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Select item 101794751.

Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)

Miok Lee, Srijana Upadhyay, Fuada Mariyam, Greg Martin, Amanuel Hailemariam, Kyongbum Lee, Arul Jayaraman, Robert S. Chapkin, Syng-Ook Lee, Stephen Safe

Int J Mol Sci. 2023 May; 24(9): 8152. Published online 2023 May 2. doi: 10.3390/ijms24098152

PMCID:: PMC10179475

Abstract Article PDF–4.0M

Select item 99216672.

Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma

Qiong-Ying Hu, Jie Liu, Xiao-Kun Zhang, Wan-Ting Yang, Yu-Tian Tao, Ce Chen, Ye-He Qian, Jin-Shan Tang, Xin-Sheng Yao, Ying-He Xu, Jing-Hui Wang

Molecules. 2023 Feb; 28(3): 1238. Published online 2023 Jan 28. doi: 10.3390/molecules28031238

PMCID:: PMC9921667

Abstract Article PDF–58M

Select item 97374753.

Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma

Xudan Li, Quancheng Chen, Jie Liu, Shenjin Lai, Minda Zhang, Tidong Zhen, Hongyu Hu, Xiang Gao, Alice S. T. Wong, Jin-Zhang Zeng

Cells. 2022 Dec; 11(23): 3870. Published online 2022 Dec 1. doi: 10.3390/cells11233870

PMCID:: PMC9737475

Abstract Article PDF–4.0M

Select item 95505564.

Nur77通过NF-κB/IL-6信号途径促进胃癌细胞的侵袭与迁移

李蔚, 石永康, 郭玉华, 田声望

Nan Fang Yi Ke Da Xue Xue Bao. 2022 Sep 20; 42(9): 1410–1417. Chinese. doi: 10.12122/j.issn.1673-4254.2022.09.19

PMCID:: PMC9550556

Abstract Article PDF–2.4M

Select item 85494655.

NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

Hongshan Guo, Gabriel Golczer, Ben S. Wittner, Adam Langenbucher, Marcus Zachariah, Taronish D. Dubash, Xin Hong, Valentine Comaills, Risa Burr, Richard Y. Ebright, Elad Horwitz, Joanna A. Vuille, Soroush Hajizadeh, Devon F. Wiley, Brittany A. Reeves, Jia-min Zhang, Kira L. Niederhoffer, Chenyue Lu, Benjamin Wesley, Uyen Ho, Linda T. Nieman, Mehmet Toner, Shobha Vasudevan, Lee Zou, Raul Mostoslavsky, Shyamala Maheswaran, Michael S. Lawrence, Daniel A. Haber

Mol Cell. Author manuscript; available in PMC 2022 Oct 7.

Published in final edited form as: Mol Cell. 2021 Oct 7; 81(19): 4041–4058.e15. doi: 10.1016/j.molcel.2021.09.016

PMCID:: PMC8549465

Abstract Article PDF–2.7M

Select item 83079776.

NR4A1 Regulates Tamoxifen Resistance by Suppressing ERK Signaling in ER-Positive Breast Cancer

Yu Cheon Kim, Clara Yuri Kim, Ji Hoon Oh, Myoung Hee Kim

Cells. 2021 Jul; 10(7): 1633. Published online 2021 Jun 29. doi: 10.3390/cells10071633

PMCID:: PMC8307977

Abstract Article PDF–4.0M

Select item 70948597.

The nuclear receptor NR4A1 is regulated by SUMO modification to induce autophagic cell death

Gabriela Zárraga-Granados, Gabriel Muciño-Hernández, María R. Sánchez-Carbente, Wendy Villamizar-Gálvez, Ana Peñas-Rincón, Cristian Arredondo, María E. Andrés, Christopher Wood, Luis Covarrubias, Susana Castro-Obregón

PLoS One. 2020; 15(3): e0222072. Published online 2020 Mar 25. doi: 10.1371/journal.pone.0222072

PMCID:: PMC7094859

Abstract Article PDF–1.9M

Select item 68255818.

INHIBITION OF NR4A1 PROMOTES ROS ACCUMULATION AND IL-24 – DEPENDENT GROWTH ARREST IN RHABDOMYOSARCOMA

Erik Hedrick, Kumaravel Mohankumar, Alexandra Lacey, Stephen Safe

Mol Cancer Res. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Mol Cancer Res. 2019 Nov; 17(11): 2221–2232. Published online 2019 Aug 28. doi: 10.1158/1541-7786.MCR-19-0408

PMCID:: PMC6825581

Abstract Article PDF–975K

Select item 65845249.

Lnc‐NA inhibits proliferation and metastasis in endometrioid endometrial carcinoma through regulation of NR4A1

Linying Sun, Rongfang Zhou, Jing Dong, Shuang Liu, Yulian Jiao, Laicheng Wang, Shengnan Hu, Pengjuan He, Xiaowen Liu, Xingbo Zhao, Guosheng Jiang, Yueran Zhao

J Cell Mol Med. 2019 Jul; 23(7): 4699–4710. Published online 2019 May 3. doi: 10.1111/jcmm.14345

PMCID:: PMC6584524

Abstract Article PDF–2.2M

Select item 645852010.

Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases

Asoka Banno, Sowmya P. Lakshmi, Aravind T. Reddy, Seong C. Kim, Raju C. Reddy

Am J Pathol. 2019 Mar; 189(3): 482–491. doi: 10.1016/j.ajpath.2018.10.002

PMCID:: PMC6458520

Abstract Article PDF–1.2M

Select item 629466311.

Orphan nuclear receptor TR3/Nur77 differentially regulates the expression of integrins in angiogenesis

Taiyang Ye, Jin Peng, Xin Liu, Shiqiang Hou, Gengming Niu, Yan Li, Huiyan Zeng, Dezheng Zhao

Microvasc Res. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Microvasc Res. 2019 Mar; 122: 22–33. Published online 2018 Nov 1. doi: 10.1016/j.mvr.2018.10.011

PMCID:: PMC6294663

Abstract Article PDF–4.2M

Select item 627559212.

Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein

Agnieszka K. Olejnik-Schmidt, Marcin T. Schmidt, Anna Goździcka-Józefiak

Cell Mol Biol Lett. 2006 Mar; 11(1): 102–108. Published online 2006 Mar 1. doi: 10.2478/s11658-006-0010-x

PMCID:: PMC6275592

Summary PDF–435K

Select item 616222613.

Cytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survival

Karoline Fechter, Julia Feichtinger, Katharina Prochazka, Julia Judith Unterluggauer, Katrin Pansy, Elisabeth Steinbauer, Martin Pichler, Johannes Haybaeck, Andreas Prokesch, Hildegard T. Greinix, Christine Beham-Schmid, Peter Neumeister, Gerhard G. Thallinger, Alexander J. A. Deutsch

Sci Rep. 2018; 8: 14528. Published online 2018 Sep 28. doi: 10.1038/s41598-018-32972-4

PMCID:: PMC6162226

Abstract Article PDF–1.5M

Select item 580268614.

NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells

Yangguang Li, Fangyu Wang, Li Lu, Fen Zhu, Shengjian Huang, Krystle Nomie, Liang Zhang, David T. Yang, Wei Huang, Brad S. Kahl, Stephen Safe, Michael Wang, Lixin Rui

Blood Cancer J. 2017 Dec; 7(12): 632. Published online 2017 Nov 23. doi: 10.1038/s41408-017-0005-z

PMCID:: PMC5802686

Article PDF–866K

Select item 541713015.

The Nuclear Orphan Receptor Nur77 Is a Lipotoxicity Sensor Regulating Glucose-Induced Insulin Secretion in Pancreatic β-Cells

Olivier Briand, Audrey Helleboid-Chapman, Maheul Ploton, Nathalie Hennuyer, Rodolphe Carpentier, François Pattou, Brigitte Vandewalle, Ericka Moerman, Valery Gmyr, Julie Kerr-Conte, Jérôme Eeckhoute, Bart Staels, Philippe Lefebvre

Mol Endocrinol. March 1, 2012; 26(3): 399–413. Published online 2012 Feb 2. doi: 10.1210/me.2011-1317

PMCID:: PMC5417130

Abstract Article

Select item 529019216.

PAX3-FOXO1A expression in rhabdomyosarcoma is driven by the targetable nuclear receptor NR4A1

Alexandra Lacey, Aline Rodrigues-Hoffman, Stephen Safe

Cancer Res. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Cancer Res. 2017 Feb 1; 77(3): 732–741. Published online 2016 Nov 18. doi: 10.1158/0008-5472.CAN-16-1546

PMCID:: PMC5290192

Abstract Article PDF–2.3M

Select item 522497117.

Endogenous Nur77 is a specific indicator of antigen receptor signaling in human T and B cells

Judith F Ashouri, Arthur Weiss

J Immunol. Author manuscript; available in PMC 2018 Jan 15.

Published in final edited form as: J Immunol. 2017 Jan 15; 198(2): 657–668. Published online 2016 Dec 9. doi: 10.4049/jimmunol.1601301

PMCID:: PMC5224971

Abstract Article PDF–2.6M

Select item 515495618.

High Expression of Orphan Nuclear Receptor NR4A1 in a Subset of Ovarian Tumors with Worse Outcome

Evan Delgado, Michelle M. Boisen, Robin Laskey, Rui Chen, Chi Song, Jad Sallit, Zachary A. Yochum, Courtney L. Andersen, Matthew J. Sikora, Jacob Wagner, Stephen Safe, Esther Elishaev, Adrian Lee, Robert P. Edwards, Paul Haluska, George Tseng, Mark Schurdak, Steffi Oesterreich

Gynecol Oncol. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Gynecol Oncol. 2016 May; 141(2): 348–356. Published online 2016 Mar 11. doi: 10.1016/j.ygyno.2016.02.030

PMCID:: PMC5154956

Abstract Article PDF–937K

Select item 505875419.

Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS)

Alexandra Lacey, Erik Hedrick, Xi Li, Ketan Patel, Ravi Doddapaneni, Mandip Singh, Stephen Safe

Oncotarget. 2016 May 24; 7(21): 31257–31269. Published online 2016 Apr 29. doi: 10.18632/oncotarget.9112

PMCID:: PMC5058754

Abstract Article PDF–8.1M

Select item 491556820.

TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles

Lin Xie, Ruifeng Yang, Shujing Liu, Stephen Lyle, George Cotsarelis, Leihong Xiang, Litao Zhang, Bin Li, Miaojian Wan, Xiaowei Xu

Lab Invest. Author manuscript; available in PMC 2016 Jun 21.

Published in final edited form as: Lab Invest. 2016 Jan; 96(1): 81–88. Published online 2015 Nov 2. doi: 10.1038/labinvest.2015.125

PMCID:: PMC4915568

Abstract Article PDF–560K

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