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Select item 95082681.

DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity

Bangfu Zhu, Tom Parsons, Christopher Foley, Yeng Shaw, Travis Dunckley, Christopher Hulme, James J. L. Hodge

Sci Rep. 2022; 12: 15847. Published online 2022 Sep 23. doi: 10.1038/s41598-022-19967-y

PMCID:: PMC9508268

Abstract Article PDF–3.6M

Select item 93453152.

DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes

Bangfu Zhu, Tom Parsons, Wenche Stensen, John S. Mjøen Svendsen, Anders Fugelli, James J. L. Hodge

Front Pharmacol. 2022; 13: 881385. Published online 2022 Jul 19. doi: 10.3389/fphar.2022.881385

PMCID:: PMC9345315

Abstract Article PDF–2.3M

Select item 64195733.

Neuronal overexpression of Alzheimer's disease and Down's syndrome associated DYRK1A/minibrain gene alters motor decline, neurodegeneration and synaptic plasticity in Drosophila

Simon A. Lowe, Maria M. Usowicz, James J.L. Hodge

Neurobiol Dis. 2019 May; 125: 107–114. doi: 10.1016/j.nbd.2019.01.017

PMCID:: PMC6419573

Abstract Article

Select item 48600414.

Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis

Kassandra M. Ori-McKenney, Richard J. McKenney, Hector H. Huang, Tun Li, Shan Meltzer, Lily Yeh Jan, Ronald D. Vale, Arun P. Wiita, Yuh Nung Jan

Neuron. Author manuscript; available in PMC 2017 May 4.

Published in final edited form as: Neuron. 2016 May 4; 90(3): 551–563. Published online 2016 Apr 21. doi: 10.1016/j.neuron.2016.03.027

PMCID:: PMC4860041

Abstract Article PDF–2.6M

Select item 108132065.

Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation

Chiara Di Vona, Laura Barba, Roberto Ferrari, Susana de la Luna

Biomolecules. 2024 Jan; 14(1): 31. Published online 2023 Dec 25. doi: 10.3390/biom14010031

PMCID:: PMC10813206

Abstract Article PDF–2.9M

Select item 72999596.

A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay

Kyu-Sun Lee, Miri Choi, Dae-Woo Kwon, Doyoun Kim, Jong-Moon Choi, Ae-Kyeong Kim, Youngwook Ham, Sang-Bae Han, Sungchan Cho, Chong Kun Cheon

Sci Rep. 2020; 10: 9849. Published online 2020 Jun 17. doi: 10.1038/s41598-020-66750-y

PMCID:: PMC7299959

Abstract Article PDF–1.9M

Select item 50079787.

A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

Hyeongki Kim, Kyu-Sun Lee, Ae-Kyeong Kim, Miri Choi, Kwangman Choi, Mingu Kang, Seung-Wook Chi, Min-Sung Lee, Jeong-Soo Lee, So-Young Lee, Woo-Joo Song, Kweon Yu, Sungchan Cho

Dis Model Mech. 2016 Aug 1; 9(8): 839–848. doi: 10.1242/dmm.025668

PMCID:: PMC5007978

Abstract Article

Select item 5537998.

Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I_A channel transcript with homology to vertebrate Na⁺ channel

A. Baumann, I. Krah-Jentgens, R. Müller, F. Müller-Holtkamp, R. Seidel, N. Kecskemethy, J. Casal, A. Ferrus, O. Pongs

EMBO J. 1987 Nov; 6(11): 3419–3429. doi: 10.1002/j.1460-2075.1987.tb02665.x

PMCID:: PMC553799

Summary Page Browse PDF–2.4M

Select item 49953029.

Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools

Junhua Geng, Liping Wang, Joo Yeun Lee, Chun-Kan Chen, Karen T. Chang

J Neurosci. 2016 Aug 24; 36(34): 8882–8894. doi: 10.1523/JNEUROSCI.1470-16.2016

PMCID:: PMC4995302

Abstract Article PDF–2.9M

Select item 269099710.

Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology

Tao Liu, David Sims, Buzz Baum

Genome Biol. 2009; 10(3): R26. Published online 2009 Mar 5. doi: 10.1186/gb-2009-10-3-r26

PMCID:: PMC2690997

Abstract Article PDF–3.3M

Select item 1052967111.

Excess glutamate release triggers subunit-specific homeostatic receptor scaling

Yifu Han, Pragya Goel, Jiawen Chen, Sarah Perry, Nancy Tran, Samantha Nishimura, Manisha Sanjani, Chun Chien, Dion Dickman

Cell Rep. Author manuscript; available in PMC 2023 Sep 27.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112775. Published online 2023 Jul 11. doi: 10.1016/j.celrep.2023.112775

PMCID:: PMC10529671

Abstract Article PDF–2.1M

Select item 379563512.

Drosophila Dyrk2 Plays a Role in the Development of the Visual System

Nathan Luebbering, Mark Charlton-Perkins, Justin P. Kumar, Stephanie M. Rollmann, Tiffany Cook, Vaughn Cleghon

PLoS One. 2013; 8(10): e76775. Published online 2013 Oct 11. doi: 10.1371/journal.pone.0076775

Correction in:: PLoS One. 2014; 9(3): e92344.

PMCID:: PMC3795635

Abstract Article PDF–5.9M

Select item 152501413.

dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX

Ross Kinstrie, Pamela A. Lochhead, Gary Sibbet, Nick Morrice, Vaughn Cleghon

Biochem J. 2006 Aug 15; 398(Pt 1): 45–54. Prepublished online 2006 May 4. Published online 2006 Jul 27. doi: 10.1042/BJ20060159

PMCID:: PMC1525014

Abstract Article PDF–492K

Select item 503587714.

Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua

Liu Yang, Sayantanee Paul, Kenneth G. Trieu, Lucas G. Dent, Francesca Froldi, Marta Forés, Kaitlyn Webster, Kellee R. Siegfried, Shu Kondo, Kieran Harvey, Louise Cheng, Gerardo Jiménez, Stanislav Y. Shvartsman, Alexey Veraksa

Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): 10583–10588. Published online 2016 Sep 6. doi: 10.1073/pnas.1609417113

PMCID:: PMC5035877

Abstract Article PDF–1.7M

Select item 820882415.

All Creatures Great and Small: New Approaches for Understanding Down syndrome Genetics

Anna J. Moyer, Katheleen Gardiner, Roger H. Reeves

Trends Genet. Author manuscript; available in PMC 2021 Jun 16.

Published in final edited form as: Trends Genet. 2021 May; 37(5): 444–459. Published online 2020 Oct 20. doi: 10.1016/j.tig.2020.09.017

PMCID:: PMC8208824

Abstract Article PDF–864K

Select item 418315916.

Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase

Chun-Kan Chen, Catherine Bregere, Jeremy Paluch, Jason Lu, Dion K. Dickman, Karen T. Chang

Nat Commun. Author manuscript; available in PMC 2014 Dec 30.

Published in final edited form as: Nat Commun. 2014; 5: 4246. Published online 2014 Jun 30. doi: 10.1038/ncomms5246

PMCID:: PMC4183159

Abstract Article PDF–1.2M

Select item 849187617.

Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin

Yi-Jheng Peng, Junhua Geng, Ying Wu, Cristian Pinales, Jennifer Langen, Yen-Ching Chang, Christopher Buser, Karen T. Chang

J Cell Biol. 2021 Dec 6; 220(12): e202011028. Published online 2021 Oct 1. doi: 10.1083/jcb.202011028

PMCID:: PMC8491876

Abstract Article PDF–7.6M

Select item 263204118.

Host Glycosaminoglycan Confers Susceptibility to Bacterial Infection in Drosophila melanogaster

Miriam J. Baron, Sandra L. Wong, Kent Nybakken, Vincent J. Carey, Lawrence C. Madoff

Infect Immun. 2009 Feb; 77(2): 860–866. Published online 2008 Dec 1. doi: 10.1128/IAI.00995-08

PMCID:: PMC2632041

Abstract Article PDF–480K

Select item 733264519.

De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay

Lisenka E.L.M. Vissers, Sreehari Kalvakuri, Elke de Boer, Sinje Geuer, Machteld Oud, Inge van Outersterp, Michael Kwint, Melde Witmond, Simone Kersten, Daniel L. Polla, Dilys Weijers, Amber Begtrup, Kirsty McWalter, Anna Ruiz, Elisabeth Gabau, Jenny E.V. Morton, Christopher Griffith, Karin Weiss, Candace Gamble, James Bartley, Hilary J. Vernon, Kendra Brunet, Claudia Ruivenkamp, Sarina G. Kant, Paul Kruszka, Austin Larson, Alexandra Afenjar, Thierry Billette de Villemeur, Kimberly Nugent, the DDD Study, F. Lucy Raymond, Hanka Venselaar, Florence Demurger, Claudia Soler-Alfonso, Dong Li, Elizabeth Bhoj, Ian Hayes, Nina Powell Hamilton, Ayesha Ahmad, Rachel Fisher, Myrthe van den Born, Marjolaine Willems, Arthur Sorlin, Julian Delanne, Sebastien Moutton, Philippe Christophe, Frederic Tran Mau-Them, Antonio Vitobello, Himanshu Goel, Lauren Massingham, Chanika Phornphutkul, Jennifer Schwab, Boris Keren, Perrine Charles, Maaike Vreeburg, Lenika De Simone, George Hoganson, Maria Iascone, Donatella Milani, Lucie Evenepoel, Nicole Revencu, D. Isum Ward, Kaitlyn Burns, Ian Krantz, Sarah E. Raible, Jill R. Murrell, Kathleen Wood, Megan T. Cho, Hans van Bokhoven, Maximilian Muenke, Tjitske Kleefstra, Rolf Bodmer, Arjan P.M. de Brouwer

Am J Hum Genet. 2020 Jul 2; 107(1): 164–172. Published online 2020 Jun 17. doi: 10.1016/j.ajhg.2020.05.017

PMCID:: PMC7332645

Abstract Article PDF–1.0M

Select item 596955120.

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

Lucía Simón-Carrasco, Gerardo Jiménez, Mariano Barbacid, Matthias Drosten

Cell Cycle. 2018; 17(6): 702–711. Published online 2018 May 18. doi: 10.1080/15384101.2018.1450029

PMCID:: PMC5969551

Abstract Article PDF–815K

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