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Select item 101542011.

Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin

Chong-Qing Gao, Zhen-Zhen Chu, Di Zhang, Yang Xiao, Xing-Yan Zhou, Jun-Ru Wu, Hui Yuan, Yu-Chuan Jiang, Dong Chen, Ji-Chun Zhang, Nan Yao, Kai-Yun Chen, Jian Hong

Oncogene. 2023; 42(18): 1492–1507. Published online 2023 Mar 16. doi: 10.1038/s41388-023-02651-4

PMCID:: PMC10154201

Abstract Article PDF–9.3M

Select item 100134132.

TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway

Qiuli Jiang, Yingying Guan, Jingmei Zheng, Huadong Lu

Immun Inflamm Dis. 2023 Mar; 11(3): e796. Published online 2023 Mar 14. doi: 10.1002/iid3.796

PMCID:: PMC10013413

Abstract Article PDF–8.0M

Select item 99177863.

Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts

Gracia Porras, Silvana Ruiz, Inés Maestro, Daniel Borrego-Hernández, Alberto G. Redondo, Ana Martínez, Ángeles Martín-Requero

Int J Mol Sci. 2023 Feb; 24(3): 2847. Published online 2023 Feb 2. doi: 10.3390/ijms24032847

PMCID:: PMC9917786

Abstract Article PDF–1.5M

Select item 93879734.

Correlation of TBK1, AR, and other serum cancer-related biomarkers in breast cancer patients: An observational study

HanCheng Liu, HuiMing Li, Jie Zhang, QingLai Meng, LiHui Ma

Medicine (Baltimore) 2022 Aug 19; 101(33): e29996. Published online 2022 Aug 19. doi: 10.1097/MD.0000000000029996

PMCID:: PMC9387973

Abstract Article PDF–707K

Select item 93427885.

TBK1 is part of a galectin 8 dependent membrane damage recognition complex and drives autophagy upon Adenovirus endosomal escape

Noémie Pied, Coralie F. Daussy, Zoé Denis, Jessica Ragues, Muriel Faure, Richard Iggo, Mario P. Tschan, Benoit Roger, Fabienne Rayne, Harald Wodrich

PLoS Pathog. 2022 Jul; 18(7): e1010736. Published online 2022 Jul 20. doi: 10.1371/journal.ppat.1010736

PMCID:: PMC9342788

Abstract Article PDF–3.6M

Select item 91348966.

TBK1 Facilitates GLUT1-Dependent Glucose Consumption by suppressing mTORC1 Signaling in Colorectal Cancer Progression

Diyuan Zhou, Yizhou Yao, Liang Zong, Guoqiang Zhou, Min Feng, Junjie Chen, Ganggang Liu, Guoliang Chen, Kang Sun, Huihui Yao, Yu Liu, Xinyu Shi, Weigang Zhang, Bo Shi, Qingliang Tai, Guanting Wu, Liang Sun, Wenqing Hu, Xinguo Zhu, Songbing He

Int J Biol Sci. 2022; 18(8): 3374–3389. Published online 2022 May 9. doi: 10.7150/ijbs.70742

PMCID:: PMC9134896

Abstract Article PDF–2.9M

Select item 91200967.

TBK1 haploinsufficiency results in changes in the K63-ubiquitination profiles in brain and fibroblasts from affected and presymptomatic mutation carriers

Behzad Khoshnood, Abbe Ullgren, Jose Laffita-Mesa, Linn Öijerstedt, Kalicharan Patra, Inger Nennesmo, Caroline Graff

J Neurol. 2022; 269(6): 3037–3049. Published online 2021 Nov 20. doi: 10.1007/s00415-021-10887-x

PMCID:: PMC9120096

Abstract Article PDF–2.6M

Select item 89942448.

The role of TBK1 in cancer pathogenesis and anticancer immunity

Austin P. Runde, Ryan Mack, Peter Breslin S.J., Jiwang Zhang

J Exp Clin Cancer Res. 2022; 41: 135. Published online 2022 Apr 9. doi: 10.1186/s13046-022-02352-y

PMCID:: PMC8994244

Abstract Article PDF–2.2M

Select item 89612729.

TBK1 is associated with ALS and ALS-FTD in Sardinian patients

Giuseppe Borghero, Maura Pugliatti, Francesco Marrosu, Maria Giovanna Marrosu, Maria Rita Murru, Gianluca Floris, Antonino Cannas, Patrizia Occhineri, Tea B. Cau, Daniela Loi, Anna Ticca, Sebastiano Traccis, Umberto Manera, Antonio Canosa, Cristina Moglia, Andrea Calvo, Marco Barberis, Maura Brunetti, J. Raphael Gibbs, Alan E. Renton, Edoardo Errichiello, Magdalena Zoledziewska, Antonella Mulas, Yong Qian, Jun Din, Hannah A. Pliner, Bryan J. Traynor, Adriano Chiòg

Neurobiol Aging. Author manuscript; available in PMC 2022 Mar 29.

Published in final edited form as: Neurobiol Aging. 2016 Jul; 43: 180.e1–180.e5. Published online 2016 Apr 9. doi: 10.1016/j.neurobiolaging.2016.03.028

PMCID:: PMC8961272

Abstract Article PDF–486K

Select item 850053310.

TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking

Yubing Lu, Sandra Almeida, Fen-Biao Gao

Acta Neuropathol. Author manuscript; available in PMC 2021 Oct 8.

Published in final edited form as: Acta Neuropathol. 2021 Jul; 142(1): 217–221. Published online 2021 Jun 3. doi: 10.1007/s00401-021-02331-1

PMCID:: PMC8500533

Article PDF–1.1M

Select item 821469011.

ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

Olivia Harding, Chantell S. Evans, Junqiang Ye, Jonah Cheung, Tom Maniatis, Erika L. F. Holzbaur

Proc Natl Acad Sci U S A. 2021 Jun 15; 118(24): e2025053118. Published online 2021 Jun 7. doi: 10.1073/pnas.2025053118

PMCID:: PMC8214690

Abstract Article PDF–3.9M

Select item 793049712.

TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration

Yuchuan Jiang, Siliang Chen, Qiang Li, Junjie Liang, Weida Lin, Jinying Li, Zhilong Liu, Mingbo Wen, Mingrong Cao, Jian Hong

Front Immunol. 2021; 12: 612139. Published online 2021 Feb 18. doi: 10.3389/fimmu.2021.612139

PMCID:: PMC7930497

Abstract Article PDF–8.9M

Select item 790766913.

Variable clinical phenotype in TBK1 mutations: case report of a novel mutation causing primary progressive aphasia and review of the literature

Imogen J. Swift, Martina Bocchetta, Hanya Benotmane, Ione OC. Woollacott, Rachelle Shafei, Jonathan D. Rohrer

Neurobiol Aging. 2021 Mar; 99: 100.e9–100.e15. doi: 10.1016/j.neurobiolaging.2020.08.014

PMCID:: PMC7907669

Abstract Article

Select item 728299814.

Long-Term Follow-Up of Normal Tension Glaucoma Patients With TBK1 Gene Mutations in One Large Pedigree

Tyler S. Quist, Chris A. Johnson, Alan L. Robin, John H. Fingert

Am J Ophthalmol. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Am J Ophthalmol. 2020 Jun; 214: 52–62. Published online 2020 Jan 24. doi: 10.1016/j.ajo.2020.01.017

PMCID:: PMC7282998

Abstract Article PDF–651K

Select item 709451315.

Negative regulation of TBK1‐mediated antiviral immunity

Wei Zhao

FEBS Lett. 2013 Mar 18; 587(6): 542–548. Published online 2013 Feb 8. doi: 10.1016/j.febslet.2013.01.052

PMCID:: PMC7094513

Abstract Article PDF–736K

Select item 698393316.

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

Martina de Majo, Simon D. Topp, Bradley N. Smith, Agnes L. Nishimura, Han-Jou Chen, Athina Soragia Gkazi, Jack Miller, Chun Hao Wong, Caroline Vance, Frank Baas, Anneloor L.M.A. ten Asbroek, Kevin P. Kenna, Nicola Ticozzi, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Karen E. Morrison, Pamela J. Shaw, Janine Kirby, Martin R. Turner, Kevin Talbot, Orla Hardiman, Jonathan D. Glass, Jacqueline de Belleroche, Cinzia Gellera, Antonia Ratti, Ammar Al-Chalabi, Robert H. Brown, Vincenzo Silani, John E. Landers, Christopher E. Shaw

Neurobiol Aging. 2018 Nov; 71: 266.e1–266.e10. doi: 10.1016/j.neurobiolaging.2018.06.015

PMCID:: PMC6983933

Abstract Article

Select item 694506317.

TBK1‐mediated phosphorylation of LC3C and GABARAP‐L2 controls autophagosome shedding by ATG4 protease

Lina Herhaus, Ramachandra M Bhaskara, Alf Håkon Lystad, Uxía Gestal‐Mato, Adriana Covarrubias‐Pinto, Florian Bonn, Anne Simonsen, Gerhard Hummer, Ivan Dikic

EMBO Rep. 2020 Jan 7; 21(1): e48317. Published online 2019 Nov 11. doi: 10.15252/embr.201948317

PMCID:: PMC6945063

Abstract Article PDF–3.0M

Select item 690053918.

Effects of ALS-associated TANK binding kinase 1 mutations on protein–protein interactions and kinase activity

Junqiang Ye, Jonah Cheung, Valeria Gerbino, Göran Ahlsén, Christina Zimanyi, David Hirsh, Tom Maniatis

Proc Natl Acad Sci U S A. 2019 Dec 3; 116(49): 24517–24526. Published online 2019 Nov 20. doi: 10.1073/pnas.1915732116

PMCID:: PMC6900539

Abstract Article PDF–1.4M

Select item 674894119.

TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877

Ricardo J. Antonia, Johnny Castillo, Laura E. Herring, D. Stephen Serafin, Pengda Liu, Lee M. Graves, Albert S. Baldwin, Robert S. Hagan

Sci Rep. 2019; 9: 13470. Published online 2019 Sep 17. doi: 10.1038/s41598-019-49707-8

PMCID:: PMC6748941

Abstract Article PDF–1.6M

Select item 669186220.

Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction

Pamela A McCombe, Shyuan T Ngo, Christine Cong Guo, Amir Fazlollahi, Saskia Bollmann, Liting Wang, Xintao Hu, Markus Barth, Olivier Salvado, Mark Davis, Amelia Ceslis, Gail Robinson, Robert D Henderson, Frederik J Steyn

J Neurol Neurosurg Psychiatry. 2019 Aug; 90(8): 952–954. Published online 2018 Sep 8. doi: 10.1136/jnnp-2018-318823

PMCID:: PMC6691862

Article PDF–1.7M

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