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Items: 1 to 20 of 45

1.
Goblet cell loss abrogates ocular surface immune tolerance
Byung Yi Ko, Yangyan Xiao, Flavia L. Barbosa, Cintia S. de Paiva, Stephen C. Pflugfelder
JCI Insight. 2018 Feb 8; 3(3): e98222. Published online 2018 Feb 8. doi: 10.1172/jci.insight.98222
PMCID:
PMC5821180
AbstractArticlePDF–2.4M
2.
Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation
Priya Rajavelu, Gang Chen, Yan Xu, Joseph A. Kitzmiller, Thomas R. Korfhagen, Jeffrey A. Whitsett
J Clin Invest. 2015 May 1; 125(5): 2021–2031. Published online 2015 Apr 13. doi: 10.1172/JCI79422
PMCID:
PMC4463206
AbstractArticlePDF–3.8M
3.
Requirement of the Epithelium-specific Ets Transcription Factor Spdef for Mucous Gland Cell Function in the Gastric Antrum
David Horst, Xuesong Gu, Manoj Bhasin, Quanli Yang, Michael Verzi, Dongxu Lin, Marie Joseph, Xiaobo Zhang, Wei Chen, Yi-Ping Li, Ramesh A. Shivdasani, Towia A. Libermann
J Biol Chem. 2010 Nov 5; 285(45): 35047–35055. Published online 2010 Aug 26. doi: 10.1074/jbc.M110.164541
PMCID:
PMC2966119
AbstractArticlePDF–3.3M
4.
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function
Elisabeth E. L. Nyström, Beatriz Martinez-Abad, Liisa Arike, George M. H. Birchenough, Eric B. Nonnecke, Patricia A. Castillo, Frida Svensson, Charles L. Bevins, Gunnar C. Hansson, Malin E. V. Johansson
Science. Author manuscript; available in PMC 2021 Oct 25.
Published in final edited form as: Science. 2021 Apr 16; 372(6539): eabb1590. doi: 10.1126/science.abb1590
PMCID:
PMC8542866
AbstractArticlePDF–4.8M
5.
Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice
Gang Chen, Allison S. Volmer, Kristen J. Wilkinson, Yangmei Deng, Lisa C. Jones, Dongfang Yu, Ximena M. Bustamante-Marin, Kimberlie A. Burns, Barbara R. Grubb, Wanda K. O’Neal, Alessandra Livraghi-Butrico, Richard C. Boucher
Am J Respir Cell Mol Biol. 2018 Sep; 59(3): 383–396. doi: 10.1165/rcmb.2017-0127OC
PMCID:
PMC6189647
AbstractArticlePDF–3.7M
6.
Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells
Yangyan Xiao, Cintia S de Paiva, Zhiyuan Yu, Rodrigo G de Souza, De-Quan Li, Stephen C Pflugfelder
Int Immunol. 2018 Oct; 30(10): 457–470. Published online 2018 Jul 12. doi: 10.1093/intimm/dxy045
PMCID:
PMC6153729
AbstractArticlePDF–3.4M
7.
Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine
Boaz E Aronson, Kelly A Stapleton, Laurens ATM Vissers, Eva Stokhuijzen, Hanneke Bruijnzeel, Stephen D Krasinski
BMC Mol Biol. 2014; 15: 3. Published online 2014 Jan 28. doi: 10.1186/1471-2199-15-3
PMCID:
PMC3917371
AbstractArticlePDF–1.6M
8.
Spdef Null Mice Lack Conjunctival Goblet Cells and Provide a Model of Dry Eye
Christina K. Marko, Balaraj B. Menon, Gang Chen, Jeffrey A. Whitsett, Hans Clevers, Ilene K. Gipson
Am J Pathol. 2013 Jul; 183(1): 35–48. doi: 10.1016/j.ajpath.2013.03.017
PMCID:
PMC3702735
AbstractArticlePDF–2.2M
9.
A non-redundant role for mouse Serpinb3a in the induction of mucus production in asthma
Umasundari Sivaprasad, David J. Askew, Mark B. Ericksen, Aaron M. Gibson, Matthew T. Stier, Eric Brandt, Stacey A. Bass, Michael O. Daines, Jamila Chakir, Keith F. Stringer, Susan E. Wert, Jeffrey A. Whitsett, Timothy D. Le Cras, Marsha Wills-Karp, Gary A. Silverman, Gurjit K. Khurana Hershey
J Allergy Clin Immunol. Author manuscript; available in PMC 2012 Jan 1.
Published in final edited form as: J Allergy Clin Immunol. 2011 Jan; 127(1): 254–261.e6. Published online 2010 Dec 3. doi: 10.1016/j.jaci.2010.10.009
PMCID:
PMC3058372
AbstractArticlePDF–3.2M
10.
IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis
Gang Chen, Ling Sun, Takafumi Kato, Kenichi Okuda, Mary B. Martino, Aiman Abzhanova, Jennifer M. Lin, Rodney C. Gilmore, Bethany D. Batson, Yvonne K. O’Neal, Allison S. Volmer, Hong Dang, Yangmei Deng, Scott H. Randell, Brian Button, Alessandra Livraghi-Butrico, Mehmet Kesimer, Carla M.P. Ribeiro, Wanda K. O’Neal, Richard C. Boucher
J Clin Invest. 2019 Oct 1; 129(10): 4433–4450. Published online 2019 Sep 16. doi: 10.1172/JCI125669
PMCID:
PMC6763234
AbstractArticlePDF–32M
11.
SPDEF Functions as a Colorectal Tumor Suppressor by Inhibiting β-Catenin Activity
TAEKO K. NOAH, YUAN–HUNG LO, ALLISON PRICE, GANG CHEN, EILEEN KING, MARY–KAY WASHINGTON, BRUCE J. ARONOW, NOAH F. SHROYER
Gastroenterology. Author manuscript; available in PMC 2014 May 1.
Published in final edited form as: Gastroenterology. 2013 May; 144(5): 1012–1023.e6. Published online 2013 Feb 1. doi: 10.1053/j.gastro.2013.01.043
PMCID:
PMC3738069
AbstractArticlePDF–3.2M
12.
Transcriptional Regulation of p21/CIP1 Cell Cycle Inhibitor by PDEF Controls Cell Proliferation and Mammary Tumor Progression
Jeremy S. Schaefer, Yamini Sabherwal, Heidi Y. Shi, Venkataraman Sriraman, JoAnne Richards, Alex Minella, David P. Turner, Dennis K. Watson, Ming Zhang
J Biol Chem. 2010 Apr 9; 285(15): 11258–11269. Published online 2010 Feb 5. doi: 10.1074/jbc.M109.073932
PMCID:
PMC2857004
AbstractArticlePDF–2.9M
13.
NF-κB determines Paneth versus goblet cell fate decision in the small intestine
Cristina Brischetto, Karsten Krieger, Christian Klotz, Inge Krahn, Séverine Kunz, Marina Kolesnichenko, Patrick Mucka, Julian Heuberger, Claus Scheidereit, Ruth Schmidt-Ullrich
Development. 2021 Nov 1; 148(21): dev199683. Published online 2021 Nov 9. doi: 10.1242/dev.199683
PMCID:
PMC8627599
AbstractArticle
14.
SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive Feedback Loop in Regulation of the Foxm1 Oncogene
Xin-Hua Cheng, Markaisa Black, Vladimir Ustiyan, Tien Le, Logan Fulford, Anusha Sridharan, Mario Medvedovic, Vladimir V. Kalinichenko, Jeffrey A. Whitsett, Tanya V. Kalin
PLoS Genet. 2014 Sep; 10(9): e1004656. Published online 2014 Sep 25. doi: 10.1371/journal.pgen.1004656
PMCID:
PMC4177813
AbstractArticlePDF–6.1M
15.
Mouse Conjunctival Forniceal Gene Expression during Postnatal Development and Its Regulation by Krüppel-like Factor 4
Divya Gupta, Stephen A. K. Harvey, Naftali Kaminski, Shivalingappa K. Swamynathan
Invest Ophthalmol Vis Sci. 2011 Jul; 52(8): 4951–4962. Published online 2011 Jul 1. doi: 10.1167/iovs.10-7068
PMCID:
PMC3176043
AbstractArticlePDF–4.9M
16.
SAM Pointed Domain ETS Factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells
Taeko K. Noah, Avedis Kazanjian, Jeffrey Whitsett, Noah F. Shroyer
Exp Cell Res. Author manuscript; available in PMC 2011 Feb 1.
Published in final edited form as: Exp Cell Res. 2010 Feb 1; 316(3): 452–465. Published online 2009 Sep 26. doi: 10.1016/j.yexcr.2009.09.020
PMCID:
PMC3004755
AbstractArticlePDF–1.8M
17.
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
Gang Chen, Thomas R. Korfhagen, Yan Xu, Joseph Kitzmiller, Susan E. Wert, Yutaka Maeda, Alexander Gregorieff, Hans Clevers, Jeffrey A. Whitsett
J Clin Invest. 2009 Oct 1; 119(10): 2914–2924. Published online 2009 Sep 14. doi: 10.1172/JCI39731
PMCID:
PMC2752084
AbstractArticlePDF–6.6M
18.
SPDEF regulates goblet cell hyperplasia in the airway epithelium
Kwon-Sik Park, Thomas R. Korfhagen, Michael D. Bruno, Joseph A. Kitzmiller, Huajing Wan, Susan E. Wert, Gurjit K. Khurana Hershey, Gang Chen, Jeffrey A. Whitsett
J Clin Invest. 2007 Apr 2; 117(4): 978–988. Published online 2007 Mar 8. doi: 10.1172/JCI29176
PMCID:
PMC1810569
AbstractArticlePDF–1.1M
19.
SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin
Yuan-Hung Lo, Taeko K. Noah, Min-Shan Chen, Winnie Zou, Ester Borras, Eduardo Vilar, Noah F. Shroyer
Gastroenterology. Author manuscript; available in PMC 2020 Jun 16.
Published in final edited form as: Gastroenterology. 2017 Jul; 153(1): 205–218.e8. Published online 2017 Apr 5. doi: 10.1053/j.gastro.2017.03.048
PMCID:
PMC7297058
AbstractArticlePDF–3.5M
20.
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium
François Gerbe, Johan H. van Es, Leila Makrini, Bénédicte Brulin, Georg Mellitzer, Sylvie Robine, Béatrice Romagnolo, Noah F. Shroyer, Jean-François Bourgaux, Christine Pignodel, Hans Clevers, Philippe Jay
J Cell Biol. 2011 Mar 7; 192(5): 767–780. doi: 10.1083/jcb.201010127
PMCID:
PMC3051826
AbstractArticlePDF–4.2M

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