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Select item 95261581.

G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin

Matthew J. Varney, Wouter Steyaert, Paul J. Coucke, Joris R. Delanghe, David E. Uehling, Babu Joseph, Richard Marcellus, Rima Al-awar, Jeffrey L. Benovic

J Biol Chem. 2022 Oct; 298(10): 102421. Published online 2022 Aug 25. doi: 10.1016/j.jbc.2022.102421

PMCID:: PMC9526158

Abstract Article PDF–2.1M

Select item 73121692.

Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization

Preeti Kumari Chaudhary, Sanggu Kim, Youngheun Jee, Seung-Hun Lee, Kyung-Mee Park, Soochong Kim

Int J Mol Sci. 2020 Jun; 21(11): 3932. Published online 2020 May 30. doi: 10.3390/ijms21113932

PMCID:: PMC7312169

Abstract Article PDF–1.9M

Select item 57921383.

Role of G protein-coupled receptor kinase-6 in Escherichia coli lung infection model in mice

Taehyung Lee, Nandakumar Packiriswamy, Eunhee Lee, Peter C. Lucas, Laura R. McCabe, Narayanan Parameswaran

Physiol Genomics. 2017 Nov 1; 49(11): 682–689. Published online 2017 Sep 22. doi: 10.1152/physiolgenomics.00066.2017

PMCID:: PMC5792138

Abstract Article

Select item 48144754.

Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization

Chad A. Grotegut, Lan Mao, Stephanie L. Pierce, Geeta K. Swamy, R. Phillips Heine, Amy P. Murtha

Mol Endocrinol. 2016 Apr; 30(4): 455–468. Published online 2016 Feb 17. doi: 10.1210/me.2015-1147

PMCID:: PMC4814475

Abstract Article

Select item 27713415.

Morphine-Induced Physiological and Behavioral Responses in Mice Lacking G Protein-Coupled Receptor Kinase 6

Kirsten M. Raehal, Cullen L. Schmid, Ivan O. Medvedev, Raul R. Gainetdinov, Richard T. Premont, Laura M. Bohn

Drug Alcohol Depend. Author manuscript; available in PMC 2010 Oct 1.

Published in final edited form as: Drug Alcohol Depend. 2009 Oct 1; 104(3): 187–196. Published online 2009 Jun 3. doi: 10.1016/j.drugalcdep.2009.04.011

PMCID:: PMC2771341

Abstract Article PDF–906K

Select item 52609046.

GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal

Qiumin Le, Wenqing Yao, Yuejun Chen, Biao Yan, Cao Liu, Man Yuan, Yuqing Zhou, Lan Ma

Cell Death Dis. 2016 Nov; 7(11): e2478. Published online 2016 Nov 24. doi: 10.1038/cddis.2016.377

PMCID:: PMC5260904

Abstract Article PDF–1.1M

Select item 36469807.

GRK6 deficiency promotes angiogenesis, tumor progression and metastasis

Sandeep K. Raghuwanshi, Nikia Smith, Elizabeth, J. Rivers, Ariel J. Thomas, Natalie Sutton, Yuhui Hu, Somnath Mukhopadhyay, Xiaoxin L. Chen, TinChung Leung, Ricardo M. Richardson

J Immunol. Author manuscript; available in PMC 2014 May 15.

Published in final edited form as: J Immunol. 2013 May 15; 190(10): 5329–5336. Published online 2013 Apr 15. doi: 10.4049/jimmunol.1202058

PMCID:: PMC3646980

Abstract Article PDF–3.7M

Select item 32931488.

The role of GRK6 in animal models of Parkinson's Disease and L-DOPA treatment

Francesca Managò, Stefano Espinoza, Ali Salahpour, Tatyana D. Sotnikova, Marc G. Caron, Richard T. Premont, Raul R. Gainetdinov

Sci Rep. 2012; 2: 301. Published online 2012 Mar 5. doi: 10.1038/srep00301

PMCID:: PMC3293148

Abstract Article PDF–599K

Select item 19526369.

β-Arrestin–mediated β₁-adrenergic receptor transactivation of the EGFR confers cardioprotection

Takahisa Noma, Anthony Lemaire, Sathyamangla V. Naga Prasad, Liza Barki-Harrington, Douglas G. Tilley, Juhsien Chen, Philippe Le Corvoisier, Jonathan D. Violin, Huijun Wei, Robert J. Lefkowitz, Howard A. Rockman

J Clin Invest. 2007 Sep 4; 117(9): 2445–2458. Published online 2007 Sep 4. doi: 10.1172/JCI31901

PMCID:: PMC1952636

Abstract Article PDF–1.8M

Select item 194938310.

Plasma Membrane and Nuclear Localization of G Protein–coupled Receptor Kinase 6A

Xiaoshan Jiang, Jeffrey L. Benovic, Philip B. Wedegaertner

Mol Biol Cell. 2007 Aug; 18(8): 2960–2969. doi: 10.1091/mbc.E07-01-0013

PMCID:: PMC1949383

Abstract Article PDF–1.2M

Select item 358672211.

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Michio Nakaya, Mitsuru Tajima, Hidetaka Kosako, Takeo Nakaya, Akiko Hashimoto, Kenji Watari, Hiroaki Nishihara, Mina Ohba, Shiori Komiya, Naoki Tani, Motohiro Nishida, Hisaaki Taniguchi, Yoji Sato, Mitsuru Matsumoto, Makoto Tsuda, Masahiko Kuroda, Kazuhide Inoue, Hitoshi Kurose

Nat Commun. 2013 Feb 26; 4: 1532. Published online 2013 Feb 26. doi: 10.1038/ncomms2540

PMCID:: PMC3586722

Abstract Article PDF–1.8M

Select item 658494612.

Chemerin-Activated Functions of CMKLR1 are Regulated by G Protein-Coupled Receptor Kinase 6 (GRK6) and β-Arrestin 2 in Inflammatory Macrophages

D. Stephen Serafin, Brittney Allyn, Maria F. Sassano, Roman G. Timoshchenko, Daniel Mattox, Jaime M. Brozowski, David P. Siderovski, Young K. Truong, Denise Esserman, Teresa K. Tarrant, Matthew J. Billard

Mol Immunol. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Mol Immunol. 2019 Feb; 106: 12–21. Published online 2018 Dec 18. doi: 10.1016/j.molimm.2018.12.016

PMCID:: PMC6584946

Abstract Article PDF–1021K

Select item 617880513.

G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts

Antonietta Franco, Lihong Zhang, Scot J. Matkovich, Attila Kovacs, Gerald W Dorn, II

J Mol Cell Cardiol. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: J Mol Cell Cardiol. 2018 Aug; 121: 60–68. Published online 2018 Jun 30. doi: 10.1016/j.yjmcc.2018.06.009

PMCID:: PMC6178805

Abstract Article PDF–1.1M

Select item 572679014.

MIGRATING MYELOID CELLS SENSE TEMPORAL DYNAMICS OF CHEMOATTRACTANT CONCENTRATIONS

Caren E. Petrie Aronin, Yun Zhao, Justine S. Yoon, Nicole Y. Morgan, Thorsten Prüstel, Ronald N. Germain, Martin Meier-Schellersheim

Immunity. Author manuscript; available in PMC 2018 Nov 21.

Published in final edited form as: Immunity. 2017 Nov 21; 47(5): 862–874.e3. doi: 10.1016/j.immuni.2017.10.020

PMCID:: PMC5726790

Abstract Article PDF–1.0M

Select item 488778715.

SCF/c-kit transactivates CXCR4-serine 339 phosphorylation through G protein-coupled receptor kinase 6 and regulates cardiac stem cell migration

Ke Zuo, Dong Kuang, Ying Wang, Yanli Xia, Weilin Tong, Xiaoyan Wang, Yaobin Chen, Yaqi Duan, Guoping Wang

Sci Rep. 2016; 6: 26812. Published online 2016 Jun 1. doi: 10.1038/srep26812

PMCID:: PMC4887787

Abstract Article PDF–1.8M

Select item 343698616.

The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions

Sandeep K. Raghuwanshi, Yingjun Su, Vandana Singh, Katherine Hayes, Ann Richmond, Ricardo M. Richardson

J Immunol. Author manuscript; available in PMC 2013 Sep 15.

Published in final edited form as: J Immunol. 2012 Sep 15; 189(6): 2824–2832. Published online 2012 Aug 6. doi: 10.4049/jimmunol.1201114

PMCID:: PMC3436986

Abstract Article PDF–5.0M

Select item 12425617.

Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice

Alan M. Fong, Richard T. Premont, Ricardo M. Richardson, Yen-Rei A. Yu, Robert J. Lefkowitz, Dhavalkumar D. Patel

Proc Natl Acad Sci U S A. 2002 May 28; 99(11): 7478–7483. Published online 2002 May 14. doi: 10.1073/pnas.112198299

PMCID:: PMC124256

Abstract Article PDF–195K

Select item 718829018.

S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson’s disease

Weiwei Wu, Chun Chau Sung, Peichun Yu, Jiahua Li, Kenny K. K. Chung

PLoS One. 2020; 15(4): e0232019. Published online 2020 Apr 28. doi: 10.1371/journal.pone.0232019

Correction in:: PLoS One. 2020; 15(6): e0235296.

PMCID:: PMC7188290

Abstract Article PDF–3.1M

Select item 663356419.

Low Nociceptor GRK2 Prolongs Prostaglandin E₂ Hyperalgesia via Biased cAMP Signaling to Epac/Rap1, Protein Kinase Cε, and MEK/ERK

Niels Eijkelkamp, Huijing Wang, Anibal Garza-Carbajal, Hanneke L. D. M. Willemen, Fried J. Zwartkruis, John N. Wood, Robert Dantzer, Keith W. Kelley, Cobi J. Heijnen, Annemieke Kavelaars

J Neurosci. 2010 Sep 22; 30(38): 12806–12815. doi: 10.1523/JNEUROSCI.3142-10.2010