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Select item 105602171.

Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

Cristina M. Viola, Orsolya Frittmann, Huw T. Jenkins, Talha Shafi, Pierre De Meyts, Andrzej M. Brzozowski

Nat Commun. 2023; 14: 6271. Published online 2023 Oct 7. doi: 10.1038/s41467-023-41862-x

PMCID:: PMC10560217

Abstract Article PDF–2.9M

Select item 113531702.

Glut1 Functions in Insulin-Producing Neurons to Regulate Lipid and Carbohydrate Storage in Drosophila

Matthew R. Kauffman, Justin R. DiAngelo

Biomolecules. 2024 Aug; 14(8): 1037. Published online 2024 Aug 20. doi: 10.3390/biom14081037

PMCID:: PMC11353170

Abstract Article PDF–1.7M

Select item 68003523.

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Jorge Iván Castillo-Quan, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, Linda Partridge

Proc Natl Acad Sci U S A. 2019 Oct 15; 116(42): 20817–20819. Published online 2019 Sep 30. doi: 10.1073/pnas.1913212116

PMCID:: PMC6800352

Abstract Article PDF–719K

Select item 61550514.

Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

Nikolaj Kulahin Roed, Cristina M. Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D. Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R. Ganderton, Johan P. Turkenburg, Pierre De Meyts, Andrzej M. Brzozowski

Nat Commun. 2018; 9: 3860. Published online 2018 Sep 21. doi: 10.1038/s41467-018-06192-3

PMCID:: PMC6155051

Abstract Article PDF–3.8M

Select item 54455805.

Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster

Jelle Zandveld, Joost van den Heuvel, Bastiaan J. Zwaan, Matthew D.W. Piper

NPJ Aging Mech Dis. 2017; 3: 4. Published online 2017 Feb 20. doi: 10.1038/s41514-017-0004-0

PMCID:: PMC5445580

Abstract Article PDF–1.0M

Select item 42311446.

The Sleeping Beauty: How Reproductive Diapause Affects Hormone Signaling, Metabolism, Immune Response and Somatic Maintenance in Drosophila melanogaster

Olga I. Kubrak, Lucie Kučerová, Ulrich Theopold, Dick R. Nässel

PLoS One. 2014; 9(11): e113051. Published online 2014 Nov 13. doi: 10.1371/journal.pone.0113051

PMCID:: PMC4231144

Abstract Article PDF–11M

Select item 38776877.

A holidic medium for Drosophila melanogaster

Matthew DW Piper, Eric Blanc, Ricardo Leitão-Gonçalves, Mingyao Yang, Xiaoli He, Nancy J. Linford, Matthew P Hoddinott, Corinna Hopfen, George A Soultoukis, Christine Niemeyer, Fiona Kerr, Scott D. Pletcher, Carlos Ribeiro, Linda Partridge

Nat Methods. Author manuscript; available in PMC 2014 Jul 1.

Published in final edited form as: Nat Methods. 2014 Jan; 11(1): 10.1038/nmeth.2731. Published online 2013 Nov 17. doi: 10.1038/nmeth.2731

Correction in:: volume 11 on page 971

PMCID:: PMC3877687

Abstract Article PDF–1.6M

Select item 32893248.

Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression

Naoki Okamoto, Yuka Nishimori, Takashi Nishimura

Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7): 2406–2411. Published online 2012 Jan 30. doi: 10.1073/pnas.1116050109

PMCID:: PMC3289324

Abstract Article PDF–1.0M

Select item 32460099.

Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth

Lucy Erin O'Brien, Sarah S. Soliman, Xinghua Li, David Bilder

Cell. Author manuscript; available in PMC 2012 Oct 28.

Published in final edited form as: Cell. 2011 Oct 28; 147(3): 603–614. doi: 10.1016/j.cell.2011.08.048

PMCID:: PMC3246009

Abstract Article PDF–2.1M

Select item 301302510.

Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation

Waseem Sajid, Nikolaj Kulahin, Gerd Schluckebier, Ulla Ribel, Hope Rosalind Henderson, Marc Tatar, Bo Falck Hansen, Angela Manegold Svendsen, Vladislav V. Kiselyov, Per Nørgaard, Per-Olof Wahlund, Jakob Brandt, Ronald A. Kohanski, Asser Sloth Andersen, Pierre De Meyts

J Biol Chem. 2011 Jan 7; 286(1): 661–673. Published online 2010 Oct 25. doi: 10.1074/jbc.M110.156018

PMCID:: PMC3013025

Abstract Article PDF–3.7M

Select item 269806311.

Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan

Dickon M. Humphrey, Janne M. Toivonen, Maria Giannakou, Linda Partridge, Martin D. Brand

Exp Gerontol. 2009 May; 44(5): 316–327. doi: 10.1016/j.exger.2009.02.001

PMCID:: PMC2698063

Abstract Article

Select item 947497212.

The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathology

Tâmie Duarte, Mônica de Medeiros Silva, Paula Michelotti, Nilda Berenice de Vargas Barbosa, Bruno César Feltes, Márcio Dorn, João Batista Teixeira da Rocha, Cristiane Lenz Dalla Corte

Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1; 1868(12): 166551. Published online 2022 Sep 15. doi: 10.1016/j.bbadis.2022.166551

PMCID:: PMC9474972

Abstract Article PDF–3.5M

Select item 806003013.

Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

Luke Stephen Tain, Robert Sehlke, Ralf Leslie Meilenbrock, Thomas Leech, Jonathan Paulitz, Manopriya Chokkalingam, Nagarjuna Nagaraj, Sebastian Grönke, Jenny Fröhlich, Ilian Atanassov, Matthias Mann, Andreas Beyer, Linda Partridge

eLife. 2021; 10: e67275. Published online 2021 Apr 21. doi: 10.7554/eLife.67275