi: 10.1002/emmm.201302752

PMCID:: PMC3779448

Abstract Article PDF–1.0M

Select item 333481212.

The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis

Philipp Kümpers, Faikah Gueler, Sascha David, Paul Van Slyke, Daniel J Dumont, Joon-Keun Park, Clemens L Bockmeyer, Samir M Parikh, Hermann Pavenstädt, Hermann Haller, Nelli Shushakova

Crit Care. 2011; 15(5): R261. Published online 2011 Oct 31. doi: 10.1186/cc10523

PMCID:: PMC3334812

Abstract Article PDF–4.5M

Select item 317850213.

An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice

Daniel Voskas, Yael Babichev, Ling S. Ling, Jennifer Alami, Yuval Shaked, Robert S. Kerbel, Brian Ciruna, Daniel J. Dumont

J Leukoc Biol. 2008 Jul; 84(1): 59–67. Published online 2008 Apr 28. doi: 10.1189/jlb.0607347

PMCID:: PMC3178502

Abstract Article

Select item 308376414.

TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

Abigail F. Welford, Daniela Biziato, Seth B. Coffelt, Silvia Nucera, Matthew Fisher, Ferdinando Pucci, Clelia Di Serio, Luigi Naldini, Michele De Palma, Gillian M. Tozer, Claire E. Lewis

J Clin Invest. 2011 May 2; 121(5): 1969–1973. Published online 2011 Apr 1. doi: 10.1172/JCI44562

PMCID:: PMC3083764

Abstract Article PDF–1.9M

Select item 284889615.

Tie2 signaling regulates osteoclastogenesis and osteolytic bone invasion of breast cancer

Yongfen Min, Xiubao Ren, David B Vaught, Jin Chen, Edwin Donnelly, Conor C. Lynch, P. Charles Lin

Cancer Res. Author manuscript; available in PMC 2011 Apr 1.

Published in final edited form as: Cancer Res. 2010 Apr 1; 70(7): 2819–2828. Published online 2010 Mar 16. doi: 10.1158/0008-5472.CAN-09-1915

PMCID:: PMC2848896

Abstract Article PDF–4.7M

Select item 275788216.

The angiopietin-1–Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice

Lakshmi Kugathasan, Julie Basu Ray, Yupu Deng, Effat Rezaei, Daniel J. Dumont, Duncan J. Stewart

J Exp Med. 2009 Sep 28; 206(10): 2221–2234. doi: 10.1084/jem.20090389

Correction in:: J Exp Med. 2009 Nov 23; 206(12): 2853.

PMCID:: PMC2757882

Abstract Article PDF–4.0M

Select item 267137517.

Keratinocyte but Not Endothelial Cell-Specific Overexpression of Tie2 Leads to the Development of Psoriasis

Julie A. Wolfram, Doina Diaconu, Denise A. Hatala, Jessica Rastegar, Dorothy A. Knutsen, Abigail Lowther, David Askew, Anita C. Gilliam, Thomas S. McCormick, Nicole L. Ward

Am J Pathol. 2009 Apr; 174(4): 1443–1458. doi: 10.2353/ajpath.2009.080858

PMCID:: PMC2671375

Abstract Article PDF–6.1M

Select item 264773218.

The Angiopoietin/Tie2 Axis Mediates Malignant Pleural Effusion Formation

Charalampos Moschos, Ioannis Psallidas, Androniki Kollintza, Sophia Karabela, Andreas Papapetropoulos, Spyros Papiris, Richard W Light, Charis Roussos, Georgios T Stathopoulos, Ioannis Kalomenidis

Neoplasia. 2009 Mar; 11(3): 298–304. doi: 10.1593/neo.81480

PMCID:: PMC2647732

Abstract Article PDF–508K

Select item 189591419.

Loss of Tie2 receptor compromises embryonic stem cell–derived endothelial but not hematopoietic cell survival

Isao Hamaguchi, Tohru Morisada, Masaki Azuma, Kyoko Murakami, Madoka Kuramitsu, Takuo Mizukami, Kazuyuki Ohbo, Kazunari Yamaguchi, Yuichi Oike, Daniel J. Dumont, Toshio Suda

Blood. 2006 Feb 1; 107(3): 1207–1213. Prepublished online 2005 Oct 11. doi: 10.1182/blood-2005-05-1823

PMCID:: PMC1895914

Abstract Article

Select item 121914520.

Functional analysis of the endothelial cell-specific Tie2/Tek promoter identifies unique protein-binding elements.

B M Fadel, S C Boutet, T Quertermous

Biochem J. 1998 Feb 15; 330(Pt 1): 335–343. doi: 10.1042/bj3300335

PMCID:: PMC1219145

Summary PDF–476K

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