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Select item 85810521.

Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3

Abinaya Chandrasekaran, Katarina Stoklund Dittlau, Giulia I. Corsi, Henriette Haukedal, Nadezhda T. Doncheva, Sarayu Ramakrishna, Sheetal Ambardar, Claudia Salcedo, Sissel I. Schmidt, Yu Zhang, Susanna Cirera, Maria Pihl, Benjamin Schmid, Troels Tolstrup Nielsen, Jørgen E. Nielsen, Miriam Kolko, Julianna Kobolák, András Dinnyés, Poul Hyttel, Dasaradhi Palakodeti, Jan Gorodkin, Ravi S. Muddashetty, Morten Meyer, Blanca I. Aldana, Kristine K. Freude

Stem Cell Reports. 2021 Nov 9; 16(11): 2736–2751. Published online 2021 Oct 21. doi: 10.1016/j.stemcr.2021.09.013

PMCID:: PMC8581052

Abstract Article PDF–5.4M

Select item 32205372.

Charged Multivesicular Body Protein 2B (CHMP2B) of the Endosomal Sorting Complex Required for Transport-III (ESCRT-III) Polymerizes into Helical Structures Deforming the Plasma Membrane

Gilles Bodon, Romain Chassefeyre, Karin Pernet-Gallay, Nicolas Martinelli, Grégory Effantin, David Lutje Hulsik, Agnès Belly, Yves Goldberg, Christine Chatellard-Causse, Béatrice Blot, Guy Schoehn, Winfried Weissenhorn, Rémy Sadoul

J Biol Chem. 2011 Nov 18; 286(46): 40276–40286. Published online 2011 Sep 16. doi: 10.1074/jbc.M111.283671

PMCID:: PMC3220537

Abstract Article PDF–5.6M

Select item 31820733.

Frontotemporal Dementia Caused by CHMP2B Mutations

A.M Isaacs, P Johannsen, I Holm, J.E Nielsen, FReJA Consortium

Curr Alzheimer Res. 2011 May; 8(3): 246–251. doi: 10.2174/156720511795563764

PMCID:: PMC3182073

Abstract Article PDF–664K

Select item 30133644.

CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines

Agnès Belly, Gilles Bodon, Béatrice Blot, Alexandre Bouron, Rémy Sadoul, Yves Goldberg

J Cell Sci. Author manuscript; available in PMC 2011 Mar 1.

Published in final edited form as: J Cell Sci. 2010 Sep; 123(Pt 17): 2943–2954. Published online 2010 Aug 10. doi: 10.1242/jcs.068817

PMCID:: PMC3013364

Abstract Article

Select item 28653755.

Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations

Hazel Urwin, Astrid Authier, Jorgen E. Nielsen, Daniel Metcalf, Caroline Powell, Kristina Froud, Denise S. Malcolm, Ida Holm, Peter Johannsen, Jeremy Brown, Elizabeth M.C. Fisher, Julie van der Zee, Marc Bruyland, the FReJA Consortium, Christine Van Broeckhoven, John Collinge, Sebastian Brandner, Clare Futter, Adrian M. Isaacs

Hum Mol Genet. 2010 Jun 1; 19(11): 2228–2238. Published online 2010 Mar 10. doi: 10.1093/hmg/ddq100

PMCID:: PMC2865375

Abstract Article PDF–12M

Select item 28444266.

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

Laura E. Cox, Laura Ferraiuolo, Emily F. Goodall, Paul R. Heath, Adrian Higginbottom, Heather Mortiboys, Hannah C. Hollinger, Judith A. Hartley, Alice Brockington, Christine E. Burness, Karen E. Morrison, Stephen B. Wharton, Andrew J. Grierson, Paul G. Ince, Janine Kirby, Pamela J. Shaw

PLoS One. 2010; 5(3): e9872. Published online 2010 Mar 24. doi: 10.1371/journal.pone.0009872

PMCID:: PMC2844426

Abstract Article PDF–1.1M

Select item 26706827.

Small molecule inhibitors of divalent metal transporter-1

Peter D. Buckett, Marianne Wessling-Resnick

Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4): G798–G804. Published online 2009 Jan 29. doi: 10.1152/ajpgi.90342.2008

PMCID:: PMC2670682

Abstract Article

Select item 110911538.

Methylation of ESCRT-III components regulates the timing of cytokinetic abscission

Aurélie Richard, Jérémy Berthelet, Delphine Judith, Tamara Advedissian, Javier Espadas, Guillaume Jannot, Angélique Amo, Damarys Loew, Berangere Lombard, Alexandre G. Casanova, Nicolas Reynoird, Aurélien Roux, Clarisse Berlioz-Torrent, Arnaud Echard, Jonathan B. Weitzman, Souhila Medjkane

Nat Commun. 2024; 15: 4023. Published online 2024 May 13. doi: 10.1038/s41467-024-47717-3

PMCID:: PMC11091153

Abstract Article PDF–3.4M

Select item 80337479.

The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization

Maryam Alqabandi, Nicola de Franceschi, Sourav Maity, Nolwenn Miguet, Marta Bally, Wouter H. Roos, Winfried Weissenhorn, Patricia Bassereau, Stéphanie Mangenot

BMC Biol. 2021; 19: 66. Published online 2021 Apr 8. doi: 10.1186/s12915-021-00983-9

PMCID:: PMC8033747

Abstract Article PDF–2.8M

Select item 467609310.

TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III

Mi-Hee Jun, Jeong-Ho Han, Yu-Kyung Lee, Deok-Jin Jang, Bong-Kiun Kaang, Jin-A Lee

Mol Brain. 2015; 8: 85. Published online 2015 Dec 10. doi: 10.1186/s13041-015-0177-z

PMCID:: PMC4676093

Abstract Article PDF–2.0M

Select item 457538711.

Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology

Emma L. Clayton, Sarah Mizielinska, James R. Edgar, Troels Tolstrup Nielsen, Sarah Marshall, Frances E. Norona, Miranda Robbins, Hana Damirji, Ida E. Holm, Peter Johannsen, Jørgen E. Nielsen, Emmanuel A. Asante, John Collinge, The FReJA consortium, Adrian M. Isaacs

Acta Neuropathol. 2015; 130(4): 511–523. Published online 2015 Sep 10. doi: 10.1007/s00401-015-1475-3

PMCID:: PMC4575387

Abstract Article PDF–11M

Select item 968273012.

The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias

Yongping Chen, Gopinath Krishnan, Sepideh Parsi, Marine Pons, Veroniki Nikolaki, Lu Cao, Zuoshang Xu, Fen-Biao Gao

Acta Neuropathol Commun. 2022; 10: 169. Published online 2022 Nov 22. doi: 10.1186/s40478-022-01476-8

PMCID:: PMC9682730

Abstract Article PDF–2.0M

Select item 828775613.

The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei

Alyssa N. Coyne, Jeffrey D. Rothstein

Acta Neuropathol Commun. 2021; 9: 127. Published online 2021 Jul 19. doi: 10.1186/s40478-021-01228-0

PMCID:: PMC8287756

Abstract Article PDF–3.9M

Select item 509022014.

TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

Benjamin M Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin H Schludi, Daniel Hornburg, Felix Meissner, Denise Orozco, Alessio Colombo, Sabina Tahirovic, Meike Michaelsen, Franziska Schreiber, Simone Haupt, Michael Peitz, Oliver Brüstle, Clemens Küpper, Thomas Klopstock, Markus Otto, Albert C Ludolph, Thomas Arzberger, Peer‐Hendrik Kuhn, Dieter Edbauer

EMBO J. 2016 Nov 2; 35(21): 2350–2370. Published online 2016 Sep 12. doi: 10.15252/embj.201694221

PMCID:: PMC5090220

Abstract Article PDF–2.4M

Select item 262534515.

Role of MAPT mutations and haplotype in frontotemporal lobar degeneration in Northern Finland

Anna-Lotta Kaivorinne, Johanna Krüger, Katja Kuivaniemi, Hannu Tuominen, Virpi Moilanen, Kari Majamaa, Anne M Remes

BMC Neurol. 2008; 8: 48. Published online 2008 Dec 17. doi: 10.1186/1471-2377-8-48

PMCID:: PMC2625345

Abstract Article PDF–262K

Select item 713187216.

Expression of a human variant of CHMP2B linked to neurodegeneration in Drosophila external sensory organs leads to cell fate transformations associated with increased Notch activity

Caroline Wilson, Joshua Kavaler, S.Tariq Ahmad

Dev Neurobiol. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Dev Neurobiol. 2020 Mar; 80(3-4): 85–97. Published online 2019 Oct 23. doi: 10.1002/dneu.22722

PMCID:: PMC7131872

Abstract Article PDF–2.5M

Select item 319748317.

ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons

Jin-A Lee, Lei Liu, Robyn Javier, Anatol C Kreitzer, Celine Delaloy, Fen-Biao Gao

Mol Brain. 2011; 4: 37. Published online 2011 Oct 5. doi: 10.1186/1756-6606-4-37

PMCID:: PMC3197483

Abstract Article PDF–2.9M

Select item 274127818.

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

Jason Howitt, Ulrich Putz, Jenny Lackovic, Anh Doan, Loretta Dorstyn, Hong Cheng, Baoli Yang, Tailoi Chan-Ling, John Silke, Sharad Kumar, Seong-Seng Tan

Proc Natl Acad Sci U S A. 2009 Sep 8; 106(36): 15489–15494. Published online 2009 Aug 25. doi: 10.1073/pnas.0904880106

PMCID:: PMC2741278

Abstract Article PDF–2.4M

Select item 753053419.

Retrovirus reactivation in CHMP2B^Intron5 models of frontotemporal dementia

Laura Fort-Aznar, Chris Ugbode, Sean T Sweeney

Hum Mol Genet. 2020 Aug 15; 29(16): 2637–2646. Published online 2020 Jul 6. doi: 10.1093/hmg/ddaa142

PMCID:: PMC7530534

Abstract Article PDF–1.1M

Select item 378302020.

ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding

Grégory Effantin, Aurélien Dordor, Virginie Sandrin, Nicolas Martinelli, Wesley I. Sundquist, Guy Schoehn, Winfried Weissenhorn

Cell Microbiol. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Cell Microbiol. 2013 Feb; 15(2): 213–226. Published online 2012 Nov 6. doi: 10.1111/cmi.12041

PMCID:: PMC3783020

Abstract Article PDF–3.2M

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