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Select item 112885041.

p53 governs an AT1 differentiation programme in lung cancer suppression

Alyssa M. Kaiser, Alberto Gatto, Kathryn J. Hanson, Richard L. Zhao, Nitin Raj, Michael G. Ozawa, José A. Seoane, Kathryn T. Bieging-Rolett, Mengxiong Wang, Irene Li, Winston L. Trope, Douglas Z. Liou, Joseph B. Shrager, Sylvia K. Plevritis, Aaron M. Newman, Capucine Van Rechem, Laura D. Attardi

Nature. Author manuscript; available in PMC 2024 Jul 30.

Published in final edited form as: Nature. 2023 Jul; 619(7971): 851–859. Published online 2023 Jul 19. doi: 10.1038/s41586-023-06253-8

PMCID:: PMC11288504

Abstract Article PDF–7.4M

Select item 112665632.

Prenatal exposure to Benzo[a]pyrene affects maternal–fetal outcomes via placental apoptosis

Nan Zhao, Jun Chu, Jieying Liu, Liangkun Ma, Ning Ma, Wei Song, Tianshu Sun

Sci Rep. 2024; 14: 17002. Published online 2024 Jul 24. doi: 10.1038/s41598-024-68029-y

PMCID:: PMC11266563

Abstract Article PDF–2.8M

Select item 112339223.

Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

Shengli Ming, Shijun Zhang, Jiayou Xing, Guoyu Yang, Lei Zeng, Jiang Wang, Beibei Chu

iScience. 2024 Jul 19; 27(7): 110144. Published online 2024 Jun 4. doi: 10.1016/j.isci.2024.110144

PMCID:: PMC11233922

Abstract Article PDF–7.4M

Select item 111666584.

iPS cell generation-associated point mutations include many C > T substitutions via different cytosine modification mechanisms

Ryoko Araki, Tomo Suga, Yuko Hoki, Kaori Imadome, Misato Sunayama, Satoshi Kamimura, Mayumi Fujita, Masumi Abe

Nat Commun. 2024; 15: 4946. Published online 2024 Jun 11. doi: 10.1038/s41467-024-49335-5

PMCID:: PMC11166658

Abstract Article PDF–1.8M

Select item 111488005.

Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice

Rasoul Pourebrahim, Rafael Heinz Montoya, Hiroki Akiyama, Lauren Ostermann, Shayuan Khazaei, Muharrem Muftuoglu, Natalia Baran, Ran Zhao, Tom Lesluyes, Bin Liu, Joseph D. Khoury, Mihai Gagea, Peter Van Loo, Michael Andreeff

Cell Rep Med. 2024 May 21; 5(5): 101558. Published online 2024 May 10. doi: 10.1016/j.xcrm.2024.101558

PMCID:: PMC11148800

Abstract Article PDF–9.3M

Select item 111468646.

The role of p53 in tumour suppression: lessons from mouse models

L. D. Attardi, T. Jacks

Cell Mol Life Sci. 1999 Jan; 55(1): 48–63. Published online 2014 Feb 6. doi: 10.1007/s000180050269

PMCID:: PMC11146864

Abstract PDF–270K

Select item 109817857.

Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis

Miles J. Pfaff, Subhradip Mukhopadhyay, Mark Hoofnagle, Christine Chabasse, Rajabrata Sarkar

J Vasc Surg. Author manuscript; available in PMC 2024 Mar 31.

Published in final edited form as: J Vasc Surg. 2018 Dec; 68(6 Suppl): 222S–233S.e1. Published online 2018 Aug 17. doi: 10.1016/j.jvs.2018.02.055

PMCID:: PMC10981785

Abstract Article PDF–1.4M

Select item 109579108.

p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice

Ross J. Hill, Nazareno Bona, Job Smink, Hannah K. Webb, Alastair Crisp, Juan I. Garaycoechea, Gerry P. Crossan

Nat Commun. 2024; 15: 2518. Published online 2024 Mar 21. doi: 10.1038/s41467-024-46844-1

PMCID:: PMC10957910

Abstract Article PDF–7.8M

Select item 108693449.

Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Isabel Reinisch, Helene Michenthaler, Alba Sulaj, Elisabeth Moyschewitz, Jelena Krstic, Markus Galhuber, Ruonan Xu, Zina Riahi, Tongtong Wang, Nemanja Vujic, Melina Amor, Riccardo Zenezini Chiozzi, Martin Wabitsch, Dagmar Kolb, Anastasia Georgiadi, Lisa Glawitsch, Ellen Heitzer, Tim J. Schulz, Michael Schupp, Wenfei Sun, Hua Dong, Adhideb Ghosh, Anne Hoffmann, Dagmar Kratky, Laura C. Hinte, Ferdinand von Meyenn, Albert J. R. Heck, Matthias Blüher, Stephan Herzig, Christian Wolfrum, Andreas Prokesch

Nat Commun. 2024; 15: 1391. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45724-y

PMCID:: PMC10869344

Abstract Article PDF–4.5M

Select item 1085094710.

Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant, Tao Tan, Bianca D. Capaldo, Michelle Palmieri, Yumiko Hirokawa, Lin Tai, Daniel S. Simpson, Catherine Chang, Allan Shuai Huang, Elizabeth Lieschke, Sarah T. Diepstraten, Deeksha Kaloni, Chris Riffkin, David C.S. Huang, Connie S.N. Li Wai Suen, Alexandra L. Garnham, Peter Gibbs, Jane E. Visvader, Oliver M. Sieber, Marco J. Herold, Luca L. Fava, Gemma L. Kelly, Andreas Strasser

Cancer Discov. 2024 Feb 8; 14(2): 362–379. Published online 2023 Oct 24. doi: 10.1158/2159-8290.CD-23-0402

PMCID:: PMC10850947

Abstract Article PDF–17M

Select item 1076660511.

Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms

Panhong Gou, Duanya Liu, Saravanan Ganesan, Evelyne Lauret, Nabih Maslah, Veronique Parietti, Wenchao Zhang, Véronique Meignin, Jean-Jacques Kiladjian, Bruno Cassinat, Stephane Giraudier

Blood Cancer J. 2024 Dec; 14(1): 1. Published online 2024 Jan 4. doi: 10.1038/s41408-023-00969-6

PMCID:: PMC10766605

Abstract Article PDF–4.1M

Select item 1076165912.

p53R245W Mutation Fuels Cancer Initiation and Metastases in NASH-driven Liver Tumorigenesis

Denada Dibra, Mihai Gagea, Yuan Qi, Gilda P. Chau, Xiaoping Su, Guillermina Lozano

Cancer Res Commun. 2023 Dec; 3(12): 2640–2652. Published online 2023 Dec 29. doi: 10.1158/2767-9764.CRC-23-0218

PMCID:: PMC10761659

Abstract Article PDF–24M

Select item 1075869013.

Gain-of-Function p53 Mutation Acts as a Genetic Switch for TGFβ Signaling–Induced Epithelial-to-Mesenchymal Transition in Intestinal Tumors

Dong Wang, Mizuho Nakayama, Chang Pyo Hong, Hiroko Oshima, Masanobu Oshima

Cancer Res. 2024 Jan 2; 84(1): 56–68. Published online 2023 Oct 18. doi: 10.1158/0008-5472.CAN-23-1490

PMCID:: PMC10758690

Abstract Article PDF–14M

Select item 1068723014.

Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse

Jiabing Li, Shujun Xiao, Fangfang Shi, Huaxin Song, Jiaqi Wu, Derun Zheng, Xueqin Chen, Kai Tan, Min Lu

Cell Death Dis. 2023 Nov; 14(11): 783. Published online 2023 Nov 29. doi: 10.1038/s41419-023-06281-2

PMCID:: PMC10687230

Abstract Article PDF–2.1M

Select item 1064678315.

The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53

Maria-Riera Piqué-Borràs, Zivojin Jevtic, Frederik Otzen Bagger, Jonathan Seguin, Rathick Sivalingam, Matheus Filgueira Bezerra, Amber Louwagie, Sabine Juge, Ioannis Nellas, Robert Ivanek, Alexandar Tzankov, Ute M. Moll, Oriano Cantillo, Ramona Schulz-Heddergott, Alexandre Fagnan, Thomas Mercher, Juerg Schwaller

Blood. 2023 May 4; 141(18): 2245–2260. Published online 2023 Feb 8. doi: 10.1182/blood.2022017273

PMCID:: PMC10646783

Abstract Article

Select item 1064490016.

TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

Iker Ausejo-Mauleon, Sara Labiano, Daniel de la Nava, Virginia Laspidea, Marta Zalacain, Lucía Marrodán, Marc García-Moure, Marisol González-Huarriz, Irati Hervás-Corpión, Laasya Dhandapani, Silvestre Vicent, Maria Collantes, Iván Peñuelas, Oren J. Becher, Mariella G. Filbin, Li Jiang, Jenna Labelle, Carlos A.O. de Biagi-Junior, Javad Nazarian, Sandra Laternser, Timothy N. Phoenix, Jasper van der Lugt, Mariette Kranendonk, Raoull Hoogendijk, Sabine Mueller, Carlos De Andrea, Ana C. Anderson, Elizabeth Guruceaga, Carl Koschmann, Viveka Nand Yadav, Jaime Gállego Pérez-Larraya, Ana Patiño-García, Fernando Pastor, Marta M. Alonso

Cancer Cell. 2023 Nov 13; 41(11): 1911–1926.e8. doi: 10.1016/j.ccell.2023.09.001