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Select item 76609251.

TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8^AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast

Emese Pataki, Luba Simhaev, Hamutal Engel, Adiel Cohen, Martin Kupiec, Ronit Weisman

PLoS Genet. 2020 Nov; 16(11): e1009196. Published online 2020 Nov 2. doi: 10.1371/journal.pgen.1009196

PMCID:: PMC7660925

Abstract Article PDF–3.4M

Select item 68029642.

TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

Karen Baker, Irene A Gyamfi, Gregory I Mashanov, Justin E Molloy, Michael A Geeves, Daniel P Mulvihill

eLife. 2019; 8: e51150. Published online 2019 Sep 30. doi: 10.7554/eLife.51150

PMCID:: PMC6802964

Abstract Article PDF–2.6M

Select item 48212363.

Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2

Wei Du, Gabriella M. Forte, Duncan Smith, Janni Petersen

Open Biol. 2016 Mar; 6(3): 150189. Published online 2016 Mar 2. doi: 10.1098/rsob.150189

PMCID:: PMC4821236

Abstract Article PDF–1.0M

Select item 38409284.

Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition

Lenka Hálová, Wei Du, Sara Kirkham, Duncan L. Smith, Janni Petersen

J Cell Biol. 2013 Nov 25; 203(4): 595–604. doi: 10.1083/jcb.201305103

PMCID:: PMC3840928

Abstract Article PDF–2.6M

Select item 1621505.

Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases

Tomohiko Matsuo, Yoshiya Kubo, Yoshinori Watanabe, Masayuki Yamamoto

EMBO J. 2003 Jun 16; 22(12): 3073–3083. doi: 10.1093/emboj/cdg298

PMCID:: PMC162150

Abstract Article PDF–381K

Select item 51203296.

Multiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast

Marisa Madrid, Beatriz Vázquez-Marín, Alejandro Franco, Teresa Soto, Jero Vicente-Soler, Mariano Gacto, José Cansado

Sci Rep. 2016; 6: 37515. Published online 2016 Nov 23. doi: 10.1038/srep37515

PMCID:: PMC5120329

Abstract Article PDF–5.7M

Select item 46124507.

Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose

Tomoyuki Hatano, Susumu Morigasaki, Hisashi Tatebe, Kyoko Ikeda, Kazuhiro Shiozaki

Cell Cycle. 2015 Mar 15; 14(6): 848–856. Published online 2015 Jan 15. doi: 10.1080/15384101.2014.1000215

PMCID:: PMC4612450

Abstract Article PDF–516K

Select item 22748958.

Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control

Kyoko Ikeda, Susumu Morigasaki, Hisashi Tatebe, Fuyuhiko Tamanoi, Kazuhiro Shiozaki

Cell Cycle. Author manuscript; available in PMC 2009 Feb 1.

Published in final edited form as: Cell Cycle. 2008 Feb; 7(3): 358–364. Published online 2007 Nov 1. doi: 10.4161/cc.7.3.5245

PMCID:: PMC2274895

Abstract Article PDF–2.3M

Select item 48614999.

Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress

Adiel Cohen, Martin Kupiec, Ronit Weisman

J Biol Chem. 2016 Apr 22; 291(17): 9371–9381. Published online 2016 Feb 24. doi: 10.1074/jbc.M115.705251

PMCID:: PMC4861499

Abstract Article PDF–1.4M

Select item 189995010.

Loss of the TOR Kinase Tor2 Mimics Nitrogen Starvation and Activates the Sexual Development Pathway in Fission Yeast

Tomohiko Matsuo, Yoko Otsubo, Jun Urano, Fuyuhiko Tamanoi, Masayuki Yamamoto

Mol Cell Biol. 2007 Apr; 27(8): 3154–3164. Published online 2007 Jan 29. doi: 10.1128/MCB.01039-06

PMCID:: PMC1899950

Abstract Article PDF–432K

Select item 534052711.

Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

Hisashi Tatebe, Shinichi Murayama, Toshiya Yonekura, Tomoyuki Hatano, David Richter, Tomomi Furuya, Saori Kataoka, Kyoko Furuita, Chojiro Kojima, Kazuhiro Shiozaki

eLife. 2017; 6: e19594. Published online 2017 Mar 7. doi: 10.7554/eLife.19594

PMCID:: PMC5340527

Abstract Article PDF–1.8M

Select item 350723112.

TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast

Wei Du, Lenka Hálová, Sara Kirkham, Jane Atkin, Janni Petersen

Biol Open. 2012 Sep 15; 1(9): 884–888. Published online 2012 Jul 17. doi: 10.1242/bio.20122022

PMCID:: PMC3507231

Abstract Article PDF–475K

Select item 526679013.

A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast

Ruth Martín, Marina Portantier, Nathalia Chica, Mari Nyquist-Andersen, Juan Mata, Sandra Lopez-Aviles

Curr Biol. 2017 Jan 23; 27(2): 175–188. doi: 10.1016/j.cub.2016.11.037

PMCID:: PMC5266790

Abstract Article

Select item 402381814.

Isp7 Is a Novel Regulator of Amino Acid Uptake in the TOR Signaling Pathway

Dana Laor, Adiel Cohen, Metsada Pasmanik-Chor, Varda Oron-Karni, Martin Kupiec, Ronit Weisman

Mol Cell Biol. 2014 Mar; 34(5): 794–806. doi: 10.1128/MCB.01473-13

Correction in:: Mol Cell Biol. 2014 Apr; 34(8): 1535.

PMCID:: PMC4023818

Abstract Article PDF–1.8M

Select item 300832315.

Rab-family GTPase regulates TOR complex 2 signaling in fission yeast

Hisashi Tatebe, Susumu Morigasaki, Shinichi Murayama, Cui Tracy Zeng, Kazuhiro Shiozaki

Curr Biol. Author manuscript; available in PMC 2011 Nov 23.

Published in final edited form as: Curr Biol. 2010 Nov 23; 20(22): 1975–1982. Published online 2010 Oct 28. doi: 10.1016/j.cub.2010.10.026

PMCID:: PMC3008323

Abstract Article PDF–1.5M

Select item 272574716.

TOR Complex 2 Controls Gene Silencing, Telomere Length Maintenance, and Survival under DNA-Damaging Conditions

Miriam Schonbrun, Dana Laor, Luis López-Maury, Jürg Bähler, Martin Kupiec, Ronit Weisman

Mol Cell Biol. 2009 Aug; 29(16): 4584–4594. Published online 2009 Jun 22. doi: 10.1128/MCB.01879-08

PMCID:: PMC2725747

Abstract Article PDF–2.2M

Select item 411813117.

Glucose Activates TORC2-Gad8 Protein via Positive Regulation of the cAMP/cAMP-dependent Protein Kinase A (PKA) Pathway and Negative Regulation of the Pmk1 Protein-Mitogen-activated Protein Kinase Pathway

Adiel Cohen, Martin Kupiec, Ronit Weisman

J Biol Chem. 2014 Aug 1; 289(31): 21727–21737. Published online 2014 Jun 13. doi: 10.1074/jbc.M114.573824

PMCID:: PMC4118131

Abstract Article PDF–1.1M

Select item 495830518.

TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis

Karen Baker, Sara Kirkham, Lenka Halova, Jane Atkin, Mirita Franz-Wachtel, David Cobley, Karsten Krug, Boris Maček, Daniel P. Mulvihill, Janni Petersen

J Cell Sci. 2016 Jul 1; 129(13): 2613–2624. doi: 10.1242/jcs.190124