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Select item 90340991.

Variants in PHF8 cause a spectrum of X-linked neurodevelopmental disorders and facial dysmorphology

Andrew K. Sobering, Laura M. Bryant, Dong Li, Julie McGaughran, Isabelle Maystadt, Stephanie Moortgat, John M. Graham, Jr., Arie van Haeringen, Claudia Ruivenkamp, Roos Cuperus, Julie Vogt, Jenny Morton, Charlotte Brasch-Andersen, Maria Steenhof, Lars Kjærsgaard Hansen, Élodie Adler, Stanislas Lyonnet, Veronique Pingault, Marlin Sandrine, Alban Ziegler, Tyhiesia Donald, Beverly Nelson, Brandon Holt, Oleksandra Petryna, Helen Firth, Kirsty McWalter, Jacob Zyskind, Aida Telegrafi, Jane Juusola, Richard Person, Michael J. Bamshad, Dawn Earl, University of Washington Center for Mendelian Genomics, Anne Chun-Hui Tsai, Katherine R. Yearwood, Elysa Marco, Catherine Nowak, Jessica Douglas, Hakon Hakonarson, Elizabeth J. Bhoj

HGG Adv. 2022 Jul 14; 3(3): 100102. Published online 2022 Mar 26. doi: 10.1016/j.xhgg.2022.100102

Correction in:: HGG Adv. 2023 Jan 12; 4(1): 100168.

PMCID:: PMC9034099

Abstract Article PDF–3.0M

Select item 78484402.

PHF8 Plays an Oncogene Function in Hepatocellular Carcinoma Formation

Hong Ye, Qing Yang, Shujie Qi, Hairong Li

Oncol Res. 2019; 27(5): 613–621. Published online 2019 May 7. doi: 10.3727/096504018X15410353669149

PMCID:: PMC7848440

Abstract Article PDF–6.5M

Select item 53896823.

Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis

Peng Shao, Qi Liu, Peterson Kariuki Maina, Jiayue Cui, Thomas B. Bair, Tiandao Li, Shaikamjad Umesalma, Weizhou Zhang, Hank Heng Qi

Nucleic Acids Res. 2017 Feb 28; 45(4): 1687–1702. Published online 2016 Nov 28. doi: 10.1093/nar/gkw1093

PMCID:: PMC5389682

Abstract Article PDF–7.4M

Select item 53427634.

c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer

Peterson Kariuki Maina, Peng Shao, Qi Liu, Ladan Fazli, Scott Tyler, Moman Nasir, Xuesen Dong, Hank Heng Qi

Oncotarget. 2016 Nov 15; 7(46): 75585–75602. Published online 2016 Sep 28. doi: 10.18632/oncotarget.12310

PMCID:: PMC5342763

Abstract Article PDF–7.9M

Select item 37956335.

Oncogenic Features of PHF8 Histone Demethylase in Esophageal Squamous Cell Carcinoma

Xiujing Sun, Jihui Julia Qiu, Shengtao Zhu, Bangwei Cao, Lin Sun, Sen Li, Peng Li, Shutian Zhang, Shuo Dong

PLoS One. 2013; 8(10): e77353. Published online 2013 Oct 11. doi: 10.1371/journal.pone.0077353

PMCID:: PMC3795633

Abstract Article PDF–2.2M

Select item 25703506.

A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

FE Abidi, MG Miano, JC Murray, CE Schwartz

Clin Genet. Author manuscript; available in PMC 2008 Oct 20.

Published in final edited form as: Clin Genet. 2007 Jul; 72(1): 19–22. doi: 10.1111/j.1399-0004.2007.00817.x

PMCID:: PMC2570350

Abstract Article PDF–204K

Select item 103963057.

PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma

Song Peng, Ze Wang, Peng Tang, Shuo Wang, Yiqiang Huang, Qiubo Xie, Yapeng Wang, Xintao Tan, Tang Tang, Xuzhi Yan, Jing Xu, Weihua Lan, Luofu Wang, Dianzheng Zhang, Bin Wang, Tiejun Pan, Jun Qin, Jun Jiang, Qiuli Liu

Sci Adv. 2023 Aug; 9(31): eadf3566. Published online 2023 Aug 2. doi: 10.1126/sciadv.adf3566

PMCID:: PMC10396305

Abstract Article PDF–2.7M

Select item 103498698.

Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons

Yanan Liu, Longmiao Hu, Zhengzhen Wu, Kun Yuan, Guangliang Hong, Zhengke Lian, Juanjuan Feng, Na Li, Dali Li, Jiemin Wong, Jiekai Chen, Mingyao Liu, Jiangping He, Xiufeng Pang

Nat Commun. 2023; 14: 4225. Published online 2023 Jul 15. doi: 10.1038/s41467-023-39943-y

PMCID:: PMC10349869

Abstract Article PDF–2.4M

Select item 88566179.

The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis

Rana S. Moubarak, Ana de Pablos-Aragoneses, Vanessa Ortiz-Barahona, Yixiao Gong, Michael Gowen, Igor Dolgalev, Sorin A. A. Shadaloey, Diana Argibay, Alcida Karz, Richard Von Itter, Eleazar Carmelo Vega-Sáenz de Miera, Elena Sokolova, Farbod Darvishian, Aristotelis Tsirigos, Iman Osman, Eva Hernando

Sci Adv. 2022 Feb; 8(7): eabi7127. Published online 2022 Feb 18. doi: 10.1126/sciadv.abi7127

PMCID:: PMC8856617

Abstract Article PDF–1.4M

Select item 775625510.

Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2

Qiuli Liu, Jian Pang, Lin‐ang Wang, Zhuowei Huang, Jing Xu, Xingxia Yang, Qiubo Xie, Yiqiang Huang, Tang Tang, Dali Tong, Gaolei Liu, Luofu Wang, Dianzheng Zhang, Qiang Ma, Hualiang Xiao, Weihua Lan, Jun Qin, Jun Jiang

J Pathol. 2021 Jan; 253(1): 106–118. Published online 2020 Nov 5. doi: 10.1002/path.5557

PMCID:: PMC7756255

Abstract Article PDF–48M

Select item 743473311.

MicroRNA‐383 inhibits proliferation, migration, and invasion in hepatocellular carcinoma cells by targeting PHF8

Yan Cheng, Na Liu, CaiFeng Yang, Jiong Jiang, Juhui Zhao, Gang Zhao, Fenrong Chen, Hongli Zhao, Yang Li

Mol Genet Genomic Med. 2020 Aug; 8(8): e1272. Published online 2020 May 22. doi: 10.1002/mgg3.1272

PMCID:: PMC7434733

Abstract Article PDF–1.1M

Select item 700035012.

Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance

Qi Liu, Nicholas C. Borcherding, Peng Shao, Peterson K. Maina, Weizhou Zhang, Hank H. Qi

EBioMedicine. 2020 Jan; 51: 102612. Published online 2020 Jan 7. doi: 10.1016/j.ebiom.2019.102612

PMCID:: PMC7000350

Abstract Article PDF–3.6M

Select item 577603913.

Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3

Peterson Kariuki Maina, Peng Shao, Xiongfei Jia, Qi Liu, Shaikamjad Umesalma, Maximo Marin, Donald Long, Jr., Samantha Concepción-Román, Hank Heng Qi

Biochim Biophys Acta Gene Regul Mech. Author manuscript; available in PMC 2018 Jan 21.

Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2017 Sep; 1860(9): 1002–1012. Published online 2017 Jul 20. doi: 10.1016/j.bbagrm.2017.07.005

PMCID:: PMC5776039

Abstract Article PDF–1.5M

Select item 564700314.

Histone demethylase PHF8 accelerates the progression of colorectal cancer and can be regulated by miR-488 in vitro

Yao Lv, Yan Shi, Quanli Han, Guanghai Dai

Mol Med Rep. 2017 Oct; 16(4): 4437–4444. Published online 2017 Aug 1. doi: 10.3892/mmr.2017.7130

PMCID:: PMC5647003

Abstract Article PDF–955K

Select item 471344815.

The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration

Lunda Gu, Juliane Hitzel, Franziska Moll, Christoph Kruse, Randa Abdel Malik, Jens Preussner, Mario Looso, Matthias S. Leisegang, Dieter Steinhilber, Ralf P. Brandes, Christian Fork

PLoS One. 2016; 11(1): e0146645. Published online 2016 Jan 11. doi: 10.1371/journal.pone.0146645

PMCID:: PMC4713448

Abstract Article PDF–2.4M

Select item 467389716.

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N^ε-dimethyl lysine demethylase

Christoph Loenarz, Wei Ge, Mathew L. Coleman, Nathan R. Rose, Christopher D. O. Cooper, Robert J. Klose, Peter J. Ratcliffe, Christopher J. Schofield

Hum Mol Genet. Author manuscript; available in PMC 2015 Dec 9.

Published in final edited form as: Hum Mol Genet. 2010 Jan 15; 19(2): 217–222. Published online 2009 Oct 19. doi: 10.1093/hmg/ddp480

PMCID:: PMC4673897

Abstract Article PDF–719K

Select item 347918417.

The histone demethylase PHF8 is essential for cytoskeleton dynamics

Elena Asensio-Juan, Carme Gallego, Marian A. Martínez-Balbás

Nucleic Acids Res. 2012 Oct; 40(19): 9429–9440. Published online 2012 Jul 31. doi: 10.1093/nar/gks716

PMCID:: PMC3479184

Abstract Article PDF–11M

Select item 173592718.

Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

F Laumonnier, S Holbert, N Ronce, F Faravelli, S Lenzner, C Schwartz, J Lespinasse, H Van Esch, D Lacombe, C Goizet, T Phan-Dinh, H van Bokhoven, J Fryns, J Chelly, H Ropers, C Moraine, B Hamel, S Briault

J Med Genet. 2005 Oct; 42(10): 780–786. doi: 10.1136/jmg.2004.029439

PMCID:: PMC1735927

Summary PDF–940K

Select item 760772519.

MYC Regulates PHF8, Which Promotes the Progression of Gastric Cancer by Suppressing miR-22-3p

Ming-Zhi Cai, Shao-Yan Wen, Xue-Jun Wang, Yong Liu, Han Liang

Technol Cancer Res Treat. 2020; 19: 1533033820967472. Published online 2020 Oct 28. doi: 10.1177/1533033820967472

PMCID:: PMC7607725

Abstract Article PDF–1.6M

Select item 681257220.

The Histone Demethylase PHF8 Governs Retinoic Acid Response in Acute Promyelocytic Leukemia

Maria Francisca Arteaga, Jan-Henrik Mikesch, Jihui Qiu, Jesper Christensen, Kristian Helin, Scott C. Kogan, Shuo Dong, Chi Wai Eric So

Cancer Cell. Author manuscript; available in PMC 2019 Oct 24.

Published in final edited form as: Cancer Cell. 2013 Mar 18; 23(3): 376–389. doi: 10.1016/j.ccr.2013.02.014

PMCID:: PMC6812572

Abstract Article PDF–2.3M

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