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Select item 29452231.

Peroxynitrite-Induced Neuronal Apoptosis Is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation

Yumin Zhang, Hong Wang, Jianrong Li, Daniel A. Jimenez, Edwin S. Levitan, Elias Aizenman, Paul A. Rosenberg

J Neurosci. 2004 Nov 24; 24(47): 10616–10627. doi: 10.1523/JNEUROSCI.2469-04.2004

PMCID:: PMC2945223

Abstract Article PDF–420K

Select item 392292.

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

D G Tang, Y Q Chen, K V Honn

Proc Natl Acad Sci U S A. 1996 May 28; 93(11): 5241–5246. doi: 10.1073/pnas.93.11.5241

PMCID:: PMC39229

Summary Page Browse PDF–2.8M

Select item 41038483.

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

Bin Deng, Chin-Wei Wang, Hildur H. Arnardottir, Yongsheng Li, Chien-Yee Cindy Cheng, Jesmond Dalli, Charles N. Serhan

PLoS One. 2014; 9(7): e102362. Published online 2014 Jul 18. doi: 10.1371/journal.pone.0102362

PMCID:: PMC4103848

Abstract Article PDF–911K

Select item 34942514.

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

Kenneth N. Ikei, Jennifer Yeung, Patrick L. Apopa, Jesús Ceja, Joanne Vesci, Theodore R. Holman, Michael Holinstat

J Lipid Res. 2012 Dec; 53(12): 2546–2559. doi: 10.1194/jlr.M026385

PMCID:: PMC3494251

Abstract Article PDF–1.6M

Select item 33149535.

Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells

T. Klampfl, E. Bogner, W. Bednar, L. Mager, D. Massudom, I. Kalny, C. Heinzle, W. Berger, S. Stättner, J. Karner, M. Klimpfinger, G. Fürstenberger, P. Krieg, B. Marian

Exp Cell Res. 2012 Apr 1; 318(6): 768–778. doi: 10.1016/j.yexcr.2011.12.017

PMCID:: PMC3314953

Abstract Article

Select item 30232046.

Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats

Swarup K. Chakrabarti, Yeshao Wen, Anca D. Dobrian, Banumathi K. Cole, Qian Ma, Hong Pei, Michael D. Williams, Melissa H. Bevard, George E. Vandenhoff, Susanna R. Keller, Jiali Gu, Jerry L. Nadler

Am J Physiol Endocrinol Metab. 2011 Jan; 300(1): E175–E187. Published online 2010 Oct 26. doi: 10.1152/ajpendo.00203.2010

PMCID:: PMC3023204

Abstract Article

Select item 29119607.

Vitamin K Prevents Oxidative Cell Death by Inhibiting Activation of 12-Lipoxygenase in Developing Oligodendrocytes

Jianrong Li, Hong Wang, Paul A. Rosenberg

J Neurosci Res. Author manuscript; available in PMC 2010 Jul 29.

Published in final edited form as: J Neurosci Res. 2009 Jul; 87(9): 1997–2005. doi: 10.1002/jnr.22029

PMCID:: PMC2911960

Abstract Article PDF–1.6M

Select item 25855038.

Association of Arachidonate 12 Lipoxygenase Genotype Variation and Glycemic Control With Albuminuria in Type 2 Diabetes

Yongmei Liu, Barry I. Freedman, Kathryn P. Burdon, Carl D. Langefeld, Timothy Howard, David Herrington, David C. Goff, Jr., Donald W. Bowden, Lynne E. Wagenknecht, Catherine C. Hedrick, Stephen S. Rich

Am J Kidney Dis. Author manuscript; available in PMC 2009 Aug 1.

Published in final edited form as: Am J Kidney Dis. 2008 Aug; 52(2): 242–250. Published online 2008 Mar 25. doi: 10.1053/j.ajkd.2007.12.033

PMCID:: PMC2585503

Abstract Article PDF–494K

Select item 11376649.

Lipoxin synthase activity of human platelet 12-lipoxygenase.

M Romano, X S Chen, Y Takahashi, S Yamamoto, C D Funk, C N Serhan

Biochem J. 1993 Nov 15; 296(Pt 1): 127–133. doi: 10.1042/bj2960127

PMCID:: PMC1137664

Summary Page Browse PDF–1.3M

Select item 5477010.

Cloning of the cDNA for human 12-lipoxygenase.

T Izumi, S Hoshiko, O Rådmark, B Samuelsson

Proc Natl Acad Sci U S A. 1990 Oct; 87(19): 7477–7481. doi: 10.1073/pnas.87.19.7477

PMCID:: PMC54770

Summary Page Browse PDF–1.0M

Select item 5438211.

Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.

C D Funk, L Furci, G A FitzGerald

Proc Natl Acad Sci U S A. 1990 Aug; 87(15): 5638–5642. doi: 10.1073/pnas.87.15.5638

PMCID:: PMC54382

Summary Page Browse PDF–1.6M

Select item 1970112.

Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase

Eric N. Johnson, Lawrence F. Brass, Colin D. Funk

Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6): 3100–3105. doi: 10.1073/pnas.95.6.3100

PMCID:: PMC19701

Abstract Article PDF–238K

Select item 368873913.

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A₄ hydrolase (LTA₄H), and shifts macrophage phenotype

Jesmond Dalli, Min Zhu, Nikita A. Vlasenko, Bin Deng, Jesper Z. Haeggström, Nicos A. Petasis, Charles N. Serhan

FASEB J. 2013 Jul; 27(7): 2573–2583. doi: 10.1096/fj.13-227728

PMCID:: PMC3688739

Abstract Article

Select item 258481514.

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by western diet

Craig S. Nunemaker, Meng Chen, Hong Pei, Sarah D. Kimble, Susanna R. Keller, Jeffrey D. Carter, Zandong Yang, Kellie M. Smith, Runpei Wu, Melissa H. Bevard, James C. Garmey, Jerry L. Nadler

Am J Physiol Endocrinol Metab. 2008 Nov; 295(5): E1065–E1075. Published online 2008 Sep 9. doi: 10.1152/ajpendo.90371.2008

PMCID:: PMC2584815

Abstract Article

Select item 424245115.

Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction

Tarvi Teder, William E. Boeglin, Alan R. Brash

J Lipid Res. 2014 Dec; 55(12): 2587–2596. doi: 10.1194/jlr.M054072

PMCID:: PMC4242451

Abstract Article PDF–959K

Select item 277449816.

Oxidative Metabolism of Lipoamino Acids and Vanilloids by Lipoxygenases and Cyclooxygenases

Jeffery J. Prusakiewicz, Melissa V. Turman, Andrew Vila, Heather L. Ball, Ahmad H. Al-Mestarihi, Vincenzo Di Marzo, Lawrence J. Marnett

Arch Biochem Biophys. Author manuscript; available in PMC 2009 Nov 8.

Published in final edited form as: Arch Biochem Biophys. 2007 Aug 15; 464(2): 260–268. Published online 2007 Apr 20. doi: 10.1016/j.abb.2007.04.007

PMCID:: PMC2774498

Abstract Article PDF–1.0M

Select item 267294917.

Role of Src Tyrosine Kinase in the Atherogenic Effects of the 12/15-Lipoxygenase Pathway in Vascular Smooth Muscle Cells

Marpadga A. Reddy, Saurabh Sahar, Louisa M. Villeneuve, Linda Lanting, Rama Natarajan

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2010 Mar 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Mar; 29(3): 387–393. Published online 2008 Dec 18. doi: 10.1161/ATVBAHA.108.179150

PMCID:: PMC2672949

Abstract Article PDF–934K

Select item 161567618.

12/15-Lipoxygenase Is Increased in Alzheimer’s Disease: Possible Involvement in Brain Oxidative Stress

Domenico Praticò, Victoria Zhukareva, Yuemang Yao, Kunihiro Uryu, Colin D. Funk, John A. Lawson, John Q. Trojanowski, Virginia M.-Y. Lee

Am J Pathol. 2004 May; 164(5): 1655–1662. doi: 10.1016/S0002-9440(10)63724-8

PMCID:: PMC1615676

Abstract Article PDF–765K

Select item 122171619.

Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes.

M Siebert, P Krieg, W D Lehmann, F Marks, G Fürstenberger

Biochem J. 2001 Apr 1; 355(Pt 1): 97–104. doi: 10.1042/0264-6021:3550097

PMCID:: PMC1221716

Summary PDF–165K

Select item 363381320.

Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia

Ann M. Gregus, Darren S. Dumlao, Spencer C. Wei, Paul C. Norris, Laura C. Catella, Flore G. Meyerstein, Matthew W. Buczynski, Joanne J. Steinauer, Bethany L. Fitzsimmons, Tony L. Yaksh, Edward A. Dennis

FASEB J. 2013 May; 27(5): 1939–1949. doi: 10.1096/fj.12-217414