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Select item 89168701.

HCK is a Potential Prognostic Biomarker that Correlates with Immune Cell Infiltration in Acute Myeloid Leukemia

Fang Cheng, Qiang Li, Jinglin Wang, Liu Wang, Weiming Li, Fang Zeng

Dis Markers. 2022; 2022: 3199589. Published online 2022 Mar 4. doi: 10.1155/2022/3199589

PMCID:: PMC8916870

Abstract Article PDF–4.4M

Select item 79464382.

Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative

Manas Pratim Chakraborty, Sudipta Bhattacharyya, Souryadip Roy, Indira Bhattacharya, Rahul Das, Arindam Mukherjee

J Biol Chem. 2021 Jan-Jun; 296: 100449. Published online 2021 Feb 20. doi: 10.1016/j.jbc.2021.100449

PMCID:: PMC7946438

Abstract Article PDF–2.7M

Select item 79329223.

Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma

Hildo C. Lantermans, Marthe Minderman, Annemieke Kuil, Marie-José Kersten, Steven T. Pals, Marcel Spaargaren

Leukemia. 2021; 35(3): 881–886. Published online 2020 Jun 26. doi: 10.1038/s41375-020-0934-6

PMCID:: PMC7932922

Abstract Article PDF–870K

Select item 76453434.

HCK can serve as novel prognostic biomarker and therapeutic target for Breast Cancer patients

Xudong Zhu, Yixiao Zhang, Yang Bai, Xi Gu, Guanglei Chen, Lisha Sun, Yulun Wang, Xinbo Qiao, Qingtian Ma, Tong Zhu, Jiawen Bu, Jinqi Xue, Caigang Liu

Int J Med Sci. 2020; 17(17): 2773–2789. Published online 2020 Sep 30. doi: 10.7150/ijms.43161

PMCID:: PMC7645343

Abstract Article PDF–3.9M

Select item 73014145.

Membrane anchoring of Hck kinase via the intrinsically disordered SH4-U and lengthscale associated with subcellular localization

Matthew P. Pond, Rebecca Eells, Bradley W. Treece, Frank Heinrich, Mathias Lösche, Benoît Roux

J Mol Biol. Author manuscript; available in PMC 2021 Apr 17.

Published in final edited form as: J Mol Biol. 2020 Apr 17; 432(9): 2985–2997. Published online 2019 Dec 23. doi: 10.1016/j.jmb.2019.11.024

PMCID:: PMC7301414

Abstract Article PDF–1.9M

Select item 73002856.

HCK promotes glioblastoma progression by TGFβ signaling

Zhenlin Wang, Chenting Ying, Anke Zhang, Houshi Xu, Yang Jiang, Meiqing Lou

Biosci Rep. 2020 Jun 26; 40(6): BSR20200975. Published online 2020 Jun 17. doi: 10.1042/BSR20200975

PMCID:: PMC7300285

Abstract Article PDF–1.2M

Select item 31961167.

Hck Is a Key Regulator of Gene Expression in Alternatively Activated Human Monocytes

Ashish Bhattacharjee, Srabani Pal, Gerald M. Feldman, Martha K. Cathcart

J Biol Chem. 2011 Oct 21; 286(42): 36709–36723. Published online 2011 Aug 30. doi: 10.1074/jbc.M111.291492

PMCID:: PMC3196116

Abstract Article PDF–3.5M

Select item 29366298.

Multidomain assembled states of Hck tyrosine kinase in solution

Sichun Yang, Lydia Blachowicz, Lee Makowski, Benoît Roux

Proc Natl Acad Sci U S A. 2010 Sep 7; 107(36): 15757–15762. Published online 2010 Aug 23. doi: 10.1073/pnas.1004569107

PMCID:: PMC2936629

Abstract Article PDF–1.3M

Select item 3653519.

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

N Quintrell, R Lebo, H Varmus, J M Bishop, M J Pettenati, M M Le Beau, M O Diaz, J D Rowley

Mol Cell Biol. 1987 Jun; 7(6): 2267–2275. doi: 10.1128/mcb.7.6.2267

PMCID:: PMC365351

Summary Page Browse PDF–1.8M

Select item 822338510.

HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML

Zheng Li, Fangce Wang, Xiaoxue Tian, Jun Long, Bin Ling, Wenjun Zhang, Jun Xu, Aibin Liang

J Exp Clin Cancer Res. 2021; 40: 210. Published online 2021 Jun 24. doi: 10.1186/s13046-021-02007-4

PMCID:: PMC8223385

Abstract Article PDF–7.8M

Select item 610366111.

Suppression of autophagy and HCK signaling promotes PTGS2^high FCGR3⁻ NK cell differentiation triggered by ectopic endometrial stromal cells

Jie Mei, Wen-Jie Zhou, Xiao-Yong Zhu, Han Lu, Ke Wu, Hui-Li Yang, Qiang Fu, Chun-Yan Wei, Kai-Kai Chang, Li-Ping Jin, Jian Wang, Yong-Ming Wang, Da-Jin Li, Ming-Qing Li

Autophagy. 2018; 14(8): 1376–1397. Published online 2018 Jul 20. doi: 10.1080/15548627.2018.1476809

PMCID:: PMC6103661

Abstract Article PDF–5.2M

Select item 583651012.

HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles

J.-H. Lee, C. Ostalecki, Z. Zhao, T. Kesti, H. Bruns, B. Simon, T. Harrer, K. Saksela, A.S. Baur

EBioMedicine. 2018 Feb; 28: 151–161. Published online 2018 Jan 4. doi: 10.1016/j.ebiom.2018.01.004

PMCID:: PMC5836510

Abstract Article PDF–3.1M

Select item 461560313.

Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor

Thomas E. Wales, James M. Hochrein, Christopher R. Morgan, Lori A. Emert-Sedlak, Thomas E. Smithgall, John R. Engen

Biochemistry. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Biochemistry. 2015 Oct 20; 54(41): 6382–6391. Published online 2015 Oct 6. doi: 10.1021/acs.biochem.5b00875

PMCID:: PMC4615603

Abstract Article PDF–2.3M

Select item 419250514.

Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment

John Jeff Alvarado, Sreya Tarafdar, Joanne I. Yeh, Thomas E. Smithgall

J Biol Chem. 2014 Oct 10; 289(41): 28539–28553. Published online 2014 Aug 13. doi: 10.1074/jbc.M114.600031

PMCID:: PMC4192505

Abstract Article PDF–4.2M

Select item 390087715.

Small molecule inhibitors of the HIV-1 virulence factor, Nef

Thomas E. Smithgall, Gary Thomas

Drug Discov Today Technol. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Drug Discov Today Technol. 2013 Dec; 10(4): e451–e548. doi: 10.1016/j.ddtec.2013.07.002

PMCID:: PMC3900877

Abstract Article PDF–1.4M

Select item 385466216.

A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction

Sebastian Breuer, Sheryll Espinola, Xavier Morelli, Bruce E Torbett, Stefan T Arold, Ingo H Engels

Curr Chem Genom Transl Med. 2013; 7: 16–20. Published online 2013 Jul 26. doi: 10.2174/2213988501307010016

PMCID:: PMC3854662

Abstract Article PDF–446K

Select item 379889817.

HIV-1 Infection of T Cells and Macrophages Are Differentially Modulated by Virion-Associated Hck: A Nef-Dependent Phenomenon

Alyssa Cornall, Johnson Mak, Alison Greenway, Gilda Tachedjian

Viruses. 2013 Sep; 5(9): 2235–2252. Published online 2013 Sep 18. doi: 10.3390/v5092235

PMCID:: PMC3798898

Abstract Article PDF–466K

Select item 355901918.

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Anti-retroviral Activity

Lori A. Emert-Sedlak, Purushottam Narute, Sherry T. Shu, Jerrod A. Poe, Haibin Shi, Naveena Yanamala, John Jeff Alvarado, John S. Lazo, Joanne I. Yeh, Paul A. Johnston, Thomas E. Smithgall

Chem Biol. Author manuscript; available in PMC 2014 Jan 24.

Published in final edited form as: Chem Biol. 2013 Jan 24; 20(1): 82–91. doi: 10.1016/j.chembiol.2012.11.005

PMCID:: PMC3559019

Abstract Article PDF–2.7M

Select item 321701619.

The Identification of a Small Molecule Compound That Reduces HIV-1 Nef-Mediated Viral Infectivity Enhancement

Nopporn Chutiwitoonchai, Masateru Hiyoshi, Philip Mwimanzi, Takamasa Ueno, Akio Adachi, Hirotaka Ode, Hironori Sato, Oliver T. Fackler, Seiji Okada, Shinya Suzu

PLoS One. 2011; 6(11): e27696. Published online 2011 Nov 15. doi: 10.1371/journal.pone.0027696