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Select item 108545081.

High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81

Jing Yang, Glenn R. Gourley, Adam Gilbertsen, Chi Chen, Lei Wang, Karen Smith, Marion Namenwirth, Libang Yang

Cells. 2024 Feb; 13(3): 236. Published online 2024 Jan 26. doi: 10.3390/cells13030236

PMCID:: PMC10854508

Abstract Article PDF–6.9M

Select item 92608792.

Lactate receptor HCAR1 regulates cell growth, metastasis and maintenance of cancer-specific energy metabolism in breast cancer cells

Lili Jin, Yanan Guo, Jiawen Chen, Zhenzhen Wen, Yibin Jiang, Jing Qian

Mol Med Rep. 2022 Aug; 26(2): 268. Published online 2022 Jun 28. doi: 10.3892/mmr.2022.12784

PMCID:: PMC9260879

Abstract Article PDF–3.6M

Select item 90128573.

The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer

Shota Ishihara, Kenji Hata, Katsutoshi Hirose, Tatsuo Okui, Satoru Toyosawa, Narikazu Uzawa, Riko Nishimura, Toshiyuki Yoneda

Sci Rep. 2022; 12: 6261. Published online 2022 Apr 15. doi: 10.1038/s41598-022-10143-w

PMCID:: PMC9012857

Abstract Article PDF–5.1M

Select item 74112944.

Effects of GPR81 silencing combined with cisplatin stimulation on biological function in hypopharyngeal squamous cell carcinoma

Qiaojing Jia, Ou Xu, Jianxing Wang, Jinhui Dong, Xiumin Ren, Xiaofang Jia, Chunguang Shan

Mol Med Rep. 2020 Sep; 22(3): 1727–1736. Published online 2020 Jun 18. doi: 10.3892/mmr.2020.11255

PMCID:: PMC7411294

Abstract Article PDF–985K

Select item 53425975.

G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

Yu Jin Lee, Kyeong Jin Shin, Soo-Ah Park, Kyeong Su Park, Seorim Park, Kyun Heo, Young-Kyo Seo, Dong-Young Noh, Sung Ho Ryu, Pann-Ghill Suh

Oncotarget. 2016 Oct 25; 7(43): 70898–70911. Published online 2016 Sep 27. doi: 10.18632/oncotarget.12286

PMCID:: PMC5342597

Abstract Article PDF–4.3M

Select item 45149916.

L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation

Waldemar Wagner, Wojciech M. Ciszewski, Katarzyna D. Kania

Cell Commun Signal. 2015; 13: 36. Published online 2015 Jul 25. doi: 10.1186/s12964-015-0114-x

PMCID:: PMC4514991

Abstract Article PDF–1.4M

Select item 41672227.

Cell surface lactate receptor GPR81 is crucial for cancer cell survival

Christina L. Roland, Thiruvengadam Arumugam, Defeng Deng, Shi He Liu, Bincy Philip, Sobeyda Gomez, William R. Burns, Vijaya Ramachandran, Huamin Wang, Zobeida Cruz-Monserrate, Craig D. Logsdon

Cancer Res. Author manuscript; available in PMC 2015 Sep 15.

Published in final edited form as: Cancer Res. 2014 Sep 15; 74(18): 5301–5310. Published online 2014 Jun 13. doi: 10.1158/0008-5472.CAN-14-0319

PMCID:: PMC4167222

Abstract Article PDF–485K

Select item 104986948.

Activation of GPR81 aggravated intestinal ischemia/reperfusion injury-induced acute lung injury via HMGB1-mediated neutrophil extracellular traps formation

Sun Yili, Dai Xinyi, Fan Kerui, Chen Kun, Yongqiang Yang, Li Zhang, Kai Hu

Int J Immunopathol Pharmacol. 2023 Jan-Dec; 37: 03946320231193832. Published online 2023 Sep 12. doi: 10.1177/03946320231193832

PMCID:: PMC10498694

Abstract Article PDF–1017K

Select item 46373159.

Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism

Claudia Stäubert, Oliver Jay Broom, Anders Nordström

Oncotarget. 2015 Aug 14; 6(23): 19706–19720. Published online 2015 Mar 14. doi: 10.18632/oncotarget.3565

PMCID:: PMC4637315

Abstract Article PDF–4.6M

Select item 410430510.

Lactate Reduces Organ Injury in Toll-like Receptor- and Inflammasome-Mediated Inflammation via GPR81-mediated Suppression of Innate Immunity

Rafaz Hoque, Ahmad Farooq, Ayaz Ghani, Fred Gorelick, Wajahat Zafar Mehal

Gastroenterology. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Gastroenterology. 2014 Jun; 146(7): 1763–1774. Published online 2014 Mar 20. doi: 10.1053/j.gastro.2014.03.014

PMCID:: PMC4104305

Abstract Article PDF–1.1M

Select item 944172111.

Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue

Marc Briquet, Anne-Bérengère Rocher, Maxime Alessandri, Nadia Rosenberg, Haissa de Castro Abrantes, Joel Wellbourne-Wood, Céline Schmuziger, Vanessa Ginet, Julien Puyal, Etienne Pralong, Roy Thomas Daniel, Stefan Offermanns, Jean-Yves Chatton

J Cereb Blood Flow Metab. 2022 Sep; 42(9): 1650–1665. Published online 2022 Mar 3. doi: 10.1177/0271678X221080324

PMCID:: PMC9441721

Abstract Article PDF–1.3M

Select item 863818412.

Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases

Cierla McGuire Sams, Kasey Shepp, Jada Pugh, Madison R. Bishop, Nancy D. Merner

BMC Med Genomics. 2021; 14: 284. Published online 2021 Dec 1. doi: 10.1186/s12920-021-01126-3

PMCID:: PMC8638184

Abstract Article PDF–4.5M

Select item 751911213.

Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study

M.-A. C. Bind, D. B. Rubin, A. Cardenas, R. Dhingra, C. Ward-Caviness, Z. Liu, J. Mirowsky, J. D. Schwartz, D. Diaz-Sanchez, R. B. Devlin

Sci Rep. 2020; 10: 15739. Published online 2020 Sep 25. doi: 10.1038/s41598-020-72068-6

PMCID:: PMC7519112

Abstract Article PDF–3.8M

Select item 705692314.

Monocarboxylate transporters in cancer

Valéry L. Payen, Erica Mina, Vincent F. Van Hée, Paolo E. Porporato, Pierre Sonveaux

Mol Metab. 2020 Mar; 33: 48–66. Published online 2019 Jul 27. doi: 10.1016/j.molmet.2019.07.006

PMCID:: PMC7056923

Abstract Article PDF–1.6M

Select item 278532615.

Peroxisome Proliferator-activated Receptor γ Regulates Expression of the Anti-lipolytic G-protein-coupled Receptor 81 (GPR81/Gpr81)

Ellen H. Jeninga, Anne Bugge, Ronni Nielsen, Sander Kersten, Nicole Hamers, Christian Dani, Martin Wabitsch, Ruud Berger, Hendrik G. Stunnenberg, Susanne Mandrup, Eric Kalkhoven

J Biol Chem. 2009 Sep 25; 284(39): 26385–26393. Published online 2009 Jul 24. doi: 10.1074/jbc.M109.040741

PMCID:: PMC2785326

Abstract Article PDF–1.2M

Select item 465716116.

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

Anna E. Dart, Gary M. Box, William Court, Madeline E. Gale, John P. Brown, Sarah E. Pinder, Suzanne A. Eccles, Claire M. Wells

J Cell Biol. 2015 Nov 23; 211(4): 863–879. doi: 10.1083/jcb.201501072

PMCID:: PMC4657161

Abstract Article PDF–8.1M

Select item 322964117.

Image-Based Genome-Wide siRNA Screen Identifies Selective Autophagy Factors

Anthony Orvedahl, Rhea Sumpter, Jr., Guanghua Xiao, Aylwin Ng, Zhongju Zou, Yi Tang, Masahiro Narimatsu, Christopher Gilpin, Qihua Sun, Michael Roth, Christian V. Forst, Jeffrey L. Wrana, Ying E. Zhang, Katherine Luby-Phelps, Ramnik Xavier, Yang Xie, Beth Levine

Nature. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: Nature. 2011 Dec 1; 480(7375): 113–117. doi: 10.1038/nature10546

PMCID:: PMC3229641

Abstract Article PDF–2.3M

Select item 276866718.

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

Ji Luo, Michael J. Emanuele, Danan Li, Chad J. Creighton, Michael R. Schlabach, Thomas F. Westbrook, Kwok-kin Wong, Stephen J. Elledge

Cell. Author manuscript; available in PMC 2009 Nov 29.

Published in final edited form as: Cell. 2009 May 29; 137(5): 835–848. doi: 10.1016/j.cell.2009.05.006

PMCID:: PMC2768667

Abstract Article PDF–4.0M

Select item 294516819.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Abstract Article PDF–153K

Select item 277583220.

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani

Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014

PMCID:: PMC2775832

Abstract Article PDF–2.8M

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