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Select item 60634981.

Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction

Samir R. Nath, Zhigang Yu, Theresa A. Gipson, Gregory B. Marsh, Eriko Yoshidome, Diane M. Robins, Sokol V. Todi, David E. Housman, Andrew P. Lieberman

J Clin Invest. 2018 Aug 1; 128(8): 3630–3641. Published online 2018 Jul 23. doi: 10.1172/JCI99042

PMCID:: PMC6063498

Abstract Article PDF–3.4M

Select item 59335132.

Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

Hrvoje Augustin, Kieran McGourty, Marcus J. Allen, Jennifer Adcott, Chi Tung Wong, Emmanuel Boucrot, Linda Partridge

Neurobiol Aging. 2018 Jun; 66: 149–157. doi: 10.1016/j.neurobiolaging.2018.02.027

PMCID:: PMC5933513

Abstract Article PDF–1.6M

Select item 55970813.

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Hrvoje Augustin, Kieran McGourty, Marcus J. Allen, Sirisha Kudumala Madem, Jennifer Adcott, Fiona Kerr, Chi Tung Wong, Alec Vincent, Tanja Godenschwege, Emmanuel Boucrot, Linda Partridge

PLoS Biol. 2017 Sep; 15(9): e2001655. Published online 2017 Sep 13. doi: 10.1371/journal.pbio.2001655

PMCID:: PMC5597081

Abstract Article PDF–7.3M

Select item 1657114.

Use of RNA Interference and Complementation To Study the Function of the Drosophila and Human 26S Proteasome Subunit S13

Josefin Lundgren, Patrick Masson, Claudio A. Realini, Patrick Young

Mol Cell Biol. 2003 Aug; 23(15): 5320–5330. doi: 10.1128/MCB.23.15.5320-5330.2003

PMCID:: PMC165711

Abstract Article PDF–447K

Select item 97857605.

The Role and Mechanism of Polysaccharides in Anti-Aging

Xinlu Guo, Junjie Luo, Jingyi Qi, Xiya Zhao, Peng An, Yongting Luo, Guisheng Wang

Nutrients. 2022 Dec; 14(24): 5330. Published online 2022 Dec 15. doi: 10.3390/nu14245330

PMCID:: PMC9785760

Abstract Article PDF–478K

Select item 87915016.

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy

Cécile Ribot, Cédric Soler, Aymeric Chartier, Sandy Al Hayek, Rima Naït-Saïdi, Nicolas Barbezier, Olivier Coux, Martine Simonelig

PLoS Genet. 2022 Jan; 18(1): e1010015. Published online 2022 Jan 13. doi: 10.1371/journal.pgen.1010015

PMCID:: PMC8791501

Abstract Article PDF–3.6M

Select item 76737497.

Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline

Liuze Gao, Shuhui Chang, Wenjuan Xia, Xiaolin Wang, Chenwang Zhang, Liping Cheng, Xu Liu, Liang Chen, Qinghua Shi, Juan Huang, Eugene Yujun Xu, Ge Shan

Sci Adv. 2020 Nov; 6(46): eabb7426. Published online 2020 Nov 11. doi: 10.1126/sciadv.abb7426

PMCID:: PMC7673749

Abstract Article PDF–2.1M

Select item 26438018.

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

Ayako Tonoki, Erina Kuranaga, Takeyasu Tomioka, Jun Hamazaki, Shigeo Murata, Keiji Tanaka, Masayuki Miura

Mol Cell Biol. 2009 Feb; 29(4): 1095–1106. Published online 2008 Dec 15. doi: 10.1128/MCB.01227-08

PMCID:: PMC2643801

Abstract Article PDF–3.2M

Select item 57705339.

Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila

Hiroyuki Uechi, Erina Kuranaga, Tomohiro Iriki, Kohei Takano, Shoshiro Hirayama, Masayuki Miura, Jun Hamazaki, Shigeo Murata

Mol Cell Biol. 2018 Feb 1; 38(3): e00195-17. Prepublished online 2017 Nov 6. Published online 2018 Jan 16. doi: 10.1128/MCB.00195-17

PMCID:: PMC5770533

Abstract Article PDF–5.6M

Select item 464963910.

Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase

Andrew M. Hudson, Katelynn M. Mannix, Lynn Cooley

Genetics. 2015 Nov; 201(3): 1117–1131. Published online 2015 Sep 16. doi: 10.1534/genetics.115.181289

PMCID:: PMC4649639

Abstract Article PDF–5.9M

Select item 437372511.

Role of the Deubiquitylating Enzyme DmUsp5 in Coupling Ubiquitin Equilibrium to Development and Apoptosis in Drosophila melanogaster

Levente Kovács, Olga Nagy, Margit Pál, Andor Udvardy, Octavian Popescu, Péter Deák

PLoS One. 2015; 10(3): e0120875. Published online 2015 Mar 25. doi: 10.1371/journal.pone.0120875

PMCID:: PMC4373725

Abstract Article PDF–6.0M

Select item 639570912.

Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster

Nga N. Nguyen, Anil Rana, Camille Goldman, Rhiannon Moore, Justin Tai, Yongchan Hong, Jingyi Shen, David W. Walker, Jae H. Hur

Sci Rep. 2019; 9: 3170. Published online 2019 Feb 28. doi: 10.1038/s41598-019-39508-4

PMCID:: PMC6395709

Abstract Article PDF–2.2M

Select item 667251913.

A Conditional Pan-Neuronal Drosophila Model of Spinocerebellar Ataxia 7 with a Reversible Adult Phenotype Suitable for Identifying Modifier Genes

Morwena Latouche, Christelle Lasbleiz, Elodie Martin, Véronique Monnier, Thomas Debeir, Annick Mouatt-Prigent, Marie-Paule Muriel, Lydie Morel, Merle Ruberg, Alexis Brice, Giovanni Stevanin, Hérvé Tricoire

J Neurosci. 2007 Mar 7; 27(10): 2483–2492. doi: 10.1523/JNEUROSCI.5453-06.2007

PMCID:: PMC6672519

Abstract Article PDF–355K

Select item 673554114.

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy

Eleni N. Tsakiri, Sentiljana Gumeni, Konstantinos Vougas, Diana Pendin, Issidora Papassideri, Andrea Daga, Vassilis Gorgoulis, Gábor Juhász, Luca Scorrano, Ioannis P. Trougakos

Autophagy. 2019; 15(10): 1757–1773. Published online 2019 Apr 19. doi: 10.1080/15548627.2019.1596477

PMCID:: PMC6735541

Abstract Article PDF–7.3M

Select item 405042815.

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

Eleni N. Tsakiri, Gerasimos P. Sykiotis, Issidora S. Papassideri, Vassilis G. Gorgoulis, Dirk Bohmann, Ioannis P. Trougakos

FASEB J. 2013 Jun; 27(6): 2407–2420. doi: 10.1096/fj.12-221408

PMCID:: PMC4050428

Abstract Article

Select item 409670316.

Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

Eleni N. Tsakiri, Gerasimos P. Sykiotis, Issidora S. Papassideri, Evangelos Terpos, Meletios A. Dimopoulos, Vassilis G. Gorgoulis, Dirk Bohmann, Ioannis P. Trougakos

Aging Cell. Author manuscript; available in PMC 2014 Jul 14.

Published in final edited form as: Aging Cell. 2013 Oct; 12(5): 802–813. Published online 2013 Jun 28. doi: 10.1111/acel.12111

PMCID:: PMC4096703

Abstract Article PDF–3.2M

Select item 793687617.

A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

Neta Erez, Lena Israitel, Eliya Bitman-Lotan, Wing H Wong, Gal Raz, Dayanne V Cornelio-Parra, Salwa Danial, Na'ama Flint Brodsly, Elena Belova, Oksana Maksimenko, Pavel Georgiev, Todd Druley, Ryan D Mohan, Amir Orian

eLife. 2021; 10: e62312. Published online 2021 Feb 25. doi: 10.7554/eLife.62312

PMCID:: PMC7936876

Abstract Article PDF–11M

Select item 573658518.

Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events

Eleni N. Tsakiri, Evangelos Terpos, Eleni-Dimitra Papanagnou, Efstathios Kastritis, Vincent Brieudes, Maria Halabalaki, Tina Bagratuni, Bogdan I. Florea, Herman S. Overkleeft, Luca Scorrano, Alexios-Leandros Skaltsounis, Meletios A. Dimopoulos, Ioannis P. Trougakos

Sci Rep. 2017; 7: 17802. Published online 2017 Dec 19. doi: 10.1038/s41598-017-17596-4

PMCID:: PMC5736585

Abstract Article PDF–3.0M

Select item 561592319.

A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance

Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge

Mol Syst Biol. 2017 Sep; 13(9): 939. Published online 2017 Sep 15. doi: 10.15252/msb.20177663