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Select item 40005771.

Conformational Analysis of Oxidized Peptide Fragments of the C-terminal Redox Center in Thioredoxin Reductases by NMR Spectroscopy

Erik L. Ruggles, P. Bruce Deker, Robert J. Hondal

J Pept Sci. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: J Pept Sci. 2014 May; 20(5): 349–360. Published online 2014 Mar 6. doi: 10.1002/psc.2620

PMCID:: PMC4000577

Abstract Article PDF–1.2M

Select item 39571962.

Why Is Mammalian Thioredoxin Reductase 1 So Dependent upon the Use of Selenium?

Adam P. Lothrop, Gregg W. Snider, Erik L. Ruggles, Robert J. Hondal

Biochemistry. 2014 Jan 28; 53(3): 554–565. Published online 2014 Jan 6. doi: 10.1021/bi400651x

PMCID:: PMC3957196

Abstract Article PDF–1.1M

Select item 39314723.

Compensating for the Absence of Selenocysteine in High-Molecular Weight Thioredoxin Reductases: The Electrophilic Activation Hypothesis

Adam P. Lothrop, Gregg W. Snider, Stevenson Flemer, Jr., Erik L. Ruggles, Ronald S. Davidson, Audrey L. Lamb, Robert J. Hondal

Biochemistry. 2014 Feb 4; 53(4): 664–674. Published online 2014 Jan 15. doi: 10.1021/bi4007258

PMCID:: PMC3931472

Abstract Article PDF–1.7M

Select item 36822154.

Selenium in Thioredoxin Reductase: A Mechanistic Perspective

Brian M. Lacey, Brian E. Eckenroth, Stevenson Flemer, Jr, Robert J. Hondal

Biochemistry. Author manuscript; available in PMC 2013 Jun 14.

Published in final edited form as: Biochemistry. 2008 Dec 2; 47(48): 12810–12821. doi: 10.1021/bi800951f

PMCID:: PMC3682215

Abstract Article PDF–1.3M

Select item 62958895.

Gain of function conferred by selenocysteine: catalytic enhancement of one‐electron transfer reactions by thioredoxin reductase

Drew R. Barber, Robert J. Hondal

Protein Sci. 2019 Jan; 28(1): 79–89. Published online 2018 Oct 31. doi: 10.1002/pro.3480

PMCID:: PMC6295889

Abstract Article PDF–1.6M

Select item 55064026.

Mitochondrial thioredoxin reductase 2 is elevated in long‐lived primate as well as rodent species and extends fly mean lifespan

Andrew M. Pickering, Marcus Lehr, Christi M. Gendron, Scott D. Pletcher, Richard A. Miller

Aging Cell. 2017 Aug; 16(4): 683–692. Published online 2017 May 5. doi: 10.1111/acel.12596

PMCID:: PMC5506402

Abstract Article PDF–1.5M

Select item 37607857.

Selenocysteine Confers Resistance to Inactivation by Oxidation in Thioredoxin Reductase: Comparison of Selenium and Sulfur Enzymes

Gregg W. Snider, Erik Ruggles, Nadeem Khan, Robert J. Hondal

Biochemistry. Author manuscript; available in PMC 2014 Aug 13.

Published in final edited form as: Biochemistry. 2013 Aug 13; 52(32): 5472–5481. Published online 2013 Jul 31. doi: 10.1021/bi400462j

PMCID:: PMC3760785

Abstract Article PDF–1.5M

Select item 36872168.

Structural and Biochemical Studies Reveal Differences in the Catalytic Mechanisms of Mammalian and Drosophila melanogaster Thioredoxin Reductases

Brian E. Eckenroth, Mark A. Rould, Robert J. Hondal, Stephen J. Everse

Biochemistry. Author manuscript; available in PMC 2013 Jun 20.

Published in final edited form as: Biochemistry. 2007 Apr 24; 46(16): 4694–4705. Published online 2007 Mar 27. doi: 10.1021/bi602394p

PMCID:: PMC3687216

Abstract Article PDF–2.4M

Select item 36822229.

Investigation of the C-Terminal Redox Center of High M_r Thioredoxin Reductase by Protein Engineering and Semisynthesis

Brian E. Eckenroth, Brian M. Lacey, Adam P. Lothrop, Katharine M. Harris, Robert J. Hondal

Biochemistry. Author manuscript; available in PMC 2013 Jun 14.

Published in final edited form as: Biochemistry. 2007 Aug 21; 46(33): 9472–9483. Published online 2007 Jul 28. doi: 10.1021/bi7004812

PMCID:: PMC3682222

Abstract Article PDF–735K

Select item 169779910.

Oxidative stress mediates tau-induced neurodegeneration in Drosophila

Dora Dias-Santagata, Tudor A. Fulga, Atanu Duttaroy, Mel B. Feany

J Clin Invest. 2007 Jan 2; 117(1): 236–245. Published online 2006 Dec 14. doi: 10.1172/JCI28769

PMCID:: PMC1697799

Abstract Article PDF–730K

Select item 300579811.

MITOCHONDRIAL PEROXIREDOXINS ARE CRITICAL FOR THE MAINTENANCE OF REDOX STATE AND THE SURVIVAL OF ADULT DROSOPHILA

Svetlana N. Radyuk, Igor Rebrin, Vladimir I. Klichko, Barbara H. Sohal, Katarzyna Michalak, Judith Benes, Rajindar S. Sohal, William C. Orr

Free Radic Biol Med. Author manuscript; available in PMC 2011 Dec 15.

Published in final edited form as: Free Radic Biol Med. 2010 Dec 15; 49(12): 1892–1902. Published online 2010 Oct 19. doi: 10.1016/j.freeradbiomed.2010.09.014

PMCID:: PMC3005798

Abstract Article PDF–2.1M

Select item 1013569712.

Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity

Abdelrahman AlOkda, Jeremy M. Van Raamsdonk

Antioxidants (Basel) 2023 Apr; 12(4): 944. Published online 2023 Apr 17. doi: 10.3390/antiox12040944

PMCID:: PMC10135697

Abstract Article PDF–1.3M

Select item 239672213.

Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants

Hongyu Ruan, Chun-Fang Wu

Proc Natl Acad Sci U S A. 2008 May 27; 105(21): 7506–7510. Published online 2008 May 27. doi: 10.1073/pnas.0711127105

PMCID:: PMC2396722

Abstract Article PDF–1.4M

Select item 1046239414.

Germline sex determination regulates sex-specific signaling between germline stem cells and their niche

Pradeep Kumar Bhaskar, Sheryl Southard, Kelly Baxter, Mark Van Doren

Cell Rep. Author manuscript; available in PMC 2023 Aug 28.

Published in final edited form as: Cell Rep. 2022 Apr 5; 39(1): 110620. doi: 10.1016/j.celrep.2022.110620

PMCID:: PMC10462394

Abstract Article PDF–3.0M

Select item 886597415.

Pterostilbene Promotes Mean Lifespan in Both Male and Female Drosophila Melanogaster Modulating Different Proteins in the Two Sexes

Daniela Beghelli, Lorenzo Zallocco, Maria Cristina Barbalace, Simona Paglia, Silvia Strocchi, Ilenia Cirilli, Valeria Marzano, Lorenza Putignani, Giulio Lupidi, Silvana Hrelia, Laura Giusti, Cristina Angeloni

Oxid Med Cell Longev. 2022; 2022: 1744408. Published online 2022 Feb 16. doi: 10.1155/2022/1744408

PMCID:: PMC8865974

Abstract Article PDF–1.5M

Select item 523872416.

Thioredoxin-dependent disulfide bond reduction is required for protamine eviction from sperm chromatin

Alexander V. Emelyanov, Dmitry V. Fyodorov

Genes Dev. 2016 Dec 15; 30(24): 2651–2656. doi: 10.1101/gad.290916.116

PMCID:: PMC5238724

Abstract Article PDF–482K

Select item 1062521117.

A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

Jin-Gu Lee, Yulong Fu, Jun-yi Zhu, Pei Wen, Joyce van de Leemput, Patricio E. Ray, Zhe Han

Cell Biosci. 2023; 13: 199. Published online 2023 Nov 4. doi: 10.1186/s13578-023-01147-8

PMCID:: PMC10625211

Abstract Article PDF–9.6M

Select item 611271718.

Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes

Boryana Petrova, Keke Liu, Caiping Tian, Maiko Kitaoka, Elizaveta Freinkman, Jing Yang, Terry L. Orr-Weaver

Proc Natl Acad Sci U S A. 2018 Aug 21; 115(34): E7978–E7986. Published online 2018 Aug 6. doi: 10.1073/pnas.1807918115

PMCID:: PMC6112717

Abstract Article PDF–4.8M

Select item 449164519.

Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster

Amos O. Abolaji, Jean P. Kamdem, Thiago H. Lugokenski, Ebenezer O. Farombi, Diogo O. Souza, Élgion L. da Silva Loreto, João B.T. Rocha

Redox Biol. 2015 Aug; 5: 328–339. Published online 2015 Jun 4. doi: 10.1016/j.redox.2015.06.001

PMCID:: PMC4491645

Abstract Article PDF–2.4M

Select item 661659920.

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

Gaynor A. Smith, Tzu-Huai Lin, Amy E. Sheehan, Wynand Van der Goes van Naters, Lukas J. Neukomm, Hillary K. Graves, Dana M. Bis-Brewer, Stephan Züchner, Marc R. Freeman

Neuron. 2019 Jul 3; 103(1): 52–65.e6. doi: 10.1016/j.neuron.2019.04.017