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Select item 108640211.

GCN2 is required to maintain core body temperature in mice during acute cold

Jordan L. Levy, Emily T. Mirek, Esther M. Rodriguez, Brian Zalma, Jeffrey Burns, William O. Jonsson, Harini Sampath, Kirk A. Staschke, Ronald C. Wek, Tracy G. Anthony

Am J Physiol Endocrinol Metab. 2023 Nov 1; 325(5): E624–E637. Published online 2023 Oct 4. doi: 10.1152/ajpendo.00181.2023

PMCID:: PMC10864021

Abstract Article

Select item 94363092.

The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages

Phoenix Toboz, Mehdi Amiri, Negar Tabatabaei, Catherine R. Dufour, Seung Hyeon Kim, Carine Fillebeen, Charles E. Ayemoba, Arkady Khoutorsky, Manfred Nairz, Lijian Shao, Kostandin V. Pajcini, Ki-Wook Kim, Vincent Giguère, Regiana L. Oliveira, Marco Constante, Manuela M. Santos, Carlos R. Morales, Kostas Pantopoulos, Nahum Sonenberg, Sandra Pinho, Soroush Tahmasebi

Proc Natl Acad Sci U S A. 2022 Aug 30; 119(35): e2121251119. Published online 2022 Aug 22. doi: 10.1073/pnas.2121251119

PMCID:: PMC9436309

Abstract Article PDF–2.3M

Select item 92049503.

Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific

William O. Jonsson, Emily T. Mirek, Ronald C. Wek, Tracy G. Anthony

FASEB J. 2022 Jul; 36(7): e22396. Published online 2022 Jun 12. doi: 10.1096/fj.202200204RR

PMCID:: PMC9204950

Abstract Article PDF–704K

Select item 89617224.

GCN2 adapts protein synthesis to scavenging-dependent growth

Michel Nofal, Tim Wang, Lifeng Yang, Connor S.R. Jankowski, Sophia Hsin-Jung Li, Seunghun Han, Lance Parsons, Alexander N. Frese, Zemer Gitai, Tracy G. Anthony, Martin Wühr, David M. Sabatini, Joshua D. Rabinowitz

Cell Syst. Author manuscript; available in PMC 2022 Aug 16.

Published in final edited form as: Cell Syst. 2022 Feb 16; 13(2): 158–172.e9. Published online 2021 Oct 26. doi: 10.1016/j.cels.2021.09.014

PMCID:: PMC8961722

Abstract Article PDF–2.6M

Select item 77079465.

GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis

Xueting Luo, Xiaowei Shi, Zhongguang Sun, Jing Xiao, Hui Song, Guo Lu, Xin Xu

Biomed Res Int. 2020; 2020: 1454396. Published online 2020 Nov 24. doi: 10.1155/2020/1454396

PMCID:: PMC7707946

Abstract Article PDF–1.0M

Select item 76885636.

The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice

Guoli Hu, Yilin Yu, Yuning J Tang, Colleen Wu, Fanxin Long, Courtney M Karner

J Bone Miner Res. Author manuscript; available in PMC 2020 Dec 9.

Published in final edited form as: J Bone Miner Res. 2020 Oct; 35(10): 2004–2014. Published online 2020 Jul 6. doi: 10.1002/jbmr.4091

PMCID:: PMC7688563

Abstract Article PDF–2.3M

Select item 71832237.

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells

Yeonjin Kim, Mark S. Sundrud, Changqian Zhou, Maja Edenius, Davide Zocco, Kristen Powers, Miao Zhang, Ralph Mazitschek, Anjana Rao, Chang-Yeol Yeo, Erika H. Noss, Michael B. Brenner, Malcolm Whitman, Tracy L. Keller

Proc Natl Acad Sci U S A. 2020 Apr 21; 117(16): 8900–8911. Published online 2020 Apr 6. doi: 10.1073/pnas.1913788117

PMCID:: PMC7183223

Abstract Article PDF–1.8M

Select item 69525598.

GCN2 is essential for CD8⁺ T cell survival and function in murine models of malignant glioma

Aida Rashidi, Jason Miska, Catalina Lee-Chang, Deepak Kanojia, Wojciech K. Panek, Aurora Lopez-Rosas, Peng Zhang, Yu Han, Ting Xiao, Katarzyna C. Pituch, Julius W. Kim, Mahsa Talebian, Jawad Fares, Maciej S. Lesniak

Cancer Immunol Immunother. 2020 Jan; 69(1): 81–94. Published online 2019 Dec 16. doi: 10.1007/s00262-019-02441-6

PMCID:: PMC6952559

Abstract Article PDF–3.6M

Select item 69199769.

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron

eLife. 2019; 8: e50149. Published online 2019 Nov 21. doi: 10.7554/eLife.50149

PMCID:: PMC6919976

Abstract Article PDF–5.2M

Select item 656476510.

Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii

Leonardo Augusto, Parth H. Amin, Ronald C. Wek, William J. Sullivan, Jr

PLoS Pathog. 2019 Jun; 15(6): e1007746. Published online 2019 Jun 13. doi: 10.1371/journal.ppat.1007746

PMCID:: PMC6564765

Abstract Article PDF–2.6M

Select item 609808511.

AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation

Alexis Bretin, Cécily Lucas, Anaïs Larabi, Guillaume Dalmasso, Elisabeth Billard, Nicolas Barnich, Richard Bonnet, Hang Thi Thu Nguyen

Sci Rep. 2018; 8: 12301. Published online 2018 Aug 17. doi: 10.1038/s41598-018-30055-y

PMCID:: PMC6098085

Abstract Article PDF–3.1M

Select item 600668112.

GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress

Yue Wang, Tong Lei, Juntao Yuan, Yongguang Wu, Xiyue Shen, Junling Gao, Wei Feng, Zhongbing Lu

Redox Biol. 2018 Jul; 17: 25–34. Published online 2018 Apr 7. doi: 10.1016/j.redox.2018.04.009

PMCID:: PMC6006681

Abstract Article PDF–3.2M

Select item 508126613.

Rapid sensing of dietary amino acid deficiency does not require GCN2

David E. Leib, Zachary A. Knight

Cell Rep. Author manuscript; available in PMC 2017 Aug 23.

Published in final edited form as: Cell Rep. 2016 Aug 23; 16(8): 2051–2052. doi: 10.1016/j.celrep.2016.08.022

PMCID:: PMC5081266

Article PDF–30K

Select item 507962314.

Loss of the eIF2α kinase GCN2 protects mice from pressure overload induced congestive heart failure without affecting ventricular hypertrophy

Zhongbing Lu, Xin Xu, John Fassett, Dongmin Kwak, Xiaoyu Liu, Xinli Hu, Huan Wang, Haipeng Guo, Dachun Xu, Shuo Yan, Edward O. McFalls, Fei Lu, Robert J. Bache, Yingjie Chen

Hypertension. Author manuscript; available in PMC 2016 Oct 25.

Published in final edited form as: Hypertension. 2014 Jan; 63(1): 128–135. Published online 2013 Oct 28. doi: 10.1161/HYPERTENSIONAHA.113.02313

PMCID:: PMC5079623

Abstract Article PDF–1.0M

Select item 493548815.

General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice

Lindsey Phillipson-Weiner, Emily T. Mirek, Yongping Wang, W. Geoffrey McAuliffe, Ronald C. Wek, Tracy G. Anthony

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1; 310(11): G1061–G1070. Published online 2016 Mar 11. doi: 10.1152/ajpgi.00052.2016

PMCID:: PMC4935488

Abstract Article

Select item 490635316.

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

Julien Averous, Sarah Lambert-Langlais, Florent Mesclon, Valérie Carraro, Laurent Parry, Céline Jousse, Alain Bruhat, Anne-Catherine Maurin, Philippe Pierre, Christopher G. Proud, Pierre Fafournoux

Sci Rep. 2016; 6: 27698. Published online 2016 Jun 14. doi: 10.1038/srep27698

PMCID:: PMC4906353

Abstract Article PDF–1.2M

Select item 483694217.

Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism

David E. Leib, Zachary A. Knight

Cell Rep. Author manuscript; available in PMC 2016 Apr 19.

Published in final edited form as: Cell Rep. 2015 Nov 10; 13(6): 1081–1089. Published online 2015 Oct 29. doi: 10.1016/j.celrep.2015.09.055

PMCID:: PMC4836942

Abstract Article PDF–629K

Select item 432949418.

GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment

Gabriel J. Wilson, Brittany A. Lennox, Pengxiang She, Emily T. Mirek, Rana J. T. Al Baghdadi, Michael E. Fusakio, Joseph L. Dixon, Gregory C. Henderson, Ronald C. Wek, Tracy G. Anthony

Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4): E283–E293. Published online 2014 Dec 9. doi: 10.1152/ajpendo.00361.2014

PMCID:: PMC4329494

Abstract Article

Select item 429756519.

L-Arginine depletion blunts anti-tumor T cell responses by inducing myeloid-derived suppressor cells

Matthew Fletcher, Maria E. Ramirez, Rosa A. Sierra, Patrick Raber, Paul Thevenot, Amir A. Al-Khami, Dulfary Sanchez-Pino, Claudia Hernandez, Dorota D. Wyczechowska, Augusto C. Ochoa, Paulo C. Rodriguez

Cancer Res. Author manuscript; available in PMC 2016 Jan 15.

Published in final edited form as: Cancer Res. 2015 Jan 15; 75(2): 275–283. Published online 2014 Nov 18. doi: 10.1158/0008-5472.CAN-14-1491

PMCID:: PMC4297565

Abstract Article PDF–2.2M

Select item 384020520.

The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment

Gabriel J. Wilson, Piyawan Bunpo, Judy K. Cundiff, Ronald C. Wek, Tracy G. Anthony

Am J Physiol Endocrinol Metab. 2013 Nov 1; 305(9): E1124–E1133. Published online 2013 Sep 3. doi: 10.1152/ajpendo.00080.2013

PMCID:: PMC3840205

Abstract Article

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