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Select item 108376351.

Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure

Marta Melis, Rebecca Marino, Jianmin Tian, Carla Johnson, Rahil Sethi, Michael Oertel, Ira J. Fox, Joseph Locker

Cell Mol Gastroenterol Hepatol. 2024; 17(3): 453–479. Published online 2023 Nov 21. doi: 10.1016/j.jcmgh.2023.11.009

PMCID:: PMC10837635

Abstract Article PDF–4.4M

Select item 77297562.

Maternal Malnutrition Affects Hepatic Metabolism through Decreased Hepatic Taurine Levels and Changes in HNF4A Methylation

Ji Eun Du, Young Ah You, Eun Jin Kwon, Soo Min Kim, Jeongae Lee, Ki Hwan Han, Young Ju Kim

Int J Mol Sci. 2020 Dec; 21(23): 9060. Published online 2020 Nov 28. doi: 10.3390/ijms21239060

PMCID:: PMC7729756

Abstract Article PDF–2.4M

Select item 72910693.

Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4α Transduction and 5’ Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis

Jennifer Bolleyn, Matthias Rombaut, Nisha Nair, Steven Branson, Anja Heymans, Marinee Chuah, Thierry VandenDriessche, Vera Rogiers, Joery De Kock, Tamara Vanhaecke

Genes (Basel) 2020 May; 11(5): 486. Published online 2020 Apr 29. doi: 10.3390/genes11050486

PMCID:: PMC7291069

Abstract Article PDF–2.2M

Select item 55574744.

Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation

Ping Wang, Min Cong, Tianhui Liu, Hufeng Xu, Lin Wang, Guangyong Sun, Aiting Yang, Dong Zhang, Jian Huang, Yameng Sun, Wenshan Zhao, Hong Ma, Jidong Jia, Hong You

Stem Cell Res Ther. 2017; 8: 183. Published online 2017 Aug 14. doi: 10.1186/s13287-017-0629-8

PMCID:: PMC5557474

Abstract Article PDF–4.0M

Select item 36186175.

Preservation of hepatocyte nuclear factor 4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats

Qiong Li, Wei Zhong, Yunping Qiu, Xinqin Kang, Xiuhua Sun, Xiaobing Tan, Yantao Zhao, Xinguo Sun, Wei Jia, Zhanxiang Zhou

Alcohol Clin Exp Res. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Alcohol Clin Exp Res. 2013 Apr; 37(4): 587–598. Published online 2012 Nov 5. doi: 10.1111/acer.12013

PMCID:: PMC3618617

Abstract Article PDF–2.2M

Select item 30691816.

Maternal diet and aging alter the epigenetic control of a promoter–enhancer interaction at the Hnf4a gene in rat pancreatic islets

Ionel Sandovici, Noel H. Smith, Marloes Dekker Nitert, Matthew Ackers-Johnson, Santiago Uribe-Lewis, Yoko Ito, R. Huw Jones, Victor E. Marquez, William Cairns, Mohammed Tadayyon, Laura P. O’Neill, Adele Murrell, Charlotte Ling, Miguel Constância, Susan E. Ozanne

Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13): 5449–5454. Published online 2011 Mar 8. doi: 10.1073/pnas.1019007108

PMCID:: PMC3069181

Abstract Article PDF–675K

Select item 28111767.

Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction

Francine Einstein, Reid F. Thompson, Tushar D. Bhagat, Melissa J. Fazzari, Amit Verma, Nir Barzilai, John M. Greally

PLoS One. 2010; 5(1): e8887. Published online 2010 Jan 26. doi: 10.1371/journal.pone.0008887

PMCID:: PMC2811176

Abstract Article PDF–405K

Select item 26461308.

HNF4alpha and HNF1alpha Dysfunction as a Molecular Rational for Cyclosporine Induced Posttransplantation Diabetes Mellitus

Jürgen Borlak, Monika Niehof

PLoS One. 2009; 4(3): e4662. Published online 2009 Mar 2. doi: 10.1371/journal.pone.0004662

PMCID:: PMC2646130

Abstract Article PDF–301K

Select item 20647069.

The nuclear receptor hepatocyte nuclear factor 4α acts as a morphogen to induce the formation of microvilli

Hideki Chiba, Naoyuki Sakai, Masaki Murata, Makoto Osanai, Takafumi Ninomiya, Takashi Kojima, Norimasa Sawada

J Cell Biol. 2006 Dec 18; 175(6): 971–980. doi: 10.1083/jcb.200608012

PMCID:: PMC2064706

Abstract Article PDF–5.1M

Select item 23227410.

Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.

B Viollet, A Kahn, M Raymondjean

Mol Cell Biol. 1997 Aug; 17(8): 4208–4219. doi: 10.1128/mcb.17.8.4208

PMCID:: PMC232274

Summary PDF–2.3M

Select item 1047173211.

Targeted Activation of HNF4α by AMPK Inhibits Apoptosis and Ameliorates Neurological Injury Caused by Cardiac Arrest in Rats

Haohong Zhan, Qiang Zhang, Chenyu Zhang, Jingge Cheng, Yilin Yang, Cong Liu, Shuhao Li, Chuyue Wang, Junqin Yang, Hanmei Ge, Dawang Zhou, Bo Li, Hongyan Wei, Chunlin Hu

Neurochem Res. 2023; 48(10): 3129–3145. Published online 2023 Jun 20. doi: 10.1007/s11064-023-03957-1

PMCID:: PMC10471732

Abstract Article PDF–11M

Select item 635682812.

HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II

Ann DeLaForest, Francesca Di Furio, Ran Jing, Amy Ludwig-Kubinski, Kirk Twaroski, Amanda Urick, Kirthi Pulakanti, Sridhar Rao, Stephen A. Duncan

Genes (Basel) 2019 Jan; 10(1): 21. Published online 2018 Dec 28. doi: 10.3390/genes10010021

PMCID:: PMC6356828

Abstract Article PDF–4.4M

Select item 592702713.

Hepatocyte Nuclear Factor (HNF)‐4α Induces Expression of Endothelial Fas Ligand (FasL) to Prevent Cancer Cell Transmigration: A Novel Defense Mechanism of Endothelium against Cancer Metastasis

Makoto Osanai, Hideki Chiba, Takashi Kojima, Masato Fujibe, Kazuhide Kuwahara, Hiromichi Kimura, Masaaki Satoh, Norimasa Sawada

Jpn J Cancer Res. 2002 May; 93(5): 532–541. doi: 10.1111/j.1349-7006.2002.tb01288.x

PMCID:: PMC5927027

Summary PDF–1.1M

Select item 388920514.

Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4α

Avery L. McIntosh, Anca D. Petrescu, Heather A. Hostetler, Ann B. Kier, Friedhelm Schroeder

FEBS Lett. Author manuscript; available in PMC 2014 Nov 29.

Published in final edited form as: FEBS Lett. 2013 Nov 29; 587(23): 3787–3791. Published online 2013 Oct 15. doi: 10.1016/j.febslet.2013.09.043

PMCID:: PMC3889205

Abstract Article PDF–1.2M

Select item 329195715.

Activation of Bile Acid Biosynthesis by the p38 Mitogen-activated Protein Kinase (MAPK): HEPATOCYTE NUCLEAR FACTOR-4α PHOSPHORYLATION BY THE p38 MAPK IS REQUIRED FOR CHOLESTEROL 7α-HYDROXYLASE EXPRESSION

Zhumei Xu, Olga L. Tavares-Sanchez, Quanzhong Li, Josephine Fernando, Carmen M. Rodriguez, Elaine J. Studer, William M. Pandak, Phillip B. Hylemon, Gregorio Gil

J Biol Chem. Author manuscript; available in PMC 2012 Mar 2.

Published in final edited form as: J Biol Chem. 2007 Aug 24; 282(34): 24607–24614. Published online 2007 Jun 30. doi: 10.1074/jbc.M611481200

PMCID:: PMC3291957

Abstract Article PDF–1.9M

Select item 275876816.

Association of Stearoyl-coA desaturase 1 Activity with Familial Combined Hyperlipidemia

Rebecca Mar-Heyming, Makoto Miyazaki, Daphna Weisglas-Volkov, Nicholas Kolaitis, Narimaan Sadaat, Christopher Plaisier, Päivi Pajukanta, Rita M. Cantor, Tjerk W. A. de Bruin, James M. Ntambi, Aldons J. Lusis

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2009 Oct 7.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6): 1193–1199. Published online 2008 Mar 13. doi: 10.1161/ATVBAHA.107.160150

PMCID:: PMC2758768

Abstract Article PDF–852K

Select item 271324117.

Expression of HNF4alpha in the human and rat choroid plexus – Implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier

Monika Niehof, Jürgen Borlak

BMC Mol Biol. 2009; 10: 68. Published online 2009 Jul 3. doi: 10.1186/1471-2199-10-68

PMCID:: PMC2713241

Abstract Article PDF–1.4M

Select item 257041618.

Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter Variants: A Lesson for Replication Studies

Inês Barroso, Jian’an Luan, Eleanor Wheeler, Pamela Whittaker, Jon Wasson, Eleftheria Zeggini, Michael N. Weedon, Sarah Hunt, Ranganath Venkatesh, Timothy M. Frayling, Marcos Delgado, Rosalind J. Neuman, Jinghua Zhao, Richard Sherva, Benjamin Glaser, Mark Walker, Graham Hitman, Mark I. McCarthy, Andrew T. Hattersley, M. Alan Permutt, Nicholas J. Wareham, Panagiotis Deloukas

Diabetes. 2008 Nov; 57(11): 3161–3165. doi: 10.2337/db08-0719

PMCID:: PMC2570416

Abstract Article PDF–393K

Select item 176933919.

Phenobarbital Regulates Nuclear Expression of HNF-4α in Mouse and Rat Hepatocytes Independent of CAR and PXR

Aaron W. Bell, George K. Michalopoulos

Hepatology. Author manuscript; available in PMC 2007 Jan 12.

Published in final edited form as: Hepatology. 2006 Jul; 44(1): 186–194. doi: 10.1002/hep.21234

PMCID:: PMC1769339

Abstract Article PDF–342K

Select item 160992020.

Hepatocyte nuclear factor-4α contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase

Aaron W. Adamson, Gabriela Suchankova, Caterina Rufo, Manabu T. Nakamura, Margarita Teran-Garcia, Steven D. Clarke, Thomas W. Gettys

Biochem J. 2006 Oct 15; 399(Pt 2): 285–295. Prepublished online 2006 Jun 27. Published online 2006 Sep 27. doi: 10.1042/BJ20060659

PMCID:: PMC1609920

Abstract Article PDF–457K

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