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Select item 110431131.

Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects

Elias Oxman, Huili Li, Hong-Yan Wang, Irene E. Zohn

Hum Genet. 2024; 143(3): 263–277. Published online 2024 Mar 7. doi: 10.1007/s00439-024-02647-4

PMCID:: PMC11043113

Abstract Article PDF–5.5M

Select item 70266562.

HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling

Laura Bennett, Eleanor C E T Madders, Jason L Parsons

Nucleic Acids Res. 2020 Feb 20; 48(3): 1301–1313. Published online 2019 Dec 4. doi: 10.1093/nar/gkz1129

PMCID:: PMC7026656

Abstract Article PDF–2.6M

Select item 71157423.

HECTD1 regulates the expression of SNAIL: Implications for epithelial-mesenchymal transition

Xinggang Wang, Christian De Geyter, Zanhui Jia, Ya Peng, Hong Zhang

Int J Oncol. 2020 May; 56(5): 1186–1198. Published online 2020 Feb 27. doi: 10.3892/ijo.2020.5002

PMCID:: PMC7115742

Abstract Article PDF–2.4M

Select item 58521134.

circHECTD1 promotes the silica-induced pulmonary endothelial–mesenchymal transition via HECTD1

Shencun Fang, Huifang Guo, Yusi Cheng, Zewei Zhou, Wei Zhang, Bing Han, Wei Luo, Jing Wang, Weiping Xie, Jie Chao

Cell Death Dis. 2018 Mar; 9(3): 396. Published online 2018 Mar 14. doi: 10.1038/s41419-018-0432-1

PMCID:: PMC5852113

Abstract Article PDF–3.5M

Select item 41162745.

A new protein fold in human FKBP25/FKBP3 and HectD1

Sara Helander, Meri Montecchio, Alexander Lemak, Christophe Farès, Jonas Almlöf, Yanjun Yi, Adelinda Yee, Cheryl Arrowsmith, Sirano DhePaganon, Maria Sunnerhagen

Biochem Biophys Res Commun. Author manuscript; available in PMC 2015 Apr 25.

Published in final edited form as: Biochem Biophys Res Commun. 2014 Apr 25; 447(1): 26–31. Published online 2014 Mar 22. doi: 10.1016/j.bbrc.2014.03.068

PMCID:: PMC4116274

Abstract Article PDF–623K

Select item 74699996.

CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism

Qiao-Li Jiang, Shu-Jiong Feng, Zhu-Ying Yang, Qi Xu, Shuang-Zhu Wang

Chin Med J (Engl) 2020 Aug 5; 133(15): 1774–1785. Published online 2020 Jul 14. doi: 10.1097/CM9.0000000000000917

PMCID:: PMC7469999

Abstract Article PDF–1.9M

Select item 52255957.

HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures

Xiaoli Shen, Zanhui Jia, Donato D’Alonzo, Xinggang Wang, Elisabeth Bruder, Fabienne Hélène Emch, Christian De Geyter, Hong Zhang

Cell Commun Signal. 2017; 15: 2. Published online 2017 Jan 5. doi: 10.1186/s12964-016-0156-8

PMCID:: PMC5225595

Abstract Article PDF–4.0M

Select item 55755578.

Activity‐Based Probes for HECT E3 Ubiquitin Ligases

Robert Byrne, Dr. Thomas Mund, Dr. Julien D. F. Licchesi

Chembiochem. 2017 Jul 18; 18(14): 1415–1427. Published online 2017 Jun 28. doi: 10.1002/cbic.201700006

PMCID:: PMC5575557

Abstract Article PDF–4.2M

Select item 72999589.

Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway

Yaping Li, Baohua Huang, Hua Yang, Shuang Kan, Yanling Yao, Xin Liu, Shiming Pu, Guozhang He, Taj-Malook Khan, Guangying Qi, Zuping Zhou, Wei Shu, Ming Chen

Sci Rep. 2020; 10: 9868. Published online 2020 Jun 17. doi: 10.1038/s41598-020-66789-x

PMCID:: PMC7299958

Abstract Article PDF–2.7M

Select item 848772110.

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase

Shuai Zhao, Wafik S. El-Deiry

Oncotarget. 2021 Sep 28; 12(20): 1970–1979. Published online 2021 Sep 28. doi: 10.18632/oncotarget.28081

PMCID:: PMC8487721

Abstract Article PDF–3.1M

Select item 356763011.

HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction

Hoanh Tran, Daisy Bustos, Ronald Yeh, Bonnee Rubinfeld, Cynthia Lam, Stephanie Shriver, Inna Zilberleyb, Michelle W. Lee, Lilian Phu, Anjali A. Sarkar, Irene E. Zohn, Ingrid E. Wertz, Donald S. Kirkpatrick, Paul Polakis

J Biol Chem. 2013 Feb 8; 288(6): 3753–3767. Published online 2012 Dec 31. doi: 10.1074/jbc.M112.415240

PMCID:: PMC3567630

Abstract Article PDF–3.0M

Select item 577018812.

Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation

Wenbo Li, Yiren Hu, Soohwan Oh, Qi Ma, Daria Merkurjev, Xiaoyuan Song, Xiang Zhou, Zhijie Liu, Bogdan Tanasa, Xin He, Aaron Yun Chen, Kenny Ohgi, Jie Zhang, Wen Liu, Michael G. Rosenfeld

Mol Cell. Author manuscript; available in PMC 2018 Jan 16.

Published in final edited form as: Mol Cell. 2015 Jul 16; 59(2): 188–202. Published online 2015 Jul 9. doi: 10.1016/j.molcel.2015.06.002

PMCID:: PMC5770188

Abstract Article PDF–2.9M

Select item 574639813.

Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity

Maria Oikonomaki, Pierre Bady, Monika E. Hegi

Oncotarget. 2017 Dec 15; 8(66): 110490–110502. Published online 2017 Nov 30. doi: 10.18632/oncotarget.22798

PMCID:: PMC5746398

Abstract Article PDF–4.2M

Select item 541467314.

Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation

Maiko Okada, Fumiaki Ohtake, Hiroyuki Nishikawa, Wenwen Wu, Yasushi Saeki, Keiji Takana, Tomohiko Ohta

Mol Endocrinol. 2015 Nov; 29(11): 1646–1657. Published online 2015 Sep 21. doi: 10.1210/me.2015-1125

PMCID:: PMC5414673

Abstract Article

Select item 661383815.

Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth

Xing Feng, Yanyan Jia, Yuyu Zhang, Fei Ma, Yuekun Zhu, Xuehui Hong, Qingxin Zhou, Ruixing He, Heng Zhang, Junfei Jin, Daxun Piao, He Huang, Qinghua Li, Xingfeng Qiu, Zhiyong Zhang

Autophagy. 2019; 15(7): 1130–1149. Published online 2019 Jan 27. doi: 10.1080/15548627.2019.1570063

PMCID:: PMC6613838

Abstract Article PDF–10M

Select item 498812516.

System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes

Wei Zhang, Kuen-Phon Wu, Maria A. Sartori, Hari B. Kamadurai, Alban Ordureau, Chong Jiang, Peter Y. Mercredi, Ryan Murchie, Jicheng Hu, Avinash Persaud, Manjeet Mukherjee, Nan Li, Anne Doye, John R. Walker, Yi Sheng, Zhenyue Hao, Yanjun Li, Kevin R. Brown, Emmanuel Lemichez, Junjie Chen, Yufeng Tong, J. Wade Harper, Jason Moffat, Daniela Rotin, Brenda A. Schulman, Sachdev S. Sidhu

Mol Cell. Author manuscript; available in PMC 2017 Apr 7.

Published in final edited form as: Mol Cell. 2016 Apr 7; 62(1): 121–136. Published online 2016 Mar 3. doi: 10.1016/j.molcel.2016.02.005

PMCID:: PMC4988125

Abstract Article PDF–1.2M

Select item 633688917.

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Woo-Jeong Jeong, Jong-Chan Park, Woo-Shin Kim, Eun Ji Ro, Soung Hoo Jeon, Sang-Kyu Lee, Young Nyun Park, Do Sik Min, Kang-Yell Choi

Nat Commun. 2019; 10: 295. Published online 2019 Jan 17. doi: 10.1038/s41467-018-08230-6

PMCID:: PMC6336889

Abstract Article PDF–2.9M

Select item 419392218.

Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates

Henrike C Besche, Zhe Sha, Nikolay V Kukushkin, Andreas Peth, Eva-Maria Hock, Woong Kim, Steven Gygi, Juan A Gutierrez, Hua Liao, Lawrence Dick, Alfred L Goldberg

EMBO J. 2014 May 16; 33(10): 1159–1176. Published online 2014 May 8. doi: 10.1002/embj.201386906

PMCID:: PMC4193922

Abstract Article PDF–1.1M

Select item 689488519.

NCOA2 promotes lytic reactivation of Kaposi’s sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA

Xiaoqin Wei, Lei Bai, Lianghui Dong, Huimei Liu, Peidong Xing, Zhiyao Zhou, Shuwen Wu, Ke Lan

PLoS Pathog. 2019 Nov; 15(11): e1008160. Published online 2019 Nov 21. doi: 10.1371/journal.ppat.1008160

PMCID:: PMC6894885

Abstract Article PDF–4.2M

Select item 587388520.

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer

Omar M. Khan, Joana Carvalho, Bradley Spencer-Dene, Richard Mitter, David Frith, Ambrosius P. Snijders, Stephen A. Wood, Axel Behrens

J Clin Invest. 2018 Apr 2; 128(4): 1326–1337. Published online 2018 Feb 26. doi: 10.1172/JCI97325

PMCID:: PMC5873885

Abstract Article PDF–16M

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