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Items: 1 to 20 of 81

1.
NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner
Hui Li, Tian Lan, Lin Xu, Hailing Liu, Jinju Wang, Jiaxin Li, Xiangzheng Chen, Jiwei Huang, Xuefeng Li, Kefei Yuan, Yong Zeng, Hong Wu
J Exp Clin Cancer Res. 2020; 39: 128. Published online 2020 Jul 6. doi: 10.1186/s13046-020-01638-3
Correction in:
J Exp Clin Cancer Res. 2023; 42: 47.
PMCID:
PMC7339515
AbstractArticlePDF–8.8M
2.
Evidence That the “Lid” Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity
Xulun Zhang, Eric Sullivan, Maggie Scimeca, Xianzhong Wu, Yue-ming Li, Sangram S. Sisodia
J Biol Chem. 2016 Mar 25; 291(13): 6748–6753. Published online 2016 Feb 17. doi: 10.1074/jbc.C115.701649
PMCID:
PMC4807262
AbstractArticlePDF–970K
3.
Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells
Aleksandra Filipović, Ylenia Lombardo, Monica Fronato, Joel Abrahams, Eric Aboagye, Quang-De Nguyen, Barbara Borda d’Aqua, Anne Ridley, Andrew Green, Emad Rahka, Ian Ellis, Chiara Recchi, Natasa Przulj, Anida Sarajlić, Jean-Rene Alattia, Patrick Fraering, Mahendra Deonarain, R. Charles Coombes
Breast Cancer Res Treat. 2014; 148(2): 455–462. Published online 2014 Sep 24. doi: 10.1007/s10549-014-3119-z
Correction in:
Breast Cancer Res Treat. 2014; 148(2): 463.
PMCID:
PMC4223543
AbstractArticlePDF–4.3M
4.
Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin
I Hayashi, S Takatori, Y Urano, Y Miyake, J Takagi, M Sakata-Yanagimoto, H Iwanari, S Osawa, Y Morohashi, T Li, PC Wong, S Chiba, T Kodama, T Hamakubo, T Tomita, T Iwatsubo
Oncogene. Author manuscript; available in PMC 2014 Jun 16.
Published in final edited form as: Oncogene. 2012 Feb 9; 31(6): 787–798. Published online 2011 Jul 4. doi: 10.1038/onc.2011.265
PMCID:
PMC4058788
AbstractArticlePDF–3.5M
5.
Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus
Gillian Hamilton, Richard Killick, The Genetic and Environmental Risk for Alzheimer's disease (GERAD1) Consortium , the Translational Genomics Research Institute (TGen) Consortium , Jean-Charles Lambert, Philippe Amouyel, the European Alzheimer Disease Initiative (EADI) , Minerva M. Carrasquillo, V. Shane Pankratz, Neill R. Graff-Radford, Dennis W. Dickson, Ronald C. Petersen, Steven G. Younkin, John F. Powell, Richard Wade-Martins
Neurobiol Aging. Author manuscript; available in PMC 2013 Aug 1.
Published in final edited form as: Neurobiol Aging. 2012 Aug; 33(8): 1848.e1–1848.13. Published online 2012 Mar 8. doi: 10.1016/j.neurobiolaging.2012.02.005
PMCID:
PMC3683320
AbstractArticlePDF–1.1M
6.
Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo
Ylenia Lombardo, Aleksandra Filipović, Gemma Molyneux, Manikandan Periyasamy, Georgios Giamas, Yunhui Hu, Pritesh S. Trivedi, Jayson Wang, Ernesto Yagüe, Loren Michel, R. Charles Coombes
Proc Natl Acad Sci U S A. 2012 Oct 9; 109(41): 16558–16563. Published online 2012 Sep 24. doi: 10.1073/pnas.1206268109
PMCID:
PMC3478621
AbstractArticlePDF–674K
7.
Single Chain Variable Fragment against Nicastrin Inhibits the γ-Secretase Activity
Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Hiroko Iwanari, Noriko Isoo, Satoko Osawa, Maiko A. Fukuda, Tatsuhiko Kodama, Takao Hamakubo, Tong Li, Philip C. Wong, Taisuke Tomita, Takeshi Iwatsubo
J Biol Chem. 2009 Oct 9; 284(41): 27838–27847. Published online 2009 Aug 14. doi: 10.1074/jbc.M109.055061
PMCID:
PMC2788834
AbstractArticlePDF–3.5M
8.
Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity
Daniel R. Dries, Sanjiv Shah, Yu-Hong Han, Cong Yu, Sophie Yu, Mark S. Shearman, Gang Yu
J Biol Chem. 2009 Oct 23; 284(43): 29714–29724. Published online 2009 Sep 3. doi: 10.1074/jbc.M109.038737
PMCID:
PMC2785603
AbstractArticlePDF–1.6M
9.
OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin
Jonghee Han, Sunmin Jung, Jiyeon Jang, Tae-In Kam, Hyunwoo Choi, Byung-Ju Kim, Jihoon Nah, Dong-Gyu Jo, Toshiyuki Nakagawa, Masaki Nishimura, Yong-Keun Jung
Cell Mol Life Sci. 2014 Jul; 71(13): 2561–2576. Published online 2013 Nov 24. doi: 10.1007/s00018-013-1515-x
PMCID:
PMC11113593
AbstractArticlePDF–2.8M
10.
High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100
Kun Yu, Ge Yang, Jörg Labahn
Sci Rep. 2017; 7: 44297. Published online 2017 Mar 9. doi: 10.1038/srep44297
PMCID:
PMC5343570
AbstractArticlePDF–1.0M
11.
Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer’s disease
A-Ryeong Gwon, Jong-Sung Park, Thiruma V. Arumugam, Yong-Kook Kwon, Sic L. Chan, Seol-Hee Kim, Sang-Ha Baik, Sunghee Yang, Young-Kwang Yun, Yuri Choi, Saerom Kim, Sung-Chun Tang, Dong-Hoon Hyun, Aiwu Cheng, Charles E. Dann, III, Michel Bernier, Jaewon Lee, William R. Markesbery, Mark P. Mattson, Dong-Gyu Jo
Aging Cell. Author manuscript; available in PMC 2014 Nov 3.
Published in final edited form as: Aging Cell. 2012 Aug; 11(4): 559–568. Published online 2012 Apr 9. doi: 10.1111/j.1474-9726.2012.00817.x
PMCID:
PMC4217088
AbstractArticlePDF–3.4M
12.
Crystal structure of the γ-secretase component nicastrin
Tian Xie, Chuangye Yan, Rui Zhou, Yanyu Zhao, Linfeng Sun, Guanghui Yang, Peilong Lu, Dan Ma, Yigong Shi
Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37): 13349–13354. Published online 2014 Sep 2. doi: 10.1073/pnas.1414837111
PMCID:
PMC4169925
AbstractArticlePDF–1.7M
13.
Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells
Ylenia Lombardo, Monica Faronato, Aleksandra Filipovic, Valentina Vircillo, Luca Magnani, R Charles Coombes
Breast Cancer Res. 2014; 16(3): R62. Published online 2014 Jun 11. doi: 10.1186/bcr3675
PMCID:
PMC4095694
AbstractArticlePDF–1.9M
14.
Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies
Xulun Zhang, Robert J. Hoey, Guoqing Lin, Akiko Koide, Brenda Leung, Kwangwook Ahn, Georgia Dolios, Marcin Paduch, Takeshi Ikeuchi, Rong Wang, Yue-Ming Li, Shohei Koide, Sangram S. Sisodia
Proc Natl Acad Sci U S A. 2012 May 29; 109(22): 8534–8539. Published online 2012 May 14. doi: 10.1073/pnas.1202691109
PMCID:
PMC3365189
AbstractArticlePDF–766K
15.
Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease
Michelle K. Lupton, Petroula Proitsi, Makrina Danillidou, Magda Tsolaki, Gillian Hamilton, Richard Wroe, Megan Pritchard, Kathryn Lord, Belinda M. Martin, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Denise Harold, Paul Hollingworth, Simon Lovestone, John F. Powell
PLoS One. 2011; 6(2): e17298. Published online 2011 Feb 25. doi: 10.1371/journal.pone.0017298
PMCID:
PMC3045431
AbstractArticlePDF–214K
16.
Reduced Alzheimer's Disease β-Amyloid Deposition in Transgenic Mice Expressing S-Palmitoylation-Deficient APH1aL and Nicastrin
Xavier Meckler, Jelita Roseman, Pritam Das, Haipeng Cheng, Susan Pei, Marcia Keat, Breanne Kassarjian, Todd E. Golde, Angèle T. Parent, Gopal Thinakaran
J Neurosci. 2010 Dec 1; 30(48): 16160–16169. doi: 10.1523/JNEUROSCI.4436-10.2010
PMCID:
PMC2999009
AbstractArticlePDF–3.8M
17.
CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production
Shuxia Zhou, Hua Zhou, Peter J. Walian, Bing K. Jap
Proc Natl Acad Sci U S A. 2005 May 24; 102(21): 7499–7504. Published online 2005 May 12. doi: 10.1073/pnas.0502768102
PMCID:
PMC1103709
AbstractArticlePDF–415K
18.
The Gene Encoding Nicastrin, a Major γ-Secretase Component, Modifies Risk for Familial Early-Onset Alzheimer Disease in a Dutch Population-Based Sample
Bart Dermaut, Jessie Theuns, Kristel Sleegers, Hiroshi Hasegawa, Marleen Van den Broeck, Krist'l Vennekens, Ellen Corsmit, Peter St. George-Hyslop, Marc Cruts, Cornelia M. van Duijn, Christine Van Broeckhoven
Am J Hum Genet. 2002 Jun; 70(6): 1568–1574. Published online 2002 Apr 24. doi: 10.1086/340732
PMCID:
PMC379144
AbstractArticlePDF–145K
19.
Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma
Weikang Zhang, Hongliang Liu, Zhensheng Liu, Dakai Zhu, Christopher I. Amos, Shenying Fang, Jeffrey E. Lee, Qingyi Wei
Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2016 Jul 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2015 Jul; 24(7): 1101–1110. Published online 2015 May 7. doi: 10.1158/1055-9965.EPI-14-1380-T
PMCID:
PMC4573541
AbstractArticlePDF–2.0M
20.
Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
Dieter Edbauer, Edith Winkler, Christian Haass, Harald Steiner
Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13): 8666–8671. Published online 2002 Jun 4. doi: 10.1073/pnas.132277899
PMCID:
PMC124353
AbstractArticlePDF–266K

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