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Select item 87488631.

Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution

S. Tsimbalyuk, C. M. Donnelly, J. K. Forwood

Sci Rep. 2022; 12: 315. Published online 2022 Jan 10. doi: 10.1038/s41598-021-03729-3

PMCID:: PMC8748863

Abstract Article PDF–2.1M

Select item 58991842.

Karyopherin Alpha 6 Is Required for Replication of Porcine Reproductive and Respiratory Syndrome Virus and Zika Virus

Liping Yang, Rong Wang, Shixing Yang, Zexu Ma, Shaoli Lin, Yuchen Nan, Qisheng Li, Qiyi Tang, Yan-Jin Zhang

J Virol. 2018 May 1; 92(9): e00072-18. Prepublished online 2018 Feb 14. Published online 2018 Apr 13. doi: 10.1128/JVI.00072-18

PMCID:: PMC5899184

Abstract Article PDF–3.1M

Select item 87686273.

KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity

Mengmeng Yu, Liuke Sun, Zhenyu Zhang, Yuan Zhang, Haili Zhang, Lei Na, Xiaojun Wang

Microbiol Spectr. 2022 Jan-Feb; 10(1): e02073-21. Published online 2022 Jan 19. doi: 10.1128/spectrum.02073-21

PMCID:: PMC8768627

Abstract Article PDF–4.2M

Select item 32620144.

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

Ben Hudjetz, Gülsah Gabriel

PLoS Pathog. 2012 Jan; 8(1): e1002488. Published online 2012 Jan 19. doi: 10.1371/journal.ppat.1002488

PMCID:: PMC3262014

Abstract Article PDF–1.5M

Select item 28928375.

A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection

Sagi D. Shapira, Irit Gat-Viks, Bennett O.V. Shum, Amelie Dricot, Marciela M. Degrace, Wu Liguo, Piyush B. Gupta, Tong Hao, Serena J. Silver, David E. Root, David E. Hill, Aviv Regev, Nir Hacohen

Cell. Author manuscript; available in PMC 2010 Jun 28.

Published in final edited form as: Cell. 2009 Dec 24; 139(7): 1255–1267. doi: 10.1016/j.cell.2009.12.018

PMCID:: PMC2892837

Abstract Article PDF–2.8M

Select item 53799946.

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins

Andrew T. Major, Yoichi Miyamoto, Camden Y. Lo, David A. Jans, Kate L. Loveland

Sci Rep. 2017; 7: 43323. Published online 2017 Feb 27. doi: 10.1038/srep43323

PMCID:: PMC5379994

Abstract Article PDF–4.2M

Select item 43461947.

Molecular determinants for nuclear import of Influenza A PB2 by importin α isoforms 3 and 7

Ruth A. Pumroy, Song Ke, Darren J. Hart, Ulrich Zachariae, Gino Cingolani

Structure. Author manuscript; available in PMC 2016 Feb 3.

Published in final edited form as: Structure. 2015 Feb 3; 23(2): 374–384. Published online 2015 Jan 15. doi: 10.1016/j.str.2014.11.015

PMCID:: PMC4346194

Abstract Article PDF–3.0M

Select item 95080958.

Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is counteracted by TBK1-p62 axis-mediated autophagy

Xuyuan Wang, Li Jiang, Guangwen Wang, Wenjun Shi, Yuzhen Hu, Bo Wang, Xianying Zeng, Guobin Tian, Guohua Deng, Jianzhong Shi, Liling Liu, Chengjun Li, Hualan Chen

Cell Mol Immunol. 2022 Oct; 19(10): 1168–1184. Published online 2022 Sep 2. doi: 10.1038/s41423-022-00906-w

PMCID:: PMC9508095

Abstract Article PDF–4.4M

Select item 45050449.

IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation

Byounghoon Hwang, Kevin McCool, Jun Wan, Shelly M. Wuerzberger-Davis, Edmond W. K. Young, Eun Young Choi, Gino Cingolani, Beth A. Weaver, Shigeki Miyamoto

J Biol Chem. 2015 Jul 17; 290(29): 17967–17984. Published online 2015 Jun 9. doi: 10.1074/jbc.M115.645960

PMCID:: PMC4505044

Abstract Article PDF–4.6M

Select item 313323210.

KPNA6 (Importin α7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response

Zheng Sun, Tongde Wu, Fei Zhao, Alexandria Lau, Christina M. Birch, Donna D. Zhang

Mol Cell Biol. 2011 May; 31(9): 1800–1811. doi: 10.1128/MCB.05036-11

PMCID:: PMC3133232

Abstract Article PDF–2.0M

Select item 222994411.

Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.

L. Dubrovsky, P. Ulrich, G. J. Nuovo, K. R. Manogue, A. Cerami, M. Bukrinsky

Mol Med. 1995 Jan; 1(2): 217–230.

PMCID:: PMC2229944

Summary Page Browse PDF–2.8M

Select item 117007912.

HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import.

R A Fouchier, B E Meyer, J H Simon, U Fischer, M H Malim

EMBO J. 1997 Aug 1; 16(15): 4531–4539. doi: 10.1093/emboj/16.15.4531

PMCID:: PMC1170079

Summary PDF–392K

Select item 18990813.

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.

P Gallay, V Stitt, C Mundy, M Oettinger, D Trono

J Virol. 1996 Feb; 70(2): 1027–1032. doi: 10.1128/jvi.70.2.1027-1032.1996

PMCID:: PMC189908

Summary PDF–526K

Select item 18912414.

Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.

E O Freed, G Englund, M A Martin

J Virol. 1995 Jun; 69(6): 3949–3954. doi: 10.1128/jvi.69.6.3949-3954.1995

PMCID:: PMC189124

Summary PDF–421K

Select item 10964015.

The Putative Alpha Helix 2 of Human Immunodeficiency Virus Type 1 Vpr Contains a Determinant Which Is Responsible for the Nuclear Translocation of Proviral DNA in Growth-Arrested Cells

Zilin Nie, Dominique Bergeron, Ramu A. Subbramanian, Xiao-Jian Yao, Florent Checroune, Nicole Rougeau, Eric A. Cohen

J Virol. 1998 May; 72(5): 4104–4115. doi: 10.1128/jvi.72.5.4104-4115.1998

PMCID:: PMC109640

Abstract Article PDF–461K

Select item 10575816.

CNI-H0294, a Nuclear Importation Inhibitor of the Human Immunodeficiency Virus Type 1 Genome, Abrogates Virus Replication in Infected Activated Peripheral Blood Mononuclear Cells

Omar K. Haffar, Molly D. Smithgall, Serguei Popov, Peter Ulrich, A. Gregory Bruce, Steven G. Nadler, Anthony Cerami, Michael I. Bukrinsky

Antimicrob Agents Chemother. 1998 May; 42(5): 1133–1138. doi: 10.1128/aac.42.5.1133

PMCID:: PMC105758

Abstract Article PDF–526K

Select item 4438917.

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

N K Heinzinger, M I Bukinsky, S A Haggerty, A M Ragland, V Kewalramani, M A Lee, H E Gendelman, L Ratner, M Stevenson, M Emerman

Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15): 7311–7315. doi: 10.1073/pnas.91.15.7311

PMCID:: PMC44389

Summary Page Browse PDF–1.2M

Select item 4432418.

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.

U von Schwedler, R S Kornbluth, D Trono

Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15): 6992–6996. doi: 10.1073/pnas.91.15.6992

PMCID:: PMC44324

Summary Page Browse PDF–907K

Select item 3814919.

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.

S Popov, L Dubrovsky, M A Lee, S Pennathur, O Haffar, Y aL-Abed, P Tonge, P Ulrich, M Rexach, G Blobel, A Cerami, M Bukrinsky

Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21): 11859–11864. doi: 10.1073/pnas.93.21.11859

PMCID:: PMC38149

Summary Page Browse PDF–1.6M

Select item 446002520.

BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells

Nam-Hee Kim, Tetsuro Yoshimaru, Yi-An Chen, Taisuke Matsuo, Masato Komatsu, Yasuo Miyoshi, Eiji Tanaka, Mitsunori Sasa, Kenji Mizuguchi, Toyomasa Katagiri

PLoS One. 2015; 10(6): e0127707. Published online 2015 Jun 8. doi: 10.1371/journal.pone.0127707