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Select item 106031811.

Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles

Natasha D. Ratnayaka-Gamage, Lauren R. Alesi, Nadeen Zerafa, Jessica M. Stringer, Karla J. Hutt

Front Endocrinol (Lausanne) 2023; 14: 1268009. Published online 2023 Oct 10. doi: 10.3389/fendo.2023.1268009

PMCID:: PMC10603181

Abstract Article PDF–1.5M

Select item 103229322.

Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes

Xuebi Cai, Jessica M. Stringer, Nadeen Zerafa, John Carroll, Karla J. Hutt

Cell Death Dis. 2023 Jul; 14(7): 397. Published online 2023 Jul 5. doi: 10.1038/s41419-023-05886-x

PMCID:: PMC10322932

Abstract Article PDF–2.6M

Select item 37215093.

Ku80-Deleted Cells are Defective at Base Excision Repair

Han Li, Teresa Marple, Paul Hasty

Mutat Res. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Mutat Res. 2013 May-Jun; 0: 16–25. Published online 2013 Apr 6. doi: 10.1016/j.mrfmmm.2013.03.010

PMCID:: PMC3721509

Abstract Article PDF–2.1M

Select item 27836344.

Knockout of Ku86 accelerates cellular senescence induced by high NaCl

Natalia I. Dmitrieva, Hua Tang Chen, André Nussenzweig, Maurice B. Burg

Aging (Albany NY) 2009 Feb; 1(2): 245–253. Published online 2009 Feb 12. doi: 10.18632/aging.100022

PMCID:: PMC2783634

Abstract Article PDF–502K

Select item 25654995.

Effect of Ku80 Deficiency on Mutation Frequencies and Spectra at a LacZ Reporter Locus in Mouse Tissues and Cells

Rita A. Busuttil, Denise P. Muñoz, Ana Maria Garcia, Francis Rodier, Woo Ho Kim, Yousin Suh, Paul Hasty, Judith Campisi, Jan Vijg

PLoS One. 2008; 3(10): e3458. Published online 2008 Oct 20. doi: 10.1371/journal.pone.0003458

PMCID:: PMC2565499

Abstract Article PDF–496K

Select item 10837256.

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

Enrique Samper, Fermín A. Goytisolo, Predrag Slijepcevic, Paul P.W. van Buul, María A. Blasco

EMBO Rep. 2000 Sep 15; 1(3): 244–252. doi: 10.1093/embo-reports/kvd051

PMCID:: PMC1083725

Abstract Article PDF–762K

Select item 283507.

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development

André Nussenzweig, Karen Sokol, Paul Burgman, Ligeng Li, Gloria C. Li

Proc Natl Acad Sci U S A. 1997 Dec 9; 94(25): 13588–13593. doi: 10.1073/pnas.94.25.13588

PMCID:: PMC28350

Abstract Article PDF–352K

Select item 179588.

Deletion of Ku86 causes early onset of senescence in mice

Hannes Vogel, Dae-Sik Lim, Gerard Karsenty, Milton Finegold, Paul Hasty

Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19): 10770–10775. doi: 10.1073/pnas.96.19.10770

PMCID:: PMC17958

Abstract Article PDF–754K

Select item 101683879.

A transposase-derived gene required for human brain development

Luz Jubierre Zapater, Sara A. Lewis, Rodrigo Lopez Gutierrez, Makiko Yamada, Elias Rodriguez-Fos, Merce Planas-Felix, Daniel Cameron, Phillip Demarest, Anika Nabila, Helen Mueller, Junfei Zhao, Paul Bergin, Casie Reed, Tzippora Chwat-Edelstein, Alex Pagnozzi, Caroline Nava, Emilie Bourel-Ponchel, Patricia Cornejo, Ali Dursun, R. Köksal Özgül, Halil Tuna Akar, Reza Maroofian, Henry Houlden, Huma Arshad Cheema, Muhammad Nadeem Anjum, Giovanni Zifarelli, Miriam Essid, Meriem Ben Hafsa, Hanene Benrhouma, Carolina Isabel Galaz Montoya, Alex Proekt, Xiaolan Zhao, Nicholas D. Socci, Matthew Hayes, Yves Bigot, Raul Rabadan, David Torrents, Claudia L Kleinmann, Michael C. Kruer, Miklos Toth, Alex Kentsis

Version 3. bioRxiv. Preprint. 2023 Apr 28 [revised 2024 Aug 13]. doi: 10.1101/2023.04.28.538770

PMCID:: PMC10168387

Abstract Article PDF–4.0M

Select item 923328410.

Characterization of Double-Strand Break Repair Protein Ku80 Location Within the Murine Retina

Brigitte Müller, Franziska Serafin, Leonie Luise Laucke, Wilhelm Rheinhard, Tobias Wimmer, Knut Stieger

Invest Ophthalmol Vis Sci. 2022 Jun; 63(6): 22. Published online 2022 Jun 23. doi: 10.1167/iovs.63.6.22

PMCID:: PMC9233284

Abstract Article PDF–29M

Select item 794885511.

Diminished or inversed dose-rate effect on clonogenic ability in Ku-deficient rodent cells

Hisayo Tsuchiya, Mikio Shimada, Kaima Tsukada, Qingmei Meng, Junya Kobayashi, Yoshihisa Matsumoto

J Radiat Res. 2021 Mar; 62(2): 198–205. Published online 2020 Dec 29. doi: 10.1093/jrr/rraa128

PMCID:: PMC7948855

Abstract Article PDF–757K

Select item 755569112.

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties

Takabumi Inagawa, Thomas Wennink, Joyce H. G. Lebbink, Guido Keijzers, Bogdan I. Florea, Nicole S. Verkaik, Dik C. van Gent

Int J Mol Sci. 2020 Sep; 21(18): 6725. Published online 2020 Sep 14. doi: 10.3390/ijms21186725

PMCID:: PMC7555691

Abstract Article PDF–1.4M

Select item 599866513.

Ku80 is required but not sufficient for Ga13-mediated endodermal differentiation in P19 embryonic carcinoma cells

Jyotshnabala Kanungo, Hsien-yu Wang, Craig C. Malbon

Biochem Biophys Res Commun. Author manuscript; available in PMC 2018 Jun 13.

Published in final edited form as: Biochem Biophys Res Commun. 2004 Oct 8; 323(1): 293–298. doi: 10.1016/j.bbrc.2004.08.092

PMCID:: PMC5998665

Abstract Article PDF–475K

Select item 472159014.

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Michael J. Difilippantonio, Jie Zhu, Hua Tang Chen, Eric Meffre, Michel C. Nussenzweig, Edward E. Max, Thomas Ried, André Nussenzweig

Nature. Author manuscript; available in PMC 2016 Jan 21.

Published in final edited form as: Nature. 2000 Mar 30; 404(6777): 510–514. doi: 10.1038/35006670

PMCID:: PMC4721590

Abstract Article PDF–1.7M

Select item 403475215.

Ku80-deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response

Valerie B. Holcomb, Francis Rodier, Yong Jun Choi, Rita A. Busuttil, Hannes Vogel, Jan Vijg, Judith Campisi, Paul Hasty

Cancer Res. Author manuscript; available in PMC 2014 May 27.

Published in final edited form as: Cancer Res. 2008 Nov 15; 68(22): 9497–9502. doi: 10.1158/0008-5472.CAN-08-2085

PMCID:: PMC4034752

Abstract Article PDF–4.6M

Select item 398918716.

The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PK_CS Deficiency

Erwin Reiling, Martijn E. T. Dollé, Sameh A. Youssef, Moonsook Lee, Bhawani Nagarajah, Marianne Roodbergen, Piet de With, Alain de Bruin, Jan H. Hoeijmakers, Jan Vijg, Harry van Steeg, Paul Hasty

PLoS One. 2014; 9(4): e93568. Published online 2014 Apr 16. doi: 10.1371/journal.pone.0093568