PMC Links for Gene (Select 309434) - PMC

Select item 12229511.

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

Luke A McNeill, Kirsty S Hewitson, Timothy D Claridge, Jürgen F Seibel, Louise E Horsfall, Christopher J Schofield

Biochem J. 2002 Nov 1; 367(Pt 3): 571–575. doi: 10.1042/BJ20021162

PMCID:: PMC1222951

Select item 11337352.

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

David E. Lancaster, Luke A. McNeill, Michael A. McDONOUGH, Robin T. Aplin, Kirsty S. Hewitson, Christopher W. Pugh, Peter J. Ratcliffe, Christopher J. Schofield

Biochem J. 2004 Nov 1; 383(Pt 3): 429–437. Prepublished online 2004 Jul 8. Published online 2004 Oct 26. doi: 10.1042/BJ20040735

PMCID:: PMC1133735

Abstract Article PDF–999K

Select item 41102723.

FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells

Yuichiro Hirose, Zariel I. Johnson, Zachary R. Schoepflin, Dessislava Z. Markova, Kazuhiro Chiba, Yoshiaki Toyama, Irving M. Shapiro, Makarand V. Risbud

J Biol Chem. 2014 Jul 25; 289(30): 20594–20605. Published online 2014 May 27. doi: 10.1074/jbc.M114.565101

PMCID:: PMC4110272

Abstract Article PDF–1.9M

Select item 35698794.

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

Ming Yang, Rasheduzzaman Chowdhury, Wei Ge, Refaat B Hamed, Michael A McDonough, Timothy D W Claridge, Benedikt M Kessler, Matthew E Cockman, Peter J Ratcliffe, Christopher J Schofield

FEBS J. 2011 Apr; 278(7): 1086–1097. Published online 2011 Feb 23. doi: 10.1111/j.1742-4658.2011.08022.x

PMCID:: PMC3569879

Abstract Article PDF–555K

Select item 1863465.

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

David Lando, Daniel J. Peet, Jeffrey J. Gorman, Dean A. Whelan, Murray L. Whitelaw, Richard K. Bruick

Genes Dev. 2002 Jun 15; 16(12): 1466–1471. doi: 10.1101/gad.991402

PMCID:: PMC186346

Abstract Article PDF–261K

Select item 34019126.

HIF1α and HIF2α: sibling rivalry in hypoxic tumor growth and progression

Brian Keith, Randall S. Johnson, M. Celeste Simon

Nat Rev Cancer. Author manuscript; available in PMC 2012 Jul 23.

Published in final edited form as: Nat Rev Cancer. 2011 Dec 15; 12(1): 9–22. Published online 2011 Dec 15. doi: 10.1038/nrc3183

PMCID:: PMC3401912

Abstract Article PDF–1.9M

Select item 30450197.

Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor

Ming Yang, Wei Ge, Rasheduzzaman Chowdhury, Timothy D. W. Claridge, Holger B. Kramer, Bernhard Schmierer, Michael A. McDonough, Lingzhi Gong, Benedikt M. Kessler, Peter J. Ratcliffe, Mathew L. Coleman, Christopher J. Schofield

J Biol Chem. 2011 Mar 4; 286(9): 7648–7660. Published online 2010 Dec 22. doi: 10.1074/jbc.M110.193540

PMCID:: PMC3045019

Abstract Article PDF–4.4M

Select item 27815908.

Mint3 Enhances the Activity of Hypoxia-inducible Factor-1 (HIF-1) in Macrophages by Suppressing the Activity of Factor Inhibiting HIF-1

Takeharu Sakamoto, Motoharu Seiki

J Biol Chem. 2009 Oct 30; 284(44): 30350–30359. Published online 2009 Sep 2. doi: 10.1074/jbc.M109.019216

PMCID:: PMC2781590

Abstract Article PDF–3.1M

Select item 22651169.

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

Xiaofeng Zheng, Sarah Linke, José M. Dias, Xiaowei Zheng, Katarina Gradin, Tristan P. Wallis, Brett R. Hamilton, Maria Gustafsson, Jorge L. Ruas, Sarah Wilkins, Rebecca L. Bilton, Kerstin Brismar, Murray L. Whitelaw, Teresa Pereira, Jeffrey J. Gorman, Johan Ericson, Daniel J. Peet, Urban Lendahl, Lorenz Poellinger

Proc Natl Acad Sci U S A. 2008 Mar 4; 105(9): 3368–3373. Published online 2008 Feb 25. doi: 10.1073/pnas.0711591105

PMCID:: PMC2265116

Abstract Article PDF–1.1M

Select item 157850410.

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Matthew E. Cockman, David E. Lancaster, Ineke P. Stolze, Kirsty S. Hewitson, Michael A. McDonough, Mathew L. Coleman, Charlotte H. Coles, Xiaohong Yu, Ronald T. Hay, Steven C. Ley, Christopher W. Pugh, Neil J. Oldham, Norma Masson, Christopher J. Schofield, Peter J. Ratcliffe

Proc Natl Acad Sci U S A. 2006 Oct 3; 103(40): 14767–14772. Published online 2006 Sep 26. doi: 10.1073/pnas.0606877103