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Select item 70054471.

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration

Katherine J. Wert, Gabriel Velez, Vijaya L. Kanchustambham, Vishnu Shankar, Lucy P. Evans, Jesse D. Sengillo, Richard N. Zare, Alexander G. Bassuk, Stephen H. Tsang, Vinit B. Mahajan

EBioMedicine. 2020 Feb; 52: 102636. Published online 2020 Feb 3. doi: 10.1016/j.ebiom.2020.102636

PMCID:: PMC7005447

Abstract Article PDF–4.8M

Select item 49794392.

Efficacy of PARP inhibition in Pde6a mutant mouse models for retinitis pigmentosa depends on the quality and composition of individual human mutations

K Jiao, A Sahaboglu, E Zrenner, M Ueffing, P A R Ekström, F Paquet-Durand

Cell Death Discov. 2016; 2: 16040. Published online 2016 Jul 4. doi: 10.1038/cddiscovery.2016.40

PMCID:: PMC4979439

Abstract Article PDF–2.6M

Select item 38693653.

Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa

Katherine J. Wert, Javier Sancho-Pelluz, Stephen H. Tsang

Hum Mol Genet. 2014 Jan 15; 23(2): 514–523. Published online 2013 Sep 18. doi: 10.1093/hmg/ddt452

PMCID:: PMC3869365

Abstract Article PDF–882K

Select item 35428654.

Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa

Katherine J. Wert, Richard J. Davis, Javier Sancho-Pelluz, Patsy M. Nishina, Stephen H. Tsang

Hum Mol Genet. 2013 Feb 1; 22(3): 558–567. Published online 2012 Oct 29. doi: 10.1093/hmg/dds466

PMCID:: PMC3542865

Abstract Article PDF–373K

Select item 88574705.

Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1

Ravi P. Yadav, Kimberly Boyd, Nikolai O. Artemyev

J Biol Chem. 2022 Mar; 298(3): 101620. Published online 2022 Jan 21. doi: 10.1016/j.jbc.2022.101620

PMCID:: PMC8857470

Abstract Article PDF–1.3M

Select item 84923446.

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa

Ashley A. Rowe, Pinkal D. Patel, Ruth Gordillo, Katherine J. Wert

JCI Insight. 2021 Sep 8; 6(17): e150898. Published online 2021 Sep 8. doi: 10.1172/jci.insight.150898

PMCID:: PMC8492344

Abstract Article PDF–2.4M

Select item 55516757.

Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase α- and β-subunits, and identification of β′-, a putative β-subunit isozyme produced by alternative splicing of the β-subunit gene

Wolfgang Baehr, Mary S. Champagne, Andrea K. Lee, Steven J. Pittler

FEBS Lett. Author manuscript; available in PMC 2017 Aug 10.

Published in final edited form as: FEBS Lett. 1991 Jan 14; 278(1): 107–114. doi: 10.1016/0014-5793(91)80095-k

PMCID:: PMC5551675

Abstract Article PDF–2.7M

Select item 37137188.

Cone Phosphodiesterase-6α′ Restores Rod Function and Confers Distinct Physiological Properties in the Rod Phosphodiesterase-6β-Deficient rd10 Mouse

Wen-Tao Deng, Keisuke Sakurai, Saravanan Kolandaivelu, Alexander V. Kolesnikov, Astra Dinculescu, Jie Li, Ping Zhu, Xuan Liu, Jijing Pang, Vince A. Chiodo, Sanford L. Boye, Bo Chang, Visvanathan Ramamurthy, Vladimir J. Kefalov, William W. Hauswirth

J Neurosci. 2013 Jul 17; 33(29): 11745–11753. doi: 10.1523/JNEUROSCI.1536-13.2013

PMCID:: PMC3713718

Abstract Article PDF–1.9M

Select item 532499.

Bovine cone photoreceptor cGMP phosphodiesterase structure deduced from a cDNA clone.

T S Li, K Volpp, M L Applebury

Proc Natl Acad Sci U S A. 1990 Jan; 87(1): 293–297. doi: 10.1073/pnas.87.1.293

PMCID:: PMC53249

Summary Page Browse PDF–1.2M

Select item 264464910.

New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene

Kenji Sakamoto, Michael McCluskey, Theodore G. Wensel, Jürgen K. Naggert, Patsy M. Nishina

Hum Mol Genet. 2009 Jan 1; 18(1): 178–192. Published online 2008 Oct 11. doi: 10.1093/hmg/ddn327

PMCID:: PMC2644649

Abstract Article PDF–1.8M

Select item 609448611.

Genetic Rescue Reverses Microglial Activation in Preclinical Models of Retinitis Pigmentosa

Lijuan Zhang, Xuan Cui, Ruben Jauregui, Karen Sophia Park, Sally Justus, Yi-Ting Tsai, Jimmy K. Duong, Chun-Wei Hsu, Wen-Hsuan Wu, Christine L. Xu, Chyuan-Sheng Lin, Stephen H. Tsang

Mol Ther. 2018 Aug 1; 26(8): 1953–1964. Published online 2018 Jun 21. doi: 10.1016/j.ymthe.2018.06.014

PMCID:: PMC6094486

Abstract Article PDF–4.8M

Select item 319086612.

Rod Phosphodiesterase-6 (PDE6) Catalytic Subunits Restore Cone Function in a Mouse Model Lacking Cone PDE6 Catalytic Subunit

Saravanan Kolandaivelu, Bo Chang, Visvanathan Ramamurthy

J Biol Chem. 2011 Sep 23; 286(38): 33252–33259. Published online 2011 Jul 28. doi: 10.1074/jbc.M111.259101

PMCID:: PMC3190866

Abstract Article PDF–1.6M

Select item 278148413.

AIPL1, a Protein Associated with Childhood Blindness, Interacts with α-Subunit of Rod Phosphodiesterase (PDE6) and Is Essential for Its Proper Assembly

Saravanan Kolandaivelu, Jing Huang, James B. Hurley, Visvanathan Ramamurthy

J Biol Chem. 2009 Nov 6; 284(45): 30853–30861. Published online 2009 Sep 16. doi: 10.1074/jbc.M109.036780

PMCID:: PMC2781484

Abstract Article PDF–973K

Select item 278209614.

Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the γ-subunit

Brandy Barren, Lokesh Gakhar, Hakim Muradov, Kimberly K Boyd, S Ramaswamy, Nikolai O Artemyev

EMBO J. 2009 Nov 18; 28(22): 3613–3622. Published online 2009 Oct 1. doi: 10.1038/emboj.2009.284

PMCID:: PMC2782096

Abstract Article PDF–1.5M

Select item 440563615.

Alternative Splicing Shapes the Phenotype of a Mutation in BBS8 To Cause Nonsyndromic Retinitis Pigmentosa

Daniel Murphy, Ratnesh Singh, Saravanan Kolandaivelu, Visvanathan Ramamurthy, Peter Stoilov

Mol Cell Biol. 2015 May; 35(10): 1860–1870. Prepublished online 2015 Mar 16. Published online 2015 Apr 21. doi: 10.1128/MCB.00040-15

PMCID:: PMC4405636

Abstract Article PDF–3.0M

Select item 578915816.

Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation

Cecinio C. Ronquillo, Christin Hanke-Gogokhia, Monica P. Revelo, Jeanne M. Frederick, Li Jiang, Wolfgang Baehr

FASEB J. 2016 Oct; 30(10): 3400–3412. Published online 2016 Jun 21. doi: 10.1096/fj.201600511R

PMCID:: PMC5789158

Abstract Article

Select item 486590117.

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

Bernice H. Wong, Jia Pei Chan, Amaury Cazenave-Gassiot, Rebecca W. Poh, Juat Chin Foo, Dwight L. A. Galam, Sujoy Ghosh, Long N. Nguyen, Veluchamy A. Barathi, Sia W. Yeo, Chi D. Luu, Markus R. Wenk, David L. Silver

J Biol Chem. 2016 May 13; 291(20): 10501–10514. Published online 2016 Mar 22. doi: 10.1074/jbc.M116.721340

PMCID:: PMC4865901

Abstract Article PDF–5.4M

Select item 684211718.

Nucleome Dynamics During Retinal Development

Jackie L. Norrie, Marybeth S. Lupo, Beisi Xu, Marc Valentine, Daniel Putnam, Issam Al Diri, Lyra Griffiths, Jiakun Zhang, Dianna Johnson, John Easton, Ying Shao, Victoria Honnell, Sharon Frase, Shondra Miller, Valerie Stewart, Xin Zhou, Xiang Chen, Michael A. Dyer

Neuron. Author manuscript; available in PMC 2020 Nov 6.

Published in final edited form as: Neuron. 2019 Nov 6; 104(3): 512–528.e11. Published online 2019 Sep 4. doi: 10.1016/j.neuron.2019.08.002

PMCID:: PMC6842117

Abstract Article PDF–4.3M

Select item 276516019.

Li Jia, Edwin C. T. Oh, Lily Ng, Maya Srinivas, Matthew Brooks, Anand Swaroop, Douglas Forrest

Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41): 17534–17539. Published online 2009 Sep 24. doi: 10.1073/pnas.0902425106

PMCID:: PMC2765160

Abstract Article PDF–2.3M

Select item 783841820.

Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract

Rupalatha Maddala, Junyuan Gao, Richard T. Mathias, Tylor R. Lewis, Vadim Y. Arshavsky, Adriana Levine, Jonathan M. Backer, Anne R. Bresnick, Ponugoti V. Rao

Sci Rep. 2021; 11: 2203. Published online 2021 Jan 26. doi: 10.1038/s41598-021-81611-y