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Select item 109519871.

The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases

Leah Rie Varner, Taro Chaya, Yamato Maeda, Ryotaro Tsutsumi, Shanshan Zhou, Toshinori Tsujii, Daisuke Okuzaki, Takahisa Furukawa

iScience. 2024 Apr 19; 27(4): 109380. Published online 2024 Mar 1. doi: 10.1016/j.isci.2024.109380

PMCID:: PMC10951987

Abstract Article PDF–8.4M

Select item 88030892.

Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling

Weiwei An, Le A Luong, Neil P Bowden, Mei Yang, Wei Wu, Xinmiao Zhou, Chenxin Liu, Kaiyuan Niu, Jun Luo, Cheng Zhang, Xiaolei Sun, Robin Poston, Li Zhang, Paul C Evans, Qingzhong Xiao

Cardiovasc Res. 2022 Feb; 118(2): 638–653. Published online 2021 Feb 18. doi: 10.1093/cvr/cvab056

PMCID:: PMC8803089

Abstract Article PDF–2.2M

Select item 56369743.

Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma

Jia-hong Wang, Xiao-ping Zhong, Yong-fa Zhang, Xiao-liang Wu, Shao-hua Li, Pei-en Jian, Yi-hong Ling, Ming Shi, Min-shan Chen, Wei Wei, Rong-ping Guo

Cell Death Dis. 2017 Sep; 8(9): e3043. Published online 2017 Sep 7. doi: 10.1038/cddis.2017.428

PMCID:: PMC5636974

Abstract Article PDF–3.0M

Select item 42649294.

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner

Anja Bremm, Sonia Moniz, Julia Mader, Sonia Rocha, David Komander

EMBO Rep. 2014 Dec; 15(12): 1268–1277. Published online 2014 Oct 29. doi: 10.15252/embr.201438850

PMCID:: PMC4264929

Abstract Article PDF–823K

Select item 108637845.

Ovarian Tumor Domain‐Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel‐Like Factor 4

Bin‐Bin Du, Jie‐Lei Zhang, Ling‐Yao Kong, Hui‐Ting Shi, Dian‐Hong Zhang, Xing Wang, Chun‐Lei Yang, Peng‐Cheng Li, Rui Yao, Cui Liang, Lei‐Ming Wu, Zhen Huang

J Am Heart Assoc. 2023 Dec 19; 12(24): e029745. Published online 2023 Dec 12. doi: 10.1161/JAHA.123.029745

PMCID:: PMC10863784

Abstract Article PDF–17M

Select item 103870846.

The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2

Kunjan Harit, Rituparna Bhattacharjee, Kai Matuschewski, Jennifer Becker, Ulrich Kalinke, Dirk Schlüter, Gopala Nishanth

Cell Death Dis. 2023 Jul; 14(7): 480. Published online 2023 Jul 29. doi: 10.1038/s41419-023-06014-5

PMCID:: PMC10387084

Abstract Article PDF–3.8M

Select item 76110657.

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination

Le A. Luong, Maria Fragiadaki, Jennifer Smith, Joseph Boyle, Jens Lutz, Jonathan L. E. Dean, Sarah Harten, Margaret Ashcroft, Sarah Walmsley, Dorian O. Haskard, Patrick H. Maxwell, Henning Walczak, Charles Pusey, Paul C. Evans

Circ Res. Author manuscript; available in PMC 2021 Jun 23.

Published in final edited form as: Circ Res. 2013 Jun 7; 112(12): 1583–91. Published online 2013 Apr 5. doi: 10.1161/CIRCRESAHA.111.300119

PMCID:: PMC7611065

Abstract Article PDF–2.0M

Select item 48136748.

Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination

Hongbo Hu, Hui Wang, Yichuan Xiao, Jin Jin, Jae-Hoon Chang, Qiang Zou, Xiaoping Xie, Xuhong Cheng, Shao-Cong Sun

J Exp Med. 2016 Mar 7; 213(3): 399–414. doi: 10.1084/jem.20151426

PMCID:: PMC4813674

Abstract Article PDF–2.8M

Select item 83365159.

OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis

Zhicheng Gong, Aicun Li, Jiancheng Ding, Qing Li, Lei Zhang, Yuanpei Li, Zhe Meng, Fei Chen, Jialiang Huang, Dawang Zhou, Ronggui Hu, Jing Ye, Wen Liu, Han You

Adv Sci (Weinh) 2021 Aug; 8(15): 2004504. Published online 2021 May 29. doi: 10.1002/advs.202004504

PMCID:: PMC8336515

Abstract Article PDF–6.5M

Select item 569554010.

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

Bin Wang, Zuliang Jie, Donghyun Joo, Alban Ordureau, Pengda Liu, Wenjian Gan, Jianping Guo, Jinfang Zhang, Brian J. North, Xiangpeng Dai, Xuhong Cheng, Xiuwu Bian, Lingqiang Zhang, J. Wade Harper, Shao-Cong Sun, Wenyi Wei

Nature. Author manuscript; available in PMC 2017 Nov 20.

Published in final edited form as: Nature. 2017 May 18; 545(7654): 365–369. Published online 2017 May 10. doi: 10.1038/nature22344

PMCID:: PMC5695540

Abstract Article PDF–2.8M

Select item 357896711.

Otud7b controls noncanonical NF-?B activation via deubiquitination of TRAF3

Hongbo Hu, George C. Brittain, Jae-Hoon Chang, Nahum Puebla-Osorio, Jin Jin, Anna Zal, Yichuan Xiao, Xuhong Cheng, Mikyoung Chang, Yang-Xin Fu, Tomasz Zal, Chengming Zhu, Shao-Cong Sun

Nature. Author manuscript; available in PMC 2013 Aug 21.

Published in final edited form as: Nature. 2013 Feb 21; 494(7437): 371–374. Published online 2013 Jan 20. doi: 10.1038/nature11831

PMCID:: PMC3578967

Abstract Article PDF–1.4M

Select item 303933812.

DJ-1 Enhances Cell Survival through the Binding of Cezanne, a Negative Regulator of NF-κB

R. Sean McNally, Beckley K. Davis, Casey M. Clements, Mary Ann Accavitti-Loper, Tak W. Mak, Jenny P.-Y. Ting

J Biol Chem. 2011 Feb 11; 286(6): 4098–4106. Published online 2010 Nov 19. doi: 10.1074/jbc.M110.147371

PMCID:: PMC3039338

Abstract Article PDF–939K

Select item 223867313.

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

Hoanh Tran, Fumihiko Hamada, Thomas Schwarz-Romond, Mariann Bienz

Genes Dev. 2008 Feb 15; 22(4): 528–542. doi: 10.1101/gad.463208

PMCID:: PMC2238673

Abstract Article PDF–1.0M

Select item 515962214.

Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice

Robert Wilson, Stefan H. Geyer, Lukas Reissig, Julia Rose, Dorota Szumska, Emily Hardman, Fabrice Prin, Christina McGuire, Ramiro Ramirez-Solis, Jacqui White, Antonella Galli, Catherine Tudor, Elizabeth Tuck, Cecilia Icoresi Mazzeo, James C. Smith, Elizabeth Robertson, David J. Adams, Timothy Mohun, Wolfgang J. Weninger

Version 2. Wellcome Open Res. 2016; 1: 1. Published online 2017 Feb 27. doi: 10.12688/wellcomeopenres.9899.2

PMCID:: PMC5159622

Abstract Article PDF–7.4M

Select item 586671915.

Placentation defects are highly prevalent in embryonic lethal mouse mutants

Vicente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline K. White, Elizabeth Tuck, Edward J. Ryder, Diane Gleeson, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth M. Busch-Nentwich, Antonella Galli, James C. Smith, Elizabeth Robertson, David J. Adams, Wolfgang J. Weninger, Timothy Mohun, Myriam Hemberger

Nature. Author manuscript; available in PMC 2018 Sep 14.

Published in final edited form as: Nature. 2018 Mar 22; 555(7697): 463–468. Published online 2018 Mar 14. doi: 10.1038/nature26002

PMCID:: PMC5866719

Abstract Article PDF–7.4M

Select item 645951016.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 16551117.

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

Doug Stryke, Michiko Kawamoto, Conrad C. Huang, Susan J. Johns, Leslie A. King, Courtney A. Harper, Elaine C. Meng, Roy E. Lee, Alice Yee, Larry L'Italien, Pao-Tien Chuang, Stephen G. Young, William C. Skarnes, Patricia C. Babbitt, Thomas E. Ferrin

Nucleic Acids Res. 2003 Jan 1; 31(1): 278–281. doi: 10.1093/nar/gkg064

PMCID:: PMC165511

Abstract Article PDF–217K

Select item 793877018.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 1683319.

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray

Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, Minoru S. H. Ko

Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16): 9127–9132. doi: 10.1073/pnas.97.16.9127

PMCID:: PMC16833

Abstract Article PDF–847K

Select item 255627020.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

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