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Select item 94331001.

Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells

Hao Wang, Zhenzhen Lin, Zhe Nian, Wei Zhang, Wenxu Liu, Fei Yan, Zengtuan Xiao, Xia Wang, Zhenfa Zhang, Zhenyi Ma, Zhe Liu

J Clin Invest. 2022 Sep 1; 132(17): e149551. Published online 2022 Sep 1. doi: 10.1172/JCI149551

PMCID:: PMC9433100

Abstract Article PDF–3.7M

Select item 91364962.

GFI1 regulates chromatin state essential in human endothelial‐to‐haematopoietic transition

Baoqiang Kang, Tian Zhang, Ke Huang, Tianyu Wang, Yuhang Li, Yuchan Mai, Jinbing Li, Shiying Dang, Zhishuai Zhang, Wenhao Huang, Junwei Wang, Minghui Gao, Yi Wang, Guangjin Pan

Cell Prolif. 2022 May; 55(5): e13244. Published online 2022 May 3. doi: 10.1111/cpr.13244

PMCID:: PMC9136496

Abstract Article PDF–8.4M

Select item 80281163.

DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health

Kunio Miyake, Chihiro Miyashita, Atsuko Ikeda-Araki, Ryu Miura, Sachiko Itoh, Keiko Yamazaki, Sumitaka Kobayashi, Hideyuki Masuda, Tadao Ooka, Zentaro Yamagata, Reiko Kishi

Clin Epigenetics. 2021; 13: 74. Published online 2021 Apr 7. doi: 10.1186/s13148-021-01063-z

PMCID:: PMC8028116

Abstract Article PDF–919K

Select item 73701164.

Epigenetic Regulation of Gfi1 in Endocrine-Related Cancers: A Role Regulating Tumor Growth

Nadia Ashour, Javier C. Angulo, Ana González-Corpas, María J. Orea, María V. T. Lobo, Ramón Colomer, Begoña Colás, Manel Esteller, Santiago Ropero

Int J Mol Sci. 2020 Jul; 21(13): 4687. Published online 2020 Jun 30. doi: 10.3390/ijms21134687

PMCID:: PMC7370116

Abstract Article PDF–2.2M

Select item 63063135.

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Priyanka Parmar, Estelle Lowry, Giovanni Cugliari, Matthew Suderman, Rory Wilson, Ville Karhunen, Toby Andrew, Petri Wiklund, Matthias Wielscher, Simonetta Guarrera, Alexander Teumer, Benjamin Lehne, Lili Milani, Niek de Klein, Pashupati P. Mishra, Phillip E. Melton, Pooja R. Mandaviya, Silva Kasela, Jana Nano, Weihua Zhang, Yan Zhang, Andre G. Uitterlinden, Annette Peters, Ben Schöttker, Christian Gieger, Denise Anderson, Dorret I. Boomsma, Hans J. Grabe, Salvatore Panico, Jan H. Veldink, Joyce B.J. van Meurs, Leonard van den Berg, Lawrence J. Beilin, Lude Franke, Marie Loh, Marleen M.J. van Greevenbroek, Matthias Nauck, Mika Kähönen, Mikko A. Hurme, Olli T. Raitakari, Oscar H. Franco, P.Eline Slagboom, Pim van der Harst, Sonja Kunze, Stephan B. Felix, Tao Zhang, Wei Chen, Trevor A. Mori, Amelie Bonnefond, Bastiaan T. Heijmans, for the BIOS Consortium, Taulant Muka, Jaspal S. Kooner, Krista Fischer, Melanie Waldenberger, Philippe Froguel, Rae-Chi Huang, Terho Lehtimäki, Wolfgang Rathmann, Caroline L. Relton, Giuseppe Matullo, Hermann Brenner, Niek Verweij, Shengxu Li, John C. Chambers, Marjo-Riitta Järvelin, Sylvain Sebert, for the GLOBAL Meth QTL Consortium

EBioMedicine. 2018 Dec; 38: 206–216. Published online 2018 Nov 13. doi: 10.1016/j.ebiom.2018.10.066

PMCID:: PMC6306313

Abstract Article PDF–1.0M

Select item 61727826.

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis

Daniela N Petrusca, Denise Toscani, Feng-Ming Wang, Cheolkyu Park, Colin D Crean, Judith L Anderson, Silvia Marino, Khalid S Mohammad, Dan Zhou, Rebecca Silbermann, Quanhong Sun, Noriyoshi Kurihara, Deborah L Galson, Nicola Giuliani, G David Roodman

J Hematol Oncol. 2018; 11: 123. Published online 2018 Oct 4. doi: 10.1186/s13045-018-0666-5

PMCID:: PMC6172782

Abstract Article PDF–5.2M

Select item 55939737.

Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature

Giacomo Volpe, David S. Walton, David E. Grainger, Carl Ward, Pierre Cauchy, Daniel Blakemore, Daniel J. L. Coleman, Peter N. Cockerill, Paloma Garcia, Jon Frampton

Sci Rep. 2017; 7: 11148. Published online 2017 Sep 11. doi: 10.1038/s41598-017-11718-8

PMCID:: PMC5593973

Abstract Article PDF–2.5M

Select item 49178888.

GFI1^36N as a therapeutic and prognostic marker for myelodysplastic syndrome

Lacramioara Botezatu, Lars C. Michel, Hideki Makishima, Thomas Schroeder, Ulrich Germing, Rainer Haas, Bert van der Reijden, Anne E. Marneth, Saskia M. Bergevoet, Joop H. Jansen, Bartlomiej Przychodzen, Marcin Wlodarski, Charlotte Niemeyer, Uwe Platzbecker, Gerhard Ehninger, Ashwin Unnikrishnan, Dominik Beck, John Pimanda, Eva Hellström-Lindberg, Luca Malcovati, Jacqueline Boultwood, Andrea Pellagatti, Elli Papaemmanuil, Philipp Le Coutre, Jaspal Kaeda, Bertram Opalka, Tarik Möröy, Ulrich Dührsen, Jaroslaw Maciejewski, Cyrus Khandanpour

Exp Hematol. 2016 Jul; 44(7): 590–595.e1. doi: 10.1016/j.exphem.2016.04.001

PMCID:: PMC4917888

Abstract Article

Select item 40227369.

The Downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 Axis and by Human Cytomegalovirus (HCMV) Associated Factors Allows the Activation of the HCMV Major IE Promoter and the Transition to Productive Infection

George Sourvinos, Antigoni Morou, Ioannis Sanidas, Ignea Codruta, Scott A. Ezell, Christina Doxaki, Sotirios C. Kampranis, Filippos Kottakis, Philip N. Tsichlis

PLoS Pathog. 2014 May; 10(5): e1004136. Published online 2014 May 15. doi: 10.1371/journal.ppat.1004136

PMCID:: PMC4022736

Abstract Article PDF–3.2M

Select item 380810410.

Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1

Jessica Purizaca, Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, Eduardo Vadillo, Lourdes Arriaga-Pizano, Silvestre Fuentes-Figueroa, Horacio Villagomez-Barragán, Patricia Flores-Guzmán, Antonio Alvarado-Moreno, Hector Mayani, Isaura Meza, Rosaura Hernandez, Sara Huerta-Yepez, Rosana Pelayo

Clin Dev Immunol. 2013; 2013: 349067. Published online 2013 Oct 3. doi: 10.1155/2013/349067

PMCID:: PMC3808104

Abstract Article PDF–2.7M

Select item 291031611.

Gfi1—Cells & Circuits: Unraveling transcriptional networks of development and disease

James D. Phelan, Noah F. Shroyer, Tiffany Cook, Brian Gebelein, H. Leighton Grimes

Curr Opin Hematol. Author manuscript; available in PMC 2011 Jul 1.

Published in final edited form as: Curr Opin Hematol. 2010 Jul; 17(4): 300–307. doi: 10.1097/MOH.0b013e32833a06f8

PMCID:: PMC2910316

Abstract Article PDF–544K

Select item 283048912.

The growth factor independence-1 transcription factor: New functions and new insights

Avedis Kazanjian, Eleanore A. Gross, H. Leighton Grimes

Crit Rev Oncol Hematol. Author manuscript; available in PMC 2010 Mar 2.

Published in final edited form as: Crit Rev Oncol Hematol. 2006 Aug; 59(2): 85–97. Published online 2006 May 23. doi: 10.1016/j.critrevonc.2006.02.002

PMCID:: PMC2830489

Abstract Article PDF–399K

Select item 898347213.

GFI1 cooperates with IKZF1/IKAROS to activate gene expression in T-cell acute lymphoblastic leukemia

Wenxiang Sun, Jingtao Guo, David McClellan, Alexandra Poeschla, Diana Bareyan, Mattie J. Casey, Bradley R. Cairns, Dean Tantin, Michael E. Engel

Mol Cancer Res. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Mol Cancer Res. 2022 Apr 1; 20(4): 501–514. doi: 10.1158/1541-7786.MCR-21-0352

PMCID:: PMC8983472

Abstract Article PDF–2.5M

Select item 841614014.

GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression

Yunlong Huang, Ran Ruan, Yanxin Fang, Kaiming Wu, Long Yao, Renquan Zhang, Wei He

Int J Mol Med. 2021 Oct; 48(4): 184. Published online 2021 Aug 3. doi: 10.3892/ijmm.2021.5017

PMCID:: PMC8416140

Abstract Article PDF–2.2M

Select item 755404015.

Gfi1 upregulates c-Myc expression and promotes c-Myc-driven cell proliferation

Yangyang Zhang, Fan Dong

Sci Rep. 2020; 10: 17115. Published online 2020 Oct 13. doi: 10.1038/s41598-020-74278-4

PMCID:: PMC7554040

Abstract Article PDF–1.8M

Select item 702699316.

Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss

Parvathy Venugopal, Lucia Gagliardi, Cecily Forsyth, Jinghua Feng, Kerry Phillips, Milena Babic, Nicola K. Poplawski, Hugh Young Rienhoff, Jr, Andreas W. Schreiber, Christopher N. Hahn, Anna L. Brown, Hamish S. Scott

BMC Med Genet. 2020; 21: 35. Published online 2020 Feb 17. doi: 10.1186/s12881-020-0971-z

PMCID:: PMC7026993

Abstract Article PDF–708K

Select item 569114817.

Enforced GFI1 expression impedes human and murine leukemic cell growth

Judith M. Hönes, Aniththa Thivakaran, Lacramioara Botezatu, Pradeep Patnana, Symone Vitoriano da Conceição Castro, Yahya S. Al-Matary, Judith Schütte, Karen B. I. Fischer, Lothar Vassen, André Görgens, Ulrich Dührsen, Bernd Giebel, Cyrus Khandanpour

Sci Rep. 2017; 7: 15720. Published online 2017 Nov 16. doi: 10.1038/s41598-017-15866-9

PMCID:: PMC5691148

Abstract Article PDF–7.5M

Select item 542311918.

GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer

Wenjing Xing, Yun Xiao, Xinliang Lu, Hongyan Zhu, Xiangchuan He, Wei Huang, Elsa S Lopez, Jerry Wong, Huanyu Ju, Linlu Tian, Fengmin Zhang, Hongwei Xu, Sheng Dian Wang, Xia Li, Michael Karin, Huan Ren

Cell Death Differ. 2017 May; 24(5): 929–943. Published online 2017 Apr 7. doi: 10.1038/cdd.2017.50

PMCID:: PMC5423119

Abstract Article PDF–4.7M

Select item 467110619.

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation

Tarik Möröy, Lothar Vassen, Brian Wilkes, Cyrus Khandanpour

Blood. 2015 Dec 10; 126(24): 2561–2569. Prepublished online 2015 Oct 7. doi: 10.1182/blood-2015-06-655043

PMCID:: PMC4671106

Abstract Article

Select item 376279020.

GFI1 Is Repressed by p53 and Inhibits DNA Damage-Induced Apoptosis

Pei Du, Fangqiang Tang, Yaling Qiu, Fan Dong

PLoS One. 2013; 8(9): e73542. Published online 2013 Sep 4. doi: 10.1371/journal.pone.0073542

PMCID:: PMC3762790

Abstract Article PDF–2.1M

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