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Select item 56974361.

A novel vector for transgenesis in the rat CNS

T. Peter Lopez, Kurt Giles, Brittany N. Dugger, Abby Oehler, Carlo Condello, Zuzana Krejciova, Julian A. Castaneda, George A. Carlson, Stanley B. Prusiner

Acta Neuropathol Commun. 2017; 5: 84. Published online 2017 Nov 21. doi: 10.1186/s40478-017-0484-y

PMCID:: PMC5697436

Abstract Article PDF–16M

Select item 52313452.

Morphine Withdrawal Modifies Prion Protein Expression in Rat Hippocampus

Vincenzo Mattei, Stefano Martellucci, Francesca Santilli, Valeria Manganelli, Tina Garofalo, Niccolò Candelise, Alessandra Caruso, Maurizio Sorice, Sergio Scaccianoce, Roberta Misasi

PLoS One. 2017; 12(1): e0169571. Published online 2017 Jan 12. doi: 10.1371/journal.pone.0169571

PMCID:: PMC5231345

Abstract Article PDF–1.9M

Select item 42731823.

Primary Blast-Induced Traumatic Brain Injury in Rats Leads to Increased Prion Protein in Plasma: A Potential Biomarker for Blast-Induced Traumatic Brain Injury

Nam Pham, Thomas W. Sawyer, Yushan Wang, Ferdous Rastgar Jazii, Cory Vair, Changiz Taghibiglou

J Neurotrauma. 2015 Jan 1; 32(1): 58–65. doi: 10.1089/neu.2014.3471

PMCID:: PMC4273182

Abstract Article PDF–281K

Select item 40322834.

Role of Lipid Rafts and GM1 in the Segregation and Processing of Prion Protein

Laura Botto, Diana Cunati, Silvia Coco, Silvia Sesana, Alessandra Bulbarelli, Emiliano Biasini, Laura Colombo, Alessandro Negro, Roberto Chiesa, Massimo Masserini, Paola Palestini

PLoS One. 2014; 9(5): e98344. Published online 2014 May 23. doi: 10.1371/journal.pone.0098344

PMCID:: PMC4032283

Abstract Article PDF–7.8M

Select item 38740365.

Solvent Microenvironments and Copper Binding Alters the Conformation and Toxicity of a Prion Fragment

Mohammed Inayathullah, K. S. Satheeshkumar, Andrey V. Malkovskiy, Antoine L. Carre, Senthilkumar Sivanesan, Jasper O. Hardesty, Jayakumar Rajadas

PLoS One. 2013; 8(12): e85160. Published online 2013 Dec 27. doi: 10.1371/journal.pone.0085160

PMCID:: PMC3874036

Abstract Article PDF–1.7M

Select item 5153386.

PrP^C Association with Lipid Rafts in the Early Secretory Pathway Stabilizes Its Cellular Conformation

Daniela Sarnataro, Vincenza Campana, Simona Paladino, Mariano Stornaiuolo, Lucio Nitsch, Chiara Zurzolo

Mol Biol Cell. 2004 Sep; 15(9): 4031–4042. doi: 10.1091/mbc.E03-05-0271

PMCID:: PMC515338

Abstract Article PDF–544K

Select item 75490387.

A soluble derivative of PrP^C activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor

Elisabetta Mantuano, Pardis Azmoon, Michael A. Banki, Michael S. Lam, Christina J. Sigurdson, Steven L. Gonias

J Biol Chem. 2020 Oct 9; 295(41): 14178–14188. Published online 2020 Aug 11. doi: 10.1074/jbc.RA120.013779

PMCID:: PMC7549038

Abstract Article PDF–1.8M

Select item 40361648.

The Mechanism of Membrane Disruption by Cytotoxic Amyloid Oligomers Formed by Prion Protein(106–126) Is Dependent on Bilayer Composition

Patrick Walsh, Gillian Vanderlee, Jason Yau, Jody Campeau, Valerie L. Sim, Christopher M. Yip, Simon Sharpe

J Biol Chem. 2014 Apr 11; 289(15): 10419–10430. Published online 2014 Feb 19. doi: 10.1074/jbc.M113.515866

PMCID:: PMC4036164

Abstract Article PDF–2.9M

Select item 37798849.

The effect of β2-α2 loop mutation on amyloidogenic properties of the prion protein

Arpana Dutta, Shugui Chen, Witold K. Surewicz

FEBS Lett. Author manuscript; available in PMC 2014 Sep 17.

Published in final edited form as: FEBS Lett. 2013 Sep 17; 587(18): 2918–2923. Published online 2013 Jul 24. doi: 10.1016/j.febslet.2013.07.023

PMCID:: PMC3779884

Abstract Article PDF–889K

Select item 337988110.

Structural organization of brain-derived mammalian prions as probed by hydrogen exchange

Vytautas Smirnovas, Gerald S. Baron, Danielle K. Offerdahl, Gregory J. Raymond, Byron Caughey, Witold K. Surewicz

Nat Struct Mol Biol. Author manuscript; available in PMC 2012 Jun 20.

Published in final edited form as: Nat Struct Mol Biol. 2011 Apr; 18(4): 504–506. Published online 2011 Mar 27. doi: 10.1038/nsmb.2035

PMCID:: PMC3379881

Abstract Article PDF–346K

Select item 299333111.

Prion disease susceptibility is affected by β-structure folding propensity and local side-chain interactions in PrP

M. Qasim Khan, Braden Sweeting, Vikram Khipple Mulligan, Pharhad Eli Arslan, Neil R. Cashman, Emil F. Pai, Avijit Chakrabartty

Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46): 19808–19813. Published online 2010 Nov 1. doi: 10.1073/pnas.1005267107

PMCID:: PMC2993331

Abstract Article PDF–886K

Select item 290530612.

Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein

Colin S. Burns, Eliah Aronoff-Spencer, Christine M. Dunham, Paula Lario, Nikolai I. Avdievich, William E. Antholine, Marilyn M. Olmstead, Alice Vrielink, Gary J. Gerfen, Jack Peisach, William G. Scott, Glenn L. Millhauser

Biochemistry. Author manuscript; available in PMC 2010 Jul 16.

Published in final edited form as: Biochemistry. 2002 Mar 26; 41(12): 3991–4001. doi: 10.1021/bi011922x

PMCID:: PMC2905306

Abstract Article PDF–765K

Select item 280838013.

Conformational diversity in prion protein variants influences intermolecular β-sheet formation

Seungjoo Lee, Lizamma Antony, Rune Hartmann, Karen J Knaus, Krystyna Surewicz, Witold K Surewicz, Vivien C Yee

EMBO J. 2010 Jan 6; 29(1): 251–262. Published online 2009 Nov 19. doi: 10.1038/emboj.2009.333

PMCID:: PMC2808380

Abstract Article PDF–1.5M

Select item 279102514.

The α-Secretase-derived N-terminal Product of Cellular Prion, N1, Displays Neuroprotective Function in Vitro and in Vivo

Marie-Victoire Guillot-Sestier, Claire Sunyach, Charlotte Druon, Sabine Scarzello, Frédéric Checler

J Biol Chem. 2009 Dec 18; 284(51): 35973–35986. Published online 2009 Oct 22. doi: 10.1074/jbc.M109.051086

PMCID:: PMC2791025

Abstract Article PDF–2.4M

Select item 276134015.

Natural and synthetic prion structure from X-ray fiber diffraction

Holger Wille, Wen Bian, Michele McDonald, Amy Kendall, David W. Colby, Lillian Bloch, Julian Ollesch, Alexander L. Borovinskiy, Fred E. Cohen, Stanley B. Prusiner, Gerald Stubbs

Proc Natl Acad Sci U S A. 2009 Oct 6; 106(40): 16990–16995. doi: 10.1073/pnas.0909006106

PMCID:: PMC2761340

Abstract Article PDF–1.1M

Select item 268807816.

Lipid Rafts and Clathrin Cooperate in the Internalization of PrP^C in Epithelial FRT Cells

Daniela Sarnataro, Anna Caputo, Philippe Casanova, Claudia Puri, Simona Paladino, Simona S. Tivodar, Vincenza Campana, Carlo Tacchetti, Chiara Zurzolo

PLoS One. 2009; 4(6): e5829. Published online 2009 Jun 8. doi: 10.1371/journal.pone.0005829

PMCID:: PMC2688078

Abstract Article PDF–1.5M

Select item 263790317.

Crystal structure of human prion protein bound to a therapeutic antibody

S. V. Antonyuk, C. R. Trevitt, R. W. Strange, G. S. Jackson, D. Sangar, M. Batchelor, S. Cooper, C. Fraser, S. Jones, T. Georgiou, A. Khalili-Shirazi, A. R. Clarke, S. S. Hasnain, J. Collinge

Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8): 2554–2558. Published online 2009 Feb 9. doi: 10.1073/pnas.0809170106